Nothing Special   »   [go: up one dir, main page]

EE03425B1 - Lihtsa koostise ja kõrge biosaadavusega tsüklosporiini preparaadid suu kaudu manustamiseks ja nende valmistamismeetod - Google Patents

Lihtsa koostise ja kõrge biosaadavusega tsüklosporiini preparaadid suu kaudu manustamiseks ja nende valmistamismeetod

Info

Publication number
EE03425B1
EE03425B1 EE9700112A EE9700112A EE03425B1 EE 03425 B1 EE03425 B1 EE 03425B1 EE 9700112 A EE9700112 A EE 9700112A EE 9700112 A EE9700112 A EE 9700112A EE 03425 B1 EE03425 B1 EE 03425B1
Authority
EE
Estonia
Prior art keywords
cyclosporin
weight
oral administration
high bioavailability
ciclosporin
Prior art date
Application number
EE9700112A
Other languages
English (en)
Other versions
EE9700112A (et
Inventor
Olbrich Matthias
P�tter Heinrich
Original Assignee
Arzneimittelwerk Dresden Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arzneimittelwerk Dresden Gmbh filed Critical Arzneimittelwerk Dresden Gmbh
Publication of EE9700112A publication Critical patent/EE9700112A/et
Publication of EE03425B1 publication Critical patent/EE03425B1/et

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Transplantation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
EE9700112A 1994-11-03 1995-07-19 Lihtsa koostise ja kõrge biosaadavusega tsüklosporiini preparaadid suu kaudu manustamiseks ja nende valmistamismeetod EE03425B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4438861 1994-11-03
PCT/DE1995/000951 WO1996014079A1 (de) 1994-11-03 1995-07-19 Neue zubereitungsformen des cyclosporins zur oralen applikation mit einfacher zusammensetzung und hoher bioverfügbarkeit und verfahren zu deren herstellung

Publications (2)

Publication Number Publication Date
EE9700112A EE9700112A (et) 1997-12-15
EE03425B1 true EE03425B1 (et) 2001-06-15

Family

ID=6532126

Family Applications (1)

Application Number Title Priority Date Filing Date
EE9700112A EE03425B1 (et) 1994-11-03 1995-07-19 Lihtsa koostise ja kõrge biosaadavusega tsüklosporiini preparaadid suu kaudu manustamiseks ja nende valmistamismeetod

Country Status (27)

Country Link
US (1) US6486124B2 (et)
EP (1) EP0789580B1 (et)
JP (1) JP3833248B2 (et)
KR (1) KR970704464A (et)
CN (1) CN1121238C (et)
AT (1) ATE218359T1 (et)
AU (1) AU715165B2 (et)
BG (1) BG62955B1 (et)
BR (1) BR9509550A (et)
CA (1) CA2231404C (et)
CZ (1) CZ287806B6 (et)
DE (2) DE59510233D1 (et)
DK (1) DK0789580T3 (et)
EE (1) EE03425B1 (et)
ES (1) ES2177652T3 (et)
FI (1) FI118722B (et)
HU (1) HUT77283A (et)
LT (1) LT4306B (et)
LV (1) LV11884B (et)
NO (1) NO970741L (et)
PL (1) PL183579B1 (et)
PT (1) PT789580E (et)
RU (1) RU2158601C2 (et)
SK (1) SK164796A3 (et)
TR (1) TR199501361A2 (et)
TW (1) TW492876B (et)
WO (1) WO1996014079A1 (et)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EE03425B1 (et) 1994-11-03 2001-06-15 Arzneimittelwerk Dresden Gmbh Lihtsa koostise ja kõrge biosaadavusega tsüklosporiini preparaadid suu kaudu manustamiseks ja nende valmistamismeetod
NZ313899A (en) * 1995-08-25 2000-03-27 Univ North Carolina Oral cyclosporin compositions comprising cyclosporin A, a solvent either ethanol or propylene glycol and one non-ionic polyoxyethylene surfactant selected from polyoxyethylene alcohols and mono-esters of ethoxylated sorbitans
US5834017A (en) * 1995-08-25 1998-11-10 Sangstat Medical Corporation Oral cyclopsporin formulations
US5766629A (en) * 1995-08-25 1998-06-16 Sangstat Medical Corporation Oral cyclosporin formulations
US5962019A (en) * 1995-08-25 1999-10-05 Sangstat Medical Corporation Oral cyclosporin formulations
DE19544507B4 (de) * 1995-11-29 2007-11-15 Novartis Ag Cyclosporin enthaltende Präparate
AU762247B2 (en) * 1997-01-30 2003-06-19 Novartis Ag Oil-free pharmaceutical compositions containing cyclosporin A
BR9807528A (pt) * 1997-01-30 2000-03-14 Novartis Ag Composições farmacêuticas isentas de óleo contendo ciclosporina a
DE19821951A1 (de) * 1998-05-15 1999-11-18 Basf Ag Cyclosporin-Zubereitungen
AUPP627498A0 (en) 1998-10-02 1998-10-22 University Of Queensland, The Novel peptides - i
US6656504B1 (en) * 1999-09-09 2003-12-02 Elan Pharma International Ltd. Nanoparticulate compositions comprising amorphous cyclosporine and methods of making and using such compositions
US6506742B2 (en) 1999-12-13 2003-01-14 Ortho-Mcneil Pharmaceutical, Inc. Soluble contraceptive liquid formulation
EP2412719A1 (en) 2002-12-02 2012-02-01 Xenome Ltd Chi-conotoxin peptides
EP1572725B1 (en) 2002-12-02 2012-02-29 Xenome Ltd Chi-conotoxin peptides having a n-terminal pyroglutamic acid
SE0301119D0 (sv) * 2003-04-14 2003-04-14 Astrazeneca Ab New non-ionic surfactants for solubilizing poorly soluble molecules
CN1863510A (zh) 2003-08-13 2006-11-15 比奥孔有限公司 用于治疗剂的微－粒子脂肪酸盐固体剂量制剂
US20050059583A1 (en) 2003-09-15 2005-03-17 Allergan, Inc. Methods of providing therapeutic effects using cyclosporin components
US7135455B2 (en) * 2004-11-15 2006-11-14 Allergan, Inc Methods for the therapeutic use of cyclosporine components
US7151085B2 (en) * 2004-11-15 2006-12-19 Allergan, Inc. Therapeutic methods using cyclosporine components
MX2007012762A (es) 2005-04-12 2008-01-14 Elan Pharma Int Ltd Composiciones de material nanoparticulado y de liberacion controlada que comprende ciclosporina.
US7288520B2 (en) * 2005-07-13 2007-10-30 Allergan, Inc. Cyclosporin compositions
US20070015691A1 (en) 2005-07-13 2007-01-18 Allergan, Inc. Cyclosporin compositions
US7297679B2 (en) 2005-07-13 2007-11-20 Allergan, Inc. Cyclosporin compositions
US7276476B2 (en) * 2005-07-13 2007-10-02 Allergan, Inc. Cyclosporin compositions
US7202209B2 (en) * 2005-07-13 2007-04-10 Allergan, Inc. Cyclosporin compositions
US20070015693A1 (en) * 2005-07-13 2007-01-18 Allergan, Inc. Cyclosporin compositions
US7501393B2 (en) 2005-07-27 2009-03-10 Allergan, Inc. Pharmaceutical compositions comprising cyclosporins
US7745400B2 (en) * 2005-10-14 2010-06-29 Gregg Feinerman Prevention and treatment of ocular side effects with a cyclosporin
US9839667B2 (en) 2005-10-14 2017-12-12 Allergan, Inc. Prevention and treatment of ocular side effects with a cyclosporin
US8796221B2 (en) * 2011-11-15 2014-08-05 Allergan, Inc. Cyclosporin A form 2 and method of making same
ES2791751T3 (es) * 2011-11-15 2020-11-05 Allergan Inc Suspensiones de forma 2 de ciclosporina A

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1274354A (fr) 1956-03-10 1961-10-27 Agents tensio-actifs obtenus à partir de triglycérides et polyéthylène glycol
GB1171125A (en) 1966-06-08 1969-11-19 Glaxo Lab Ltd Improvements in or relating to Injectable Preparations
US3954967A (en) 1971-08-05 1976-05-04 Vanguard Chemical Company, Inc. Method of producing microcolloidal aqueous emulsions of unsaturated organic insecticidal compounds
US3813345A (en) 1971-08-05 1974-05-28 Vanguard Chem Co Inc Method of producing microcolloidal aqueous emulsions of unsaturated organic compounds
DE2455859C2 (de) 1973-12-06 1983-12-15 Sandoz-Patent-GmbH, 7850 Lörrach Das Antibiotikum Cyclosporin A (S 7481/F-1), seine Herstellung und Verwendung
US4073943A (en) 1974-09-11 1978-02-14 Apoteksvarucentralen Vitrum Ab Method of enhancing the administration of pharmalogically active agents
US4117118A (en) 1976-04-09 1978-09-26 Sandoz Ltd. Organic compounds
US4146499A (en) 1976-09-18 1979-03-27 Rosano Henri L Method for preparing microemulsions
JPS53107408A (en) 1977-02-28 1978-09-19 Yamanouchi Pharmaceut Co Ltd Micellar preparation for rectal infusion
CH636013A5 (en) 1978-03-07 1983-05-13 Sandoz Ag More readily absorbable pharmaceutical composition
SE445174B (sv) 1978-03-07 1986-06-09 Sandoz Ag Farmaceutisk komposition innehallande en cyklosporin och en berarsubstans
CH641356A5 (en) 1979-02-27 1984-02-29 Sandoz Ag Pharmaceutical compositions containing cyclosporin
AU543727B2 (en) 1980-06-02 1985-05-02 Ayerst Mckenna & Harrison Inc. Injectable composition of rapamycin
FR2502951B1 (fr) 1981-04-06 1985-12-06 Sandoz Sa Compositions pharmaceutiques topiques sous forme d'une micro-emulsion
AU558155B2 (en) 1982-02-01 1987-01-22 Sandoz Ltd. Treating multiple sclerosis with dihydro-cyclosporin d
DE3225706C2 (de) 1982-07-09 1984-04-26 A. Nattermann & Cie GmbH, 5000 Köln Flüssige Wirkstofformulierungen in Form von Konzentraten für Mikroemulsionen
DE3235612A1 (de) 1982-09-25 1984-03-29 Bayer Ag, 5090 Leverkusen Mikroemulsionen
DE3237814A1 (de) 1982-10-12 1984-04-12 Warner-Lambert Co., 07950 Morris Plains, N.J. Wasserfreie emulsionen und verwendung derselben
DE3315805A1 (de) 1983-04-30 1984-11-08 Bayer Ag, 5090 Leverkusen Wirkstoffzubereitungen
JPS6061535A (ja) 1983-08-24 1985-04-09 エフ・ホフマン・ラ・ロシユ・ウント・コンパニ−・アクチエンゲゼルシヤフト 製薬学的組成物
FR2553661B1 (fr) 1983-10-19 1985-12-20 Rhone Poulenc Sante Nouvelles microemulsions pharmaceutiquement acceptables
DE3406497A1 (de) 1984-02-23 1985-09-05 Mueller Bernhard Willi Werner Hochdisperse pharmazeutische mehrkomponentensysteme und verfahren zu ihrer herstellung
US4963367A (en) 1984-04-27 1990-10-16 Medaphore, Inc. Drug delivery compositions and methods
US4794000A (en) 1987-01-08 1988-12-27 Synthetic Blood Corporation Coacervate-based oral delivery system for medically useful compositions
US5639724A (en) 1984-07-24 1997-06-17 Sandoz Ltd. Cyclosporin galenic forms
GB8903804D0 (en) 1989-02-20 1989-04-05 Sandoz Ltd Improvements in or relating to organic compounds
EP0170623B1 (en) 1984-08-02 1990-11-28 Sandoz Ag Novel pharmaceutical use of (nva)2-cyclosporine
CH662944A5 (it) 1984-10-18 1987-11-13 Pier Luigi Prof Dr Luisi Procedimento per la preparazione di biocompatibili di micelle inverse di biocompatibili e loro utilizzazione.
JPS61280435A (ja) 1985-04-04 1986-12-11 Kanji Takada サイクロスポリン類のリンパ指向性製剤
JPS61249918A (ja) 1985-04-26 1986-11-07 Yutaka Mizushima 点眼剤
IL78929A0 (en) 1985-07-29 1986-09-30 Abbott Lab Microemulsion compositions for parenteral administration
US5023271A (en) 1985-08-13 1991-06-11 California Biotechnology Inc. Pharmaceutical microemulsions
US4797272A (en) 1985-11-15 1989-01-10 Eli Lilly And Company Water-in-oil microemulsions for cosmetic uses
SE457693B (sv) 1986-07-01 1989-01-23 Drilletten Ab Komposition med reglerad frigoering vari ett biologiskt material aer loest eller dispergerat i en l2-fas
EP0256856A3 (en) 1986-08-14 1989-01-11 Synthetic Blood Corporation A parenterally administrable composition
DE3629386A1 (de) 1986-08-29 1988-03-03 Scherer Gmbh R P Gelatinekapseln und verfahren zu ihrer herstellung
DE3707711A1 (de) 1987-03-11 1988-09-22 Hoechst Ag Oel-in-wasser-emulsionen, verfahren zu deren herstellung und deren verwendung
CA1301642C (en) 1987-03-30 1992-05-26 Howard Bernard Dawson Chemical formulations
US4798823A (en) 1987-06-03 1989-01-17 Merck & Co., Inc. New cyclosporin analogs with modified "C-9 amino acids"
ATE95193T1 (de) 1987-06-17 1993-10-15 Sandoz Ag Cyclosporine und deren benutzung als arzneimittel.
GB2206119B (en) 1987-06-22 1990-10-31 Merck & Co Inc A new cyclosporin derivative with modified "8-amino acid"
US4835002A (en) 1987-07-10 1989-05-30 Wolf Peter A Microemulsions of oil in water and alcohol
HU205010B (en) 1987-09-15 1992-03-30 Sandoz Ag Process for producing pharmaceutical compositions comprising compounds soluble up to 1 per cent and having medical activity
US5756450A (en) 1987-09-15 1998-05-26 Novartis Corporation Water soluble monoesters as solubilisers for pharmacologically active compounds and pharmaceutical excipients and novel cyclosporin galenic forms
IL88076A (en) 1987-10-28 1993-01-14 Nippon Shinyaku Co Ltd Fat emulsions as drug carriers
US4914188A (en) 1987-11-16 1990-04-03 Merck & Co., Inc. Novel 6-position cyclosporin analogs as non-immunosuppressive antagonists of cyclosporin binding to cyclophilin
HU203564B (en) 1987-12-21 1991-08-28 Sandoz Ag Process for producing new orthorombos cyclosporin without solvatation
ES2033086T3 (es) 1988-01-29 1993-03-01 Sankyo Company Limited Un procedimiento para la preparacion de una composicion farmaceutica.
CH679119A5 (et) 1988-05-13 1991-12-31 Sandoz Ag
HU201567B (en) * 1988-07-21 1990-11-28 Gyogyszerkutato Intezet Process for production of intravenous medical compositions containing cyclosphorin
KR0148748B1 (ko) 1988-09-16 1998-08-17 장 크라메르, 한스 루돌프 하우스 사이클로스포린을 함유하는 약학조성물
US5342625A (en) 1988-09-16 1994-08-30 Sandoz Ltd. Pharmaceutical compositions comprising cyclosporins
ES2052016T3 (es) 1988-09-29 1994-07-01 Shiseido Co Ltd Composicion emulsionada.
BE1003578A4 (fr) 1988-10-26 1992-04-28 Sandoz Sa Nouvelles compositions ophtalmiques a base d'une cyclosporine.
WO1990008537A1 (en) 1989-02-06 1990-08-09 Abbott Laboratories Pharmaceutical compositions for oral administration
GB2230440B (en) 1989-02-09 1993-05-19 Sandoz Ltd Novel cyclosporin galenic forms
US4996193A (en) 1989-03-03 1991-02-26 The Regents Of The University Of California Combined topical and systemic method of administration of cyclosporine
US5177110A (en) 1989-10-27 1993-01-05 Ciba-Geigy Corporation Injectable parasiticidal composition
HU207222B (en) 1990-02-15 1993-03-29 Chinoin Gyogyszer Es Vegyeszet Process for producing eyedrops containing primycin
US5260301A (en) 1990-03-01 1993-11-09 Fujisawa Pharmaceutical Co., Ltd. Pharmaceutical solution containing FK-506
HU208491B (en) 1990-11-27 1993-11-29 Gyogyszerkutato Intezet Process for producing oral pharmaceutical composition containing cyclosporin
GB9113872D0 (en) 1991-06-27 1991-08-14 Sandoz Ag Improvements in or relating to organic compounds
US5206219A (en) 1991-11-25 1993-04-27 Applied Analytical Industries, Inc. Oral compositions of proteinaceous medicaments
GB9208712D0 (en) 1992-04-22 1992-06-10 Sandoz Ltd Pharmaceutical compositions containing cyclosporin derivates
EP0589843B1 (en) 1992-09-25 2001-11-28 Novartis AG Pharmaceutical compositions containing cyclosporins
CH686761A5 (de) 1993-05-27 1996-06-28 Sandoz Ag Galenische Formulierungen.
IL111003A0 (en) 1993-09-30 1994-11-28 American Home Prod Multi-component oral rapamycin formulation
KR0146671B1 (ko) * 1994-02-25 1998-08-17 김충환 사이클로스포린-함유 분말 조성물
DE59409088D1 (de) 1994-10-04 2000-02-24 Lohmann Rudolf Lomapharm Lösungen von Anthrachinonen zur parenteralen Applikation
EE03425B1 (et) 1994-11-03 2001-06-15 Arzneimittelwerk Dresden Gmbh Lihtsa koostise ja kõrge biosaadavusega tsüklosporiini preparaadid suu kaudu manustamiseks ja nende valmistamismeetod

Also Published As

Publication number Publication date
AU715165B2 (en) 2000-01-20
NO970741D0 (no) 1997-02-18
BG101117A (en) 1997-08-29
BG62955B1 (bg) 2000-12-29
LV11884A (lv) 1997-12-20
PT789580E (pt) 2002-09-30
TR199501361A2 (tr) 1996-06-21
ATE218359T1 (de) 2002-06-15
FI970634A (fi) 1997-02-14
BR9509550A (pt) 1997-09-16
EP0789580A1 (de) 1997-08-20
NO970741L (no) 1997-02-18
CZ287806B6 (en) 2001-02-14
EE9700112A (et) 1997-12-15
ES2177652T3 (es) 2002-12-16
LV11884B (lv) 1998-03-20
KR970704464A (ko) 1997-09-06
WO1996014079A1 (de) 1996-05-17
CA2231404A1 (en) 1996-05-17
CN1121238C (zh) 2003-09-17
DE19539860A1 (de) 1996-05-09
JP3833248B2 (ja) 2006-10-11
US6486124B2 (en) 2002-11-26
FI970634A0 (fi) 1997-02-14
CA2231404C (en) 2009-02-17
DE59510233D1 (de) 2002-07-11
PL318560A1 (en) 1997-06-23
EP0789580B1 (de) 2002-06-05
US20020025927A1 (en) 2002-02-28
LT4306B (lt) 1998-03-25
PL183579B1 (pl) 2002-06-28
RU2158601C2 (ru) 2000-11-10
FI118722B (fi) 2008-02-29
SK164796A3 (en) 1997-06-04
TW492876B (en) 2002-07-01
HUT77283A (hu) 1998-03-30
LT97002A (en) 1997-11-25
CZ361696A3 (en) 1997-07-16
JPH10508306A (ja) 1998-08-18
DK0789580T3 (da) 2002-09-09
AU2975195A (en) 1996-05-31
CN1162265A (zh) 1997-10-15

Similar Documents

Publication Publication Date Title
EE03425B1 (et) Lihtsa koostise ja kõrge biosaadavusega tsüklosporiini preparaadid suu kaudu manustamiseks ja nende valmistamismeetod
KR100666016B1 (ko) 테스토스테론 운데카노에이트 및 피마자유를 포함하는 제제
DE59409644D1 (de) Cyclosporin enthaltende flüssige Zubereitungen und Verfahren zu ihrer Herstellung
CO4940469A1 (es) Composicion oral de estabilidad mejorada que comprende un derivado de indolinona y una mezcla de gliceridos o esteres de polietilenglicol
ATE299017T1 (de) Arzneimittel
GB9907715D0 (en) Pharmaceutical compositions
MY111841A (en) Injectable liposomal pharmaceutical preparations
RU97108682A (ru) Новые лекарственные формы циклоспорина для орального применения с простым составом и с высокой биоготовностью и способ их получения
MXPA04000535A (es) FORMULACIONES ANTIHISTAMINICAS PARA FORMAS DE DOSIFICACION DE CaPSULAS SUAVES.
ES2172172T3 (es) Composiciones farmaceuticas solidas para la administracion por via oral que permiten la liberacion modulada de nicorandil y su procedimiento de preparacion.
CA2572498A1 (en) Biphasic capsule formulation
TH23398A (th) ตำหรับใหม่ของไซโคลสปอรินสำหรับการให้ยาทางปากด้วยส่วนประกอบที่ง่ายและความสามารถที่คงอยู่ของฤทธิ์ทางชีวภาพที่สูงและกระบวนการสำหรับการผลิต
JP2000159660A (ja) シクロスポリンカプセル剤

Legal Events

Date Code Title Description
KB4A Valid patent at the end of a year

Effective date: 20021231

MM4A Lapsed by not paying the annual fees

Effective date: 20020719