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DE69232832D1 - Bindungsdomänen in notch- und delta-proteinen - Google Patents

Bindungsdomänen in notch- und delta-proteinen

Info

Publication number
DE69232832D1
DE69232832D1 DE69232832T DE69232832T DE69232832D1 DE 69232832 D1 DE69232832 D1 DE 69232832D1 DE 69232832 T DE69232832 T DE 69232832T DE 69232832 T DE69232832 T DE 69232832T DE 69232832 D1 DE69232832 D1 DE 69232832D1
Authority
DE
Germany
Prior art keywords
notch
binding domains
toporythmic protein
delta proteins
fragment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69232832T
Other languages
English (en)
Other versions
DE69232832T2 (de
DE69232832T3 (de
Inventor
Spyridon Artavanis-Tsakonas
Marc Alan Telander Muskavitch
Richard Grant Fehon
Ilaria Rebay
Christine Marie Blaumueller
Scott Brockwell Shepard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yale University
Indiana University Research and Technology Corp
Original Assignee
Yale University
Indiana University Research and Technology Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27105529&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69232832(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Yale University, Indiana University Research and Technology Corp filed Critical Yale University
Publication of DE69232832D1 publication Critical patent/DE69232832D1/de
Publication of DE69232832T2 publication Critical patent/DE69232832T2/de
Application granted granted Critical
Publication of DE69232832T3 publication Critical patent/DE69232832T3/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/839—Nerves; brain

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Use Of Switch Circuits For Exchanges And Methods Of Control Of Multiplex Exchanges (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE69232832T 1991-05-03 1992-05-01 Bindungsdomänen in notch- und delta-proteinen Expired - Lifetime DE69232832T3 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US69518991A 1991-05-03 1991-05-03
US695189 1991-05-03
US79192391A 1991-11-14 1991-11-14
US791923 1991-11-14
PCT/US1992/003651 WO1992019734A1 (en) 1991-05-03 1992-05-01 Binding domains in notch and delta proteins

Publications (3)

Publication Number Publication Date
DE69232832D1 true DE69232832D1 (de) 2002-11-28
DE69232832T2 DE69232832T2 (de) 2003-06-18
DE69232832T3 DE69232832T3 (de) 2008-02-28

Family

ID=27105529

Family Applications (4)

Application Number Title Priority Date Filing Date
DE69232832T Expired - Lifetime DE69232832T3 (de) 1991-05-03 1992-05-01 Bindungsdomänen in notch- und delta-proteinen
DE69233724T Expired - Lifetime DE69233724T2 (de) 1991-05-03 1992-05-01 Bindungsdomänen des Serrate-Proteins
DE69233735T Expired - Lifetime DE69233735D1 (de) 1991-05-03 1992-05-01 Bindungsdomänen des Delta-proteins
DE69233791T Expired - Lifetime DE69233791D1 (de) 1991-05-03 1992-05-01 Verfahren zur Manipulation der Zelldifferenzierung

Family Applications After (3)

Application Number Title Priority Date Filing Date
DE69233724T Expired - Lifetime DE69233724T2 (de) 1991-05-03 1992-05-01 Bindungsdomänen des Serrate-Proteins
DE69233735T Expired - Lifetime DE69233735D1 (de) 1991-05-03 1992-05-01 Bindungsdomänen des Delta-proteins
DE69233791T Expired - Lifetime DE69233791D1 (de) 1991-05-03 1992-05-01 Verfahren zur Manipulation der Zelldifferenzierung

Country Status (12)

Country Link
US (1) US5849869A (de)
EP (4) EP0933082B1 (de)
JP (7) JPH07503123A (de)
AT (4) ATE473754T1 (de)
AU (1) AU675203B2 (de)
CA (1) CA2102208C (de)
DE (4) DE69232832T3 (de)
DK (4) DK0576623T4 (de)
ES (4) ES2303363T3 (de)
IE (2) IE921367A1 (de)
IL (1) IL101728A (de)
WO (1) WO1992019734A1 (de)

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IL101728A (en) * 1991-05-03 2007-08-19 Univ Yale Human Abandonment and Delta, Restrictive Areas of Effect in Tophoric Proteins, and Methods Based on Them
US6004924A (en) * 1991-12-11 1999-12-21 Imperial Cancer Research Technology, Ltd. Protein sequences of serrate gene products
US5869282A (en) * 1991-12-11 1999-02-09 Imperial Cancer Research Technology, Ltd. Nucleotide and protein sequences of the serrate gene and methods based thereon
US20050112121A1 (en) * 1992-04-30 2005-05-26 Yale University Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids
US5786158A (en) * 1992-04-30 1998-07-28 Yale University Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids
US5750652A (en) * 1994-01-21 1998-05-12 Yale University Deltex proteins
ES2334953T3 (es) * 1995-06-28 2010-03-17 Imperial Cancer Research Technology Limited Secuencias de nucleotidos y proteinas de genes delta de vertebrados y metodos basados en los mismos.
US5780300A (en) * 1995-09-29 1998-07-14 Yale University Manipulation of non-terminally differentiated cells using the notch pathway
US20050158859A1 (en) * 1995-09-29 2005-07-21 Yale University Manipulation of non-terminally differentiated cells using the Notch pathway
JP4283891B2 (ja) 1995-11-17 2009-06-24 旭化成株式会社 分化抑制ポリペプチド
AU728798B2 (en) * 1995-11-22 2001-01-18 Yale University Vertebrate deltex proteins, nucleic acids, and antibodies, and related methods and compositions
JP3922726B2 (ja) 1996-07-16 2007-05-30 旭化成株式会社 分化抑制剤
US6887475B1 (en) 1996-11-07 2005-05-03 Lorantis Limited Notch
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US6664098B1 (en) 1997-05-14 2003-12-16 Asahi Kasei Kabushiki Kaisha Differentiation inhibitory agent
US6692919B1 (en) 1997-07-23 2004-02-17 Yale University Activated forms of notch and methods based thereon
US6436650B1 (en) * 1997-07-23 2002-08-20 Yale University Activated forms of notch and methods based thereon
US6808890B2 (en) 1999-07-28 2004-10-26 Nuvelo, Inc. Method of detecting a cancerous cell expressing EGFL6, and EGF mutif protein
US6392019B1 (en) 1997-11-22 2002-05-21 John Ford Antibodies specific for EGF motif proteins
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US8084258B2 (en) 1999-07-12 2011-12-27 University Of Basel Manipulation of tissue of organ type using the notch pathway
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US6448197B1 (en) * 2000-07-13 2002-09-10 Exxonmobil Chemical Patents Inc. Method for making a metal containing small pore molecular sieve catalyst
US6984522B2 (en) 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
US8044259B2 (en) 2000-08-03 2011-10-25 The Regents Of The University Of Michigan Determining the capability of a test compound to affect solid tumor stem cells
US20020151487A1 (en) * 2000-08-31 2002-10-17 Loyola University Chicago Method and reagents for epithelial barrier formation and treatment of malignant and benign skin disorders by modulating the notch pathway
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US8068607B2 (en) 2007-07-31 2011-11-29 Ricoh Company, Limited Information processing apparatus and information processing method
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US5115096A (en) * 1988-04-15 1992-05-19 Oncogen Amphiregulin: a bifunctional growth modulating glycoprotein
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IL101728A (en) * 1991-05-03 2007-08-19 Univ Yale Human Abandonment and Delta, Restrictive Areas of Effect in Tophoric Proteins, and Methods Based on Them
WO1993012141A1 (en) * 1991-12-11 1993-06-24 Yale University Nucleotide and protein sequences of the serrate gene and methods based thereon
DE69329037T2 (de) * 1992-12-11 2001-03-22 The Government Of The United States Of America As Represented By The Secretary Of National Institute Of Health, Office Of Technology Transfer Delta ähnliches gen welches in neuroendokrinen tumoren exprimiert wird

Also Published As

Publication number Publication date
DE69233735D1 (de) 2008-07-17
IE85350B1 (en) 2009-10-14
JP2007330259A (ja) 2007-12-27
AU1919792A (en) 1992-12-21
ATE473754T1 (de) 2010-07-15
DE69232832T2 (de) 2003-06-18
DK0933082T3 (da) 2010-10-25
EP0576623A4 (de) 1995-01-18
DK0576623T4 (da) 2008-01-02
DE69232832T3 (de) 2008-02-28
JPH07503123A (ja) 1995-04-06
EP0576623A1 (de) 1994-01-05
ES2303363T3 (es) 2008-08-01
JP4604228B2 (ja) 2011-01-05
EP0930365B1 (de) 2008-02-13
IL101728A0 (en) 1992-12-30
DE69233724D1 (de) 2008-03-27
IE20030774A1 (en) 2003-12-10
DK0576623T3 (da) 2003-02-24
EP0933082A1 (de) 1999-08-04
EP0930366B1 (de) 2008-06-04
EP0576623B1 (de) 2002-10-23
CA2102208A1 (en) 1992-11-12
DE69233724T2 (de) 2009-04-02
JP2004065243A (ja) 2004-03-04
EP0930366A3 (de) 1999-07-28
EP0930366A2 (de) 1999-07-21
EP0576623B2 (de) 2007-10-03
ES2181674T5 (es) 2008-03-01
WO1992019734A1 (en) 1992-11-12
ES2310933T3 (es) 2009-01-16
EP0933082B1 (de) 2010-07-14
EP0930365A2 (de) 1999-07-21
JP4604227B2 (ja) 2011-01-05
JP2011155979A (ja) 2011-08-18
JP2007330258A (ja) 2007-12-27
JP4430891B2 (ja) 2010-03-10
ES2181674T3 (es) 2003-03-01
JP2011135886A (ja) 2011-07-14
AU675203B2 (en) 1997-01-30
ES2348919T3 (es) 2010-12-16
IE921367A1 (en) 1992-11-04
ATE226633T1 (de) 2002-11-15
EP0930365A3 (de) 1999-07-28
ATE397661T1 (de) 2008-06-15
DE69233791D1 (de) 2010-08-26
CA2102208C (en) 2003-04-29
ATE386116T1 (de) 2008-03-15
JP2008005843A (ja) 2008-01-17
DK0930365T3 (da) 2008-06-02
IL101728A (en) 2007-08-19
DK0930366T3 (da) 2008-10-13
US5849869A (en) 1998-12-15

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Owner name: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY COR, US

Owner name: YALE UNIVERSITY, NEW HAVEN, CONN., US