DK0970213T3 - Dödsdomæneholdig receptor - Google Patents
Dödsdomæneholdig receptorInfo
- Publication number
- DK0970213T3 DK0970213T3 DK98912966T DK98912966T DK0970213T3 DK 0970213 T3 DK0970213 T3 DK 0970213T3 DK 98912966 T DK98912966 T DK 98912966T DK 98912966 T DK98912966 T DK 98912966T DK 0970213 T3 DK0970213 T3 DK 0970213T3
- Authority
- DK
- Denmark
- Prior art keywords
- death domain
- containing receptor
- proteins
- antagonists
- receptor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Neurology (AREA)
- Gastroenterology & Hepatology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurosurgery (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Transplantation (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Microbiology (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4084697P | 1997-03-17 | 1997-03-17 | |
US5402197P | 1997-07-29 | 1997-07-29 | |
PCT/US1998/005377 WO1998041629A2 (en) | 1997-03-17 | 1998-03-17 | Death domain containing receptor 5 |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0970213T3 true DK0970213T3 (da) | 2007-05-21 |
Family
ID=26717514
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK98912966T DK0970213T3 (da) | 1997-03-17 | 1998-03-17 | Dödsdomæneholdig receptor |
Country Status (15)
Country | Link |
---|---|
US (2) | US7803615B1 (da) |
EP (1) | EP0970213B1 (da) |
JP (2) | JP4330180B2 (da) |
KR (1) | KR100527638B1 (da) |
CN (2) | CN1184315C (da) |
AT (1) | ATE352618T1 (da) |
AU (1) | AU747635B2 (da) |
CA (2) | CA2644454A1 (da) |
DE (1) | DE69836956T2 (da) |
DK (1) | DK0970213T3 (da) |
ES (1) | ES2281126T3 (da) |
HK (1) | HK1025352A1 (da) |
NZ (2) | NZ337795A (da) |
PT (1) | PT970213E (da) |
WO (1) | WO1998041629A2 (da) |
Families Citing this family (82)
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---|---|---|---|---|
US7888466B2 (en) | 1996-01-11 | 2011-02-15 | Human Genome Sciences, Inc. | Human G-protein chemokine receptor HSATU68 |
WO1997033904A1 (en) | 1996-03-12 | 1997-09-18 | Human Genome Sciences, Inc. | Death domain containing receptors |
US7357927B2 (en) | 1996-03-12 | 2008-04-15 | Human Genome Sciences, Inc. | Death domain containing receptors |
US6713061B1 (en) | 1996-03-12 | 2004-03-30 | Human Genome Sciences, Inc. | Death domain containing receptors |
US7964190B2 (en) | 1996-03-22 | 2011-06-21 | Human Genome Sciences, Inc. | Methods and compositions for decreasing T-cell activity |
US6635743B1 (en) | 1996-03-22 | 2003-10-21 | Human Genome Sciences, Inc. | Apoptosis inducing molecule II and methods of use |
US7452538B2 (en) | 1997-01-28 | 2008-11-18 | Human Genome Sciences, Inc. | Death domain containing receptor 4 antibodies and methods |
US8329179B2 (en) | 1997-01-28 | 2012-12-11 | Human Genome Sciences, Inc. | Death domain containing receptor 4 antibodies and methods |
US6433147B1 (en) | 1997-01-28 | 2002-08-13 | Human Genome Sciences, Inc. | Death domain containing receptor-4 |
PT1012274E (pt) | 1997-01-28 | 2007-08-14 | Craig A Rosen | Receptor 4 contendo um domínio de morte (dm4; receptor de morte 4), membro da super-família do ftn e ligação a liart (ap02) |
US6072047A (en) | 1997-02-13 | 2000-06-06 | Immunex Corporation | Receptor that binds trail |
US7528239B1 (en) * | 1997-02-13 | 2009-05-05 | Immunex Corporation | Receptor that binds trail |
US20080248046A1 (en) * | 1997-03-17 | 2008-10-09 | Human Genome Sciences, Inc. | Death domain containing receptor 5 |
US6872568B1 (en) | 1997-03-17 | 2005-03-29 | Human Genome Sciences, Inc. | Death domain containing receptor 5 antibodies |
NZ337795A (en) | 1997-03-17 | 2001-06-29 | Human Genome Sciences Inc | Death domain containing receptor 5 and it's use in the treatment of DR5 related disease |
US20050233958A1 (en) * | 1997-03-17 | 2005-10-20 | Human Genome Sciences, Inc. | Death domain containing receptor 5 |
IL132067A0 (en) * | 1997-05-15 | 2001-03-19 | Genentech Inc | Apo-2 receptor |
US6342369B1 (en) | 1997-05-15 | 2002-01-29 | Genentech, Inc. | Apo-2-receptor |
US20100152426A1 (en) * | 1997-05-15 | 2010-06-17 | Ashkenazi Avi J | Apo-2 receptor fusion proteins |
WO1999011791A2 (en) * | 1997-09-05 | 1999-03-11 | University Of Washington | Tumor necrosis factor family receptors and ligands, encoding nucleic acids and related binding agents |
WO1999012963A2 (en) * | 1997-09-12 | 1999-03-18 | Biogen, Inc. | Cysteine rich receptors: trail |
CA2328498A1 (en) * | 1998-06-12 | 1999-12-16 | Genentech, Inc. | Monoclonal antibodies, cross-reactive antibodies and method for producing the same____________________________________ |
AU3501700A (en) | 1999-02-26 | 2000-09-14 | Human Genome Sciences, Inc. | Human endokine alpha and methods of use |
JP2002543151A (ja) * | 1999-05-04 | 2002-12-17 | ヒューマン ジノーム サイエンシーズ, インコーポレイテッド | 死ドメイン含有レセプター5 |
AU6928200A (en) * | 1999-08-25 | 2001-03-19 | Genome Therapeutics Corporation | A transmembrane trap for isolating membrane bound proteins |
WO2001058954A2 (en) * | 2000-02-11 | 2001-08-16 | Genetics Institute, Llc. | Trade molecules and uses related thereto |
DE60028830T2 (de) | 2000-02-16 | 2007-01-18 | Genentech, Inc., South San Francisco | Anti-april antikörper und hybridomazellen |
HUP0300369A2 (hu) | 2000-04-11 | 2003-06-28 | Genentech, Inc. | Többértékű antitestek és alkalmazásuk |
US7279160B2 (en) | 2000-05-02 | 2007-10-09 | The Uab Research Foundation | Combinations of DR5 antibodies and other therapeutic agents |
US7476383B2 (en) | 2000-05-02 | 2009-01-13 | The Uab Research Foundation | Antibody selective for DR4 and uses thereof |
TWI318983B (en) | 2000-05-02 | 2010-01-01 | Uab Research Foundation | An antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof |
WO2001096528A2 (en) | 2000-06-15 | 2001-12-20 | Human Genome Sciences, Inc. | Human tumor necrosis factor delta and epsilon |
ATE494304T1 (de) | 2000-06-16 | 2011-01-15 | Human Genome Sciences Inc | Immunspezifisch bindende antikörper gegen blys |
EP1303293B1 (en) | 2000-07-27 | 2008-12-03 | Genentech, Inc. | Sequential administration of cpt-11 and apo-2l polypeptide |
US20030228309A1 (en) * | 2000-11-08 | 2003-12-11 | Theodora Salcedo | Antibodies that immunospecifically bind to TRAIL receptors |
US20060062786A1 (en) * | 2000-11-08 | 2006-03-23 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to TRAIL receptors |
AU2002256895B2 (en) | 2001-05-18 | 2008-09-18 | Kirin Beer Kabushiki Kaisha | Anti-TRAIL-R antibodies |
KR100942393B1 (ko) | 2001-05-25 | 2010-02-17 | 휴먼 게놈 사이언시즈, 인코포레이티드 | Trail 수용체에 면역특이적으로 결합하는 항체 |
US20090226429A1 (en) * | 2001-05-25 | 2009-09-10 | Human Genome Sciences, Inc. | Antibodies That Immunospecifically Bind to TRAIL Receptors |
US20050129616A1 (en) * | 2001-05-25 | 2005-06-16 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to TRAIL receptors |
US7348003B2 (en) | 2001-05-25 | 2008-03-25 | Human Genome Sciences, Inc. | Methods of treating cancer using antibodies that immunospecifically bind to TRAIL receptors |
US7361341B2 (en) * | 2001-05-25 | 2008-04-22 | Human Genome Sciences, Inc. | Methods of treating cancer using antibodies that immunospecifically bind to trail receptors |
US20050214209A1 (en) * | 2001-05-25 | 2005-09-29 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to TRAIL receptors |
WO2003066661A2 (en) | 2001-07-03 | 2003-08-14 | Genentech, Inc. | Human dr4 antibodies and uses thereof |
WO2003011318A1 (en) * | 2001-08-01 | 2003-02-13 | Genset S.A. | Agonists and antagonists of famoset for use in the treatment of metabolic disorders |
EP1501866A4 (en) | 2001-10-02 | 2006-02-08 | Genentech Inc | VARIANTS OF THE LIGAND APO-2 AND USES THEREOF |
WO2003038087A1 (fr) * | 2001-10-04 | 2003-05-08 | Kansai Technology Licensing Organization Co., Ltd. | Promoteur du gene dr5 et promoteur du gene siah-1 |
DE60237841D1 (de) | 2001-11-13 | 2010-11-11 | Genentech Inc | Zusammensetzungen basierend auf APO2-Ligand/ TRAIL und ihre Verwendung |
US7741285B2 (en) | 2001-11-13 | 2010-06-22 | Genentech, Inc. | APO-2 ligand/trail formulations |
US7842668B1 (en) | 2001-11-13 | 2010-11-30 | Genentech, Inc. | Apo-2 ligand/trail formulations |
JP2005516958A (ja) * | 2001-12-20 | 2005-06-09 | ヒューマン ジノーム サイエンシーズ, インコーポレイテッド | Trailレセプターに免疫特異的に結合する抗体 |
US20040101915A1 (en) * | 2002-06-18 | 2004-05-27 | Irm Llc, A Delaware Limited Liability Company | Diagnosis and treatment of chemoresistant tumors |
CA2489348A1 (en) | 2002-06-24 | 2003-12-31 | Genentech, Inc. | Apo-2 ligand/trail variants and uses thereof |
CN1980957A (zh) | 2004-03-23 | 2007-06-13 | 比奥根艾迪克Ma公司 | 受体偶联剂及其治疗用途 |
CA2575755C (en) * | 2004-08-06 | 2014-04-08 | Genentech, Inc. | Assays and methods using biomarkers |
CN102978277A (zh) | 2004-08-06 | 2013-03-20 | 健泰科生物技术公司 | 使用生物标志的测定法和方法 |
US20090317384A1 (en) * | 2004-09-08 | 2009-12-24 | Genentech, Inc. | Methods of using death receptor ligands and cd20 antibodies |
WO2006029275A2 (en) * | 2004-09-08 | 2006-03-16 | Genentech, Inc. | Methods of using death receptor ligands and cd20 antibodies |
JO3000B1 (ar) * | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
EP1846034A4 (en) | 2005-02-02 | 2010-11-10 | Uab Research Foundation | AGENTS AND METHODS OF REDUCING THE RESISTANCE TO APOPTOSIS INDUCING DEATH RECEPTOR AGONISTS |
US8029783B2 (en) | 2005-02-02 | 2011-10-04 | Genentech, Inc. | DR5 antibodies and articles of manufacture containing same |
AU2006279618A1 (en) * | 2005-08-16 | 2007-02-22 | Genentech, Inc. | Apoptosis sensitivity to Apo2L/TRAIL by testing for 'GalNac-T14 expression in cells/tissues |
PE20071101A1 (es) | 2005-08-31 | 2007-12-21 | Amgen Inc | Polipeptidos y anticuerpos |
NZ568204A (en) | 2005-10-13 | 2012-01-12 | Human Genome Sciences Inc | Methods and compositions for use in treatment of patients with autoantibody positive diseases |
JP6088723B2 (ja) | 2005-11-23 | 2017-03-01 | ジェネンテック, インコーポレイテッド | B細胞アッセイに関する組成物及び方法。 |
CN102317314A (zh) | 2008-10-10 | 2012-01-11 | 阿纳福公司 | 结合trail-r1和trail-r2的多肽 |
EP2415781A4 (en) * | 2009-04-03 | 2012-10-17 | Inst Basic Med Sciences Pla | ANTIGENIC DETERMINANTS RECOGNIZED BY A MONOCLONAL ANTIBODY AD5-10 HUMAN DR5 HUMAN DEATH RECEPTOR, DERIVATIVES AND USES THEREOF |
CN102906104B (zh) | 2009-09-10 | 2015-04-22 | 朗萨生物制剂有限公司 | 用于多肽纯化的方法和系统 |
BR112012010698A2 (pt) | 2009-11-05 | 2016-11-29 | Uab Research Foundation | método para tratamento de um sujeito com câncer, método de triagem de uma célula de câncer de mama, e , anticorpo |
WO2011116344A2 (en) | 2010-03-18 | 2011-09-22 | The Uab Research Foundation | Targeting cancer stem cells |
CN103282495B (zh) | 2010-10-29 | 2017-06-09 | 第一三共株式会社 | 新的抗dr5抗体 |
TWI589587B (zh) | 2010-11-19 | 2017-07-01 | 衛材R&D企管股份有限公司 | 中和性抗-ccl20抗體 |
EP2681238A2 (en) | 2011-02-28 | 2014-01-08 | Istituto di Ricovero E Cura A Carattere Scientifico Materno-Infantile Burlo Garofolo- Ospedale di Alta Specializzazione E di Rilievo | Apoptosis-inducing molecules and uses therefor |
JP2014513128A (ja) | 2011-05-03 | 2014-05-29 | ジェネンテック, インコーポレイテッド | 血管破壊剤とその使用 |
DK2970473T3 (da) | 2013-03-14 | 2017-11-27 | Bristol Myers Squibb Co | Kombination af dr5-agonist og anti-pd-1-antagonist og fremgangsmåder til anvendelse heraf |
BR112015023959A2 (pt) | 2013-03-22 | 2017-07-18 | Koninklijke Philips Nv | dispositivo não invasivo para tratamento de pele com o uso de luz laser, método não invasivo para tratamento de pele com o uso de um dispositivo que gera luz laser, e uso de um dispositivo |
CN104693308B (zh) * | 2013-12-05 | 2020-08-04 | 同济大学 | 感受胞内pH变化的Smad5蛋白及其应用 |
EP3323428A1 (en) | 2016-11-17 | 2018-05-23 | CNRS Centre National de la Recherche Scientifique | Selective c-flip inhibitors as anticancer agents |
CN108997503B (zh) * | 2017-06-06 | 2021-07-23 | 深圳市中科艾深医药有限公司 | 人sDR5-Fc重组融合蛋白及其作为制备治疗生殖系统炎症的药物中的应用 |
EP3910331A1 (en) | 2020-05-15 | 2021-11-17 | iOmx Therapeutics AG | Intracellular kinase associated with resistance against t-cell mediated cytotoxicity, and uses thereof |
EP4257132A1 (en) | 2022-04-08 | 2023-10-11 | iOmx Therapeutics AG | Sik3 inhibitors for treating diseases resistant to death receptor signalling |
WO2024175554A1 (en) | 2023-02-21 | 2024-08-29 | Institut Curie | Trail agonists for use in the treatment of cancer in patients having an activating alteration of fgfr3 |
Family Cites Families (29)
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---|---|---|---|---|
US4002531A (en) * | 1976-01-22 | 1977-01-11 | Pierce Chemical Company | Modifying enzymes with polyethylene glycol and product produced thereby |
US5807715A (en) * | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
US4946778A (en) * | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
GB8928874D0 (en) * | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
US5349053A (en) * | 1990-06-01 | 1994-09-20 | Protein Design Labs, Inc. | Chimeric ligand/immunoglobulin molecules and their uses |
EP0510691B1 (en) * | 1991-04-26 | 2004-11-03 | Osaka Bioscience Institute | DNA coding for human cell surface antigen |
IL99120A0 (en) * | 1991-08-07 | 1992-07-15 | Yeda Res & Dev | Multimers of the soluble forms of tnf receptors,their preparation and pharmaceutical compositions containing them |
US5565332A (en) * | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
US5447851B1 (en) * | 1992-04-02 | 1999-07-06 | Univ Texas System Board Of | Dna encoding a chimeric polypeptide comprising the extracellular domain of tnf receptor fused to igg vectors and host cells |
GB9214857D0 (en) * | 1992-07-13 | 1992-08-26 | Medical Res Council | Human nucleic acid fragments and their use |
US5643575A (en) * | 1993-10-27 | 1997-07-01 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
DE69635480T2 (de) * | 1995-06-29 | 2006-08-17 | Immunex Corp., Thousand Oaks | Apoptosis induzierendes cytokin |
PT1012274E (pt) | 1997-01-28 | 2007-08-14 | Craig A Rosen | Receptor 4 contendo um domínio de morte (dm4; receptor de morte 4), membro da super-família do ftn e ligação a liart (ap02) |
US6433147B1 (en) | 1997-01-28 | 2002-08-13 | Human Genome Sciences, Inc. | Death domain containing receptor-4 |
US6072047A (en) | 1997-02-13 | 2000-06-06 | Immunex Corporation | Receptor that binds trail |
US20020160446A1 (en) | 2000-11-14 | 2002-10-31 | Holtzman Douglas A. | Novel genes encoding proteins having prognostic diagnostic preventive therapeutic and other uses |
US20010010924A1 (en) | 1997-03-14 | 2001-08-02 | Keith Charles Deen | Tumor necrosis factor related receptor, tr6 polynecleotides |
US6313269B1 (en) | 1997-03-14 | 2001-11-06 | Smithkline Beecham Corporation | Tumor necrosis factor related receptor, TR6 |
US6872568B1 (en) | 1997-03-17 | 2005-03-29 | Human Genome Sciences, Inc. | Death domain containing receptor 5 antibodies |
NZ337795A (en) | 1997-03-17 | 2001-06-29 | Human Genome Sciences Inc | Death domain containing receptor 5 and it's use in the treatment of DR5 related disease |
EP1007562A4 (en) | 1997-04-16 | 2000-09-27 | Millennium Pharm Inc | TANGO-63d AND TANGO-63e PROTEINS RELATED TO THE TUMOR NECROSIS FACTOR RECEPTOR |
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IL132067A0 (en) | 1997-05-15 | 2001-03-19 | Genentech Inc | Apo-2 receptor |
AU740227B2 (en) * | 1997-06-18 | 2001-11-01 | Genentech Inc. | Apo-2DcR |
CA2294704A1 (en) | 1997-06-26 | 1999-01-07 | Immunex Corporation | Protein that binds trail |
WO2000073349A1 (en) | 1999-05-28 | 2000-12-07 | Genentech, Inc. | Dr4 antibodies and uses thereof |
DK1192185T3 (da) | 1999-06-09 | 2006-10-23 | Genentech Inc | Apo-2L-receptoragonist og CPT-11-synergisme |
TWI318983B (en) | 2000-05-02 | 2010-01-01 | Uab Research Foundation | An antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof |
-
1998
- 1998-03-17 NZ NZ337795A patent/NZ337795A/en not_active IP Right Cessation
- 1998-03-17 EP EP98912966A patent/EP0970213B1/en not_active Revoked
- 1998-03-17 US US09/042,583 patent/US7803615B1/en not_active Expired - Fee Related
- 1998-03-17 PT PT98912966T patent/PT970213E/pt unknown
- 1998-03-17 CN CNB988045370A patent/CN1184315C/zh not_active Expired - Lifetime
- 1998-03-17 WO PCT/US1998/005377 patent/WO1998041629A2/en active IP Right Grant
- 1998-03-17 JP JP54079098A patent/JP4330180B2/ja not_active Expired - Fee Related
- 1998-03-17 AU AU67635/98A patent/AU747635B2/en not_active Withdrawn - After Issue
- 1998-03-17 CN CNA2004100949179A patent/CN1624128A/zh active Pending
- 1998-03-17 DK DK98912966T patent/DK0970213T3/da active
- 1998-03-17 CA CA002644454A patent/CA2644454A1/en not_active Abandoned
- 1998-03-17 CA CA002285040A patent/CA2285040C/en not_active Expired - Lifetime
- 1998-03-17 DE DE69836956T patent/DE69836956T2/de not_active Revoked
- 1998-03-17 NZ NZ508381A patent/NZ508381A/xx not_active IP Right Cessation
- 1998-03-17 ES ES98912966T patent/ES2281126T3/es not_active Expired - Lifetime
- 1998-03-17 KR KR10-1999-7008466A patent/KR100527638B1/ko not_active IP Right Cessation
- 1998-03-17 AT AT98912966T patent/ATE352618T1/de active
-
2000
- 2000-07-12 HK HK00104295A patent/HK1025352A1/xx not_active IP Right Cessation
-
2001
- 2001-12-07 US US10/005,842 patent/US20020098550A1/en not_active Abandoned
-
2007
- 2007-10-03 JP JP2007260427A patent/JP2008081503A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
ATE352618T1 (de) | 2007-02-15 |
NZ337795A (en) | 2001-06-29 |
CA2285040C (en) | 2009-01-27 |
NZ508381A (en) | 2002-09-27 |
CA2285040A1 (en) | 1998-09-24 |
AU6763598A (en) | 1998-10-12 |
HK1025352A1 (en) | 2000-11-10 |
DE69836956T2 (de) | 2007-10-31 |
WO1998041629A2 (en) | 1998-09-24 |
AU747635B2 (en) | 2002-05-16 |
US7803615B1 (en) | 2010-09-28 |
JP4330180B2 (ja) | 2009-09-16 |
PT970213E (pt) | 2007-04-30 |
ES2281126T3 (es) | 2007-09-16 |
DE69836956D1 (de) | 2007-03-15 |
CN1184315C (zh) | 2005-01-12 |
WO1998041629A3 (en) | 1998-10-29 |
CN1275162A (zh) | 2000-11-29 |
CA2644454A1 (en) | 1998-09-24 |
KR20000076364A (ko) | 2000-12-26 |
JP2008081503A (ja) | 2008-04-10 |
CN1624128A (zh) | 2005-06-08 |
EP0970213B1 (en) | 2007-01-24 |
KR100527638B1 (ko) | 2005-11-23 |
EP0970213A2 (en) | 2000-01-12 |
JP2001520513A (ja) | 2001-10-30 |
US20020098550A1 (en) | 2002-07-25 |
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