Nothing Special   »   [go: up one dir, main page]

DE68922491D1 - Monoklonale antikörper gegen protein c. - Google Patents

Monoklonale antikörper gegen protein c.

Info

Publication number
DE68922491D1
DE68922491D1 DE68922491T DE68922491T DE68922491D1 DE 68922491 D1 DE68922491 D1 DE 68922491D1 DE 68922491 T DE68922491 T DE 68922491T DE 68922491 T DE68922491 T DE 68922491T DE 68922491 D1 DE68922491 D1 DE 68922491D1
Authority
DE
Germany
Prior art keywords
protein
antibody
activation
isolation
peptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE68922491T
Other languages
English (en)
Other versions
DE68922491T2 (de
Inventor
Charles Esmon
Naomi Esmon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oklahoma Medical Research Foundation
Original Assignee
Oklahoma Medical Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oklahoma Medical Research Foundation filed Critical Oklahoma Medical Research Foundation
Application granted granted Critical
Publication of DE68922491D1 publication Critical patent/DE68922491D1/de
Publication of DE68922491T2 publication Critical patent/DE68922491T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6464—Protein C (3.4.21.69)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2405/00—Assays, e.g. immunoassays or enzyme assays, involving lipids
    • G01N2405/04—Phospholipids, i.e. phosphoglycerides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE68922491T 1988-12-30 1989-12-28 Monoklonale antikörper gegen protein c. Expired - Lifetime DE68922491T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29244788A 1988-12-30 1988-12-30
PCT/US1989/005851 WO1990007524A1 (en) 1988-12-30 1989-12-28 Monoclonal antibody against protein c

Publications (2)

Publication Number Publication Date
DE68922491D1 true DE68922491D1 (de) 1995-06-08
DE68922491T2 DE68922491T2 (de) 1995-11-09

Family

ID=23124711

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68922491T Expired - Lifetime DE68922491T2 (de) 1988-12-30 1989-12-28 Monoklonale antikörper gegen protein c.

Country Status (11)

Country Link
EP (1) EP0407544B1 (de)
JP (1) JP2559537B2 (de)
KR (1) KR940002033B1 (de)
AT (1) ATE122057T1 (de)
AU (2) AU641634B2 (de)
CA (1) CA2006684C (de)
DE (1) DE68922491T2 (de)
DK (1) DK171826B1 (de)
ES (1) ES2074562T3 (de)
FI (1) FI101476B1 (de)
WO (1) WO1990007524A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5298599A (en) * 1988-12-30 1994-03-29 Oklahoma Medical Research Foundation Expression and purification of recombinant soluble tissue factor
AT402262B (de) * 1991-06-20 1997-03-25 Immuno Ag Arzneimittel enthaltend aktiviertes protein c
WO1994002172A1 (en) * 1992-07-24 1994-02-03 Oklahoma Medical Research Foundation Blockade of protein c activation reduces microvascular surgical blood loss
DK0658168T3 (da) * 1992-08-27 2001-01-22 Sanquin Bloedvoorziening Antistoffer, som er specifikke for et hæmostatisk protein, anvendelse heraf til isolering af intakt protein, hæmostatiske p
DE4320294A1 (de) * 1993-06-18 1994-12-22 Immuno Ag Verwendung von humanem Protein C zur Verhinderung und Behandlung von Thrombozytenablagerungen
US5532136A (en) * 1993-06-22 1996-07-02 Bionebraska, Inc. Monoclonal antibody assay and kit for detecting metal cations in body fluids
CN1130353A (zh) * 1993-07-09 1996-09-04 史密丝克莱恩比彻姆公司 蛋白质的纯化
HRP940645A2 (en) * 1993-10-06 1996-12-31 Immuno Ag Process for virus deactivation in the presence of polyalkylene glycol and the pharmaceutical preparation thus obtained
EP0804580B1 (de) * 1994-06-10 2008-10-08 Oklahoma Medical Research Foundation Calciumbindende rekombinante antikörper gegen protein c
TW200407335A (en) 2002-07-22 2004-05-16 Chugai Pharmaceutical Co Ltd Non-neutralizing antibody to inhibit the inactivation of activated protein C
HUE037386T2 (hu) 2008-04-11 2018-08-28 Chugai Pharmaceutical Co Ltd Két vagy több antigén molekulát, ismétlõdõen megkötni képes antigénkötõ molekula
JP6030452B2 (ja) 2010-11-30 2016-11-24 中外製薬株式会社 複数分子の抗原に繰り返し結合する抗原結合分子
CN112812184A (zh) 2011-02-25 2021-05-18 中外制药株式会社 FcγRIIb特异性Fc抗体
EP3939996A1 (de) 2011-09-30 2022-01-19 Chugai Seiyaku Kabushiki Kaisha Antigenbindende moleküle zur förderung der zersetzung von antigenen mit mehreren biologischen aktivitäten
EP3047857A4 (de) * 2013-09-20 2017-08-09 Chugai Seiyaku Kabushiki Kaisha Behandlung von hämorrhagischen erkrankungen durch anti-protein-c-antikörper
SI3233921T1 (sl) 2014-12-19 2022-01-31 Chugai Seiyaku Kabushiki Kaisha Protitelesa proti C5 in postopki za uporabo
KR20240042169A (ko) 2014-12-19 2024-04-01 추가이 세이야쿠 가부시키가이샤 항-마이오스타틴 항체, 변이체 Fc 영역을 함유하는 폴리펩타이드, 및 사용 방법
EP3394098A4 (de) 2015-12-25 2019-11-13 Chugai Seiyaku Kabushiki Kaisha Anti-myostatin-antikörper und verfahren zur verwendung
CN109689099B (zh) 2016-08-05 2023-02-28 中外制药株式会社 用于预防或治疗il-8相关疾病的组合物
WO2018139623A1 (en) 2017-01-30 2018-08-02 Chugai Seiyaku Kabushiki Kaisha Anti-sclerostin antibodies and methods of use

Also Published As

Publication number Publication date
DE68922491T2 (de) 1995-11-09
ATE122057T1 (de) 1995-05-15
DK209090D0 (da) 1990-08-30
FI101476B (fi) 1998-06-30
WO1990007524A1 (en) 1990-07-12
FI101476B1 (fi) 1998-06-30
EP0407544B1 (de) 1995-05-03
EP0407544A1 (de) 1991-01-16
ES2074562T3 (es) 1995-09-16
DK209090A (da) 1990-08-30
AU641634B2 (en) 1993-09-30
AU4968390A (en) 1990-08-01
JPH03504332A (ja) 1991-09-26
DK171826B1 (da) 1997-06-23
FI904262A0 (fi) 1990-08-29
AU4422893A (en) 1994-01-27
CA2006684C (en) 1996-12-17
JP2559537B2 (ja) 1996-12-04
AU669540B2 (en) 1996-06-13
KR940002033B1 (ko) 1994-03-14
KR910700266A (ko) 1991-03-14
CA2006684A1 (en) 1990-06-30

Similar Documents

Publication Publication Date Title
DE68922491D1 (de) Monoklonale antikörper gegen protein c.
KITAHARA et al. Large-scale purification of porcine calpain I and calpain II and comparison of proteolytic fragments of their subunits
EP0930366A3 (de) Bindungsdomänen des Serrate-proteins
RU94045919A (ru) Антитела, клетки, полипептид, днк векторы, способ получения полипептида, способ получения антитела, фармацевтическая композиция
BG60256B1 (bg) Рекомбинантен метод за получаване на лимфотоксин
US20050214852A1 (en) Peptides for the treatment and diagnosis of systemic lupus erythematosus
Singh et al. Different forms of human liver glutathione S-transferases arise from dimeric combinations of at least four immunologically and functionally distinct subunits
DE69435020D1 (en) Protein-tyrosin-phosphatase ptp-s31
DE69535855D1 (de) Calciumbindende rekombinante antikörper gegen protein c
Cesbron et al. Human coumarin prothrombin
Ewins et al. Mapping epitope specificities of monoclonal antibodies to thyroid peroxidase using recombinant antigen preparations
Barnes et al. Glass-bead affinity chromatography of cell attachment and spreading-promoting factors of human serum
Imamura et al. A novel nonmuscle alpha-actinin. Purification and characterization of chicken lung alpha-actinin.
Williams et al. Dye-ligand affinity purification of human complement factor B and β2 glycoprotein I
Ratcliffe et al. The localization of the binding site (s) on human IgG1 for the Fc receptors on homologous monocytes and heterologous mouse macrophages.
NO903788L (no) Monoklonalt antistoff mot protein c.
Zibirre et al. Detection and localization of a cytoplasmic domain on the beta-subunit of Na+, K+-ATPase. A monoclonal antibody study.
Solomon et al. Affinity purification of antibodies using immobilized FB domain of protein A
Naguib et al. Purification of Chironex fleckeri venom components using Chironex immunoaffinity chromatography
Mannhalter Purification of plasma protein
ATE134218T1 (de) Methode zur reinigung rekombinanter t-pa von den ihren entsprechenden wirtszellproteinen
Werrbach-Perez et al. De novo synthesis of NGF subunits in S-180 mouse sarcoma cell line
WO2000017363A3 (en) Interleukin-1 like molecule: interleukin-1-zeta; nucleic acids, polypeptides, antibodies, their uses
Yasuda et al. Use of antibodies against synthetic peptides for analysis of molecular multiplicity: human deoxyribonuclease I polymorphism
Warr et al. β2 microglobulin-like polypeptide of the goldfish, Carassius auratus

Legal Events

Date Code Title Description
8364 No opposition during term of opposition