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EP1054676A1 - Preparation combinee d'oestrogene et d'anti-oestrogene - Google Patents

Preparation combinee d'oestrogene et d'anti-oestrogene

Info

Publication number
EP1054676A1
EP1054676A1 EP99908916A EP99908916A EP1054676A1 EP 1054676 A1 EP1054676 A1 EP 1054676A1 EP 99908916 A EP99908916 A EP 99908916A EP 99908916 A EP99908916 A EP 99908916A EP 1054676 A1 EP1054676 A1 EP 1054676A1
Authority
EP
European Patent Office
Prior art keywords
fluoro
radical
estra
triene
estrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99908916A
Other languages
German (de)
English (en)
Inventor
Rudolf Knauthe
Christa Hegele-Hartung
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of EP1054676A1 publication Critical patent/EP1054676A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens

Definitions

  • the invention relates to a combination preparation of an estrogen and an anti-estrogen.
  • the aim of hormone replacement therapy is to replace the loss of endogenous estrogens that begins with menopause and thus to prevent both acute and long-term symptoms.
  • Today the therapy is carried out either as estrogen-only therapy or as combination therapy with progestogens.
  • a disadvantage of monotherapy is the proliferative effect of estrogen on the endometrium, which can lead to endometrial hyperplasia and adenocarcinomas.
  • In combination therapy there is a stopping bleeding or intermenstrual bleeding, which significantly limits the acceptance of the therapy and often leads to the therapy being stopped.
  • negative effects of progestogens on the cardioprotective and positive central effects of estrogens are discussed.
  • Another option for hormone replacement is the combination of an estrogen with an anti-estrogen.
  • the protective effects of estrogen on the bone are to be retained, while the undesirable effects on the endometrium are antagonized (EP0346014).
  • EP0346014 antagonized
  • the anti-estrogen gets into the central nervous system and antagonizes the positive properties of the estrogen there.
  • tamoxifen is reported to cause typical acute menopausal symptoms such as hot flashes (S. Litherland, M. Jackson, 1987, Cancer Treat Revs. 15, 183). It could be shown that the substance gets into the central nervous system and acts there as an estrogenic antagonist (A. Biegon et al., 1996, Cancer Research 56, 4328).
  • the anti-estrogen counteracts the protective effect of the estrogen in Alzheimer's disease.
  • the technical problem now is to find a combination preparation of an estrogen and an anti-estrogen in which the anti-estrogen component does not get into the central nervous system and at the same time has an antiproliferative effect on the endometrium.
  • n is 0, 1 or 2
  • x 0, 1 or 2
  • A is a hydrogen atom or a C 5 alkyl group
  • B and D each represent a hydrogen atom
  • E is an unsubstituted or mono- to pentafly fluorinated ethyl radical, or the terminal substituent - (CH2) 3-E in the side chain by an optionally substituted aryl or heteroaryl radical which is attached to the sulfur atom directly or via a mono-, di- or trimethylene group is bound, replaced,
  • R ⁇ is a hydrogen atom, a hydrocarbon radical having up to 8 carbon atoms or a radical of the partial formula R ⁇ '- C (O) -, wherein R ⁇ ' is a hydrogen atom or a
  • RU is a hydrogen atom, a halogen atom or a nitrooxy group - O-NO2,
  • R 14, R 15 ⁇ , R 15 Q, R 16 ⁇ and R 16 ß each a hydrogen atom or
  • R15CC un ( j Rl5ß each a methyl group, or
  • Rl6 ⁇ unf j Rl6ß together are a methylidene group and the other of the substituents R 14, R 15 ⁇ , R 15 Q, R 16 ⁇ and R 16 are each a ß
  • Rl7 'in the ⁇ - or ß-position is a hydrogen atom, a C ⁇ _5-alkyl, C2-5-alkenyl or C2-5-alkynyl group or a trifluoromethyl group and
  • RI 7 " is a hydrogen atom or a radical of the partial formula R ⁇ 7 '" - C (O) -, wherein R1 7 "' is a hydrogen atom or a hydrocarbon radical having up to 8
  • Ethano bridge means that, unless A and B together represent - (CH2) - or A and D together represent - (CH2) q-, at least one of the substituents R ⁇ , R ⁇ 4 , R ⁇ a ,
  • R 15 ß, R 16 ⁇ and R 16 ß is not a hydrogen atom, and their physiologically tolerable addition salts with organic and inorganic acids.
  • a combination preparation in which the estrogen from the group consisting of 17- ⁇ -estradiol, 17- ⁇ -ethynyl estradiol, estriol, estrone, estrone sulfate, estrogen sulfamate, 17 ⁇ -estradiol, mestranol, stilbestrol, esters of 17ß-estradiol, such as eg estradiol valerate and natural conjugated estrogens is selected and the anti-estrogen is a llß-halogen-7 ⁇ -substituted ostratriene of the general formula II
  • R3 is a hydrogen atom, a hydrocarbon radical having up to 8 carbon atoms or a radical of the partial formula R ⁇ '- C (O) -, where R- *' is a hydrogen atom or a hydrocarbon radical having up to 8 carbon atoms or a phenyl radical,
  • R 7 represents a radical of the formula -ABZR 20 , wherein
  • B represents a straight or branched chain alkylene, alkenylene or alkynylene group having 3 to 14 carbon atoms
  • Z represents -NR 21 - and R 21 represents a C 1 -C 3 -alkyl group, where R 20 is a hydrogen atom, 5 is a straight or branched chain alkyl, alkenyl or alkynyl group with up to 10 carbon atoms, or one of the groupings -DC n F 2n + 1 , where D is a straight or branched chain alkylene, alkenylene or alkynylene group with up to 8 carbon atoms and n is an integer from 1 to 8,
  • -L-CH CF-C p F 2p + ⁇
  • L is a straight or branched chain alkylene, alkenylene or alkynylene group with 2 to 7 carbon atoms and p is an integer from 2 to 7, -DO- (CH2) q
  • D has the meaning already given, q is 0, 1, 2 or 3 and aryl is an optionally mono- or disubstituted phenyl, 1- or 2-naphthyl or a heteroaryl radical, -DO- (CH2 ) r -C n F2 n + ⁇ , where D and n have the meanings already given and r is an integer from 1 to 5, or
  • R 20 and R 21 with the nitrogen atom to which they are attached form a saturated or unsaturated heterocycle with 5 or 6 chain links, which optionally contains one or two further heteroatoms selected from nitrogen, oxygen and sulfur and is optionally substituted, or
  • Z is -SO x - and x is 0, 1 or 2, where R 20 is then a straight or branched chain alkyl, alkenyl or alkynyl group having up to 10 carbon atoms, or one of the groupings
  • Alkenylene or alkynylene group with up to 8 carbon atoms and n is an integer from 1 to 8, -L-CH CF-C p F 2p + 1 , where L is a straight-chain or branched-chain alkylene,
  • R ⁇ O is a straight-chain or branched-chain alkyl, alkenyl or alkynyl radical having up to 14 carbon atoms, which has one to three heteroatoms -O- and -S- and groupings -NR 32 -, in which R 32 is a hydrogen atom or a C 1 -C 3 -alkyl radical, can be interrupted and / or partially fluorinated, an optionally mono- or disubstituted aryl or heteroaryl radical, an optionally mono- or disubstituted C 3 -C 10 - Cycloalkyl radical, an optionally mono- or disubstituted C 4 -C 15 cycloalkylalkyl radical, an optionally mono- or disubstituted C 7 -C 20 aralkyl radical, an optionally mono- or disubstituted heteroaryl-C 1-4 alkyl radical or an optionally substituted one Amino
  • R 31 is a radical of the formula -C (O) R 33 or -CH 2 -R 33 , in which case R 33 is a straight-chain or branched-chain alkyl, alkenyl or alkynyl radical having up to 14 carbon atoms, through one to three
  • Heteroatoms -O- and -S- and groupings -NR 32 -, in which R 32 is a hydrogen atom or a Cj-C ⁇ -alkylene radical, can be interrupted and / or partially fluorinated, an optionally mono- or disubstituted aryl or heteroaryl radical, an optionally mono- or disubstituted C 3 -C 10 cycloalkyl radical, an optionally mono- or disubstituted C 4 -C 15 cycloalkylalkyl radical, an optionally mono- or disubstituted C 7 -C 20 aralkyl radical, an optionally mono- or doubly substituted heteroaryl-C 1 -C 6 -alkyl radical, an optionally substituted aminoalkyl radical or a biphenylene radical, with the exception of the compounds 11 ⁇ -fluoro-7 ⁇ - ⁇ 5- [N-methyl-N-3- (4, 4,5,5 , 5-pentafluo ⁇ entyl
  • R 11 is a fluorine or chlorine atom
  • R 7 is a hydrogen atom or a radical of the partial formula R 17 '- C (O) -, wherein R ⁇ 7 ' is a hydrogen atom or a hydrocarbon radical having up to 8 carbon atoms.
  • combination preparation it is meant that the estrogen and the anti-estrogen are provided in the same application form or in different application forms in a pharmaceutical package and are used either simultaneously or in succession.
  • Anti-estrogen means a substance that has little or no estrogenic activity, binds to the estrogen receptor and prevents the effects of estrogen.
  • An anti-estrogen counteracts the increase in uterine weight and / or the increase in uterine epithelial height in castrated female rats or mice that have been substituted with ostradiol benzoate. The sole treatment of castrated rats with the anti-estrogen does not stimulate (increase) the uterine weight or the height of the epithelium compared to untreated animals.
  • the compounds of general formula I and II have a very strong anti-estrogenic effect and do not get into the central nervous system. Therefore, they are particularly suitable to be combined with an estrogen, since they do not inhibit the positive properties of estrogen in the brain.
  • the ratio of the dose of estrogen to the dose of anti-estrogen is 1: 5 to 1: 100, preferably 1:20 to 1: 200, most preferably 1:50 to 1: 100.
  • Preferred is the combination of an estrogen with the anti-estrogen IIß-fluorine -7 ⁇ - ⁇ 5- [N-methyl-N-3- (4,4,5,5,5-pentafluorpentylthio) propylamino] pentyl ⁇ estra-l, 3,5 (10) -triene-3, 17ß-diol.
  • an estrogen with an anti-estrogen selected from the group consisting of 1 lß-fluoro-7 ⁇ ⁇ 5- [methyl- (8, 8,9,9, 9-pentafluoro-nonyl) amino] pentyl ⁇ estra-l, 3,5 (10) -triene-3,17ß-diol llß-fluoro-7 ⁇ - ⁇ 6- [methyl- (8,8,9,9,9-pentafluoro-nonyl) amino] - hexyl ⁇ - estra, 1, 3.5 (10) -triene-3, 17 ⁇ -diol
  • the anti-estrogen can be administered orally, transdermally, as an implant or intravenously.
  • the estrogen can be administered orally, transdermally, intravenously or as an implant. All possible combinations of the application forms for estrogen and anti-estrogen are possible.
  • the invention relates to the use of the combination preparation according to the invention for the manufacture of a medicament for male and female hormone replacement therapy.
  • arteriosclerosis the prevention of bone mass loss in hysterectomized women or women treated with LHRH agonists or antagonists, the treatment of endometriosis and fibroids in combination with LHRH analogues and the inhibition of the proliferation of arterial smooth muscle cells.
  • the invention further relates to pharmaceutical compositions or compositions which optionally contain the combination preparation according to the invention together with the formulations and additives customary in pharmacy.
  • 1 control (solvent only)
  • 2 0.3 ⁇ g ostradiol
  • 3 75 ⁇ g test substance
  • 4 75 ⁇ g test substance + 0.03 ⁇ g ostradiol
  • 5 75 ⁇ g test substance + 0.1 ⁇ g ostradiol
  • 6 75 ⁇ g test substance + 0.3 ⁇ g ostradiol
  • 7 75 ⁇ g test substance + 1.0 ⁇ g ostradiol
  • 8 75 ⁇ g test substance + 3.0 ⁇ g ostradiol.
  • 1 control (solvent only)
  • 2 0.3 ⁇ g ostradiol
  • 3 75 ⁇ g test substance
  • 4 75 ⁇ g test substance + 0.03 ⁇ g ostradiol
  • 5 75 ⁇ g test substance + 0.1 ⁇ g ostradiol
  • 6 75 ⁇ g test substance + 0.3 ⁇ g ostradiol
  • 7 75 ⁇ g test substance + 1.0 ⁇ g ostradiol
  • 8 75 ⁇ g test substance + 3.0 ⁇ g ostradiol.
  • 1 control (solvent only)
  • 2 0.3 ⁇ g ostradiol
  • 3 75 ⁇ g test substance
  • 4 75 ⁇ g test substance + 0.03 ⁇ g ostradiol
  • 5 75 ⁇ g test substance + 0.1 ⁇ g ostradiol
  • 6 75 ⁇ g test substance + 0.3 ⁇ g ostradiol
  • 7 75 ⁇ g test substance + 1.0 ⁇ g ostradiol
  • 8 75 ⁇ g test substance + 3.0 ⁇ g ostradiol.
  • Figure 4 shows that llß-fluoro-7 ⁇ - ⁇ 5- [N-methyl-N-3- (4,4,5,5,5-pentafluoropentylthio) propylamino] pentyl ⁇ estra-1,3,5 (10) -triene-3, 17ß-diol did not get into the central nervous system.
  • Example 1 Synthesis of 11 ⁇ -fluoro-7 ⁇ - ⁇ 5- [N-methyl-N-3- (4,4,5,5,5-pentafluoropentylthio) propylamino] pentyl ⁇ estra-1,3,5 (10) -triene-3,17ß-diol
  • the solution is diluted with ethyl acetate, washed with saturated sodium chloride solution, dried and concentrated in vacuo.
  • the crude product is chromatographed on silica gel using a hexane-ethyl acetate gradient.
  • Example 2 Effect of the combination preparation on the uterus and bones
  • the dosages of estrogen and anti-estrogen to be used for the test for selective bone action must be determined in advance in preliminary examinations.
  • the dose of anti-estrogen to be used is determined by an anti-uterine growth test in the oestradiol-substituted, ovariectomized rat.
  • the dose to be selected should lower the uterine weight to the level of untreated, ovariectomized, female rats.
  • the estrogen dose is determined by the uterine growth test in the ovariectomized female rat.
  • the dose that is used in this model to stimulate the uterine weight is found in intact control animals.
  • the anti-estrogen is administered in the dose defined above.
  • the estrogen is administered in various combinations with the anti-estrogen in a 10 times smaller to 100 times larger dose, as was found in the uterine growth test for the respective estrogen.
  • the animals are sacrificed and the uterine weight and trabecular bone density in the proximal tibia are measured.
  • the uterine weight is determined by weighing the uterine wet weight immediately after organ removal.
  • the trabecular bone density is determined ex vivo by measuring the bone density in the secondary cancellous bone of the proximal tibia with a QCT (Stratec XCT 960A).
  • FIG. 1-3 A typical example of a selectively effective combination of an estrogen with an anti-estrogen is shown in Figures 1-3 for the active ingredients 17-ß estradiol and 1 lß-fluoro-7 ⁇ - ⁇ 5- [N-methyl-N-3- (4,4 , 5,5,5-pentafluo ⁇ entylthio) - propylamino] -pentyl ⁇ -estra-l, 3,5 (10) -triene-3,17ß-diol (substance from Example 1).
  • Example 3 Evidence that the anti-estrogen does not get into the central nervous system
  • mice Female rats (approx. 180 g) are treated once with 1 mg / kg of the 1 C-labeled test substance (2 MBq / kg). The test substance is dissolved in propylene glycol / water and administered intravenously. 0.5 and 3.0 hours after application, one test animal is sacrificed and sagittal whole body sections are made. The tissue distribution is determined by whole body autoradiography. A typical example is shown in Figure 4 for llß-fluoro-7 ⁇ - ⁇ 5- [N-methyl-N-3- (4,4,5,5,5-pentafluo ⁇ entylthio) propylamino] pentyl ⁇ estra-l, 3,5 (10) -triene-3,17ß-diol (substance from Example 1) shown.
  • a solution of 2 g of 7 ⁇ - (5-bromopentyl) -llß-fluoro-estra-l, 3,5 (10) -triene-3,17ß-diol in 20 ml of dimethylformamide is mixed with 8 ml of a 40% aqueous methylamine solution 3 , Stirred at 80 ° C for 5 hours. Then it is poured onto water, extracted three times with ethyl acetate, washed with water and brine, dried over sodium sulfate and evaporated down i. constricted.
  • a solution of 28 g of the crude 5-bromo-1-pentanol in 144 ml of tetrahydrofuran is mixed with 24 g of imidazole.
  • a solution of 30.3 g of tert-butyldimethylchlorosilane in 46 ml of tetrahydrofuran is then added dropwise and the mixture is stirred at room temperature for 4 hours.
  • the reaction mixture is poured into water, shaken out with diethyl ether, the organic phase is washed 4 times with water, dried over sodium sulfate and concentrated.
  • the crude product is chromatographed on silica gel with hexane / diethyl ether. 42 g of the title compound are obtained as a colorless liquid.
  • Nitrogen was initially added to 20% of a solution of 39 ml of l-bromo-5-chlorotentane in 300 ml of THF. After the start of the reaction, which can be achieved by adding iodine and dibromomethane, the remaining solution is added dropwise so that the internal temperature does not exceed 35 ° C.
  • 51.2 g of lithium bromide are added to a suspension of 28.1 g of copper (I) iodide in 130 ml of THF at 0 ° C., the internal temperature rising to 40 ° C.
  • the mixture is stirred in the cold for 30 minutes, then 34.7 ml of glacial acetic acid are added dropwise, the cooling bath is removed and the mixture is stirred at room temperature for 1 hour.
  • the reaction mixture is added to 1.51 of water, diluted with the same amount of ethyl acetate, the precipitate is separated off on Celite, washed with ethyl acetate, the aqueous phase is extracted 3 times with ethyl acetate, washed with sodium bicarbonate and brine, dried over magnesium sulfate and i . Vak. constricted.
  • Example 6 IIß-Fluoro-7 ⁇ - ⁇ 6- [methyl- (8,8,9,9,9-pentafluorononyl) amino] hexyl ⁇ -estral, 3,5 (10) -triene-3 , 17 ⁇ -diol a) 7 ⁇ - (6-chlorohexyl) -llß-fluor-estr-4-en-3,17-dione
  • the mixture is then stirred at -30 ° C for 30 minutes and dropwise at -50 ° C with a solution of 23.5 gl of lß-fluoro-estra-4,6-diene-3, 17-dione in 230 ml of THF, 24.6 ml of 1,3-dimethyl-3,4,5, 6-tetrahydro- (1H) -pyrimidin-2-one and 55 ml of trimethylchlorosilane are added so that the internal temperature does not exceed -40 ° C.
  • the mixture is stirred for 1 h in the cold, then 32 ml of glacial acetic acid are added dropwise, the cooling bath is removed and the mixture is stirred at room temperature for 1 hour.
  • reaction mixture is poured into 1.51 of water, diluted with the same amount of ethyl acetate, the precipitate is separated off over Celite, washed with ethyl acetate, and the aqueous phase is washed 3 times
  • Example 7 II ß-Fluoro-7 ⁇ - ⁇ 5- [methyl- (7,7,8,8,9,9,10,10,10-nonafluorodecyl) amino] pentyl ⁇ - estra-1,3. 5 (10) -triene-3,17ß-diol
  • a solution of 466 mg 7 ⁇ - (5-bromopentyl) -llß-fluoro-estra-1,3,5 (10) -triene-3,17-diol in 10 ml l-Methyl-2-pyrrolidinone is stirred with 1.0 g of methyl- (7,7,8, 8,9,9, 10, 10,10-nonafluorodecyl) amine for 3 hours at 80 ° C.
  • Example 8 IIß-Fluoro-7 - ⁇ 5 - [(3,4,4,5,5,5-hexafluoropent-2-enyl) methylamino] pentyl ⁇ - estra-1,3,5 ( 10) -triene-3,17ß-diol a) 11ß-fluoro-7 ⁇ - ⁇ 5 - [(3,4,4,5,5,5-hexafluoropent-2-enyl) methylamino] pentyl ⁇ -3-hydroxy-estra-l, 3,5 (10) -trien-17-one

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Abstract

L'invention concerne une préparation combinée d'un oestrogène et d'un anti-oestrogène, caractérisée en ce que l'oestrogène est choisi dans le groupe constitué de 17-β-oestradiol, 17-α-éthinylestradiol, estriol, estrone, sulfate d'estrone, sulfamate d'estrogène, 17-α-estradiol, mestranol, stilbestrol et des oestrogènes conjugués naturels, et en ce que l'anti-oestrogène est un 7α-(κ-aminoalkyl)-estratriène de la formule générale (I). Cette préparation combinée peut s'utiliser pour l'hormonothérapie substitutive.
EP99908916A 1998-02-19 1999-02-18 Preparation combinee d'oestrogene et d'anti-oestrogene Withdrawn EP1054676A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19807791 1998-02-19
DE19807791A DE19807791A1 (de) 1998-02-19 1998-02-19 Kombinationspräparat aus Östrogen und Antiöstrogen
PCT/EP1999/001023 WO1999042109A1 (fr) 1998-02-19 1999-02-18 Preparation combinee d'oestrogene et d'anti-oestrogene

Publications (1)

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EP1054676A1 true EP1054676A1 (fr) 2000-11-29

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Country Status (12)

Country Link
US (1) US6677324B1 (fr)
EP (1) EP1054676A1 (fr)
JP (1) JP2002503695A (fr)
AR (1) AR017982A1 (fr)
AU (1) AU2834799A (fr)
BR (1) BR9908094A (fr)
CA (1) CA2321427A1 (fr)
DE (1) DE19807791A1 (fr)
IL (1) IL137491A0 (fr)
PE (1) PE20000261A1 (fr)
WO (1) WO1999042109A1 (fr)
ZA (1) ZA991370B (fr)

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US7335650B2 (en) 2000-01-14 2008-02-26 Sterix Limited Composition
US6653298B2 (en) 2000-01-14 2003-11-25 Sterix Limited Composition
DE10039199A1 (de) * 2000-08-10 2002-02-21 Schering Ag Kombinationspräparate aus einem ERß selektiven Estrogen und einem SERM oder Antiestrogen
DE10159217A1 (de) * 2001-11-27 2003-06-05 Schering Ag 17alpha-Alkyl-17ß-oxy-estratriene und Zwischenprodukte zu deren Herstellung, Verwendung der 17alpha-Alkyl-17ß-oxy-estratriene zur Herstellung von Arzneimitteln sowie pharmazeutische Präparate
US20040242551A1 (en) * 2003-05-28 2004-12-02 Schering Ag Composition comprising antiprogestins and pure antiestrogens for prophylaxis and treatment of hormone-dependent diseases
AU2005247948A1 (en) * 2004-05-27 2005-12-08 Migenix Corp. 2-substituted 17-imino estrogen compounds for cytoprotection
ATE482966T1 (de) 2004-07-27 2010-10-15 Sicor Inc Verfahren zur herstellung von 7-alpha-alkylierte 19-norsteroide
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ZA991370B (en) 1999-11-24
WO1999042109A1 (fr) 1999-08-26
IL137491A0 (en) 2001-07-24
BR9908094A (pt) 2000-10-31
DE19807791A1 (de) 1999-08-26
JP2002503695A (ja) 2002-02-05
CA2321427A1 (fr) 1999-08-26
AU2834799A (en) 1999-09-06
AR017982A1 (es) 2001-10-24
PE20000261A1 (es) 2000-05-22

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