NO20022656D0 - Caspaseinhibitorer og anvendelse derav - Google Patents
Caspaseinhibitorer og anvendelse deravInfo
- Publication number
- NO20022656D0 NO20022656D0 NO20022656A NO20022656A NO20022656D0 NO 20022656 D0 NO20022656 D0 NO 20022656D0 NO 20022656 A NO20022656 A NO 20022656A NO 20022656 A NO20022656 A NO 20022656A NO 20022656 D0 NO20022656 D0 NO 20022656D0
- Authority
- NO
- Norway
- Prior art keywords
- caspase inhibitors
- caspase
- inhibitors
- Prior art date
Links
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- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
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- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US16981299P | 1999-12-08 | 1999-12-08 | |
PCT/US2000/033260 WO2001042216A2 (en) | 1999-12-08 | 2000-12-08 | Caspase inhibitors and uses thereof |
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NO20022656D0 true NO20022656D0 (no) | 2002-06-05 |
NO20022656L NO20022656L (no) | 2002-08-06 |
NO324776B1 NO324776B1 (no) | 2007-12-10 |
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NO20022656A NO324776B1 (no) | 1999-12-08 | 2002-06-05 | Okso-2H-pyridin-, okso-2H-kinolin- og okso-1H-isokinolinderivater, deres fremstilling, farmasoytiske sammensetninger inneholdende dem og deres anvendelse |
NO20074773A NO20074773L (no) | 1999-12-08 | 2007-09-19 | Caspaseinhibitorer og anvendelse derav |
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NO20074773A NO20074773L (no) | 1999-12-08 | 2007-09-19 | Caspaseinhibitorer og anvendelse derav |
Country Status (24)
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US (4) | US7517987B2 (no) |
EP (4) | EP2308846A3 (no) |
JP (3) | JP5021131B2 (no) |
KR (3) | KR100904697B1 (no) |
CN (2) | CN100415718C (no) |
AP (1) | AP2002002535A0 (no) |
AR (1) | AR026748A1 (no) |
AU (3) | AU2428301A (no) |
BR (1) | BR0016282A (no) |
CA (2) | CA2393710C (no) |
CO (1) | CO5261609A1 (no) |
CZ (1) | CZ20021970A3 (no) |
EA (1) | EA200200645A1 (no) |
HU (1) | HUP0300782A3 (no) |
IL (1) | IL150077A0 (no) |
IS (1) | IS6411A (no) |
MX (1) | MXPA02005779A (no) |
NO (2) | NO324776B1 (no) |
NZ (2) | NZ530485A (no) |
PL (1) | PL356066A1 (no) |
SK (1) | SK8072002A3 (no) |
TW (1) | TWI275586B (no) |
WO (1) | WO2001042216A2 (no) |
ZA (1) | ZA200204390B (no) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002541237A (ja) | 1999-04-09 | 2002-12-03 | サイトビア インコーポレイテッド | カスパーゼインヒビターおよびその使用 |
US6723711B2 (en) | 1999-05-07 | 2004-04-20 | Texas Biotechnology Corporation | Propanoic acid derivatives that inhibit the binding of integrins to their receptors |
ATE409688T1 (de) | 1999-08-27 | 2008-10-15 | Cytovia Inc | Substituierte alpha-hydroxy-säuren als caspase- hemmer und ihre verwendung |
US6545004B1 (en) | 1999-10-27 | 2003-04-08 | Cytokinetics, Inc. | Methods and compositions utilizing quinazolinones |
AR026748A1 (es) * | 1999-12-08 | 2003-02-26 | Vertex Pharma | Un compuesto inhibidor de caspasas, una composicion farmaceutica que lo comprende, un metodo para la sintesis del mismo y un compuesto intermediario paradicha sintesis |
PE20011350A1 (es) | 2000-05-19 | 2002-01-15 | Vertex Pharma | PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE) |
US7351702B2 (en) * | 2001-05-23 | 2008-04-01 | Vertex Pharmaceuticals Incorporated | Caspase inhibitors and uses thereof |
EP1499898A2 (en) * | 2002-04-19 | 2005-01-26 | Vertex Pharmaceuticals Incorporated | Regulation of tnf-alpha |
IL165986A0 (en) * | 2002-06-28 | 2006-01-15 | Vertex Pharma | Isoquinoline and quinazoline derivatives and pharmaceutical compositions containing the same |
EP1581501A1 (en) * | 2002-12-20 | 2005-10-05 | Vertex Pharmaceuticals Incorporated | 4-oxo-3-(1-oxo-1h-isoquinolin-2-ylacetylamino)-pentanoic acid ester and amide derivatives and their use as caspase inhibitors |
PE20050159A1 (es) * | 2003-05-27 | 2005-04-19 | Vertex Pharma | Derivados de acido 3-[2-(3-amino-2-oxo-2h-piridin-1-il)-acetilamino]-4-oxo-pentanoico como inhibidores de caspasa |
WO2004113305A2 (en) * | 2003-06-16 | 2004-12-29 | Vertex Pharmaceuticals Incorporated | Diamino substituted quinazoline derivatives as promoters of smn2 |
JP4898658B2 (ja) | 2004-03-12 | 2012-03-21 | バーテックス ファーマシューティカルズ インコーポレイテッド | アスパラギン酸アセタールカスパーゼ阻害剤の製造のための方法および中間体 |
CN1980648A (zh) * | 2004-05-15 | 2007-06-13 | 沃泰克斯药物股份有限公司 | 使用ice抑制剂治疗癫痫发作 |
CN1980658A (zh) | 2004-05-27 | 2007-06-13 | 沃泰克斯药物股份有限公司 | 治疗自身炎性疾病的ice抑制剂 |
ATE543803T1 (de) | 2004-11-24 | 2012-02-15 | Vertex Pharma | 3-ä2-(3-azylamino-2-oxo-2h-pyridin-1- yl)acetylaminoü-4-oxopentansäurederivate und deren verwendung als caspase-inhibitoren |
ZA200801172B (en) * | 2005-07-28 | 2009-04-29 | Vertex Pharma | Caspase inhibitor prodrugs |
US8034822B2 (en) * | 2006-03-08 | 2011-10-11 | Takeda San Diego, Inc. | Glucokinase activators |
AR063417A1 (es) * | 2006-11-01 | 2009-01-28 | Astrazeneca Ab | Compuestos inhibidores del activador de plasminogeno tipo 1(pai-1) |
US8163779B2 (en) * | 2006-12-20 | 2012-04-24 | Takeda San Diego, Inc. | Glucokinase activators |
US8173645B2 (en) | 2007-03-21 | 2012-05-08 | Takeda San Diego, Inc. | Glucokinase activators |
DK2288615T3 (en) | 2008-05-21 | 2017-09-04 | Genesis Tech Ltd | SELECTIVE CASPASE INHIBITORS AND APPLICATIONS THEREOF |
US8518942B2 (en) * | 2008-08-06 | 2013-08-27 | Buck Institute For Research On Aging | Caspase inhibitors and uses thereof |
EP2344479B1 (en) * | 2008-09-23 | 2015-04-08 | Georgetown University | 1,2-benzisothiazolinone and isoindolinone derivatives |
CA2738313A1 (en) | 2008-09-23 | 2010-04-08 | Georgetown University | Viral and fungal inhibitors |
WO2010133000A1 (en) | 2009-05-21 | 2010-11-25 | New World Laboratories Inc. | Selective caspase inhibitors and uses thereof |
WO2010138585A1 (en) * | 2009-05-29 | 2010-12-02 | Merck Sharp & Dohme Corp. | Pyrimidinones as pde10 inhibitors |
EP2470336B1 (en) | 2009-08-25 | 2013-08-14 | Lasermax Roll Systems, Inc. | System and method for inline cutting and stacking of sheets for formation of books |
US8882099B2 (en) | 2009-08-25 | 2014-11-11 | Lasermax Roll Systems, Inc. | System and method for inline cutting and stacking of sheets for formation of books |
WO2011094426A1 (en) | 2010-01-29 | 2011-08-04 | The United State Of America, As Represented By The Secretary, Department Of Health & Human Services | Caspase inhibitors |
JP5980790B2 (ja) | 2010-11-05 | 2016-08-31 | ブランダイス ユニバーシティBrandeis University | バイオマーカーとしての、ice切断されたアルファ−シヌクレイン |
US9090585B2 (en) | 2011-03-28 | 2015-07-28 | Deuterx, Llc | 2,6-dioxo-3-deutero-piperdin-3-yl-isoindoline compounds |
EP2697246B1 (en) | 2011-04-15 | 2018-03-07 | Genesis Technologies Limited | Selective cysteine protease inhibitors and uses thereof |
US9956260B1 (en) | 2011-07-22 | 2018-05-01 | The J. David Gladstone Institutes | Treatment of HIV-1 infection and AIDS |
CA2845551C (en) | 2011-08-16 | 2020-06-09 | Georgetown University | Methods of treating bacterial infections with 1,2-benzisothiazolinone and isoindolinone derivatives |
CA2935495C (en) | 2013-01-14 | 2021-04-20 | Deuterx, Llc | 3-(5-substituted-4-oxoquinazolin-3(4h)-yl)-3-deutero-piperidine-2,6-dione derivatives |
EP2968334A4 (en) * | 2013-03-14 | 2016-08-03 | Deuterx Llc | 3- (SUBSTITIERTES-4-OXO-quinazolin-3 (4H) -yl) -3-deutero-PIPERIDINE-2,6-DIONE DERIVATIVES |
WO2014160592A2 (en) * | 2013-03-27 | 2014-10-02 | Merck Sharp & Dohme Corp. | FACTOR XIa INHIBITORS |
US9809603B1 (en) | 2015-08-18 | 2017-11-07 | Deuterx, Llc | Deuterium-enriched isoindolinonyl-piperidinonyl conjugates and oxoquinazolin-3(4H)-yl-piperidinonyl conjugates and methods of treating medical disorders using same |
JP7113831B2 (ja) * | 2017-01-23 | 2022-08-05 | チア タイ ティエンチン ファーマシューティカル グループ カンパニー リミテッド | カスパーゼ阻害薬としての二環式化合物 |
CN106749045B (zh) * | 2017-03-03 | 2020-02-14 | 上海交通大学 | 一种d-氨基酸氧化酶抑制剂及其制法和应用 |
US11345950B2 (en) * | 2017-10-04 | 2022-05-31 | Battelle Memorial Institute | Probe for selectively characterizing enzymes involved in xenobiotic metabolism and method of making and using the same |
CN115551494A (zh) * | 2020-03-13 | 2022-12-30 | 纽约市哥伦比亚大学理事会 | Gpx4化合物和组合物以及使用它们的治疗方法 |
AU2021321068A1 (en) * | 2020-08-05 | 2023-02-02 | Lg Chem, Ltd. | Use of caspase inhibitor for alleviating or treating osteoarthritis |
KR102670554B1 (ko) * | 2022-01-04 | 2024-05-30 | 주식회사 이노보테라퓨틱스 | 캐스파제 저해제로서의 신규한 이소인돌리논 유도체 화합물 |
WO2024073426A1 (en) * | 2022-09-26 | 2024-04-04 | Edgewise Therapeutics, Inc. | 1,4-dihydroquinazolinone compounds and uses thereof |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6204261B1 (en) | 1995-12-20 | 2001-03-20 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β Converting enzyme inhibitors |
FR2582514B1 (fr) | 1985-05-30 | 1988-02-19 | Rhone Poulenc Sante | Medicaments a base d'amides, nouveaux amides et leur preparation |
WO1993016710A1 (en) | 1992-02-21 | 1993-09-02 | Merck & Co., Inc. | PEPTIDYL DERIVATIVES AS INHIBITORS OF INTERLEUKIN-1β CONVERTING ENZYME |
US5714484A (en) * | 1993-12-08 | 1998-02-03 | Prototek, Inc. | α-(1,3-dicarbonylenol ether) methyl ketones as cysteine protease inhibitors |
US5756466A (en) | 1994-06-17 | 1998-05-26 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1β converting enzyme |
US5847135A (en) | 1994-06-17 | 1998-12-08 | Vertex Pharmaceuticals, Incorporated | Inhibitors of interleukin-1β converting enzyme |
GB2292149A (en) | 1994-08-09 | 1996-02-14 | Ferring Res Ltd | Peptide inhibitors of pro-interleukin-1beta converting enzyme |
US5618792A (en) * | 1994-11-21 | 1997-04-08 | Cortech, Inc. | Substituted heterocyclic compounds useful as inhibitors of (serine proteases) human neutrophil elastase |
WO1996035711A1 (en) * | 1995-05-10 | 1996-11-14 | Chiroscience Limited | Peptide compounds which inhibit metalloproteinase and tnf liberation, and their therapeutic use |
US6252076B1 (en) * | 1996-05-04 | 2001-06-26 | Yuhan Corporation | Process for preparation of pyrimidine derivatives |
CA2268086A1 (en) * | 1996-10-11 | 1998-04-23 | Warner-Lambert Company | Sulfonamide interleukin-1.beta. converting enzyme inhibitors |
JP2001506974A (ja) * | 1996-10-11 | 2001-05-29 | ワーナー―ランバート・コンパニー | インターロイキン―1β変換酵素のアスパルテートエステル阻害剤 |
US6063794A (en) * | 1996-10-11 | 2000-05-16 | Cor Therapeutics Inc. | Selective factor Xa inhibitors |
AU6908398A (en) * | 1996-10-28 | 1998-05-22 | Versicor Inc | Fused 2,4-pyrimidinedione combinatorial libraries and biologically active fused 2,4-pyramidinediones |
US6972296B2 (en) | 1999-05-07 | 2005-12-06 | Encysive Pharmaceuticals Inc. | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors |
WO2000067746A1 (en) | 1999-05-07 | 2000-11-16 | Texas Biotechnology Corporation | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors |
ES2228527T5 (es) * | 1999-05-07 | 2013-05-23 | Encysive Pharmaceuticals, Inc. | Derivados del ácido propanoico que inhiben la unión de las integrinas a sus receptores |
AR026748A1 (es) * | 1999-12-08 | 2003-02-26 | Vertex Pharma | Un compuesto inhibidor de caspasas, una composicion farmaceutica que lo comprende, un metodo para la sintesis del mismo y un compuesto intermediario paradicha sintesis |
US7410956B2 (en) * | 2002-02-11 | 2008-08-12 | Vertex Pharmaceuticals Incorporated | Caspase inhibitor prodrugs |
EP1499898A2 (en) * | 2002-04-19 | 2005-01-26 | Vertex Pharmaceuticals Incorporated | Regulation of tnf-alpha |
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2000
- 2000-12-06 AR ARP000106476A patent/AR026748A1/es unknown
- 2000-12-07 CO CO00093694A patent/CO5261609A1/es not_active Application Discontinuation
- 2000-12-07 TW TWCASPASEIA patent/TWI275586B/zh not_active IP Right Cessation
- 2000-12-08 IL IL15007700A patent/IL150077A0/xx unknown
- 2000-12-08 EP EP10196409A patent/EP2308846A3/en not_active Withdrawn
- 2000-12-08 CA CA2393710A patent/CA2393710C/en not_active Expired - Fee Related
- 2000-12-08 EA EA200200645A patent/EA200200645A1/ru unknown
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- 2000-12-08 KR KR1020027007337A patent/KR100904697B1/ko not_active IP Right Cessation
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- 2000-12-08 WO PCT/US2000/033260 patent/WO2001042216A2/en active IP Right Grant
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- 2000-12-08 MX MXPA02005779A patent/MXPA02005779A/es active IP Right Grant
- 2000-12-08 JP JP2001543517A patent/JP5021131B2/ja not_active Expired - Fee Related
- 2000-12-08 SK SK807-2002A patent/SK8072002A3/sk not_active Application Discontinuation
- 2000-12-08 PL PL00356066A patent/PL356066A1/xx not_active Application Discontinuation
- 2000-12-08 CN CNB008182558A patent/CN100415718C/zh not_active Expired - Fee Related
- 2000-12-08 NZ NZ519424A patent/NZ519424A/en not_active IP Right Cessation
- 2000-12-08 BR BR0016282-5A patent/BR0016282A/pt not_active Application Discontinuation
- 2000-12-08 EP EP10196401A patent/EP2308844A3/en not_active Withdrawn
- 2000-12-08 AU AU24283/01A patent/AU2428301A/en not_active Abandoned
- 2000-12-08 CN CNA2008101443995A patent/CN101348455A/zh active Pending
- 2000-12-08 EP EP10196405A patent/EP2308845A3/en not_active Withdrawn
- 2000-12-08 CA CA2733434A patent/CA2733434A1/en not_active Abandoned
- 2000-12-08 EP EP00988026A patent/EP1244626A2/en not_active Withdrawn
- 2000-12-08 CZ CZ20021970A patent/CZ20021970A3/cs unknown
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2002
- 2002-05-31 ZA ZA200204390A patent/ZA200204390B/xx unknown
- 2002-06-05 NO NO20022656A patent/NO324776B1/no not_active IP Right Cessation
- 2002-06-06 IS IS6411A patent/IS6411A/is unknown
- 2002-06-10 US US10/166,437 patent/US7517987B2/en not_active Expired - Fee Related
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2006
- 2006-10-10 AU AU2006225317A patent/AU2006225317A1/en not_active Abandoned
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2007
- 2007-09-19 NO NO20074773A patent/NO20074773L/no not_active Application Discontinuation
- 2007-12-05 JP JP2007315252A patent/JP2008101019A/ja not_active Withdrawn
-
2008
- 2008-02-18 KR KR1020087003852A patent/KR100910195B1/ko not_active IP Right Cessation
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2009
- 2009-01-26 US US12/359,749 patent/US7906650B2/en not_active Expired - Fee Related
- 2009-03-12 KR KR1020097005203A patent/KR100919654B1/ko not_active IP Right Cessation
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2010
- 2010-05-21 AU AU2010202075A patent/AU2010202075B2/en not_active Ceased
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2011
- 2011-02-08 US US13/022,820 patent/US8093392B2/en not_active Expired - Fee Related
- 2011-10-25 JP JP2011234386A patent/JP2012021032A/ja not_active Withdrawn
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