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EA200301101A1 - Производные пиперазина и их применение в качестве ингибиторов pde4 - Google Patents

Производные пиперазина и их применение в качестве ингибиторов pde4

Info

Publication number
EA200301101A1
EA200301101A1 EA200301101A EA200301101A EA200301101A1 EA 200301101 A1 EA200301101 A1 EA 200301101A1 EA 200301101 A EA200301101 A EA 200301101A EA 200301101 A EA200301101 A EA 200301101A EA 200301101 A1 EA200301101 A1 EA 200301101A1
Authority
EA
Eurasian Patent Office
Prior art keywords
application
piperazine
derivatives
pde4 inhibitors
pde4
Prior art date
Application number
EA200301101A
Other languages
English (en)
Inventor
Армин Хатцельманн
Даниела Бундшу
Иоганнес Барзиг
Ханс-Петер Клей
Герхард Грундлер
Беате Шмидт
Герт Ян Стерк
Original Assignee
Алтана Фарма Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Алтана Фарма Аг filed Critical Алтана Фарма Аг
Publication of EA200301101A1 publication Critical patent/EA200301101A1/ru

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
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Abstract

В заявке описаны соединения формулы I, в которых R1, R2, R3, A, X, s и R9 имеют значения, указанные в описании заявки, причем указанные соединения являются новыми эффективными ингибиторами PDE4.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200301101A 2001-04-25 2002-04-24 Производные пиперазина и их применение в качестве ингибиторов pde4 EA200301101A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01110227 2001-04-25
PCT/EP2002/004494 WO2002085885A1 (en) 2001-04-25 2002-04-24 Piperazino-derivatives and their use as pde4 inhibitor

Publications (1)

Publication Number Publication Date
EA200301101A1 true EA200301101A1 (ru) 2004-04-29

Family

ID=8177248

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200301101A EA200301101A1 (ru) 2001-04-25 2002-04-24 Производные пиперазина и их применение в качестве ингибиторов pde4

Country Status (22)

Country Link
US (1) US7022696B2 (ru)
EP (1) EP1385838A1 (ru)
JP (2) JP4021329B2 (ru)
KR (1) KR20030089723A (ru)
CN (1) CN1505624A (ru)
AU (1) AU2002315311B2 (ru)
BG (1) BG108187A (ru)
BR (1) BR0209076A (ru)
CA (1) CA2445236A1 (ru)
CZ (1) CZ20033205A3 (ru)
EA (1) EA200301101A1 (ru)
EE (1) EE200300513A (ru)
HR (1) HRP20030869A2 (ru)
HU (1) HUP0303469A3 (ru)
IL (1) IL157870A0 (ru)
MX (1) MXPA03009806A (ru)
NO (1) NO20034804L (ru)
NZ (1) NZ529363A (ru)
PL (1) PL363544A1 (ru)
SK (1) SK14352003A3 (ru)
WO (1) WO2002085885A1 (ru)
ZA (1) ZA200308931B (ru)

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BR0215429A (pt) * 2001-12-28 2004-12-14 Acadia Pharm Inc Composto de fórmula i e seus usos, métodos de inibição da atividade e método de inibição da ativação de um receptor de monoamina, métodos de tratamento, método de identificação de polimorfismo genético e método de identificação de paciente
US20060166995A1 (en) * 2002-08-10 2006-07-27 Altana Pharma Ag Piperidine-n-oxide-derivatives
CA2494650A1 (en) * 2002-08-10 2004-03-04 Altana Pharma Ag Pyridazinone-derivatives as pde4 inhibitors
JP4555684B2 (ja) 2002-08-10 2010-10-06 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｐｄｅ４阻害剤としての、ピロリジンジオンにより置換されたピペリジン−フタラゾン
EP1716123A1 (en) * 2004-02-04 2006-11-02 Altana Pharma AG Pyridazinone derivatives and their use as pde4 inhibitors
AU2005210042B2 (en) * 2004-02-04 2011-04-21 Takeda Gmbh 2-(piperidin-4-yl) -4, 5-dihydro-2H-pyridazin-3-one derivatives as PDE4 inhibitors
CA2605383A1 (en) * 2005-04-21 2006-11-02 Nippon Shinyaku Co., Ltd. Phthalazinone derivative and pharmaceutical comprising the same
AU2006326540A1 (en) 2005-12-14 2007-06-21 Amgen Inc. Diaza heterocyclic sulfonamide derivatives and their uses
KR100843352B1 (ko) * 2007-01-30 2008-07-03 한국과학기술연구원 세로토닌 수용체 5-ＨＴ2ａ 또는 5-ＨＴ2ｃ의 길항제로활성을 갖는 1,2-다이하이드로-1-옥소프탈라지닐 피페라진화합물 및 이의 제조방법
US20150119399A1 (en) 2012-01-10 2015-04-30 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use

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HUP0303469A2 (hu) 2004-03-01
MXPA03009806A (es) 2004-01-29
US7022696B2 (en) 2006-04-04
NO20034804L (no) 2003-12-29
CN1505624A (zh) 2004-06-16
JP2006096766A (ja) 2006-04-13
BG108187A (bg) 2004-09-30
CZ20033205A3 (en) 2004-03-17
JP4021329B2 (ja) 2007-12-12
HRP20030869A2 (en) 2005-08-31
IL157870A0 (en) 2004-03-28
SK14352003A3 (sk) 2004-04-06
WO2002085885A1 (en) 2002-10-31
AU2002315311B2 (en) 2007-12-06
NO20034804D0 (no) 2003-10-27
ZA200308931B (en) 2004-06-09
JP2004526785A (ja) 2004-09-02
NZ529363A (en) 2005-08-26
PL363544A1 (en) 2004-11-29
BR0209076A (pt) 2004-08-10
EE200300513A (et) 2004-02-16
HUP0303469A3 (en) 2004-04-28
EP1385838A1 (en) 2004-02-04
CA2445236A1 (en) 2002-10-31
US20040132721A1 (en) 2004-07-08
KR20030089723A (ko) 2003-11-22

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