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DE3855177D1 - Makrozyklische tetraaza-verbindungen - Google Patents

Makrozyklische tetraaza-verbindungen

Info

Publication number
DE3855177D1
DE3855177D1 DE3855177T DE3855177T DE3855177D1 DE 3855177 D1 DE3855177 D1 DE 3855177D1 DE 3855177 T DE3855177 T DE 3855177T DE 3855177 T DE3855177 T DE 3855177T DE 3855177 D1 DE3855177 D1 DE 3855177D1
Authority
DE
Germany
Prior art keywords
connections
antibody
metal
macrocyclic tetraaza
tetraaza
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE3855177T
Other languages
English (en)
Other versions
DE3855177T2 (de
Inventor
David Parker
Thomas Millican
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UCB Celltech Ltd
Original Assignee
Celltech R&D Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10622173&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3855177(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Celltech R&D Ltd filed Critical Celltech R&D Ltd
Application granted granted Critical
Publication of DE3855177D1 publication Critical patent/DE3855177D1/de
Publication of DE3855177T2 publication Critical patent/DE3855177T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6887—Antibody-chelate conjugates using chelates for therapeutic purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65G—TRANSPORT OR STORAGE DEVICES, e.g. CONVEYORS FOR LOADING OR TIPPING, SHOP CONVEYOR SYSTEMS OR PNEUMATIC TUBE CONVEYORS
    • B65G49/00—Conveying systems characterised by their application for specified purposes not otherwise provided for
    • B65G49/05—Conveying systems characterised by their application for specified purposes not otherwise provided for for fragile or damageable materials or articles
    • B65G49/06—Conveying systems characterised by their application for specified purposes not otherwise provided for for fragile or damageable materials or articles for fragile sheets, e.g. glass
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cephalosporin Compounds (AREA)
  • External Artificial Organs (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
DE3855177T 1987-08-12 1988-08-12 Makrozyklische tetraaza-verbindungen Expired - Fee Related DE3855177T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB878719042A GB8719042D0 (en) 1987-08-12 1987-08-12 Conjugate compounds
PCT/GB1988/000671 WO1989001476A1 (en) 1987-08-12 1988-08-12 Tetra-aza macrocycles and metal complexes thereof

Publications (2)

Publication Number Publication Date
DE3855177D1 true DE3855177D1 (de) 1996-05-09
DE3855177T2 DE3855177T2 (de) 1996-10-02

Family

ID=10622173

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3855177T Expired - Fee Related DE3855177T2 (de) 1987-08-12 1988-08-12 Makrozyklische tetraaza-verbindungen

Country Status (11)

Country Link
US (1) US6774228B1 (de)
EP (1) EP0328589B1 (de)
JP (1) JPH02501141A (de)
KR (1) KR920700206A (de)
AT (1) ATE136302T1 (de)
AU (1) AU629515B2 (de)
CA (1) CA1341102C (de)
DE (1) DE3855177T2 (de)
DK (1) DK172789A (de)
GB (1) GB8719042D0 (de)
WO (1) WO1989001476A1 (de)

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GB8719042D0 (en) 1987-08-12 1987-09-16 Parker D Conjugate compounds
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WO1989001476A1 (en) 1989-02-23
DE3855177T2 (de) 1996-10-02
CA1341102C (en) 2000-09-26
GB8719042D0 (en) 1987-09-16
KR920700206A (ko) 1992-02-19
JPH02501141A (ja) 1990-04-19
US6774228B1 (en) 2004-08-10
EP0328589A1 (de) 1989-08-23
ATE136302T1 (de) 1996-04-15
EP0328589B1 (de) 1996-04-03
AU2253388A (en) 1989-03-09
DK172789D0 (da) 1989-04-11
DK172789A (da) 1989-04-11
AU629515B2 (en) 1992-10-08

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