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EE200200550A - Karbamaatsed kaspaasi inhibiitorid ja nende kasutamine - Google Patents

Karbamaatsed kaspaasi inhibiitorid ja nende kasutamine

Info

Publication number
EE200200550A
EE200200550A EEP200200550A EEP200200550A EE200200550A EE 200200550 A EE200200550 A EE 200200550A EE P200200550 A EEP200200550 A EE P200200550A EE P200200550 A EEP200200550 A EE P200200550A EE 200200550 A EE200200550 A EE 200200550A
Authority
EE
Estonia
Prior art keywords
caspase inhibitors
carbamate
carbamate caspase
inhibitors
caspase
Prior art date
Application number
EEP200200550A
Other languages
English (en)
Inventor
Bebbington David
Charrier Jaen-Damien
Kay David
Knegtel Ronald
Golec Julian
Mortimore Michael
Studley John
Original Assignee
Vertex Pharmaceuticals Incorporated
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharmaceuticals Incorporated filed Critical Vertex Pharmaceuticals Incorporated
Publication of EE200200550A publication Critical patent/EE200200550A/et

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
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    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • AHUMAN NECESSITIES
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    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
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    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
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    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/08Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
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    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56Ring systems containing three or more rings
    • C07D209/80[b, c]- or [b, d]-condensed
    • C07D209/82Carbazoles; Hydrogenated carbazoles
    • C07D209/86Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D221/00Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04Ortho- or peri-condensed ring systems
    • C07D221/06Ring systems of three rings
    • C07D221/10Aza-phenanthrenes
    • C07D221/12Phenanthridines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D223/00Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C07D223/24Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
    • C07D223/26Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a double bond between positions 10 and 11
    • CCHEMISTRY; METALLURGY
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    • C07DHETEROCYCLIC COMPOUNDS
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    • C07D223/14Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C07D223/24Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
    • C07D223/28Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a single bond between positions 10 and 11
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    • C07D279/101,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/141,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/18[b, e]-condensed with two six-membered rings
    • C07D279/22[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom
    • C07D279/30[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom with acyl radicals attached to the ring nitrogen atom

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  • Health & Medical Sciences (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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EEP200200550A 2000-03-29 2001-03-29 Karbamaatsed kaspaasi inhibiitorid ja nende kasutamine EE200200550A (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19282600P 2000-03-29 2000-03-29
PCT/US2001/010182 WO2001072707A2 (en) 2000-03-29 2001-03-29 Carbamate caspase inhibitors and uses thereof

Publications (1)

Publication Number Publication Date
EE200200550A true EE200200550A (et) 2004-02-16

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200200550A EE200200550A (et) 2000-03-29 2001-03-29 Karbamaatsed kaspaasi inhibiitorid ja nende kasutamine

Country Status (32)

Country Link
US (2) US6689784B2 (et)
EP (1) EP1268425B1 (et)
JP (2) JP4298200B2 (et)
KR (1) KR100858640B1 (et)
CN (2) CN1994298A (et)
AR (1) AR027993A1 (et)
AT (1) ATE384695T1 (et)
AU (2) AU2001249619B2 (et)
BG (1) BG107136A (et)
BR (1) BR0109588A (et)
CA (1) CA2403959A1 (et)
CZ (1) CZ20023227A3 (et)
DE (1) DE60132567T2 (et)
DK (1) DK1268425T3 (et)
EA (1) EA005740B1 (et)
EE (1) EE200200550A (et)
ES (1) ES2296742T3 (et)
HK (1) HK1052355B (et)
HR (1) HRP20020782A2 (et)
HU (1) HUP0301472A3 (et)
IL (2) IL151829A0 (et)
MX (1) MXPA02009633A (et)
NO (1) NO325062B1 (et)
NZ (1) NZ521639A (et)
PE (1) PE20011267A1 (et)
PL (1) PL201081B1 (et)
PT (1) PT1268425E (et)
SK (1) SK13922002A3 (et)
TW (1) TWI318207B (et)
WO (1) WO2001072707A2 (et)
YU (1) YU73702A (et)
ZA (1) ZA200207483B (et)

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* Cited by examiner, † Cited by third party
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JP2002541237A (ja) 1999-04-09 2002-12-03 サイトビア インコーポレイテッド カスパーゼインヒビターおよびその使用
ATE409688T1 (de) 1999-08-27 2008-10-15 Cytovia Inc Substituierte alpha-hydroxy-säuren als caspase- hemmer und ihre verwendung
CN1994298A (zh) * 2000-03-29 2007-07-11 沃泰克斯药物股份有限公司 氨基甲酸酯天冬氨酸特异性半胱氨酸蛋白酶抑制剂及其用途
PE20011350A1 (es) 2000-05-19 2002-01-15 Vertex Pharma PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE)
US20040192889A1 (en) * 2001-03-30 2004-09-30 Dale Bredesen Cytotoxic peptides and peptidomimetics based thereon, and methods for use thereof
US7351702B2 (en) 2001-05-23 2008-04-01 Vertex Pharmaceuticals Incorporated Caspase inhibitors and uses thereof
US7410956B2 (en) 2002-02-11 2008-08-12 Vertex Pharmaceuticals Incorporated Caspase inhibitor prodrugs
EP1499898A2 (en) * 2002-04-19 2005-01-26 Vertex Pharmaceuticals Incorporated Regulation of tnf-alpha
EP1447093A1 (en) * 2003-02-14 2004-08-18 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Inhibition of the CD95 ligand/receptor system for the treatment of neurological disorders and injuries
EP1607101A4 (en) * 2003-02-24 2007-10-24 Daiichi Seiyaku Co INHIBITOR OF DEGRADATION OF PROTEIN INTERACTING WITH HEPATITIS B VIRUS PROTEIN X
AU2003902704A0 (en) * 2003-05-29 2003-06-19 Crc For Waste Management And Pollution Control Limited Of Unsw Process for producing a nanoscale zero-valent metal
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