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EA200970948A1 - Антиангиогенные агенты и способы их применения - Google Patents

Антиангиогенные агенты и способы их применения

Info

Publication number
EA200970948A1
EA200970948A1 EA200970948A EA200970948A EA200970948A1 EA 200970948 A1 EA200970948 A1 EA 200970948A1 EA 200970948 A EA200970948 A EA 200970948A EA 200970948 A EA200970948 A EA 200970948A EA 200970948 A1 EA200970948 A1 EA 200970948A1
Authority
EA
Eurasian Patent Office
Prior art keywords
angiogenesis
methods
application
present
antiangiogenic agents
Prior art date
Application number
EA200970948A
Other languages
English (en)
Inventor
Жикан Ку
Эншу Миттал Рой
Субраманиам Анансан
Original Assignee
Саузерн Рисерч Инститьют
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Саузерн Рисерч Инститьют filed Critical Саузерн Рисерч Инститьют
Publication of EA200970948A1 publication Critical patent/EA200970948A1/ru

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/4465—Non condensed piperidines, e.g. piperocaine only substituted in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Pregnancy & Childbirth (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Настоящее изобретение в целом относится к лечению или профилактике заболеваний, связанных с ангиогенезом путем введения указанному пациенту определенных соединений, подавляющих или существенно уменьшающих ангиогенез. Соединения, используемые согласно настоящему изобретению, проявляют хорошую антиангиогенную активность, а также демонстрируют профилактический эффект предотвращения и существенного уменьшения ангиогенеза. Примеры таких соединений включают ритансерин, амиодарон, терфенадин, перфеназин, битионол и кломипрамин.
EA200970948A 2007-04-13 2008-04-14 Антиангиогенные агенты и способы их применения EA200970948A1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US91164507P 2007-04-13 2007-04-13

Publications (1)

Publication Number Publication Date
EA200970948A1 true EA200970948A1 (ru) 2010-08-30

Family

ID=40351375

Family Applications (2)

Application Number Title Priority Date Filing Date
EA200970948A EA200970948A1 (ru) 2007-04-13 2008-04-14 Антиангиогенные агенты и способы их применения
EA200970947A EA019919B1 (ru) 2007-04-13 2008-04-14 Способ подавления роста или метастазирования ангиогенез-зависимой опухоли

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA200970947A EA019919B1 (ru) 2007-04-13 2008-04-14 Способ подавления роста или метастазирования ангиогенез-зависимой опухоли

Country Status (13)

Country Link
US (4) US8367737B2 (ru)
EP (6) EP2420239B1 (ru)
JP (4) JP5291700B2 (ru)
KR (1) KR101519028B1 (ru)
CN (3) CN102772415A (ru)
AU (2) AU2008287285B2 (ru)
BR (2) BRPI0810621A2 (ru)
CA (4) CA2681267C (ru)
EA (2) EA200970948A1 (ru)
ES (3) ES2534589T3 (ru)
MX (1) MX2009011068A (ru)
NZ (4) NZ592289A (ru)
WO (1) WO2009023299A2 (ru)

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CA2681267C (en) 2013-11-19
US8367737B2 (en) 2013-02-05
US20150164873A1 (en) 2015-06-18
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