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EA199900021A1 - Бициклические гетероароматические соединения в качестве ингибиторов протеинтирозинкиназы - Google Patents

Бициклические гетероароматические соединения в качестве ингибиторов протеинтирозинкиназы

Info

Publication number
EA199900021A1
EA199900021A1 EA199900021A EA199900021A EA199900021A1 EA 199900021 A1 EA199900021 A1 EA 199900021A1 EA 199900021 A EA199900021 A EA 199900021A EA 199900021 A EA199900021 A EA 199900021A EA 199900021 A1 EA199900021 A1 EA 199900021A1
Authority
EA
Eurasian Patent Office
Prior art keywords
inhibitors
compounds
heteroaromatic compounds
proteinthyrosinkinase
bicyclic heteroaromatic
Prior art date
Application number
EA199900021A
Other languages
English (en)
Inventor
Джордж Стюарт Кокерилл
Мэлкем Клайв Картер
Стивен Бэрри Гантрип
Кэтрин Джейн Смит
Original Assignee
Глаксо, Груп Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9614756.6A external-priority patent/GB9614756D0/en
Priority claimed from GBGB9625495.8A external-priority patent/GB9625495D0/en
Application filed by Глаксо, Груп Лимитед filed Critical Глаксо, Груп Лимитед
Publication of EA199900021A1 publication Critical patent/EA199900021A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • C07C217/82—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring
    • C07C217/84—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
    • C07C217/86—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
    • C07C317/36—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring with the nitrogen atoms of the amino groups bound to hydrogen atoms or to carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Замещенные гетероароматические соединения и, в частности, замещенные бициклические гетероароматические соединения, в которых одно кольцо является пиридином или пиримидином, формулы (I) являются ингибиторами протеинтирозинкиназы. Описаны соединения, а также способы их получения, фармацевтические композиции, включающие в себя такие соединения, и их применение в медицине, например при лечении рака и псориаза.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199900021A 1996-07-13 1997-07-11 Бициклические гетероароматические соединения в качестве ингибиторов протеинтирозинкиназы EA199900021A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9614756.6A GB9614756D0 (en) 1996-07-13 1996-07-13 Heterocyclic compounds
GBGB9625495.8A GB9625495D0 (en) 1996-12-07 1996-12-07 Heterocyclic compounds
PCT/EP1997/003673 WO1998002437A1 (en) 1996-07-13 1997-07-11 Bicyclic heteroaromatic compounds as protein tyrosine kinase inhibitors

Publications (1)

Publication Number Publication Date
EA199900021A1 true EA199900021A1 (ru) 1999-08-26

Family

ID=26309691

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199900021A EA199900021A1 (ru) 1996-07-13 1997-07-11 Бициклические гетероароматические соединения в качестве ингибиторов протеинтирозинкиназы

Country Status (22)

Country Link
US (1) US6207669B1 (ru)
EP (1) EP0912572B1 (ru)
JP (1) JP2000515136A (ru)
KR (1) KR20000023813A (ru)
CN (1) CN1230185A (ru)
AP (1) AP9901435A0 (ru)
AR (1) AR007855A1 (ru)
AT (1) ATE231148T1 (ru)
AU (1) AU3693697A (ru)
BR (1) BR9710362A (ru)
CA (1) CA2260058A1 (ru)
CZ (1) CZ8799A3 (ru)
DE (1) DE69718472T2 (ru)
EA (1) EA199900021A1 (ru)
ES (1) ES2191187T3 (ru)
ID (1) ID19430A (ru)
IS (1) IS4936A (ru)
NO (1) NO990123L (ru)
PE (1) PE91098A1 (ru)
PL (1) PL331154A1 (ru)
TR (1) TR199900048T2 (ru)
WO (1) WO1998002437A1 (ru)

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