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EA202192588A1 - Фармацевтическая композиция, включающая вариант ph20 гиалуронидазы человека, и лекарственное средство для подкожного введения - Google Patents

Фармацевтическая композиция, включающая вариант ph20 гиалуронидазы человека, и лекарственное средство для подкожного введения

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EA202192588A1
EA202192588A1 EA202192588A EA202192588A EA202192588A1 EA 202192588 A1 EA202192588 A1 EA 202192588A1 EA 202192588 A EA202192588 A EA 202192588A EA 202192588 A EA202192588 A EA 202192588A EA 202192588 A1 EA202192588 A1 EA 202192588A1
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pharmaceutical composition
variant
human
drug
amino acid
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EA202192588A
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Сун Чэ ПАК
Хе-Син ЧОН
Сон Чу ЛИ
Кёван Ким
Минсо Бён
Ки Сок Нам
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Алтеоген Инк.
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    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2474—Hyaluronoglucosaminidase (3.2.1.35), i.e. hyaluronidase
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    • C12Y302/01035—Hyaluronoglucosaminidase (3.2.1.35), i.e. hyaluronidase

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Abstract

Изобретение относится к фармацевтической композиции, включающей (a) лекарственное средство и (b) вариант PH20 человека. Вариант PH20 человека, содержащийся в фармацевтической композиции согласно настоящему изобретению, включает замену(ы) аминокислотного остатка в одной или нескольких областях, выбранных из области альфа-спирали 8 (S347-C381) и линкерной области (A333-R346) между альфа-спиралью 7 и альфа-спиралью 8 в PH20 человека дикого типа, имеющей аминокислотную последовательность SEQ ID NO: 1, где аминокислотный остаток(и), расположенный(ые) на N-конце или C-конце, избирательно удален(ы). Кроме того, фармацевтическая композиция согласно настоящему изобретению может дополнительно включать фармацевтически приемлемую добавку, в частности стабилизатор. Фармацевтическая композиция согласно настоящему изобретению может максимизировать терапевтический эффект лекарственного средства, используемого в комбинации с ней, благодаря эффекту вариантов PH20 человека.
EA202192588A 2019-03-25 2020-03-24 Фармацевтическая композиция, включающая вариант ph20 гиалуронидазы человека, и лекарственное средство для подкожного введения EA202192588A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20190033880 2019-03-25
PCT/KR2020/003975 WO2020197230A1 (ko) 2019-03-25 2020-03-24 인간 히알루로니다제 ph20의 변이체와 약물을 포함하는 피하투여용 약학 조성물

Publications (1)

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EA202192588A1 true EA202192588A1 (ru) 2022-03-17

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AU (2) AU2020248612B9 (ru)
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EA (1) EA202192588A1 (ru)
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Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI3130347T1 (sl) 2011-12-30 2020-02-28 Halozyme, Inc. Variante polipeptida PH20, formulacije in uporabe le-teh
LT3448391T (lt) 2016-04-27 2024-06-25 AbbVie Manufacturing Management Unlimited Company Ligų, kurių atveju il-13 aktyvumas yra žalingas, gydymo būdas, panaudojant anti-il-13 antikūnus
WO2018156180A1 (en) 2017-02-24 2018-08-30 Kindred Biosciences, Inc. Anti-il31 antibodies for veterinary use
JOP20200275A1 (ar) 2018-05-10 2020-11-02 Regeneron Pharma صيغ تحتوي على بروتين اندماج لمستقبلvegf مرتفعة التركيز
CN111971387A (zh) * 2018-07-25 2020-11-20 阿特根公司 新型透明质酸水解酶突变体和包含其的药物组合物
JP7137696B2 (ja) 2019-05-14 2022-09-14 プロヴェンション・バイオ・インコーポレイテッド １型糖尿病を予防するための方法および組成物
CA3137324A1 (en) * 2020-01-23 2021-07-29 Alteogen, Inc. Novel hyaluronidase variants with improved stability and pharmaceutical composition containing the same
AU2021287998A1 (en) 2020-06-11 2023-02-02 Benaroya Research Institute At Virginia Mason Methods and compositions for preventing type 1 diabetes
IL303350A (en) 2020-12-04 2023-08-01 Macrogenics Inc Preparations containing an antibody against HER2/NEU and their use
JP2024503265A (ja) 2020-12-28 2024-01-25 ブリストル－マイヤーズ スクイブ カンパニー 抗体組成物およびその使用の方法
AU2021416156A1 (en) 2020-12-28 2023-06-22 Bristol-Myers Squibb Company Methods of treating tumors
JP2024530152A (ja) 2021-08-02 2024-08-16 アルジェニクス ビーブイ 皮下単位剤形
JP2024535021A (ja) 2021-09-14 2024-09-26 武田薬品工業株式会社 ヒアルロニダーゼを用いた濃縮抗体製剤の容易化された送達
AU2022376750A1 (en) * 2021-10-29 2024-05-16 Alteogen Inc. Pharmaceutical composition comprising human hyaluronidase ph20 and drug
WO2023168305A1 (en) 2022-03-01 2023-09-07 Exuma Biotech Corp. Viral particles with membrane-bound hyaluronidase
MX2024009994A (es) * 2022-03-07 2024-08-22 Mabxience Res S L Formulaciones estables para anticuerpos.
KR20230150203A (ko) * 2022-04-20 2023-10-30 주식회사 알토스바이오로직스 오크렐리주맙(Ocrelizumab)을 포함하는 약학적 조성물과 그의 용도
WO2023235847A1 (en) 2022-06-02 2023-12-07 Bristol-Myers Squibb Company Antibody compositions and methods of use thereof
CN118401661A (zh) * 2022-06-22 2024-07-26 阿特根公司 N-末端和/或c-末端切割的可溶性ph20多肽及其用途
WO2024005502A1 (ko) * 2022-06-29 2024-01-04 주식회사 오디스젠 중성 ph에서 활성을 나타내는 히알루로니다제 hyal1 변이체
KR20240038901A (ko) * 2022-09-16 2024-03-26 (주)피앤피바이오팜 신규한 히알루로니다제 ph-20 변이체 및 그 용도
WO2024117476A1 (ko) * 2022-11-28 2024-06-06 주식회사 대웅제약 생체이용률이 개선된 니클로사마이드 함유 조성물
KR102554775B1 (ko) * 2023-02-07 2023-07-12 한국코러스 주식회사 히알루로니다제의 안정화제 및 이를 포함하는 히알루로니다제 제형
WO2024196173A1 (ko) * 2023-03-23 2024-09-26 (주)알테오젠 신규 히알루론산 가수분해 효소 변이체 및 이를 포함하는 약제학적 조성물

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1603541B2 (en) * 2003-03-05 2013-01-23 Halozyme, Inc. SOLUBLE HYALURONIDASE GLYCOPROTEIN (sHASEGP), PROCESS FOR PREPARING THE SAME, USES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEREOF
KR20080082628A (ko) 2005-11-10 2008-09-11 리셉터 바이오로직스 인크 수용체 및 리간드 이소형태의 제조 방법
TWI532498B (zh) * 2008-03-17 2016-05-11 巴克斯特保健公司 供免疫球蛋白及玻尿酸酶之皮下投藥之用的組合及方法
NZ588638A (en) * 2008-04-14 2012-09-28 Halozyme Inc Screening method for identifying a subject for treatment with a modified hyaluronidase polypeptides
CA2746181C (en) * 2008-12-09 2016-03-15 Halozyme, Inc. Extended soluble ph20 polypeptides and uses thereof
US20100305500A1 (en) * 2009-05-29 2010-12-02 Pacira Pharmaceuticals, Inc. Hyaluronidase as an adjuvant for increasing the injection volume and dispersion of large diameter synthetic membrane vesicles containing a therapeutic agent
US9345661B2 (en) * 2009-07-31 2016-05-24 Genentech, Inc. Subcutaneous anti-HER2 antibody formulations and uses thereof
SI3130347T1 (sl) * 2011-12-30 2020-02-28 Halozyme, Inc. Variante polipeptida PH20, formulacije in uporabe le-teh
TW201534726A (zh) 2013-07-03 2015-09-16 Halozyme Inc 熱穩定ｐｈ２０玻尿酸酶變異體及其用途
JP6537076B2 (ja) * 2014-07-31 2019-07-03 国立大学法人神戸大学 分泌シグナルペプチドならびにそれを利用したタンパク質の分泌および細胞表層提示
HUE043847T2 (hu) 2014-08-28 2019-09-30 Halozyme Inc Hialuronán-lebontó enzimmel és egy immun checkpoint inhibitorral végzett kombinációs terápia
CA3045007A1 (en) * 2016-11-30 2018-06-07 Memorial Sloan Kettering Cancer Center Inhibitor-functionalized ultrasmall nanoparticles and methods thereof
HUE064898T2 (hu) * 2017-03-02 2024-04-28 Genentech Inc HER2-pozitív emlõrák adjuváns kezelése
JOP20190260A1 (ar) * 2017-05-02 2019-10-31 Merck Sharp & Dohme صيغ ثابتة لأجسام مضادة لمستقبل الموت المبرمج 1 (pd-1) وطرق استخدامها
CN111971387A (zh) * 2018-07-25 2020-11-20 阿特根公司 新型透明质酸水解酶突变体和包含其的药物组合物

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DOP2021000197A (es) 2021-11-15
AU2020248612B2 (en) 2023-11-23
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CN116870164B (zh) 2024-07-23
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CL2021002464A1 (es) 2022-07-22
MX2021011278A (es) 2022-03-17
JP2021526542A (ja) 2021-10-07
JP2023078146A (ja) 2023-06-06
AU2020248612B9 (en) 2023-11-30
ZA202209369B (en) 2023-07-26
JP7166478B2 (ja) 2022-11-07
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SG11202110512WA (en) 2021-10-28
KR102650991B1 (ko) 2024-03-27
CN112203642A (zh) 2021-01-08
JOP20210262A1 (ar) 2023-01-30
EP3785701A4 (en) 2022-03-16
KR20220075238A (ko) 2022-06-07
KR20200130451A (ko) 2020-11-18
ZA202108027B (en) 2022-12-21
EP3785701A1 (en) 2021-03-03
AU2020248612A1 (en) 2021-10-21
KR20230037691A (ko) 2023-03-16
CO2021012380A2 (es) 2021-10-20
CR20210489A (es) 2021-12-07
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