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EA201000494A1 - Новые гидрокси-8-гетероарилфенантридины и их применение в качестве ингибиторов pde4 - Google Patents

Новые гидрокси-8-гетероарилфенантридины и их применение в качестве ингибиторов pde4

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Publication number
EA201000494A1
EA201000494A1 EA201000494A EA201000494A EA201000494A1 EA 201000494 A1 EA201000494 A1 EA 201000494A1 EA 201000494 A EA201000494 A EA 201000494A EA 201000494 A EA201000494 A EA 201000494A EA 201000494 A1 EA201000494 A1 EA 201000494A1
Authority
EA
Eurasian Patent Office
Prior art keywords
application
heteroarryfenanthridines
pde4 inhibitors
new hydroxy
hydroxy
Prior art date
Application number
EA201000494A
Other languages
English (en)
Other versions
EA017282B1 (ru
Inventor
Беате Шмидт
Дитер Флоккерци
Армин Хатцельманн
Кристоф Цитт
Иоганнес Барзиг
Дегенхард Маркс
Ханс-Петер Клей
Ульрих Каутц
Original Assignee
Никомед Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Никомед Гмбх filed Critical Никомед Гмбх
Publication of EA201000494A1 publication Critical patent/EA201000494A1/ru
Publication of EA017282B1 publication Critical patent/EA017282B1/ru

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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
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Abstract

В заявке описаны соединения формулы (I), в которых Rl, R2, R3, R4, R5 и Har имеют значения, указанные в описании заявки, причем указанные соединения являются эффективными ингибиторами PDE4.
EA201000494A 2004-03-03 2005-03-02 Производное гидрокси-6-гетероарилфенантридина и его применение в качестве ингибитора pde4 EA017282B1 (ru)

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