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ECSP16070447A - Moleculas de anticuerpo para tim-3 y sus usos - Google Patents

Moleculas de anticuerpo para tim-3 y sus usos

Info

Publication number
ECSP16070447A
ECSP16070447A ECIEPI201670447A ECPI201670447A ECSP16070447A EC SP16070447 A ECSP16070447 A EC SP16070447A EC IEPI201670447 A ECIEPI201670447 A EC IEPI201670447A EC PI201670447 A ECPI201670447 A EC PI201670447A EC SP16070447 A ECSP16070447 A EC SP16070447A
Authority
EC
Ecuador
Prior art keywords
seq
amino acid
acid sequence
vhcdr1
vhcdr2
Prior art date
Application number
ECIEPI201670447A
Other languages
English (en)
Inventor
T Umetsu Dale
Vasquez Maximiliano
Xu Fangmin
Huber Thomas
J Hicklin Daniel
A Blattler Walter
Hu Tiancen
James Freeman Gordon
Anne Sabatos-Peyton Catherine
Brannetti Barbara
A Taraszka John
Pietzonka Thomas
S Harris Alan
Marie Mataraza Jennifer
H Dekruyff Rosemarie
Original Assignee
Childrens Medical Center
Novartis Ag
Dana Farber Cancer Inst Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52478098&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP16070447(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Childrens Medical Center, Novartis Ag, Dana Farber Cancer Inst Inc filed Critical Childrens Medical Center
Publication of ECSP16070447A publication Critical patent/ECSP16070447A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
    • G—PHYSICS
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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Abstract

1. Una molécula de anticuerpo aislada capaz de unirse al dominio de inmunoglobulina de células T humanas y al dominio de mucina 3 (TIM-3), que comprende: (a) una región variable de cadena pesada (VH) que comprende una secuencia de aminoácidos VHCDR1 elegida a partir de la SEQ ID NO: 9 y la secuencia de aminoácidos VHCDR2 de la SEC ID NO: 10 y la secuencia de aminoácidos VHCDR3 de la SEC ID NO: 5; y una cadena ligera de la región variable (VL) que comprende una secuencia de aminoácidos VLCDR1 de SEC ID NO: 12, una secuencia de aminoácidos VLCDR2 de la SEC ID NO: 13 y la secuencia de aminoácidos VLCDR3 de la SEC ID NO: 14; (b) una VH que comprende una secuencia de aminoácidos VHCDR1 elegida a partir de la SEQ ID NO: 3 y la secuencia de aminoácidos VHCDR2 de la SEC ID NO: 4 y la secuencia de aminoácidos VHCDR3 de la SEC ID NO: 5, y una VL que comprende una secuencia de aminoácidos VLCDR1 de la SEC ID NO: 6, una secuencia de aminoácidos VLCDR2 de la SEC ID NO: 7 y la secuencia de aminoácidos VLCDR3 de la SEC ID NO: 8; (c) una VH que comprende una secuencia de aminoácidos VHCDR1 elegida a partir de la SEQ ID NO: 9; una secuencia de aminoácidos VHCDR2 de la SEC ID NO: 25 y la secuencia de aminoácidos VHCDR3 de la SEC ID NO: 5, y una VL que comprende una secuencia de aminoácidos VLCDR1 de la SEC ID NO: 12, una secuencia de aminoácidos VLCDR2 de la SEC ID NO: 13 y la secuencia de aminoácidos VLCDR3 de la SEC ID NO: 14; (d) una VH que comprende una secuencia de aminoácidos VHCDR1
ECIEPI201670447A 2014-01-31 2016-08-29 Moleculas de anticuerpo para tim-3 y sus usos ECSP16070447A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461934469P 2014-01-31 2014-01-31
US201462094912P 2014-12-19 2014-12-19

Publications (1)

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ECSP16070447A true ECSP16070447A (es) 2019-07-31

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US (6) US9605070B2 (es)
EP (3) EP4324518A3 (es)
JP (3) JP6539667B2 (es)
KR (2) KR20220028145A (es)
CN (2) CN113896791A (es)
AU (2) AU2015210750B2 (es)
BR (1) BR112016016436A2 (es)
CA (1) CA2936863A1 (es)
CL (1) CL2016001716A1 (es)
CR (1) CR20160347A (es)
CU (1) CU24427B1 (es)
CY (1) CY1121893T1 (es)
DK (1) DK3099717T3 (es)
EA (1) EA201691556A1 (es)
EC (1) ECSP16070447A (es)
ES (2) ES2732901T3 (es)
HR (1) HRP20191083T1 (es)
HU (1) HUE045065T2 (es)
IL (1) IL246693B2 (es)
JO (2) JOP20200096A1 (es)
LT (1) LT3099717T (es)
ME (1) ME03489B (es)
MX (2) MX2016009961A (es)
MY (1) MY187296A (es)
NZ (2) NZ722042A (es)
PE (1) PE20170330A1 (es)
PH (1) PH12016501482A1 (es)
PL (1) PL3099717T3 (es)
PT (1) PT3099717T (es)
RS (1) RS59065B1 (es)
SG (1) SG11201605627TA (es)
SI (1) SI3099717T1 (es)
TW (2) TWI769434B (es)
UY (1) UY35973A (es)
WO (1) WO2015117002A1 (es)

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NZ564243A (en) * 2005-06-08 2011-03-31 Dana Farber Cancer Inst Inc Methods and compositions for the treatment of persistent infections by inhibiting the programmed cell death 1 (PD-1) pathway
US20120064096A1 (en) * 2009-03-17 2012-03-15 Universite De La Mediterranee BTLA Antibodies and Uses Thereof
WO2012123586A1 (en) 2011-03-16 2012-09-20 arGEN-X BV Antibodies to cd70
DK2734205T3 (en) 2011-07-21 2018-06-14 Tolero Pharmaceuticals Inc Heterocyclic Protein Kinase Inhibitors
US10570204B2 (en) 2013-09-26 2020-02-25 The Medical College Of Wisconsin, Inc. Methods for treating hematologic cancers
JOP20200094A1 (ar) 2014-01-24 2017-06-16 Dana Farber Cancer Inst Inc جزيئات جسم مضاد لـ pd-1 واستخداماتها
JOP20200096A1 (ar) 2014-01-31 2017-06-16 Children’S Medical Center Corp جزيئات جسم مضاد لـ tim-3 واستخداماتها
US10519237B2 (en) 2014-03-12 2019-12-31 Yeda Research And Development Co. Ltd Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS
AU2015228372B2 (en) 2014-03-12 2018-05-31 Yeda Research And Development Co. Ltd Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS
US9394365B1 (en) 2014-03-12 2016-07-19 Yeda Research And Development Co., Ltd Reducing systemic regulatory T cell levels or activity for treatment of alzheimer's disease
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