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ES2061848T3 - Compuestos triciclos, procedimientos para su preparacion y composiciones farmaceuticas que los comprenden. - Google Patents

Compuestos triciclos, procedimientos para su preparacion y composiciones farmaceuticas que los comprenden.

Info

Publication number
ES2061848T3
ES2061848T3 ES89116504T ES89116504T ES2061848T3 ES 2061848 T3 ES2061848 T3 ES 2061848T3 ES 89116504 T ES89116504 T ES 89116504T ES 89116504 T ES89116504 T ES 89116504T ES 2061848 T3 ES2061848 T3 ES 2061848T3
Authority
ES
Spain
Prior art keywords
preparation
pharmaceutical compositions
procedures
reduced
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89116504T
Other languages
English (en)
Inventor
Yoshinari Sato
Teruaki Matuo
Takatomo Ogahara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB888821257A external-priority patent/GB8821257D0/en
Priority claimed from GB888829265A external-priority patent/GB8829265D0/en
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2061848T3 publication Critical patent/ES2061848T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Nutrition Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

UN COMPONENTE DE LA FORMULA: EN DONDE R1 ES ARIL QUE DEBE TENER CONVENIENTE(S) SUSTITUYENTE(S), X ES -O- O (EN EL QUE R3 ES HIDROGENO O ALQUILICO REBAJADO), A ES UN ENLACE O ALQUILENO REBAJADO QUE DEBE TENER GRUPO(S) ALQUILICO(S) REBAJADO(S), Y R2 ES HIDROGENO O UN GRUPO ACIL, Y UNA SAL DE ELLO ACEPTABLE FARMACEUTICAMENTE, PROCESO PARA SU PREPARACION Y COMPOSICIONES FARMACEUTICAS QUE LOS COMPRENDEN COMO UN INGREDIENTE ACTIVO EN MEZCLA CON PORTADORES ACEPTABLES FARMACEUTICAMENTE.
ES89116504T 1988-09-09 1989-09-07 Compuestos triciclos, procedimientos para su preparacion y composiciones farmaceuticas que los comprenden. Expired - Lifetime ES2061848T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB888821257A GB8821257D0 (en) 1988-09-09 1988-09-09 Tricyclic compounds
GB888829265A GB8829265D0 (en) 1988-12-15 1988-12-15 Tricyclic compounds

Publications (1)

Publication Number Publication Date
ES2061848T3 true ES2061848T3 (es) 1994-12-16

Family

ID=26294376

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89116504T Expired - Lifetime ES2061848T3 (es) 1988-09-09 1989-09-07 Compuestos triciclos, procedimientos para su preparacion y composiciones farmaceuticas que los comprenden.

Country Status (18)

Country Link
US (2) US4981847A (es)
EP (1) EP0360079B1 (es)
JP (3) JPH0665673B2 (es)
KR (1) KR900004737A (es)
CN (1) CN1022187C (es)
AU (1) AU628370B2 (es)
DE (1) DE68912858T2 (es)
DK (1) DK444789A (es)
ES (1) ES2061848T3 (es)
FI (1) FI92401C (es)
HK (1) HK101996A (es)
HU (2) HUT54152A (es)
IE (1) IE62916B1 (es)
IL (1) IL91361A (es)
NO (1) NO171913C (es)
PH (1) PH27358A (es)
PT (1) PT91664B (es)
RU (1) RU2007406C1 (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2630440B1 (fr) * 1988-04-25 1991-09-20 Jouveinal Sa Benzodiazepines, leur procede et intermediaires de preparation et leurs applications en therapeutique
US5248679A (en) * 1988-09-09 1993-09-28 Fujisawa Pharmaceutical Co., Ltd. Tricyclic compounds
IL91361A (en) * 1988-09-09 1994-10-07 Fujisawa Pharmaceutical Co Benzodiazepinone compounds [4,1] connected via positions 1 and 9 and carrying two transducers, processes for their preparation and pharmaceutical preparations containing them
IL93401A (en) * 1989-03-08 1994-08-26 Kali Chemie Pharma Gmbh H1 - Indole - 2 - Carboxylic acid 1, 7 - Consolidated N -) 1, 4 - Benzodiazepine - 3 - Il (amides, their preparation and drugs containing them
FR2652352A1 (fr) * 1989-09-28 1991-03-29 Jouveinal Sa Benzodiazepines, leur procede et intermediaires de preparation et leurs applications en therapeutique.
GB9018601D0 (en) * 1990-08-24 1990-10-10 Fujisawa Pharmaceutical Co Tricyclic compounds
CA2056809A1 (en) * 1990-12-07 1992-06-08 Mark G. Bock Benzodiazepine analogs
EP0572235A3 (en) * 1992-05-28 1994-06-01 Tanabe Seiyaku Co Beta-carboline derivatives with anticholecystoquinine activity
GB2271354A (en) * 1992-10-07 1994-04-13 Merck Sharp & Dohme Tricyclic derivatives of benzodiazepines
CA2157383A1 (en) * 1993-03-03 1994-09-15 Shinichi Fukuyama Optical isomerization inhibitor
EP0731091B1 (en) * 1993-11-26 2002-01-02 Tanabe Seiyaku Co., Ltd. 2-oxoindoline derivatives as cholecystokinin receptor antagonists
US5763437A (en) * 1994-07-29 1998-06-09 Fujisawa Pharmaceutical Co., Ltd. Benzodiazepine derivatives
IL115089A0 (en) * 1994-08-30 1995-12-08 Fujisawa Pharmaceutical Co A liposome preparation containing a tricyclic compound and process for the preparation thereof
FR2725719B1 (fr) * 1994-10-14 1996-12-06 Jouveinal Inst Rech Diazepino-indoles inhibiteurs de phosphodiesterases iv
US5716958A (en) 1994-10-27 1998-02-10 Tobishi Pharmaceutical Co., Ltd. Amino acid derivative having anti-CCK activity
AUPO284396A0 (en) 1996-10-08 1996-10-31 Fujisawa Pharmaceutical Co., Ltd. Benzodiazepine derivatives
FR2776660B1 (fr) * 1998-03-27 2000-05-12 Parke Davis Diazepino-indoles de phosphodiesterases iv
JP2015531792A (ja) 2012-09-21 2015-11-05 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ １，４−ベンゾジアゼピノン化合物のプロドラッグ
JP2015529250A (ja) 2012-09-21 2015-10-05 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ フルオロアルキルジベンゾジアゼピノン化合物
US9427442B2 (en) 2012-09-21 2016-08-30 Bristol-Myers Squibb Company Fluoroalkyl and fluorocycloalkyl 1,4-benzodiazepinone compounds
JP2015534553A (ja) 2012-09-21 2015-12-03 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ 置換１，５−ベンゾジアゼピノン化合物
EP2897954B1 (en) 2012-09-21 2016-10-26 Bristol-Myers Squibb Company Fluoroalkyl-1,4-benzodiazepinone compounds
US9242941B2 (en) 2012-09-21 2016-01-26 Bristol-Myers Squibb Company Alkyl, fluoroalkyl-1,4-benzodiazepinone compounds
JP2015533811A (ja) 2012-09-21 2015-11-26 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Ｎ−置換ビス（フルオロアルキル）１，４−ベンゾジアゼピノン化合物
WO2014047390A1 (en) * 2012-09-21 2014-03-27 Bristol-Myers Squibb Company Tricyclic heterocyclic compounds as notch inhibitors
CN105101968A (zh) 2013-04-04 2015-11-25 百时美施贵宝公司 治疗增殖性疾病的组合疗法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3651083A (en) * 1969-11-03 1972-03-21 Upjohn Co Tetra- and hexahydro-phenylpyrrolo benzodiazepines and intermediates
US3794646A (en) * 1970-04-14 1974-02-26 Robins Co Inc A H 5,7-disubstituted-1,9-tetramethylene-1,4-benzodiazepin-2-ones
AU2733371A (en) * 1970-04-14 1972-10-12 A. H. Robins Company, Incorporated 5, 7-DISUBSTITUTED-l, 9-ALKYLENE-l, 4-BENZODIAZEPIN-2 ONES
CA1332410C (en) * 1984-06-26 1994-10-11 Roger M. Freidinger Benzodiazepine analogs
US4735941A (en) * 1986-12-23 1988-04-05 Merck & Co., Inc. 1,4-benzodiazepines with 5- and 6-membered heterocyclic rings, useful as gastrointestinal and CNS agents
FR2630440B1 (fr) * 1988-04-25 1991-09-20 Jouveinal Sa Benzodiazepines, leur procede et intermediaires de preparation et leurs applications en therapeutique
IL91361A (en) * 1988-09-09 1994-10-07 Fujisawa Pharmaceutical Co Benzodiazepinone compounds [4,1] connected via positions 1 and 9 and carrying two transducers, processes for their preparation and pharmaceutical preparations containing them

Also Published As

Publication number Publication date
EP0360079A1 (en) 1990-03-28
FI894169A (fi) 1990-03-10
PT91664B (pt) 1995-05-31
AU4025789A (en) 1990-03-15
US5155101A (en) 1992-10-13
JP2848230B2 (ja) 1999-01-20
EP0360079B1 (en) 1994-02-02
DK444789D0 (da) 1989-09-08
PT91664A (pt) 1990-03-30
IE62916B1 (en) 1995-03-08
NO171913C (no) 1993-05-19
DE68912858T2 (de) 1994-06-01
CN1022187C (zh) 1993-09-22
AU628370B2 (en) 1992-09-17
JPH0665673B2 (ja) 1994-08-24
FI894169A0 (fi) 1989-09-05
FI92401C (fi) 1994-11-10
HU211264A9 (en) 1995-11-28
IL91361A0 (en) 1990-03-19
CN1040981A (zh) 1990-04-04
KR900004737A (ko) 1990-04-12
NO893616D0 (no) 1989-09-08
US4981847A (en) 1991-01-01
RU2007406C1 (ru) 1994-02-15
HK101996A (en) 1996-06-21
IE892840L (en) 1990-03-09
HUT54152A (en) 1991-01-28
DK444789A (da) 1990-03-10
DE68912858D1 (de) 1994-03-17
PH27358A (en) 1993-06-21
JPH02111774A (ja) 1990-04-24
FI92401B (fi) 1994-07-29
NO171913B (no) 1993-02-08
JPH0741480A (ja) 1995-02-10
NO893616L (no) 1990-03-12
IL91361A (en) 1994-10-07
JPH0748373A (ja) 1995-02-21

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