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DK3818078T3 - Fremgangsmåder til fremstilling af rekombinante proteiner - Google Patents

Fremgangsmåder til fremstilling af rekombinante proteiner Download PDF

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Publication number
DK3818078T3
DK3818078T3 DK19745845.8T DK19745845T DK3818078T3 DK 3818078 T3 DK3818078 T3 DK 3818078T3 DK 19745845 T DK19745845 T DK 19745845T DK 3818078 T3 DK3818078 T3 DK 3818078T3
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DK
Denmark
Prior art keywords
production
methods
recombinant proteins
recombinant
proteins
Prior art date
Application number
DK19745845.8T
Other languages
English (en)
Inventor
Jianlin Xu
Andrew Yongky
Jun Tian
Michael C Borys
Zhengjian Li
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of DK3818078T3 publication Critical patent/DK3818078T3/da

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018Culture media for cell or tissue culture
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/10Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14Specific host cells or culture conditions, e.g. components, pH or temperature
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/30Organic components
    • C12N2500/34Sugars

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
DK19745845.8T 2018-07-03 2019-07-02 Fremgangsmåder til fremstilling af rekombinante proteiner DK3818078T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862693606P 2018-07-03 2018-07-03
PCT/US2019/040298 WO2020010080A1 (en) 2018-07-03 2019-07-02 Methods of producing recombinant proteins

Publications (1)

Publication Number Publication Date
DK3818078T3 true DK3818078T3 (da) 2024-05-21

Family

ID=67470657

Family Applications (1)

Application Number Title Priority Date Filing Date
DK19745845.8T DK3818078T3 (da) 2018-07-03 2019-07-02 Fremgangsmåder til fremstilling af rekombinante proteiner

Country Status (23)

Country Link
US (1) US20210253996A1 (da)
EP (2) EP4368699A3 (da)
JP (2) JP7419273B2 (da)
KR (1) KR20210027427A (da)
CN (1) CN112839954A (da)
AU (1) AU2019299358A1 (da)
BR (1) BR112020025623A2 (da)
CA (1) CA3104684A1 (da)
DK (1) DK3818078T3 (da)
EA (1) EA202092904A1 (da)
ES (1) ES2976708T3 (da)
FI (1) FI3818078T3 (da)
HR (1) HRP20240584T1 (da)
HU (1) HUE066560T2 (da)
IL (1) IL279782A (da)
LT (1) LT3818078T (da)
MX (1) MX2020013633A (da)
PL (1) PL3818078T3 (da)
PT (1) PT3818078T (da)
RS (1) RS65472B1 (da)
SG (1) SG11202012582QA (da)
SI (1) SI3818078T1 (da)
WO (1) WO2020010080A1 (da)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023242238A1 (en) * 2022-06-15 2023-12-21 UCB Biopharma SRL Cell culture processes
EP4339274A1 (en) 2022-09-13 2024-03-20 Sartorius Stedim Biotech GmbH Method for operating a bioprocess installation for production of a bioproduct

Family Cites Families (28)

* Cited by examiner, † Cited by third party
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US4515893A (en) 1979-04-26 1985-05-07 Ortho Pharmaceutical Corporation Hybrid cell line for producing complement-fixing monoclonal antibody to human T cells
US5672347A (en) 1984-07-05 1997-09-30 Genentech, Inc. Tumor necrosis factor antagonists and their use
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
US5091313A (en) 1988-08-05 1992-02-25 Tanox Biosystems, Inc. Antigenic epitopes of IgE present on B cell but not basophil surface
US5720937A (en) 1988-01-12 1998-02-24 Genentech, Inc. In vivo tumor detection assay
EP0420937B1 (en) 1988-06-21 1994-11-09 Genentech, Inc. Therapeutic compositions for the treatment of myocardial infarction
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
EP1260521B1 (en) 1991-08-14 2007-11-21 Genentech Inc. Immunoglobulin variants for specific Fc epsilon receptors
AU687755B2 (en) 1992-08-21 1998-03-05 Genentech Inc. Method for treating an LFA-1-mediated disorder
US5736137A (en) 1992-11-13 1998-04-07 Idec Pharmaceuticals Corporation Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma
CA2176811C (en) 1993-12-10 2008-01-29 David Tai Wai Fei Methods for diagnosis of allergy and screening of anti-allergy therapeutics
JP3825798B2 (ja) 1994-01-18 2006-09-27 ジェネンテク,インコーポレイテッド IgEアンタゴニストを用いる寄生虫感染症の治療法
EP0749488A1 (en) 1994-03-03 1996-12-27 Genentech, Inc. Anti-il-8 monoclonal antibodies for treatment of inflammatory disorders
IL117645A (en) 1995-03-30 2005-08-31 Genentech Inc Vascular endothelial cell growth factor antagonists for use as medicaments in the treatment of age-related macular degeneration
WO1996040210A1 (en) 1995-06-07 1996-12-19 Imclone Systems Incorporated Antibody and antibody fragments for inhibiting the growth of tumors
IL125255A (en) 1996-01-23 2002-02-10 Genentech Inc Anti-cd18 antibodies for treating stroke
US7147851B1 (en) 1996-08-15 2006-12-12 Millennium Pharmaceuticals, Inc. Humanized immunoglobulin reactive with α4β7 integrin
IL130143A0 (en) 1996-11-27 2000-06-01 Genentech Inc Humanized anti-CD11a antibodies
DE69836729T2 (de) 1997-04-07 2007-12-13 Genentech, Inc., South San Francisco Anti-vefg antibodies
CA2287911C (en) 1997-05-15 2014-05-06 Genentech, Inc. Apo-2 receptor
US6946129B1 (en) 1999-06-08 2005-09-20 Seattle Genetics, Inc. Recombinant anti-CD40 antibody and uses thereof
EP1226177B1 (en) 1999-10-29 2008-07-09 Genentech, Inc. Anti-prostate stem cell antigen (psca) antibody compositions and methods of use
US7335491B2 (en) * 2004-08-27 2008-02-26 Wyeth Research Ireland Limited Production of anti-abeta
RU2518289C2 (ru) * 2006-09-13 2014-06-10 Эббви Инк, Способ получения антитела или его фрагмента с подпиткой (варианты)
PT2673296T (pt) * 2011-02-07 2019-01-31 Cerenis Therapeutics Holding Sa Complexos de lipoproteínas e sua fabricação e utilização
ES2788132T3 (es) * 2011-07-01 2020-10-20 Amgen Inc Cultivo de células de mamífero
WO2015186075A1 (en) * 2014-06-03 2015-12-10 Lupin Limited Cell culture process for producing a protein
WO2015198451A1 (ja) 2014-06-26 2015-12-30 楽天株式会社 情報処理装置、情報処理方法及び情報処理プログラム

Also Published As

Publication number Publication date
SI3818078T1 (sl) 2024-05-31
EP3818078A1 (en) 2021-05-12
WO2020010080A1 (en) 2020-01-09
IL279782A (en) 2021-03-01
EP4368699A2 (en) 2024-05-15
HUE066560T2 (hu) 2024-08-28
AU2019299358A1 (en) 2021-02-18
RS65472B1 (sr) 2024-05-31
CN112839954A (zh) 2021-05-25
KR20210027427A (ko) 2021-03-10
LT3818078T (lt) 2024-04-25
BR112020025623A2 (pt) 2021-03-23
EP3818078B1 (en) 2024-02-28
EA202092904A1 (ru) 2021-04-22
CA3104684A1 (en) 2020-01-09
SG11202012582QA (en) 2021-01-28
JP2021529527A (ja) 2021-11-04
PT3818078T (pt) 2024-04-18
JP2024050590A (ja) 2024-04-10
HRP20240584T1 (hr) 2024-07-19
ES2976708T3 (es) 2024-08-07
FI3818078T3 (fi) 2024-05-14
PL3818078T3 (pl) 2024-04-29
MX2020013633A (es) 2021-03-25
JP7419273B2 (ja) 2024-01-22
EP4368699A3 (en) 2024-09-11
US20210253996A1 (en) 2021-08-19

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