DK1471074T3 - Fremgangsmåder til forbedring af konformationen af proteiner ved hjælp af reduktionsmidler - Google Patents

Fremgangsmåder til forbedring af konformationen af proteiner ved hjælp af reduktionsmidler

Info

Publication number: DK1471074T3
Authority: DK; Denmark
Prior art keywords: recombinant protein; purification; recombinant; conformation; proteins
Prior art date: 1998-04-17

Application number

DK04103238T

Other languages

Danish (da)

English (en)

Inventor

Geert Maertens

Joost Louwagie

Alfons Bosman

Erwin Sablon

Maan Zrein

Original Assignee

Innogenetics Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-04-17

Filing date

1999-04-15

Publication date

2008-11-17

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8237028&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1471074(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1999-04-15 Application filed by Innogenetics Nv filed Critical Innogenetics Nv

2008-11-17 Application granted granted Critical

2008-11-17 Publication of DK1471074T3 publication Critical patent/DK1471074T3/da

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
- C12Q1/706—Specific hybridization probes for hepatitis
- C12Q1/707—Specific hybridization probes for hepatitis non-A, non-B Hepatitis, excluding hepatitis D
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54306—Solid-phase reaction mechanisms
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
- G01N33/5767—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis non-A, non-B hepatitis
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Immunology (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Organic Chemistry (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
Pathology (AREA)
Communicable Diseases (AREA)
General Physics & Mathematics (AREA)
Food Science & Technology (AREA)
Cell Biology (AREA)
Virology (AREA)
Chemical Kinetics & Catalysis (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Gastroenterology & Hepatology (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
General Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Oncology (AREA)
Peptides Or Proteins (AREA)

DK04103238T 1998-04-17 1999-04-15 Fremgangsmåder til forbedring af konformationen af proteiner ved hjælp af reduktionsmidler DK1471074T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP98870087		1998-04-17
PCT/EP1999/002547 WO1999054735A1 (en)	1998-04-17	1999-04-15	Improved immunodiagnostic assays using reducing agents

Publications (1)

Publication Number	Publication Date
DK1471074T3 true DK1471074T3 (da)	2008-11-17

Family

ID=8237028

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK04103238T DK1471074T3 (da)	1998-04-17	1999-04-15	Fremgangsmåder til forbedring af konformationen af proteiner ved hjælp af reduktionsmidler
DK99920678T DK1071955T4 (da)	1998-04-17	1999-04-15	Forbedrede immundiagnostiske assays, som anvender reduktionsmidler

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK99920678T DK1071955T4 (da)	1998-04-17	1999-04-15	Forbedrede immundiagnostiske assays, som anvender reduktionsmidler

Country Status (22)

Country	Link
US (1)	US7935490B2 (ja)
EP (2)	EP1471074B1 (ja)
JP (2)	JP2002512370A (ja)
KR (1)	KR20010042807A (ja)
CN (1)	CN1305589A (ja)
AT (2)	ATE278960T1 (ja)
AU (1)	AU751362B2 (ja)
BR (1)	BRPI9909678B8 (ja)
CA (2)	CA2324970C (ja)
CY (1)	CY1108424T1 (ja)
CZ (1)	CZ298268B6 (ja)
DE (2)	DE69939132D1 (ja)
DK (2)	DK1471074T3 (ja)
ES (2)	ES2230851T5 (ja)
HK (1)	HK1036653A1 (ja)
HU (1)	HUP0101719A3 (ja)
IL (1)	IL138791A0 (ja)
PL (1)	PL343469A1 (ja)
PT (2)	PT1071955E (ja)
TR (4)	TR200202213T2 (ja)
WO (1)	WO1999054735A1 (ja)
ZA (1)	ZA200005445B (ja)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2237115T5 (es) *	1998-06-24	2008-05-16	Innogenetics N.V.	Particulas de proteinas de la envoltura del hcv: uso para la vacunacion.
US7022830B2 (en)	2000-08-17	2006-04-04	Tripep Ab	Hepatitis C virus codon optimized non-structural NS3/4A fusion gene
PL360990A1 (en) *	2000-08-17	2004-09-20	Tripep Ab	Vaccines containing ribavirin and methods of use thereof
NZ529324A (en)	2001-04-24	2005-08-26	Innogenetics N	Core-glycosylated HCV envelope proteins made in yeast cells
JP2004108914A (ja) *	2002-09-18	2004-04-08	Kudo Norio	コラーゲンの測定方法
WO2004041853A2 (en) *	2002-11-08	2004-05-21	Innogenetics N.V.	Hcv vaccine compositions comprising e1 and ns3 peptides
US20050014136A1 (en) *	2003-05-28	2005-01-20	Innogenetics N.V.	Modified HCV NS5
CN101892199A (zh)	2003-10-28	2010-11-24	株式会社先端生命科学研究所	丙型肝炎病毒的检测方法
JP2009543099A (ja) *	2006-07-07	2009-12-03	ポール・コーポレーション	親和性捕捉中の変性剤の使用
EP2178363A4 (en) *	2007-07-16	2010-07-21	Pfizer	METHOD FOR IMPROVING A GENOMMARKER INDEX OF MILK PRODUCTS AND PRODUCTS
WO2009035560A1 (en) *	2007-09-12	2009-03-19	Pfizer, Inc.	Methods of using genetic markers and related epistatic interactions
BRPI0818300A2 (pt) *	2007-10-03	2017-05-09	Pfizer	marcadores genéticos para gado com chifres e sem chifres e processos relacionados
WO2009085689A2 (en) *	2007-12-17	2009-07-09	Pfizer Inc.	Methods of improving genetic profiles of dairy animals and products
JP5476376B2 (ja) *	2008-07-16	2014-04-23	ラジオメーター・メディカル・アー・ペー・エス	高性能固相
CN102081018A (zh) *	2009-11-30	2011-06-01	希森美康株式会社	样品的预处理方法及hcv的免疫测定方法
FR2984328B1 (fr)	2011-12-20	2016-12-30	Bio-Rad Innovations	Procede de detection d'une infection par le virus de l'hepatite c
EP3213083B1 (en)	2014-10-29	2020-08-19	Abbott Laboratories	Subject anti-hcv antibody detection assays employing ns3 capture peptides
CN109870581B (zh) *	2017-12-04	2021-05-04	厦门万泰凯瑞生物技术有限公司	一种定量检测HBsAg的试剂盒及方法
CN109678954B (zh) *	2018-12-29	2022-01-07	山东莱博生物科技有限公司	一对能够特异性识别hcv ns3蛋白的单克隆抗体及其应用
CN110988362B (zh) *	2019-12-20	2023-11-14	迈克生物股份有限公司	抗组蛋白抗体测定试剂、试剂盒及其使用方法
CN112225783B (zh) *	2020-09-16	2021-08-31	东莞市朋志生物科技有限公司	Hcv重组抗原及其突变体
CN112285361B (zh) *	2020-09-27	2023-12-05	中国人民解放军空军军医大学	排除抗-cd38单克隆抗体药物对抗人球蛋白检测干扰的试剂
CN113219169B (zh) *	2021-05-22	2021-12-17	北京金诺百泰生物技术有限公司	生物检测用封闭剂及其制备方法、包被板及应用该包被板的试剂盒
CN115112897B (zh) *	2021-12-10	2024-11-01	中山大学附属第八医院（深圳福田）	一种用于鉴别抗体检测生物学假阳性的方法

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0139526A2 (en) *	1983-10-20	1985-05-02	Warner-Lambert Company	An insolubilized stable specific binding protein
US4616078A (en) *	1985-04-08	1986-10-07	Eli Lilly And Company	Process for purifying proinsulin-like materials
CA1340877C (en) *	1987-12-28	2000-01-18	Takashi Sugiyama	Elastase inhibitory polypeptide and process for production thereof by recombinant gene technology
ATE92633T1 (de) *	1988-05-11	1993-08-15	Abbott Lab	Verfahren zur erhoehung der spezifizitaet in kompetitiven immuntests.
US4923967A (en) *	1988-09-26	1990-05-08	Eli Lilly And Company	Purification and refolding of recombinant proteins
US6194140B1 (en) *	1990-04-04	2001-02-27	Chiron Corporation	HCV NS3 protein fragments having helicase activity and improved solubility
ATE270326T1 (de)	1990-04-04	2004-07-15	Chiron Corp	Protease von hepatitis-c-virus
US5606031A (en) *	1990-04-06	1997-02-25	Lile; Jack	Production and purification of biologically active recombinant neurotrophic protein in bacteria
HU227547B1 (en) *	1991-06-24	2011-08-29	Novartis Vaccines & Diagnostic	Hepatitis c virus (hcv) polypeptides
JP3225468B2 (ja)	1992-08-28	2001-11-05	ダイナボット株式会社	抗体測定用試薬
ATE552340T1 (de)	1993-04-27	2012-04-15	Innogenetics Nv	Hepatitis c virus genotypsequenzen sowie ihre verwendung als behandlungs- und nachweismitteln
ATE274578T1 (de)	1993-11-04	2004-09-15	Innogenetics Nv	Von menschlichen t-zellen immunodominante epitopen des virus der c-hepatitis
DE69429017T2 (de)	1994-06-23	2002-07-04	Energy Answers Corp., Albany	Anlage zur erzeugung von asche enthaltenden produkten und energie aus abfällen
PT721505E (pt) *	1994-07-29	2002-10-31	Innogenetics Nv	Proteinas do envelope do virus da hepatite c purificadas para utilizacao em diagnostico e terapeutica
DE4428705A1 (de) *	1994-08-12	1996-02-15	Boehringer Mannheim Gmbh	Rekombinantes Antigen aus der NS3-Region des Hepatitis C Virus
JPH0862219A (ja)	1994-08-19	1996-03-08	Dainabotsuto Kk	還元型抗原に対する抗体アッセイ試薬及びそれを使用した測定方法
US7129337B1 (en)	1994-10-21	2006-10-31	Innogenetics N.V.	Sequences of hepatitis C virus genotypes and their use as prophylactic, therapeutic and diagnostic agents
US5705330A (en) *	1995-04-14	1998-01-06	Abbott Laboratories	Chemiluminescent immunoassay for antibody detection
US5616460A (en)	1995-06-07	1997-04-01	Abbott Laboratories	Buffer composition for reagents for immunoassay
ATE311463T1 (de)	1996-05-24	2005-12-15	Chiron Corp	Fusionsprotein mit multiplen epitopen
WO1998030356A1 (en) *	1997-01-13	1998-07-16	Rodel, Inc.	Polymeric polishing pad having photolithographically induced surface pattern(s) and methods relating thereto

1999
- 1999-04-15 DE DE69939132T patent/DE69939132D1/de not_active Expired - Lifetime
- 1999-04-15 TR TR2002/02213T patent/TR200202213T2/xx unknown
- 1999-04-15 EP EP04103238A patent/EP1471074B1/en not_active Expired - Lifetime
- 1999-04-15 IL IL13879199A patent/IL138791A0/xx unknown
- 1999-04-15 ES ES99920678T patent/ES2230851T5/es not_active Expired - Lifetime
- 1999-04-15 CN CN99807283A patent/CN1305589A/zh active Pending
- 1999-04-15 JP JP2000545027A patent/JP2002512370A/ja active Pending
- 1999-04-15 WO PCT/EP1999/002547 patent/WO1999054735A1/en active IP Right Grant
- 1999-04-15 EP EP99920678A patent/EP1071955B2/en not_active Expired - Lifetime
- 1999-04-15 TR TR2001/01647T patent/TR200101647T2/xx unknown
- 1999-04-15 PT PT99920678T patent/PT1071955E/pt unknown
- 1999-04-15 CZ CZ20003819A patent/CZ298268B6/cs not_active IP Right Cessation
- 1999-04-15 AU AU38171/99A patent/AU751362B2/en not_active Expired
- 1999-04-15 BR BRPI9909678A patent/BRPI9909678B8/pt not_active IP Right Cessation
- 1999-04-15 AT AT99920678T patent/ATE278960T1/de active
- 1999-04-15 DE DE69920895T patent/DE69920895T3/de not_active Expired - Lifetime
- 1999-04-15 TR TR2001/01648T patent/TR200101648T2/xx unknown
- 1999-04-15 CA CA002324970A patent/CA2324970C/en not_active Expired - Lifetime
- 1999-04-15 CA CA2658218A patent/CA2658218C/en not_active Expired - Lifetime
- 1999-04-15 DK DK04103238T patent/DK1471074T3/da active
- 1999-04-15 ES ES04103238T patent/ES2310701T3/es not_active Expired - Lifetime
- 1999-04-15 AT AT04103238T patent/ATE401340T1/de active
- 1999-04-15 DK DK99920678T patent/DK1071955T4/da active
- 1999-04-15 TR TR2000/03024T patent/TR200003024T2/xx unknown
- 1999-04-15 PT PT04103238T patent/PT1471074E/pt unknown
- 1999-04-15 PL PL99343469A patent/PL343469A1/xx unknown
- 1999-04-15 HU HU0101719A patent/HUP0101719A3/hu unknown
- 1999-04-15 KR KR1020007011555A patent/KR20010042807A/ko not_active Application Discontinuation
2000
- 2000-10-05 ZA ZA200005445A patent/ZA200005445B/en unknown
2001
- 2001-07-31 HK HK01105349A patent/HK1036653A1/xx not_active IP Right Cessation
2005
- 2005-01-05 JP JP2005000767A patent/JP3974620B2/ja not_active Expired - Lifetime
2006
- 2006-08-02 US US11/497,259 patent/US7935490B2/en not_active Expired - Fee Related
2008
- 2008-10-16 CY CY20081101157T patent/CY1108424T1/el unknown

Also Published As

Publication number	Publication date
AU3817199A (en)	1999-11-08
TR200202213T2 (tr)	2002-11-21
ES2230851T3 (es)	2005-05-01
ZA200005445B (en)	2003-01-06
HUP0101719A2 (hu)	2001-09-28
ATE401340T1 (de)	2008-08-15
ES2310701T3 (es)	2009-01-16
ATE278960T1 (de)	2004-10-15
BR9909678A (pt)	2000-12-19
US20060263854A1 (en)	2006-11-23
KR20010042807A (ko)	2001-05-25
EP1471074A2 (en)	2004-10-27
DE69939132D1 (de)	2008-08-28
BRPI9909678B8 (pt)	2021-05-25
WO1999054735A1 (en)	1999-10-28
EP1071955B1 (en)	2004-10-06
TR200101647T2 (tr)	2002-06-21
US7935490B2 (en)	2011-05-03
AU751362B2 (en)	2002-08-15
TR200101648T2 (tr)	2002-06-21
CZ298268B6 (cs)	2007-08-08
PT1071955E (pt)	2005-02-28
CA2324970C (en)	2009-06-30
EP1071955B2 (en)	2009-02-18
DK1071955T3 (da)	2005-02-07
HUP0101719A3 (en)	2006-05-29
CA2324970A1 (en)	1999-10-28
EP1471074B1 (en)	2008-07-16
DE69920895T2 (de)	2005-10-13
IL138791A0 (en)	2001-10-31
CY1108424T1 (el)	2014-04-09
DE69920895T3 (de)	2009-09-03
EP1071955A1 (en)	2001-01-31
CN1305589A (zh)	2001-07-25
JP3974620B2 (ja)	2007-09-12
PT1471074E (pt)	2008-10-23
CA2658218C (en)	2014-10-28
EP1471074A3 (en)	2004-11-10
BR9909678B1 (pt)	2013-11-12
HK1036653A1 (en)	2002-01-11
PL343469A1 (en)	2001-08-13
ES2230851T5 (es)	2009-06-25
DE69920895D1 (de)	2004-11-11
CZ20003819A3 (cs)	2001-10-17
TR200003024T2 (tr)	2000-12-21
CA2658218A1 (en)	1999-10-28
DK1071955T4 (da)	2009-06-15
JP2002512370A (ja)	2002-04-23
JP2005185285A (ja)	2005-07-14

Publication	Publication Date	Title
DK1471074T3 (da)	2008-11-17	Fremgangsmåder til forbedring af konformationen af proteiner ved hjælp af reduktionsmidler
DK1075488T4 (da)	2013-10-21	Proteinoprensning ved ionbytningskromatografi
WO2004024866A3 (en)	2004-10-14	Protein purification
ID23172A (id)	2000-03-23	Metode yang diperbaiki untuk pengolahan protein c teraktivasi
DE69409457D1 (de)	1998-05-14	Mittel zur Entfernung von Photoresist, das zur Verminderung von Metallkorrosion reduzierende Stoffe enthält
AU4052389A (en)	1990-03-05	Derivatized glass supports for peptide and protein sequencing
DK0495918T3 (da)	1996-02-19	Aminosyre-beta-lyaseenzyminhibitorer som deodoranter
NO2006006I1 (no)	2006-05-15	Aktivert protein C
EA200400392A1 (ru)	2004-10-28	Связывающий каспазу-8 белок, его получение и применение
ES2193349T3 (es)	2003-11-01	Metodo para la produccion de rdspa alfa1.
NO985902D0 (no)	1998-12-16	FremgangsmÕte ved ekstrahering og rensning av rekombinant, ikke-lipidert Osp-protein
BR9807616A (pt)	2000-02-22	Aminopeptidase derivada de bacillus licheniformis e processo para preparação de proteìnas tipo natural
Linder et al.	1993	Separation of human pancreatic carboxypeptidase A isoenzymes by high performance liquid chromatography
ATE386112T1 (de)	2008-03-15	Stabilisierung von doppelsträngigen nukleinsäuren mit proteinen