GB2230440B - Novel cyclosporin galenic forms - Google Patents

Novel cyclosporin galenic forms

Info

Publication number: GB2230440B
Authority: GB; United Kingdom
Prior art keywords: galenic forms; novel cyclosporin; cyclosporin galenic; novel; forms
Prior art date: 1989-02-09
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

GB9002504A

Other versions

GB9002504D0 (en

GB2230440A (en

Inventor

Birgit Hauer

Ulrich Posanski

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Sandoz AG

Original Assignee

Sandoz AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-02-09

Filing date

1990-02-05

Publication date

1993-05-19

1989-02-09 Priority claimed from GB898902898A external-priority patent/GB8902898D0/en

1989-02-09 Priority claimed from GB898902901A external-priority patent/GB8902901D0/en

1989-02-13 Priority claimed from GB898903147A external-priority patent/GB8903147D0/en

1989-02-17 Priority claimed from GB898903663A external-priority patent/GB8903663D0/en

1990-02-05 Application filed by Sandoz AG filed Critical Sandoz AG

1990-04-04 Publication of GB9002504D0 publication Critical patent/GB9002504D0/en

1990-10-24 Publication of GB2230440A publication Critical patent/GB2230440A/en

1993-05-19 Application granted granted Critical

1993-05-19 Publication of GB2230440B publication Critical patent/GB2230440B/en

2010-02-05 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/485—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Immunology (AREA)
Epidemiology (AREA)
Physical Education & Sports Medicine (AREA)
Gastroenterology & Hepatology (AREA)
Molecular Biology (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Transplantation (AREA)
Oil, Petroleum & Natural Gas (AREA)
Neurology (AREA)
Biophysics (AREA)
Inorganic Chemistry (AREA)
Tropical Medicine & Parasitology (AREA)
Dermatology (AREA)
Pain & Pain Management (AREA)
Diabetes (AREA)
Biochemistry (AREA)
Hematology (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

GB9002504A 1989-02-09 1990-02-05 Novel cyclosporin galenic forms Expired - Lifetime GB2230440B (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GB898902898A GB8902898D0 (en)	1989-02-09	1989-02-09	Improvements in or relating to organic compounds
GB898902901A GB8902901D0 (en)	1989-02-09	1989-02-09	Improvements in or relating to organic compounds
GB898903147A GB8903147D0 (en)	1989-02-13	1989-02-13	Improvements in or relating to organic compounds
GB898903663A GB8903663D0 (en)	1989-02-17	1989-02-17	Improvements in or relating to organic compounds

Publications (3)

Publication Number	Publication Date
GB9002504D0 GB9002504D0 (en)	1990-04-04
GB2230440A GB2230440A (en)	1990-10-24
GB2230440B true GB2230440B (en)	1993-05-19

Family

ID=27450262

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
GB9002504A Expired - Lifetime GB2230440B (en)	1989-02-09	1990-02-05	Novel cyclosporin galenic forms

Country Status (25)

Country	Link
JP (3)	JP3484190B2 (en)
KR (1)	KR0170769B1 (en)
AT (1)	AT404552B (en)
AU (1)	AU630413B2 (en)
BE (1)	BE1003009A5 (en)
CA (1)	CA2009533C (en)
CH (1)	CH679277A5 (en)
CY (1)	CY1903A (en)
DE (1)	DE4003844B4 (en)
DK (1)	DK176209B1 (en)
ES (1)	ES2021942A6 (en)
FI (1)	FI97524C (en)
FR (1)	FR2642650B1 (en)
GB (1)	GB2230440B (en)
HK (1)	HK37296A (en)
HU (1)	HU213394B (en)
IT (1)	IT1240758B (en)
LU (1)	LU87675A1 (en)
MY (1)	MY107377A (en)
NL (1)	NL195028C (en)
NO (1)	NO301576B1 (en)
NZ (1)	NZ232401A (en)
PH (1)	PH30917A (en)
PT (1)	PT93079B (en)
SE (1)	SE511398C2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8580954B2 (en)	2006-03-28	2013-11-12	Hospira, Inc.	Formulations of low dose diclofenac and beta-cyclodextrin

Families Citing this family (32)

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KR0148748B1 (en) *	1988-09-16	1998-08-17	장 크라메르, 한스 루돌프 하우스	A multiphase cyclosporin composition
HU208491B (en) *	1990-11-27	1993-11-29	Gyogyszerkutato Intezet	Process for producing oral pharmaceutical composition containing cyclosporin
MX9201782A (en) †	1991-04-19	1992-10-01	Sandoz Ag	PARTICLES OF BIOLOGICALLY ACTIVE SUBSTANCES, SUBSTANTIALLY INSOLUBLE IN WATER, PROCESS FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITION THAT CONTAINS THEM.
US6262022B1 (en)	1992-06-25	2001-07-17	Novartis Ag	Pharmaceutical compositions containing cyclosporin as the active agent
GB9113872D0 (en) *	1991-06-27	1991-08-14	Sandoz Ag	Improvements in or relating to organic compounds
ES2098739T3 (en)	1992-05-13	1997-05-01	Sandoz Ltd	OPHTHALMIC COMPOSITIONS CONTAINING A CYCLOSPORIN.
US5759566A (en) *	1992-07-28	1998-06-02	Poli Industria Chimica Spa	Microemulsion pharmaceutical compositions for the delivery of pharmaceutically active agents
EP0589843B1 (en)	1992-09-25	2001-11-28	Novartis AG	Pharmaceutical compositions containing cyclosporins
PT697881E (en) †	1993-04-20	2002-10-31	Novartis Ag	NEW PHARMACEUTICAL COMPOSITIONS CONTAINING CYCLOSPORINE FOR ORAL ADMINISTRATION
DE4412201A1 (en) *	1993-04-20	1994-11-10	Rentschler Arzneimittel	New pharmaceutical preparations for oral administration containing cyclosporin
DE4340781C3 (en) *	1993-11-30	2000-01-27	Novartis Ag	Liquid preparations containing cyclosporin and process for their preparation
KR0146671B1 (en) *	1994-02-25	1998-08-17	김충환	Cyclosporin-containing powder composition
ATE218359T1 (en)	1994-11-03	2002-06-15	Novartis Erfind Verwalt Gmbh	NEW PREPARATION FORMS OF CYCLOSPORIN FOR ORAL APPLICATION WITH SIMPLE COMPOSITION AND HIGH BIOAVAILABILITY AND METHOD FOR THE PRODUCTION THEREOF
US5679566A (en) *	1995-01-20	1997-10-21	University Of Massachusetts Medical Center	Yeast NMD2 gene
US5962019A (en) *	1995-08-25	1999-10-05	Sangstat Medical Corporation	Oral cyclosporin formulations
US5766629A (en)	1995-08-25	1998-06-16	Sangstat Medical Corporation	Oral cyclosporin formulations
US5827822A (en) *	1996-03-25	1998-10-27	Sangstat Medical Corporation	Cyclosporin a formulations as nanoparticles
US5834017A (en) *	1995-08-25	1998-11-10	Sangstat Medical Corporation	Oral cyclopsporin formulations
DE19544507B4 (en)	1995-11-29	2007-11-15	Novartis Ag	Cyclosporin containing preparations
US5798333A (en) *	1996-09-17	1998-08-25	Sherman; Bernard C.	Water-soluble concentrates containing cyclosporins
AU762247B2 (en) *	1997-01-30	2003-06-19	Novartis Ag	Oil-free pharmaceutical compositions containing cyclosporin A
CA2278675A1 (en) *	1997-01-30	1998-08-06	Novartis Ag	Hard gelatine capsules containing pharmaceutical compositions substantially free of any oil
JP4718653B2 (en) *	1997-03-12	2011-07-06	アボツト・ラボラトリーズ	Hydrophilic two-component system for administration of cyclosporine
NZ328751A (en) *	1997-09-16	1999-01-28	Bernard Charles Sherman	Solid medicament containing an anionic surfactant and cyclosporin
US6447806B1 (en)	1999-02-25	2002-09-10	Novartis Ag	Pharmaceutical compositions comprised of stabilized peptide particles
US6979672B2 (en)	2002-12-20	2005-12-27	Polichem, S.A.	Cyclosporin-based pharmaceutical compositions
JP4521554B2 (en) *	2004-03-31	2010-08-11	マイラン製薬株式会社	Cyclosporine preparation
EP1959935A2 (en) *	2005-10-26	2008-08-27	Banner Pharmacaps Inc.	Hydrophilic vehicle-based dual controlled release matrix system as capsule fill
US7495024B2 (en)	2006-08-07	2009-02-24	Via Pharmaceuticals, Inc.	Phenylalkyl N-hydroxyureas for combating atherosclerotic plaque
DE102008059201A1 (en) *	2008-11-27	2010-06-02	GÖPFERICH, Achim, Prof. Dr.	In situ precipitating drug solutions
KR102146704B1 (en)	2018-04-13	2020-08-21	가천대학교 산학협력단	Cyclosporin a containing microstructures for transdermal and intradermal drug delivery
WO2023063376A1 (en) *	2021-10-13	2023-04-20	中外製薬株式会社	Composition including peptide compound and surfactant

Citations (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2209671A (en) *	1987-09-15	1989-05-24	Sandoz Ltd	Water soluble monoesters as solubilisers
WO1990001329A1 (en) *	1988-07-30	1990-02-22	Kanji Takada	Enteric formulations of physiologically active peptides and proteins
GB2222770A (en) *	1988-09-16	1990-03-21	Sandoz Ltd	Cyclosporin emulsion compositions
JPH1038029A (en) *	1996-07-26	1998-02-13	Ebara Corp	Dick shape structure with vibration damping function
JPH10280435A (en) *	1997-04-03	1998-10-20	Sekisui Chem Co Ltd	Construction method of basement

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Publication number	Priority date	Publication date	Assignee	Title
DE2907460A1 (en) *	1978-03-07	1979-09-13	Sandoz Ag	NEW RESORBABLE GALENIC COMPOSITIONS
JPS61280435A (en) *	1985-04-04	1986-12-11	Kanji Takada	Lymph orienting preparation of cyclosporin
NL8600050A (en) *	1986-01-13	1987-08-03	Sanico Nv	PHARMACEUTICAL PREPARATION WITH DELAYED DELIVERY OF THE ACTIVE SUBSTANCE AND METHOD FOR PREPARING IT.
GB8602372D0 (en) *	1986-01-31	1986-03-05	Sandoz Ltd	Organic compounds
CA1290249C (en) *	1986-04-09	1991-10-08	Cetus Corporation	COMBINATION THERAPY USING INTERLEUKIN-2 AND/OR INTERFERON-.beta. AND TUMOR NECROSIS FACTOR
EP0267615A3 (en) *	1986-11-13	1989-05-03	Sloan-Kettering Institute For Cancer Research	Compositions and method for treatment of cancer using monoclonal antibody against gd3 ganglioside together with il-2
EP0296122B1 (en) *	1987-06-17	1993-09-29	Sandoz Ag	Cyclosporins and their use as pharmaceuticals
JP2536876B2 (en) *	1987-07-31	1996-09-25	寛治高田	Dissolvable powder formulation of cyclosporine
US5756450A (en) *	1987-09-15	1998-05-26	Novartis Corporation	Water soluble monoesters as solubilisers for pharmacologically active compounds and pharmaceutical excipients and novel cyclosporin galenic forms
DE3830494B4 (en) *	1987-09-15	2006-05-18	Novartis Ag	Water-soluble monoesters as solubilizers for pharmacologically active substances and pharmaceutical excipients

1990
- 1990-02-05 GB GB9002504A patent/GB2230440B/en not_active Expired - Lifetime
- 1990-02-05 CH CH359/90A patent/CH679277A5/de not_active IP Right Cessation
- 1990-02-05 BE BE9000133A patent/BE1003009A5/en not_active IP Right Cessation
- 1990-02-05 FR FR9001389A patent/FR2642650B1/en not_active Expired - Lifetime
- 1990-02-07 HU HU90701A patent/HU213394B/en unknown
- 1990-02-07 PH PH40014A patent/PH30917A/en unknown
- 1990-02-07 LU LU87675A patent/LU87675A1/en unknown
- 1990-02-07 PT PT93079A patent/PT93079B/en not_active IP Right Cessation
- 1990-02-07 FI FI900604A patent/FI97524C/en active IP Right Grant
- 1990-02-07 CA CA002009533A patent/CA2009533C/en not_active Expired - Lifetime
- 1990-02-07 NO NO900577A patent/NO301576B1/en not_active IP Right Cessation
- 1990-02-07 SE SE9000441A patent/SE511398C2/en not_active Application Discontinuation
- 1990-02-07 NZ NZ232401A patent/NZ232401A/en unknown
- 1990-02-07 DK DK199000327A patent/DK176209B1/en not_active IP Right Cessation
- 1990-02-07 MY MYPI90000191A patent/MY107377A/en unknown
- 1990-02-08 AT AT0027290A patent/AT404552B/en not_active IP Right Cessation
- 1990-02-08 DE DE4003844A patent/DE4003844B4/en not_active Expired - Lifetime
- 1990-02-08 KR KR1019900001492A patent/KR0170769B1/en not_active IP Right Cessation
- 1990-02-08 NL NL9000299A patent/NL195028C/en not_active IP Right Cessation
- 1990-02-08 JP JP03134890A patent/JP3484190B2/en not_active Expired - Lifetime
- 1990-02-08 IT IT47609A patent/IT1240758B/en active IP Right Grant
- 1990-02-08 AU AU49252/90A patent/AU630413B2/en not_active Expired
- 1990-02-09 ES ES9000397A patent/ES2021942A6/en not_active Expired - Lifetime
1996
- 1996-03-07 HK HK37296A patent/HK37296A/en not_active IP Right Cessation
- 1996-11-22 CY CY190396A patent/CY1903A/en unknown
2001
- 2001-04-25 JP JP2001127538A patent/JP4073641B2/en not_active Expired - Lifetime
2005
- 2005-09-13 JP JP2005265724A patent/JP2006001947A/en active Pending

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2209671A (en) *	1987-09-15	1989-05-24	Sandoz Ltd	Water soluble monoesters as solubilisers
WO1990001329A1 (en) *	1988-07-30	1990-02-22	Kanji Takada	Enteric formulations of physiologically active peptides and proteins
GB2222770A (en) *	1988-09-16	1990-03-21	Sandoz Ltd	Cyclosporin emulsion compositions
JPH1038029A (en) *	1996-07-26	1998-02-13	Ebara Corp	Dick shape structure with vibration damping function
JPH10280435A (en) *	1997-04-03	1998-10-20	Sekisui Chem Co Ltd	Construction method of basement

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8580954B2 (en)	2006-03-28	2013-11-12	Hospira, Inc.	Formulations of low dose diclofenac and beta-cyclodextrin
US8946292B2 (en)	2006-03-28	2015-02-03	Javelin Pharmaceuticals, Inc.	Formulations of low dose diclofenac and beta-cyclodextrin

Also Published As

Publication number	Publication date
BE1003009A5 (en)	1991-10-22
LU87675A1 (en)	1991-10-08
HU213394B (en)	1997-06-30
HK37296A (en)	1996-03-15
DK32790A (en)	1990-08-10
FR2642650A1 (en)	1990-08-10
KR900012625A (en)	1990-09-01
JPH02235817A (en)	1990-09-18
DE4003844A1 (en)	1990-08-16
GB9002504D0 (en)	1990-04-04
JP2001302538A (en)	2001-10-31
CA2009533A1 (en)	1990-08-09
HU900701D0 (en)	1990-04-28
IT9047609A0 (en)	1990-02-08
PH30917A (en)	1997-12-23
CY1903A (en)	1996-11-22
AU4925290A (en)	1990-08-16
CH679277A5 (en)	1992-01-31
JP4073641B2 (en)	2008-04-09
FR2642650B1 (en)	1994-12-09
MY107377A (en)	1995-11-30
FI900604A0 (en)	1990-02-07
FI97524C (en)	1997-01-10
ES2021942A6 (en)	1991-11-16
NO900577D0 (en)	1990-02-07
DK176209B1 (en)	2007-02-05
AU630413B2 (en)	1992-10-29
ATA27290A (en)	1998-05-15
JP3484190B2 (en)	2004-01-06
PT93079A (en)	1990-08-31
PT93079B (en)	1996-04-30
JP2006001947A (en)	2006-01-05
DK32790D0 (en)	1990-02-07
NO301576B1 (en)	1997-11-17
SE9000441D0 (en)	1990-02-07
NO900577L (en)	1990-08-10
IT1240758B (en)	1993-12-17
SE9000441L (en)	1991-08-08
SE511398C2 (en)	1999-09-20
IT9047609A1 (en)	1991-08-08
NL195028C (en)	2003-12-02
NL195028B (en)	2003-08-01
NZ232401A (en)	1992-10-28
DE4003844B4 (en)	2007-09-20
FI97524B (en)	1996-09-30
GB2230440A (en)	1990-10-24
CA2009533C (en)	2002-11-12
AT404552B (en)	1998-12-28
NL9000299A (en)	1990-09-03
KR0170769B1 (en)	1999-02-01

Publication	Publication Date	Title
GB2228198B (en)	1992-12-16	Novel cyclosporin galenic forms
GB2230440B (en)	1993-05-19	Novel cyclosporin galenic forms
HK35697A (en)	1997-03-27	Cyclosporin compositions
GB2224205B (en)	1992-04-15	Cyclosporin ophthalmic compositions
GB8908250D0 (en)	1989-05-24	Formulations
HK41196A (en)	1996-03-15	Signal-source arrangement
EP0423928A3 (en)	1992-06-10	Multi-ferrule structure
ZA899459B (en)	1990-09-26	Separator
GB2228843B (en)	1993-01-20	Integration arrangement
GB9027564D0 (en)	1991-02-06	Microlaminated structure
AP9000174A0 (en)	1990-04-30	Antiparasitical formulations
ZA90993B (en)	1991-10-30	Novel cyclosporin galenic forms
GB2227744B (en)	1992-08-05	Pharmaceutically useful nitromethyl-sulphones
GB2231507B (en)	1993-06-09	Separator
HUT60012A (en)	1992-07-28	Height-limiting structure
EP0419411A3 (en)	1991-09-04	Additional alkanophenones
IE893439L (en)	1990-04-26	Cyclosporin ophthalmic compositions
IL90524A0 (en)	1990-01-18	Improved hair-comb
GB8908716D0 (en)	1989-06-07	Improved skipole
GB8907728D0 (en)	1989-05-17	Improved chessboards
GB8906859D0 (en)	1989-05-10	Separator
HUT56427A (en)	1991-08-28	Door-case structure
HUT60011A (en)	1992-07-28	Height-limiting structure
GB8927241D0 (en)	1990-01-31	Kerbing structure
HUT55086A (en)	1991-04-29	Pump-protecting arrangement

Legal Events

Date	Code	Title	Description
1997-06-25	732E	Amendments to the register in respect of changes of name or changes affecting rights (sect. 32/1977)
2010-02-24	PE20	Patent expired after termination of 20 years	Expiry date: 20100204