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DE69413933D1 - Antitussiva - Google Patents

Antitussiva

Info

Publication number
DE69413933D1
DE69413933D1 DE69413933T DE69413933T DE69413933D1 DE 69413933 D1 DE69413933 D1 DE 69413933D1 DE 69413933 T DE69413933 T DE 69413933T DE 69413933 T DE69413933 T DE 69413933T DE 69413933 D1 DE69413933 D1 DE 69413933D1
Authority
DE
Germany
Prior art keywords
antitussiva
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69413933T
Other languages
English (en)
Other versions
DE69413933T2 (de
Inventor
Hiroshi Nagase
Koji Kawai
Takashi Endoh
Shinya Ueno
Yuji Negishi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toray Industries Inc
Original Assignee
Toray Industries Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries Inc filed Critical Toray Industries Inc
Application granted granted Critical
Publication of DE69413933D1 publication Critical patent/DE69413933D1/de
Publication of DE69413933T2 publication Critical patent/DE69413933T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69413933T 1993-06-30 1994-06-28 Antitussiva Expired - Fee Related DE69413933T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP16162693 1993-06-30
PCT/JP1994/001047 WO1995001178A1 (fr) 1993-06-30 1994-06-28 Antitussif

Publications (2)

Publication Number Publication Date
DE69413933D1 true DE69413933D1 (de) 1998-11-19
DE69413933T2 DE69413933T2 (de) 1999-04-08

Family

ID=15738765

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69413933T Expired - Fee Related DE69413933T2 (de) 1993-06-30 1994-06-28 Antitussiva

Country Status (11)

Country Link
US (1) US5739145A (de)
EP (1) EP0657163B1 (de)
KR (1) KR950702833A (de)
CN (1) CN1111900A (de)
AU (1) AU683664B2 (de)
CA (1) CA2143318A1 (de)
DE (1) DE69413933T2 (de)
FI (1) FI950908A (de)
NO (1) NO950757L (de)
TW (1) TW329386B (de)
WO (1) WO1995001178A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE172201T1 (de) * 1992-01-23 1998-10-15 Toray Industries Morphinan-derivate und medizinische verwendung
DE69414085T2 (de) * 1993-07-19 1999-03-18 Toray Industries, Inc., Tokio/Tokyo Wirkstoff zum schutze von gehirnzellen
DE69424853T2 (de) 1993-07-23 2000-10-05 Toray Industries, Inc. Morphinan-derivate und ihre medizinische verwendung
EP0829481A1 (de) * 1996-09-16 1998-03-18 Pfizer Inc. Morphinan-Hydroxamsäure-Derivate
US6440987B1 (en) 1996-11-25 2002-08-27 Toray Industries, Inc. Antipruritic
EP0897726B1 (de) * 1996-11-25 2007-04-11 Toray Industries, Inc. Mittel gegen juckreiz
US6403602B1 (en) * 1997-02-20 2002-06-11 The University Of Kentucky Research Foundation Morphine-6-sulfate analogues and their use for the treatment of pain
ES2308990T3 (es) * 1999-08-24 2008-12-16 Toray Industries, Inc. Remedios para el dolor neuropatico y modelos animales de dolor neuropatico.
WO2002080918A1 (fr) * 2001-04-02 2002-10-17 Toray Industries, Inc. Agent therapeutique ou prophylactique en cas de miction frequente ou d'incontinence urinaire
BRPI0608671B1 (pt) * 2005-04-06 2022-07-19 Toray Industries, Inc Processos para produzir um cristal de forma a de cloridrato de 17-ciclopropilmetil-3,14 b-diidróxi-4,5a-epóxi-6b-[n-metil-trans-3-(3-furil)-acril amido]-morfinano
CA2685126C (en) 2007-04-24 2015-04-14 Toray Industries, Inc. Therapeutic or prophylactic agent for dyskinesia
JP5343848B2 (ja) * 2007-06-22 2013-11-13 東レ株式会社 統合失調症の治療または予防剤
CA2714331C (en) 2008-02-14 2016-08-09 Alkermes, Inc. Selective opioid compounds
WO2010096791A1 (en) * 2009-02-23 2010-08-26 Mallinckrodt Inc. (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
US8946419B2 (en) 2009-02-23 2015-02-03 Mallinckrodt Llc (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
US8436174B2 (en) * 2009-02-23 2013-05-07 Mallinckrodt Llc (+)-morphinanium quaternary salts and processes for their production
CN102325777B (zh) * 2009-02-23 2015-08-12 马林克罗特公司 (+)-吗啡喃*n-氧化物及其制备方法
WO2011009020A2 (en) 2009-07-16 2011-01-20 Mallinckrodt Inc. Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
CA2787323C (en) 2010-01-29 2017-08-29 Toray Industries, Inc. Therapeutic or prophylactic agent for biliary tract diseases
BR112013009505B1 (pt) * 2010-10-19 2022-06-21 Memorial Sloan-Kettering Cancer Center Composto, composição farmacêutica, métodos para ensaio quanto a um receptor, e, usos de um composto
EP2671585B1 (de) 2011-01-31 2016-07-13 Toray Industries, Inc. (-)-17-(Cyclopropylmethyl)-3,14ß-Dihydroxy-4,5a-Epoxy-6ß-[N-Methyl-trans-3-(3-Furyl)acrylamido]Morphinan zur Verwendung bei der Behandlung oder Vorbeugung von Krebskachexie
MX2014002630A (es) 2011-09-08 2014-04-14 Mallinckrodt Llc Produccion de alcaloides sin el aislamiento de compuestos intermediarios.
US11046692B2 (en) 2015-04-30 2021-06-29 Memorial Sloan-Kettering Cancer Center Mitragynine analogs and uses thereof
CN105461727A (zh) * 2015-12-01 2016-04-06 吕涛 一种纳呋拉啡的精制方法
CN106866688B (zh) * 2015-12-10 2019-05-03 山东诚创医药技术开发有限公司 一种纳呋拉啡的精制方法
CN115181109B (zh) * 2021-04-02 2024-06-04 南京正大天晴制药有限公司 吗啡喃衍生物的晶体及其制备方法
CN114736210A (zh) * 2022-03-29 2022-07-12 伊诺药物研究(南京)有限公司 吗啡喃衍生物的一种晶型的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB843908A (en) * 1957-12-20 1960-08-10 Hoffmann La Roche Novel morphinan derivatives and the manufacture thereof
FR1503524A (fr) * 1964-10-17 1967-12-01 Tanabe Seiyaku Co Morphine à noyaux b/c condensés en configuration trans, et son procédé de préparation
US3865943A (en) * 1971-02-19 1975-02-11 Boehringer Sohn Ingelheim Pharmaceutical compositions containing an n-(furyl-methyl)-3-oxy-morphinan and method of use
DE2217420C3 (de) * 1972-04-12 1981-03-12 C.H. Boehringer Sohn, 6507 Ingelheim N-Thienylmethyl-Heterocyclen, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zubereitungen
US3880863A (en) * 1973-08-31 1975-04-29 Warner Lambert Co 17-Aralkyl-6 beta-azido-4,5 alpha-epox-ymorphinan-3-01{hu s
US4521601A (en) * 1981-05-20 1985-06-04 The United States Of America As Represented By The Department Of Health & Human Services Practical total synthesis unnatural enantiomers of opium-derived morphinans
US4401672A (en) * 1981-10-13 1983-08-30 Regents Of The University Of Minnesota Non-addictive narcotic antitussive preparation
US4613668A (en) * 1983-12-22 1986-09-23 The United States Of America As Represented By The Department Of Health And Human Services Short total synthesis or morphinan compounds which uses cyclization of a cycloalkylcarbonyl compound selected from cyclopropylcarbonyl and cyclobutylcarbonyl
US4730048A (en) * 1985-12-12 1988-03-08 Regents Of The University Of Minnesota Gut-selective opiates
US4912114A (en) * 1988-03-18 1990-03-27 Sandoz Ltd. Morphinan derivatives
DE415693T1 (de) * 1989-08-28 1991-10-17 Arizona Technology Development Corp., Tucson, Ariz. Zusammensetzung und verfahren zur selektiven verstaerkung der opiat-wirkung und verminderung von opiat-toleranz und abhaengigkeit.
ATE172201T1 (de) * 1992-01-23 1998-10-15 Toray Industries Morphinan-derivate und medizinische verwendung

Also Published As

Publication number Publication date
KR950702833A (ko) 1995-08-23
DE69413933T2 (de) 1999-04-08
FI950908A (fi) 1995-04-28
NO950757D0 (no) 1995-02-27
US5739145A (en) 1998-04-14
CA2143318A1 (en) 1995-01-12
AU6984494A (en) 1995-01-24
WO1995001178A1 (fr) 1995-01-12
NO950757L (no) 1995-04-27
EP0657163B1 (de) 1998-10-14
FI950908A0 (fi) 1995-02-28
TW329386B (en) 1998-04-11
AU683664B2 (en) 1997-11-20
CN1111900A (zh) 1995-11-15
EP0657163A4 (de) 1995-12-13
EP0657163A1 (de) 1995-06-14

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee