DE69833297D1 - Substituierte Pyridylmethylpiperazin- und piperidinderivate, deren Herstellung und deren Verwendung in der Behandlung von Erkrankungen des Zentralnervensystems (ZNS) - Google Patents

Substituierte Pyridylmethylpiperazin- und piperidinderivate, deren Herstellung und deren Verwendung in der Behandlung von Erkrankungen des Zentralnervensystems (ZNS)

Info

Publication number: DE69833297D1
Authority: DE; Germany
Prior art keywords: pyridylmethylpiperazine; cns; diseases; substituted; preparation
Prior art date: 1997-09-24
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69833297T

Other languages

English (en)

Other versions

DE69833297T2 (de

Inventor

R W Feenstra

Hartog J A J Den

C G Kruse

M T M Tulp

S K Long

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Duphar International Research BV

Original Assignee

Duphar International Research BV

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-09-24

Filing date

1998-09-21

Publication date

2006-04-13

1998-09-21 Application filed by Duphar International Research BV filed Critical Duphar International Research BV

2006-04-13 Publication of DE69833297D1 publication Critical patent/DE69833297D1/de

2006-07-20 Application granted granted Critical

2006-07-20 Publication of DE69833297T2 publication Critical patent/DE69833297T2/de

2018-09-22 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Psychology (AREA)
Otolaryngology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Pyridine Compounds (AREA)

DE69833297T 1997-09-24 1998-09-21 Substituierte Pyridylmethylpiperazin- und piperidinderivate, deren Herstellung und deren Verwendung in der Behandlung von Erkrankungen des Zentralnervensystems (ZNS) Expired - Lifetime DE69833297T2 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP97202950		1997-09-24
EP97202950		1997-09-24

Publications (2)

Publication Number	Publication Date
DE69833297D1 true DE69833297D1 (de)	2006-04-13
DE69833297T2 DE69833297T2 (de)	2006-07-20

Family

ID=8228755

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69833297T Expired - Lifetime DE69833297T2 (de)	1997-09-24	1998-09-21	Substituierte Pyridylmethylpiperazin- und piperidinderivate, deren Herstellung und deren Verwendung in der Behandlung von Erkrankungen des Zentralnervensystems (ZNS)

Country Status (31)

Country	Link
US (2)	US6090812A (de)
EP (1)	EP0908458B1 (de)
JP (1)	JP4191826B2 (de)
KR (1)	KR100632188B1 (de)
CN (1)	CN1093857C (de)
AR (1)	AR017127A1 (de)
AT (1)	ATE316529T1 (de)
AU (1)	AU733526B2 (de)
BR (1)	BR9803497A (de)
CA (1)	CA2247734C (de)
CY (1)	CY1107494T1 (de)
CZ (1)	CZ296741B6 (de)
DE (1)	DE69833297T2 (de)
DK (1)	DK0908458T3 (de)
DZ (1)	DZ2613A1 (de)
ES (1)	ES2255127T3 (de)
HK (1)	HK1018272A1 (de)
HU (1)	HU227422B1 (de)
ID (1)	ID20895A (de)
IL (1)	IL126295A (de)
NO (1)	NO312835B1 (de)
NZ (1)	NZ331984A (de)
PL (1)	PL190622B1 (de)
PT (1)	PT908458E (de)
RU (1)	RU2197488C2 (de)
SI (1)	SI0908458T1 (de)
SK (1)	SK285205B6 (de)
TR (1)	TR199801866A1 (de)
TW (1)	TW530054B (de)
UA (1)	UA66756C2 (de)
ZA (1)	ZA988749B (de)

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US6200994B1 (en)	1999-01-07	2001-03-13	American Home Products Corp	1,4-Disubstituted cyclohexane derivatives for the treatment of depression
DK1140919T3 (da) *	1999-01-07	2002-12-30	Wyeth Corp	1,4-Disubstituerede cyclohexanderivater til behandling af depression
DE10005150A1 (de) *	2000-02-07	2001-08-09	Merck Patent Gmbh	Verfahren zur Herstellung von 5-Arylnicotinaldehyden
DE10115922A1 (de) *	2001-03-30	2002-10-10	Bayer Ag	Cyclisch substituierte 2-Thio-3,5-dicyano-4-aryl-6-aminopyridine und ihre Verwendung
WO2003007956A1 (en) *	2001-07-20	2003-01-30	Psychogenics, Inc.	Treatment for attention-deficit hyperactivity disorder
US7435738B2 (en)	2003-08-18	2008-10-14	Solvay Pharmaceuticals, Inc.	Stable crystalline form of bifeprunox mesylate (7-[4-([1,1′-biphenyl]-3-ylmethyl)-1-piperazinyl]-2(3H)-benzoxazolone monomethanesulfonate)
US7405216B2 (en)	2004-08-18	2008-07-29	Solvay Pharmaceuticals, B.V.	Stable crystalline form of bifeprunox mesylate (7-[4-([1,1′-biphenyl]-3-ylmethyl)-1-piperazinyl]-2(3H)-benzoxazolone monomethanesulfonate)
US7423040B2 (en)	2005-02-18	2008-09-09	Irene Eijgendaal	Stable crystalline form of bifeprunox mesylate, dosage forms thereof and methods for using same
US7964604B2 (en)	2005-02-18	2011-06-21	Solvay Pharmaceuticals B.V.	Bifeprunox mesylate maintenance dose compositions and methods for using the same
US20070275977A1 (en) *	2006-05-02	2007-11-29	Van Aar Marcel P	N-oxides of pyridylmethyl -piperazine and -piperidine derivatives
MX2008013887A (es)	2006-05-02	2009-01-29	Solvay Pharm Bv	N-oxidos de derivados de piridilmetilpiperazina y piridilmetilpiperdina.
US8106056B2 (en)	2006-06-16	2012-01-31	Solvay Pharmaceuticals B.V.	Combination preparations comprising bifeprunox and a dopamine agonist
US7786126B2 (en)	2006-06-16	2010-08-31	Solvay Pharmaceuticals B.V.	Combination preparations comprising SLV308 and a dopamine agonist
WO2011088838A1 (en)	2010-01-25	2011-07-28	H. Lundbeck A/S	Novel 6,6a,7,8,9,10-hexahydro-4h-4,8,10a-triaza-acephenanthrylene derivatives as dopamine d2 ligands
US8877778B2 (en) *	2010-12-15	2014-11-04	Hoffmann-La Roche Inc.	Benzofurane compounds
US8921397B2 (en)	2011-05-04	2014-12-30	Hoffmann-La Roche Inc.	Benzofurane-piperidine compounds
BR112019000941A2 (pt)	2016-07-20	2019-04-30	Novartis Ag	derivados de aminopiridina e seu uso como inibidores seletivos de alk-2
KR101665971B1 (ko)	2016-08-10	2016-10-13	(주)글로벌 로보틱스	차량용 발포패드 부착장치
JP2023502742A (ja)	2019-11-22	2023-01-25	インサイトコーポレーション	Ａｌｋ２阻害剤及びｊａｋ２阻害剤を含む併用療法
US11723899B2 (en)	2020-06-16	2023-08-15	Incyte Corporation	ALK2 inhibitors for the treatment of anemia

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DE3586794T2 (de)	1984-12-21	1993-05-27	Duphar Int Res	Arzneimittel mit psychotroper wirkung.
DE3571436D1 (en) *	1984-12-21	1989-08-17	Duphar Int Res	New pharmaceutical compositions having anti-psychotic properties
ZA871335B (en) *	1986-02-27	1987-09-30	Duphar Int Res	New aryl-substituted(n-piperidinyl)methyl-and(n-piperazinyl)-methylazoles having antipsychotic properties
EP0508347A1 (de)	1991-04-10	1992-10-14	Hoechst Aktiengesellschaft	5,7-Dihydroxy-2-Methyl-8-[4-(3-Hydroxy-1-(1-Propyl))Piperidinyl]-4H-1-Benzopyran-4-on, seine Herstellung und Verwendung
IE914218A1 (en) *	1991-09-11	1993-03-24	Mcneilab Inc	Novel 4-arylpiperazines and 4-arylpiperidines
JPH05262765A (ja)	1992-03-18	1993-10-12	Sumitomo Chem Co Ltd	ベンゾフラン誘導体およびそれを有効成分とする除草剤
FR2692264B1 (fr) *	1992-06-12	1994-08-05	Adir	Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les contenant.
US5332732A (en) *	1992-09-11	1994-07-26	Mcneilab, Inc.	Thiophene and pyridine antipsychotic agents
US5436246A (en) *	1992-09-17	1995-07-25	Merrell Dow Pharmaceuticals Inc.	Serotonin receptor agents
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GB9314758D0 (en) *	1993-07-16	1993-08-25	Wyeth John & Brother Ltd	Heterocyclic derivatives
EP0650964A1 (de)	1993-11-02	1995-05-03	Duphar International Research B.V	1- 2H-1-Benzopyran-2-on-8-yl -Piperazin Derivate
DE4425146A1 (de) *	1994-07-15	1996-01-18	Basf Ag	Verwendung heterocyclischer Verbindungen
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DE19637237A1 (de)	1996-09-13	1998-03-19	Merck Patent Gmbh	Piperazin-Derivate

1998
- 1998-09-11 TW TW087115179A patent/TW530054B/zh not_active IP Right Cessation
- 1998-09-18 IL IL12629598A patent/IL126295A/xx not_active IP Right Cessation
- 1998-09-21 KR KR1019980038929A patent/KR100632188B1/ko not_active IP Right Cessation
- 1998-09-21 AU AU86079/98A patent/AU733526B2/en not_active Ceased
- 1998-09-21 RU RU98117621/04A patent/RU2197488C2/ru not_active IP Right Cessation
- 1998-09-21 ES ES98203154T patent/ES2255127T3/es not_active Expired - Lifetime
- 1998-09-21 DE DE69833297T patent/DE69833297T2/de not_active Expired - Lifetime
- 1998-09-21 BR BR9803497-9A patent/BR9803497A/pt not_active IP Right Cessation
- 1998-09-21 TR TR1998/01866A patent/TR199801866A1/xx unknown
- 1998-09-21 DK DK98203154T patent/DK0908458T3/da active
- 1998-09-21 AR ARP980104704A patent/AR017127A1/es active IP Right Grant
- 1998-09-21 SI SI9830822T patent/SI0908458T1/sl unknown
- 1998-09-21 ID IDP981269A patent/ID20895A/id unknown
- 1998-09-21 HU HU9802129A patent/HU227422B1/hu not_active IP Right Cessation
- 1998-09-21 AT AT98203154T patent/ATE316529T1/de active
- 1998-09-21 SK SK1294-98A patent/SK285205B6/sk not_active IP Right Cessation
- 1998-09-21 CZ CZ0303098A patent/CZ296741B6/cs not_active IP Right Cessation
- 1998-09-21 JP JP28357898A patent/JP4191826B2/ja not_active Expired - Lifetime
- 1998-09-21 NO NO19984380A patent/NO312835B1/no not_active IP Right Cessation
- 1998-09-21 EP EP98203154A patent/EP0908458B1/de not_active Expired - Lifetime
- 1998-09-21 NZ NZ331984A patent/NZ331984A/en not_active IP Right Cessation
- 1998-09-21 PT PT98203154T patent/PT908458E/pt unknown
- 1998-09-21 CA CA002247734A patent/CA2247734C/en not_active Expired - Fee Related
- 1998-09-21 CN CN98119652A patent/CN1093857C/zh not_active Expired - Fee Related
- 1998-09-21 PL PL98328754A patent/PL190622B1/pl not_active IP Right Cessation
- 1998-09-22 UA UA98094970A patent/UA66756C2/uk unknown
- 1998-09-22 DZ DZ980223A patent/DZ2613A1/xx active
- 1998-09-22 US US09/158,520 patent/US6090812A/en not_active Ceased
- 1998-09-23 ZA ZA988749A patent/ZA988749B/xx unknown
1999
- 1999-08-03 HK HK99103334A patent/HK1018272A1/xx not_active IP Right Cessation
2006
- 2006-04-07 CY CY20061100484T patent/CY1107494T1/el unknown
2008
- 2008-04-18 US US12/081,710 patent/USRE41425E1/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DZ2613A1 (fr)	2003-03-01
ES2255127T3 (es)	2006-06-16
ATE316529T1 (de)	2006-02-15
CN1093857C (zh)	2002-11-06
IL126295A0 (en)	1999-05-09
CY1107494T1 (el)	2013-03-13
EP0908458B1 (de)	2006-01-25
EP0908458A1 (de)	1999-04-14
US6090812A (en)	2000-07-18
CA2247734A1 (en)	1999-03-24
AU8607998A (en)	1999-04-15
RU2197488C2 (ru)	2003-01-27
JPH11302279A (ja)	1999-11-02
JP4191826B2 (ja)	2008-12-03
NO984380D0 (no)	1998-09-21
NZ331984A (en)	2000-02-28
USRE41425E1 (en)	2010-07-06
SK285205B6 (sk)	2006-08-03
AR017127A1 (es)	2001-08-22
HU227422B1 (en)	2011-05-30
TW530054B (en)	2003-05-01
CN1220265A (zh)	1999-06-23
ID20895A (id)	1999-03-25
PL190622B1 (pl)	2005-12-30
CZ303098A3 (cs)	1999-04-14
HUP9802129A1 (hu)	2000-03-28
AU733526B2 (en)	2001-05-17
ZA988749B (en)	1999-03-26
NO984380L (no)	1999-03-25
SI0908458T1 (sl)	2006-06-30
PT908458E (pt)	2006-05-31
CA2247734C (en)	2007-08-07
DK0908458T3 (da)	2006-06-06
BR9803497A (pt)	2000-05-02
DE69833297T2 (de)	2006-07-20
NO312835B1 (no)	2002-07-08
SK129498A3 (en)	1999-04-13
KR100632188B1 (ko)	2007-04-25
KR19990029982A (ko)	1999-04-26
IL126295A (en)	2003-02-12
TR199801866A1 (xx)	1999-04-21
UA66756C2 (uk)	2004-06-15
HU9802129D0 (en)	1998-11-30
CZ296741B6 (cs)	2006-06-14
HK1018272A1 (en)	1999-12-17
PL328754A1 (en)	1999-03-29

Publication	Publication Date	Title
ATE316529T1 (de)	2006-02-15	Substituierte pyridylmethylpiperazin- und piperidinderivate, deren herstellung und deren verwendung in der behandlung von erkrankungen des zentralnervensystems (zns)
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