DE3780454D1 - Im wesentlichen wasserfreies kristallines cefadroxil und verfahren zu dessen herstellung. - Google Patents
Im wesentlichen wasserfreies kristallines cefadroxil und verfahren zu dessen herstellung.Info
- Publication number
- DE3780454D1 DE3780454D1 DE8787117225T DE3780454T DE3780454D1 DE 3780454 D1 DE3780454 D1 DE 3780454D1 DE 8787117225 T DE8787117225 T DE 8787117225T DE 3780454 T DE3780454 T DE 3780454T DE 3780454 D1 DE3780454 D1 DE 3780454D1
- Authority
- DE
- Germany
- Prior art keywords
- cefadroxil
- production
- water
- free crystalline
- essential water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229960004841 cefadroxil Drugs 0.000 title abstract 5
- NBFNMSULHIODTC-CYJZLJNKSA-N cefadroxil monohydrate Chemical compound O.C1([C@@H](N)C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)C)C(O)=O)=CC=C(O)C=C1 NBFNMSULHIODTC-CYJZLJNKSA-N 0.000 title abstract 5
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 3
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 abstract 2
- ATHHXGZTWNVVOU-UHFFFAOYSA-N N-methylformamide Chemical compound CNC=O ATHHXGZTWNVVOU-UHFFFAOYSA-N 0.000 abstract 2
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/02—Preparation
- C07D501/12—Separation; Purification
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB878714180A GB8714180D0 (en) | 1987-06-17 | 1987-06-17 | Anhydrous crystalline cefadroxil |
| US07/825,737 US5329001A (en) | 1987-06-17 | 1992-01-27 | Substantially anhydrous crystalline cefadroxil and method for producing it |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE3780454D1 true DE3780454D1 (de) | 1992-08-20 |
| DE3780454T2 DE3780454T2 (de) | 1992-12-17 |
Family
ID=26292369
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8787117225T Expired - Lifetime DE3780454T2 (de) | 1987-06-17 | 1987-11-23 | Im wesentlichen wasserfreies kristallines cefadroxil und verfahren zu dessen herstellung. |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5329001A (de) |
| EP (1) | EP0295333B1 (de) |
| JP (1) | JPS63316785A (de) |
| KR (1) | KR950011744B1 (de) |
| CN (1) | CN1022922C (de) |
| AT (1) | ATE78257T1 (de) |
| AU (1) | AU595410B2 (de) |
| CA (1) | CA1339213C (de) |
| DE (1) | DE3780454T2 (de) |
| DK (1) | DK680487A (de) |
| ES (1) | ES2051724T3 (de) |
| FI (1) | FI87787C (de) |
| GB (1) | GB8714180D0 (de) |
| GR (1) | GR3005733T3 (de) |
| HK (1) | HK32793A (de) |
| NO (1) | NO168360C (de) |
| PH (1) | PH24594A (de) |
| PT (1) | PT86525B (de) |
| SU (1) | SU1595340A3 (de) |
| YU (1) | YU44650B (de) |
| ZA (1) | ZA879700B (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4898938A (en) * | 1987-08-03 | 1990-02-06 | Rifar S.R.L. | Method for preparing crystalline cefadroxil monohydrate |
| JP2005509637A (ja) * | 2001-10-24 | 2005-04-14 | セプラコア インク． | アムロジピンラセミ体の分離方法 |
| US20040077849A1 (en) * | 2002-10-16 | 2004-04-22 | Orchid Chemicals & Pharmaceuticals Limited | Process for the preparation of cefadroxil |
| CN1311830C (zh) * | 2004-02-27 | 2007-04-25 | 石药集团中奇制药技术（石家庄）有限公司 | 头孢羟氨苄口腔崩解片及其制备方法 |
| MX2008014711A (es) * | 2006-05-19 | 2008-12-03 | Dsm Ip Assets Bv | Procedimiento para la cristalizacion de cefadroxilo. |
| CN102134250B (zh) * | 2011-01-19 | 2013-03-13 | 天津大学 | 一种头孢羟氨苄单水合物的结晶方法及结晶 |
| CN105534937B (zh) * | 2015-12-30 | 2019-12-03 | 石药集团欧意药业有限公司 | 一种头孢羟氨苄片剂及其制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2163514A1 (de) * | 1971-12-21 | 1973-07-05 | Toyama Chemical Co Ltd | Verfahren zur herstellung von cephalosporinen |
| BE793191A (fr) * | 1971-12-28 | 1973-06-22 | Toyama Chemical Co Ltd | Procede pour produire des acides 7-acylamido-3-cephem-4- carboxyliques |
| US3985741A (en) * | 1972-09-15 | 1976-10-12 | Bristol-Myers Company | Production of p-hydroxycephalexin |
| GB1532682A (en) * | 1976-04-27 | 1978-11-22 | Bristol Myers Co | Process for the preparation of cephadroxil |
| DE3313818A1 (de) * | 1983-04-16 | 1984-10-18 | Hoechst Ag, 6230 Frankfurt | Neue kristallmodifikation von ceftazidim |
| JPS60231683A (ja) * | 1984-05-02 | 1985-11-18 | Teijin Ltd | セフアロスポリン誘導体その製造法及びそれを有効成分とする抗菌剤 |
| US4904776A (en) * | 1987-04-24 | 1990-02-27 | Rifar S.R.L. | Method for producing crystalline cefadroxil hemihydrate |
-
1987
- 1987-06-17 GB GB878714180A patent/GB8714180D0/en active Pending
- 1987-11-23 EP EP87117225A patent/EP0295333B1/de not_active Expired - Lifetime
- 1987-11-23 ES ES87117225T patent/ES2051724T3/es not_active Expired - Lifetime
- 1987-11-23 AT AT87117225T patent/ATE78257T1/de not_active IP Right Cessation
- 1987-11-23 DE DE8787117225T patent/DE3780454T2/de not_active Expired - Lifetime
- 1987-12-22 DK DK680487A patent/DK680487A/da not_active Application Discontinuation
- 1987-12-24 AU AU83041/87A patent/AU595410B2/en not_active Ceased
- 1987-12-28 ZA ZA879700A patent/ZA879700B/xx unknown
- 1987-12-29 CA CA000555491A patent/CA1339213C/en not_active Expired - Fee Related
- 1987-12-29 YU YU2428/87A patent/YU44650B/xx unknown
-
1988
- 1988-01-05 NO NO880027A patent/NO168360C/no unknown
- 1988-01-11 KR KR1019880000124A patent/KR950011744B1/ko not_active IP Right Cessation
- 1988-01-11 PT PT86525A patent/PT86525B/pt not_active IP Right Cessation
- 1988-01-25 SU SU884355130A patent/SU1595340A3/ru active
- 1988-02-04 JP JP63024867A patent/JPS63316785A/ja active Pending
- 1988-02-10 CN CN88100566A patent/CN1022922C/zh not_active Expired - Fee Related
- 1988-03-07 FI FI881039A patent/FI87787C/fi not_active IP Right Cessation
- 1988-04-04 PH PH36728A patent/PH24594A/en unknown
-
1992
- 1992-01-27 US US07/825,737 patent/US5329001A/en not_active Expired - Fee Related
- 1992-09-17 GR GR920402056T patent/GR3005733T3/el unknown
-
1993
- 1993-04-01 HK HK327/93A patent/HK32793A/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ES2051724T3 (es) | 1994-07-01 |
| EP0295333B1 (de) | 1992-07-15 |
| YU44650B (en) | 1990-10-31 |
| FI881039A0 (fi) | 1988-03-07 |
| KR950011744B1 (ko) | 1995-10-09 |
| ZA879700B (de) | 1988-06-23 |
| FI87787C (fi) | 1993-02-25 |
| GB8714180D0 (en) | 1987-07-22 |
| PH24594A (en) | 1990-08-17 |
| NO880027D0 (no) | 1988-01-05 |
| GR3005733T3 (de) | 1993-06-07 |
| DE3780454T2 (de) | 1992-12-17 |
| AU595410B2 (en) | 1990-03-29 |
| JPS63316785A (ja) | 1988-12-26 |
| NO168360B (no) | 1991-11-04 |
| HK32793A (en) | 1993-04-08 |
| DK680487D0 (da) | 1987-12-22 |
| FI881039A (fi) | 1988-12-18 |
| NO168360C (no) | 1992-02-12 |
| SU1595340A3 (ru) | 1990-09-23 |
| CA1339213C (en) | 1997-08-05 |
| FI87787B (fi) | 1992-11-13 |
| PT86525B (pt) | 1992-07-31 |
| AU8304187A (en) | 1988-12-22 |
| KR890000496A (ko) | 1989-03-15 |
| US5329001A (en) | 1994-07-12 |
| EP0295333A3 (en) | 1989-10-18 |
| PT86525A (en) | 1989-05-31 |
| CN88100566A (zh) | 1988-12-28 |
| CN1022922C (zh) | 1993-12-01 |
| EP0295333A2 (de) | 1988-12-21 |
| ATE78257T1 (de) | 1992-08-15 |
| NO880027L (no) | 1988-12-19 |
| YU242887A (en) | 1988-12-31 |
| DK680487A (da) | 1988-12-18 |
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|---|---|---|
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| JPS6442487A (en) | Manufacture of crystalline cephadroxyl monohydrate | |
| DE3780454D1 (de) | Im wesentlichen wasserfreies kristallines cefadroxil und verfahren zu dessen herstellung. | |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |