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NO20022656D0 - Caspaseinhibitorer og anvendelse derav - Google Patents

Caspaseinhibitorer og anvendelse derav

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Publication number
NO20022656D0
NO20022656D0 NO20022656A NO20022656A NO20022656D0 NO 20022656 D0 NO20022656 D0 NO 20022656D0 NO 20022656 A NO20022656 A NO 20022656A NO 20022656 A NO20022656 A NO 20022656A NO 20022656 D0 NO20022656 D0 NO 20022656D0
Authority
NO
Norway
Prior art keywords
caspase inhibitors
caspase
inhibitors
Prior art date
Application number
NO20022656A
Other languages
English (en)
Other versions
NO324776B1 (no
NO20022656L (no
Inventor
Julian M C Golec
Paul S Charifson
Jean-Damien Charrier
Hayley Binch
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of NO20022656D0 publication Critical patent/NO20022656D0/no
Publication of NO20022656L publication Critical patent/NO20022656L/no
Publication of NO324776B1 publication Critical patent/NO324776B1/no

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    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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NO20022656A 1999-12-08 2002-06-05 Okso-2H-pyridin-, okso-2H-kinolin- og okso-1H-isokinolinderivater, deres fremstilling, farmasoytiske sammensetninger inneholdende dem og deres anvendelse NO324776B1 (no)

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Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002541237A (ja) 1999-04-09 2002-12-03 サイトビア インコーポレイテッド カスパーゼインヒビターおよびその使用
US6723711B2 (en) 1999-05-07 2004-04-20 Texas Biotechnology Corporation Propanoic acid derivatives that inhibit the binding of integrins to their receptors
ATE409688T1 (de) 1999-08-27 2008-10-15 Cytovia Inc Substituierte alpha-hydroxy-säuren als caspase- hemmer und ihre verwendung
US6545004B1 (en) 1999-10-27 2003-04-08 Cytokinetics, Inc. Methods and compositions utilizing quinazolinones
AR026748A1 (es) * 1999-12-08 2003-02-26 Vertex Pharma Un compuesto inhibidor de caspasas, una composicion farmaceutica que lo comprende, un metodo para la sintesis del mismo y un compuesto intermediario paradicha sintesis
PE20011350A1 (es) 2000-05-19 2002-01-15 Vertex Pharma PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE)
US7351702B2 (en) * 2001-05-23 2008-04-01 Vertex Pharmaceuticals Incorporated Caspase inhibitors and uses thereof
EP1499898A2 (en) * 2002-04-19 2005-01-26 Vertex Pharmaceuticals Incorporated Regulation of tnf-alpha
IL165986A0 (en) * 2002-06-28 2006-01-15 Vertex Pharma Isoquinoline and quinazoline derivatives and pharmaceutical compositions containing the same
EP1581501A1 (en) * 2002-12-20 2005-10-05 Vertex Pharmaceuticals Incorporated 4-oxo-3-(1-oxo-1h-isoquinolin-2-ylacetylamino)-pentanoic acid ester and amide derivatives and their use as caspase inhibitors
PE20050159A1 (es) * 2003-05-27 2005-04-19 Vertex Pharma Derivados de acido 3-[2-(3-amino-2-oxo-2h-piridin-1-il)-acetilamino]-4-oxo-pentanoico como inhibidores de caspasa
WO2004113305A2 (en) * 2003-06-16 2004-12-29 Vertex Pharmaceuticals Incorporated Diamino substituted quinazoline derivatives as promoters of smn2
JP4898658B2 (ja) 2004-03-12 2012-03-21 バーテックス ファーマシューティカルズ インコーポレイテッド アスパラギン酸アセタールカスパーゼ阻害剤の製造のための方法および中間体
CN1980648A (zh) * 2004-05-15 2007-06-13 沃泰克斯药物股份有限公司 使用ice抑制剂治疗癫痫发作
CN1980658A (zh) 2004-05-27 2007-06-13 沃泰克斯药物股份有限公司 治疗自身炎性疾病的ice抑制剂
ATE543803T1 (de) 2004-11-24 2012-02-15 Vertex Pharma 3-ä2-(3-azylamino-2-oxo-2h-pyridin-1- yl)acetylaminoü-4-oxopentansäurederivate und deren verwendung als caspase-inhibitoren
ZA200801172B (en) * 2005-07-28 2009-04-29 Vertex Pharma Caspase inhibitor prodrugs
US8034822B2 (en) * 2006-03-08 2011-10-11 Takeda San Diego, Inc. Glucokinase activators
AR063417A1 (es) * 2006-11-01 2009-01-28 Astrazeneca Ab Compuestos inhibidores del activador de plasminogeno tipo 1(pai-1)
US8163779B2 (en) * 2006-12-20 2012-04-24 Takeda San Diego, Inc. Glucokinase activators
US8173645B2 (en) 2007-03-21 2012-05-08 Takeda San Diego, Inc. Glucokinase activators
DK2288615T3 (en) 2008-05-21 2017-09-04 Genesis Tech Ltd SELECTIVE CASPASE INHIBITORS AND APPLICATIONS THEREOF
US8518942B2 (en) * 2008-08-06 2013-08-27 Buck Institute For Research On Aging Caspase inhibitors and uses thereof
EP2344479B1 (en) * 2008-09-23 2015-04-08 Georgetown University 1,2-benzisothiazolinone and isoindolinone derivatives
CA2738313A1 (en) 2008-09-23 2010-04-08 Georgetown University Viral and fungal inhibitors
WO2010133000A1 (en) 2009-05-21 2010-11-25 New World Laboratories Inc. Selective caspase inhibitors and uses thereof
WO2010138585A1 (en) * 2009-05-29 2010-12-02 Merck Sharp & Dohme Corp. Pyrimidinones as pde10 inhibitors
EP2470336B1 (en) 2009-08-25 2013-08-14 Lasermax Roll Systems, Inc. System and method for inline cutting and stacking of sheets for formation of books
US8882099B2 (en) 2009-08-25 2014-11-11 Lasermax Roll Systems, Inc. System and method for inline cutting and stacking of sheets for formation of books
WO2011094426A1 (en) 2010-01-29 2011-08-04 The United State Of America, As Represented By The Secretary, Department Of Health & Human Services Caspase inhibitors
JP5980790B2 (ja) 2010-11-05 2016-08-31 ブランダイス ユニバーシティBrandeis University バイオマーカーとしての、ice切断されたアルファ−シヌクレイン
US9090585B2 (en) 2011-03-28 2015-07-28 Deuterx, Llc 2,6-dioxo-3-deutero-piperdin-3-yl-isoindoline compounds
EP2697246B1 (en) 2011-04-15 2018-03-07 Genesis Technologies Limited Selective cysteine protease inhibitors and uses thereof
US9956260B1 (en) 2011-07-22 2018-05-01 The J. David Gladstone Institutes Treatment of HIV-1 infection and AIDS
CA2845551C (en) 2011-08-16 2020-06-09 Georgetown University Methods of treating bacterial infections with 1,2-benzisothiazolinone and isoindolinone derivatives
CA2935495C (en) 2013-01-14 2021-04-20 Deuterx, Llc 3-(5-substituted-4-oxoquinazolin-3(4h)-yl)-3-deutero-piperidine-2,6-dione derivatives
EP2968334A4 (en) * 2013-03-14 2016-08-03 Deuterx Llc 3- (SUBSTITIERTES-4-OXO-quinazolin-3 (4H) -yl) -3-deutero-PIPERIDINE-2,6-DIONE DERIVATIVES
WO2014160592A2 (en) * 2013-03-27 2014-10-02 Merck Sharp & Dohme Corp. FACTOR XIa INHIBITORS
US9809603B1 (en) 2015-08-18 2017-11-07 Deuterx, Llc Deuterium-enriched isoindolinonyl-piperidinonyl conjugates and oxoquinazolin-3(4H)-yl-piperidinonyl conjugates and methods of treating medical disorders using same
JP7113831B2 (ja) * 2017-01-23 2022-08-05 チア タイ ティエンチン ファーマシューティカル グループ カンパニー リミテッド カスパーゼ阻害薬としての二環式化合物
CN106749045B (zh) * 2017-03-03 2020-02-14 上海交通大学 一种d-氨基酸氧化酶抑制剂及其制法和应用
US11345950B2 (en) * 2017-10-04 2022-05-31 Battelle Memorial Institute Probe for selectively characterizing enzymes involved in xenobiotic metabolism and method of making and using the same
CN115551494A (zh) * 2020-03-13 2022-12-30 纽约市哥伦比亚大学理事会 Gpx4化合物和组合物以及使用它们的治疗方法
AU2021321068A1 (en) * 2020-08-05 2023-02-02 Lg Chem, Ltd. Use of caspase inhibitor for alleviating or treating osteoarthritis
KR102670554B1 (ko) * 2022-01-04 2024-05-30 주식회사 이노보테라퓨틱스 캐스파제 저해제로서의 신규한 이소인돌리논 유도체 화합물
WO2024073426A1 (en) * 2022-09-26 2024-04-04 Edgewise Therapeutics, Inc. 1,4-dihydroquinazolinone compounds and uses thereof

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6204261B1 (en) 1995-12-20 2001-03-20 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β Converting enzyme inhibitors
FR2582514B1 (fr) 1985-05-30 1988-02-19 Rhone Poulenc Sante Medicaments a base d'amides, nouveaux amides et leur preparation
WO1993016710A1 (en) 1992-02-21 1993-09-02 Merck & Co., Inc. PEPTIDYL DERIVATIVES AS INHIBITORS OF INTERLEUKIN-1β CONVERTING ENZYME
US5714484A (en) * 1993-12-08 1998-02-03 Prototek, Inc. α-(1,3-dicarbonylenol ether) methyl ketones as cysteine protease inhibitors
US5756466A (en) 1994-06-17 1998-05-26 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1β converting enzyme
US5847135A (en) 1994-06-17 1998-12-08 Vertex Pharmaceuticals, Incorporated Inhibitors of interleukin-1β converting enzyme
GB2292149A (en) 1994-08-09 1996-02-14 Ferring Res Ltd Peptide inhibitors of pro-interleukin-1beta converting enzyme
US5618792A (en) * 1994-11-21 1997-04-08 Cortech, Inc. Substituted heterocyclic compounds useful as inhibitors of (serine proteases) human neutrophil elastase
WO1996035711A1 (en) * 1995-05-10 1996-11-14 Chiroscience Limited Peptide compounds which inhibit metalloproteinase and tnf liberation, and their therapeutic use
US6252076B1 (en) * 1996-05-04 2001-06-26 Yuhan Corporation Process for preparation of pyrimidine derivatives
CA2268086A1 (en) * 1996-10-11 1998-04-23 Warner-Lambert Company Sulfonamide interleukin-1.beta. converting enzyme inhibitors
JP2001506974A (ja) * 1996-10-11 2001-05-29 ワーナー―ランバート・コンパニー インターロイキン―1β変換酵素のアスパルテートエステル阻害剤
US6063794A (en) * 1996-10-11 2000-05-16 Cor Therapeutics Inc. Selective factor Xa inhibitors
AU6908398A (en) * 1996-10-28 1998-05-22 Versicor Inc Fused 2,4-pyrimidinedione combinatorial libraries and biologically active fused 2,4-pyramidinediones
US6972296B2 (en) 1999-05-07 2005-12-06 Encysive Pharmaceuticals Inc. Carboxylic acid derivatives that inhibit the binding of integrins to their receptors
WO2000067746A1 (en) 1999-05-07 2000-11-16 Texas Biotechnology Corporation Carboxylic acid derivatives that inhibit the binding of integrins to their receptors
ES2228527T5 (es) * 1999-05-07 2013-05-23 Encysive Pharmaceuticals, Inc. Derivados del ácido propanoico que inhiben la unión de las integrinas a sus receptores
AR026748A1 (es) * 1999-12-08 2003-02-26 Vertex Pharma Un compuesto inhibidor de caspasas, una composicion farmaceutica que lo comprende, un metodo para la sintesis del mismo y un compuesto intermediario paradicha sintesis
US7410956B2 (en) * 2002-02-11 2008-08-12 Vertex Pharmaceuticals Incorporated Caspase inhibitor prodrugs
EP1499898A2 (en) * 2002-04-19 2005-01-26 Vertex Pharmaceuticals Incorporated Regulation of tnf-alpha

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US8288537B2 (en) 2012-10-16
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US7906650B2 (en) 2011-03-15
TWI275586B (en) 2007-03-11
NO324776B1 (no) 2007-12-10
KR100910195B1 (ko) 2009-07-30
US8093392B2 (en) 2012-01-10
AU2428301A (en) 2001-06-18
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NO20022656L (no) 2002-08-06
US7517987B2 (en) 2009-04-14
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