DE60117096D1 - Dihydroindol- und tetrahydrochinolinderivate - Google Patents

Dihydroindol- und tetrahydrochinolinderivate

Info

Publication number: DE60117096D1
Authority: DE; Germany
Prior art keywords: dihydroindol; tetrahydrochinoline; derivatives; tetrahydrochinoline derivatives
Prior art date: 2000-12-21
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60117096T

Other languages

English (en)

Other versions

DE60117096T2 (de

Inventor

Johannes Aebi

Jean Ackermann

Alexander Chucholowski

Henrietta Dehmlow

Olivier Morand

Sabine Wallbaum

Thomas Weller

Narendra Panday

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

F Hoffmann La Roche AG

Original Assignee

F Hoffmann La Roche AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-12-21

Filing date

2001-12-12

Publication date

2006-04-20

2001-12-12 Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG

2006-04-20 Application granted granted Critical

2006-04-20 Publication of DE60117096D1 publication Critical patent/DE60117096D1/de

2006-11-23 Publication of DE60117096T2 publication Critical patent/DE60117096T2/de

2021-12-13 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Obesity (AREA)
Hematology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Endocrinology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Emergency Medicine (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Tropical Medicine & Parasitology (AREA)
Dermatology (AREA)
Gastroenterology & Hepatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Quinoline Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)

DE60117096T 2000-12-21 2001-12-12 Dihydroindol- und tetrahydrochinolinderivate Expired - Lifetime DE60117096T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP00128063		2000-12-21
EP00128063		2000-12-21
PCT/EP2001/014620 WO2002050041A1 (en)	2000-12-21	2001-12-12	Dihydroindole and tetrahydroquinoline derivatives

Publications (2)

Publication Number	Publication Date
DE60117096D1 true DE60117096D1 (de)	2006-04-20
DE60117096T2 DE60117096T2 (de)	2006-11-23

Family

ID=8170751

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60117096T Expired - Lifetime DE60117096T2 (de)	2000-12-21	2001-12-12	Dihydroindol- und tetrahydrochinolinderivate

Country Status (15)

Country	Link
US (2)	US6706751B2 (de)
EP (1)	EP1358162B1 (de)
JP (1)	JP4068459B2 (de)
KR (1)	KR100530408B1 (de)
CN (1)	CN1208322C (de)
AR (1)	AR035408A1 (de)
AT (1)	ATE317386T1 (de)
AU (2)	AU2002219176B2 (de)
BR (1)	BR0116263A (de)
CA (1)	CA2431100C (de)
DE (1)	DE60117096T2 (de)
ES (1)	ES2257381T3 (de)
MX (1)	MXPA03005395A (de)
WO (1)	WO2002050041A1 (de)
ZA (1)	ZA200304646B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW200406374A (en)	2002-05-29	2004-05-01	Novartis Ag	Diaryl urea derivatives useful for the treatment of protein kinase dependent diseases
WO2004020408A1 (en) *	2002-08-29	2004-03-11	Merck & Co., Inc.	Indoles having anti-diabetic activity
WO2005014755A1 (ja) *	2003-08-08	2005-02-17	Ube Industries, Ltd.	アルキニル基置換縮合ヘテロ環化合物及びその製法並びにそれを使用する有機エレクトロルミネッセンス素子
TWI329102B (en) *	2006-08-15	2010-08-21	Nat Health Research Institutes	Thiourea compounds and method for inhibiting hepatitis c virus infection
US7985763B2 (en) *	2007-04-10	2011-07-26	National Health Research Institutes	Hepatitis C virus inhibitors
US7897764B2 (en) *	2007-06-08	2011-03-01	National Health Research Institutes	Thiourea derivatives
TWI361808B (en) *	2008-01-08	2012-04-11	Nat Health Research Institutes	Imidazolidinone and imidazolidinethione derivatives
US8198284B2 (en) *	2008-04-30	2012-06-12	National Health Research Institutes	Treatment of neurodegenerative disorders with thiourea compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3997542A (en) *	1975-06-23	1976-12-14	Sterling Drug Inc.	1-(Halogenated-acetyl)-1,2,3,4-tetrahydro-6-quinolinols and esters thereof
NZ227042A (en)	1987-11-27	1991-05-28	Banyu Pharma Co Ltd	Substituted alkylamine derivatives and pharmaceutical compositions
US5288749A (en)	1991-12-20	1994-02-22	Abbott Laboratories	Tertiary and secondary amines as alpha-2 antagonists and serotonin uptake inhibitors
TW438774B (en)	1993-07-14	2001-06-07	Hoffmann La Roche	Pharmaceutical composition for lowering cholesterol containing phenalkylamines and certain novel phenalkylamines
EP0880501A1 (de)	1996-02-02	1998-12-02	Zeneca Limited	Heterocyclische verbindungen verwendbar als pharmazeutische mittel
DE19727117A1 (de)	1997-06-26	1999-01-07	Boehringer Ingelheim Pharma	Phenylalkylderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
WO2001087834A1 (fr)	2000-05-16	2001-11-22	Takeda Chemical Industries, Ltd.	Antagoniste de l'hormone de concentration de la melanine

2001
- 2001-12-11 US US10/014,959 patent/US6706751B2/en not_active Expired - Fee Related
- 2001-12-12 EP EP01271362A patent/EP1358162B1/de not_active Expired - Lifetime
- 2001-12-12 DE DE60117096T patent/DE60117096T2/de not_active Expired - Lifetime
- 2001-12-12 KR KR10-2003-7008393A patent/KR100530408B1/ko not_active IP Right Cessation
- 2001-12-12 AU AU2002219176A patent/AU2002219176B2/en not_active Ceased
- 2001-12-12 CA CA002431100A patent/CA2431100C/en not_active Expired - Fee Related
- 2001-12-12 BR BR0116263-2A patent/BR0116263A/pt not_active IP Right Cessation
- 2001-12-12 WO PCT/EP2001/014620 patent/WO2002050041A1/en active IP Right Grant
- 2001-12-12 MX MXPA03005395A patent/MXPA03005395A/es active IP Right Grant
- 2001-12-12 ES ES01271362T patent/ES2257381T3/es not_active Expired - Lifetime
- 2001-12-12 JP JP2002551538A patent/JP4068459B2/ja not_active Expired - Fee Related
- 2001-12-12 AU AU1917602A patent/AU1917602A/xx active Pending
- 2001-12-12 AT AT01271362T patent/ATE317386T1/de not_active IP Right Cessation
- 2001-12-12 CN CNB018210120A patent/CN1208322C/zh not_active Expired - Fee Related
- 2001-12-20 AR ARP010105925A patent/AR035408A1/es unknown
2003
- 2003-06-13 ZA ZA200304646A patent/ZA200304646B/en unknown
- 2003-08-26 US US10/648,451 patent/US7102007B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
AU2002219176B2 (en)	2006-02-09
KR20030063453A (ko)	2003-07-28
MXPA03005395A (es)	2003-09-25
US20050020624A1 (en)	2005-01-27
JP4068459B2 (ja)	2008-03-26
CA2431100A1 (en)	2002-06-27
US20030004156A1 (en)	2003-01-02
JP2004519441A (ja)	2004-07-02
DE60117096T2 (de)	2006-11-23
US7102007B2 (en)	2006-09-05
WO2002050041A1 (en)	2002-06-27
EP1358162A1 (de)	2003-11-05
US6706751B2 (en)	2004-03-16
BR0116263A (pt)	2003-12-30
ZA200304646B (en)	2004-09-13
CN1481366A (zh)	2004-03-10
AU1917602A (en)	2002-07-01
CA2431100C (en)	2009-03-24
EP1358162B1 (de)	2006-02-08
ES2257381T3 (es)	2006-08-01
ATE317386T1 (de)	2006-02-15
AR035408A1 (es)	2004-05-26
CN1208322C (zh)	2005-06-29
KR100530408B1 (ko)	2005-11-22

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IS6385A (is)	2002-05-15	Ný notkun og nýjar N-asabísýkló-amíð afleiður
AR028343A1 (es)	2003-05-07	Derivados de pirrolidina y piperidina
ATE540013T1 (de)	2012-01-15	Naphthalinderivate
EE200300071A (et)	2004-12-15	Kinasoliini derivaadid
ATE288437T1 (de)	2005-02-15	Tetrahydro-heterocycloazepinyl-pyrimidin-deriva e
ATE298332T1 (de)	2005-07-15	Decahydro-isochinolinderivate
DK1280809T3 (da)	2005-11-07	Antitumorecteinascidinderivater
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DK1368299T3 (da)	2006-11-27	Substituerede C-cyclohexylmethylaminderivater
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DE60032898D1 (de)	2007-02-22	Arylthiazolidindion- und aryloxazolidinderivate
DK1322593T3 (da)	2004-10-11	O-substituerede-6-methyl-tramadol-derivater
ATE282021T1 (de)	2004-11-15	Substituierte aminomethyl-phenyl- cyclohexanderivate
DE50113112D1 (de)	2007-11-22	Schaltungsanordnung
DE60117096D1 (de)	2006-04-20	Dihydroindol- und tetrahydrochinolinderivate
DK1246791T3 (da)	2005-02-14	Aminomethyl-phenyl-cyklohexanonderivater
NO20024617D0 (no)	2002-09-26	Aryl- og heteroarylsulfonater
ATE299873T1 (de)	2005-08-15	Substituierte c-furan-2-yl-methylamin- und c- thiophen-2-yl-methylamin-derivate
DE50112454D1 (de)	2007-06-14	Substituierte 5-amino-1-penten-3-ol-derivate
DE60118970D1 (de)	2006-05-24	Indol- und dihydroindolderivate
ATE374776T1 (de)	2007-10-15	Pyrrolotriazolopyrimidinonderivate
NO20024393D0 (no)	2002-09-13	2-fenylpyran-4-on-derivater

Legal Events

Date	Code	Title	Description
2007-03-08	8364	No opposition during term of opposition