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DE2963526D1 - Derivatives of 4,5-dihydro-4-oxofuran-2-carboxylic acid, especially for use as hypolipidemic agents, processes for their preparation, pharmaceutical compositions comprising them, tetrahydropyran-2,3,5-triones useful in the preparation of the said derivatives and a process for preparing these tetrahydropyran-2,3,5-triones - Google Patents

Derivatives of 4,5-dihydro-4-oxofuran-2-carboxylic acid, especially for use as hypolipidemic agents, processes for their preparation, pharmaceutical compositions comprising them, tetrahydropyran-2,3,5-triones useful in the preparation of the said derivatives and a process for preparing these tetrahydropyran-2,3,5-triones

Info

Publication number
DE2963526D1
DE2963526D1 DE7979300928T DE2963526T DE2963526D1 DE 2963526 D1 DE2963526 D1 DE 2963526D1 DE 7979300928 T DE7979300928 T DE 7979300928T DE 2963526 T DE2963526 T DE 2963526T DE 2963526 D1 DE2963526 D1 DE 2963526D1
Authority
DE
Germany
Prior art keywords
triones
tetrahydropyran
derivatives
preparation
oxofuran
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE7979300928T
Other languages
English (en)
Inventor
Ivo Ladislav Jirkovsky
Dushan Michael Dvornik
Mitchell Ness Cayen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
American Home Products Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Products Corp filed Critical American Home Products Corp
Application granted granted Critical
Publication of DE2963526D1 publication Critical patent/DE2963526D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/28—Alcohols containing only six-membered aromatic rings as cyclic part with unsaturation outside the aromatic rings
    • C07C33/30—Alcohols containing only six-membered aromatic rings as cyclic part with unsaturation outside the aromatic rings monocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/31—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with compounds containing mercury atoms, which may be regenerated in situ, e.g. by oxygen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DE7979300928T 1978-06-05 1979-05-24 Derivatives of 4,5-dihydro-4-oxofuran-2-carboxylic acid, especially for use as hypolipidemic agents, processes for their preparation, pharmaceutical compositions comprising them, tetrahydropyran-2,3,5-triones useful in the preparation of the said derivatives and a process for preparing these tetrahydropyran-2,3,5-triones Expired DE2963526D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/912,798 US4169202A (en) 1978-06-05 1978-06-05 Process for preparing 4,5-dihydro-4-oxofuran-2-carboxylic acid derivatives

Publications (1)

Publication Number Publication Date
DE2963526D1 true DE2963526D1 (en) 1982-10-07

Family

ID=25432464

Family Applications (1)

Application Number Title Priority Date Filing Date
DE7979300928T Expired DE2963526D1 (en) 1978-06-05 1979-05-24 Derivatives of 4,5-dihydro-4-oxofuran-2-carboxylic acid, especially for use as hypolipidemic agents, processes for their preparation, pharmaceutical compositions comprising them, tetrahydropyran-2,3,5-triones useful in the preparation of the said derivatives and a process for preparing these tetrahydropyran-2,3,5-triones

Country Status (15)

Country Link
US (1) US4169202A (de)
EP (1) EP0006305B1 (de)
JP (1) JPS648629B2 (de)
AU (1) AU537177B2 (de)
CA (1) CA1118777A (de)
CY (1) CY1305A (de)
DE (1) DE2963526D1 (de)
DK (1) DK165005C (de)
ES (1) ES481233A0 (de)
HK (1) HK76785A (de)
HU (1) HU180199B (de)
MY (1) MY8600277A (de)
PH (1) PH15720A (de)
WO (1) WO1980000025A1 (de)
ZA (1) ZA792773B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL128510B1 (en) * 1980-03-01 1984-02-29 Wyeth John & Brother Ltd Method of obtaining new piperidine derivatives
DE3141194A1 (de) * 1981-10-16 1983-05-11 Lentia GmbH Chem. u. pharm. Erzeugnisse - Industriebedarf, 8000 München Verbundwerkstoff und verfahren zu seiner herstellung
JPS58175487A (ja) * 1982-04-08 1983-10-14 Meito Sangyo Kk 改質微生物レンネツト及びその製法
US4537623A (en) * 1984-03-29 1985-08-27 Chevron Research Company Herbicidal 2-(oxa or thia heterocycle)5-amino-3-oxo-4-(substituted-phenyl)-2,3-dihydrofurans
DE3577384D1 (de) * 1985-08-02 1990-06-07 Chevron Res Unkrautvertilgende 2-(oxa- oder thiaheterozyklische) 5-amino-3-oxo-4-(substituierte phenyl)-2,3-dihydrofurane.
US4704475A (en) * 1986-06-02 1987-11-03 American Home Products Corporation (Del.) Preparation of 3-hydroxy-3-phenylbutan-2-one
JPH0753678B2 (ja) * 1986-07-25 1995-06-07 ダイセル化学工業株式会社 アセトイン誘導体の直接光学分割方法
WO2003018575A1 (en) * 2001-08-24 2003-03-06 Wyeth Holdings Corporation 5-substituted-3(2h)-furanones useful for inhibition of farnesyl-protein transferase
JP2007512346A (ja) 2003-11-21 2007-05-17 アリーナ ファーマシューティカルズ， インコーポレイテッド ４−オキソ−４，５−ジヒドロ−フラン−２−カルボン酸誘導体およびその代謝関連障害の処置方法
US20160237054A1 (en) * 2013-09-27 2016-08-18 Sun Pharmaceutical Industries Limited Process for the purification of dapagliflozin

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2436532A (en) * 1945-02-24 1948-02-24 Robertson Co H H Production of 4-keto pimelic acid
US2744917A (en) * 1950-06-30 1956-05-08 Lilly Co Eli Process for the preparation of thiophene dicarboxylic acid
US2745845A (en) * 1950-06-30 1956-05-15 Lilly Co Eli 1-formyl-2-dialkoxymethyl-succinic acid esters and their cyclization to heterocyclic compounds
US3344150A (en) * 1962-04-18 1967-09-26 Technion Res & Dev Foundation 6-substituted 2, 3, 5-trioxo-tetrahydropyrans and their 3-enol esters and ethers
US3393204A (en) * 1963-04-23 1968-07-16 Cais Michael Heterocyclic compound and use
DE1518369A1 (de) * 1965-01-28 1969-11-06 Technion Res & Dev Foundation 4-Halogen-3,5,6-trioxotetrahydropyrane und Verfahren zu ihrer Herstellung
US3442913A (en) * 1965-10-06 1969-05-06 Richardson Merrell Inc 2-(trifluoromethyl)-3-fuoricacid esters and other 2 - fluoromethyl furan derivatives
US3439000A (en) * 1965-10-06 1969-04-15 Richardson Merrell Inc Aldehydes and ketones of trifluoromethylfurans
US3393206A (en) * 1966-02-15 1968-07-16 Cais Michael Heterocyclic compound and use
US3393205A (en) * 1966-02-15 1968-07-16 Cais Michael Heterocyclic compound and use
GB1199101A (en) * 1967-03-15 1970-07-15 Ajinomoto Kk Substance and Reaction Products Suitable for Improving the Flavour and Aroma of Food and Medicines
CH474500A (fr) * 1967-06-16 1969-06-30 Firmenich & Cie Procédé pour la préparation d'un dérivé furannique
NL6712748A (de) * 1967-09-18 1969-03-20
US3887589A (en) * 1968-03-28 1975-06-03 Lever Brothers Ltd 2,5-Diethyl-4-hydroxy-2,3,-dihydrofuran-3-one
GB1271082A (en) * 1968-05-07 1972-04-19 Wyeth John & Brother Ltd Furan, pyrrole and thiophene derivatives
US3743656A (en) * 1969-05-01 1973-07-03 Wyeth John & Brother Ltd Thiophene and furan lower alkanoic acids and derivatives
US3904655A (en) * 1969-06-26 1975-09-09 Lever Brothers Ltd Process for the preparation of a flavor substance by reacting a 4-oxy-5-alkyl-3-furanone with a hydrogen sulfide liberating substance
DE2013261A1 (de) * 1970-03-20 1971-10-07 Badische Anilin & Soda Fabnk AG, 6700 Ludwigshafen Verfahren zur Herstellung von Furanen
GB1383492A (en) * 1970-12-21 1974-02-12 Unilever Ltd Dicarbonyl compounds and preparation of dihydrofuranones therefrom
NL7216271A (de) * 1972-11-30 1974-06-04
US4000164A (en) * 1973-04-02 1976-12-28 Richardson-Merrell Inc. Hypolipidemic agents
GB1489734A (en) * 1975-04-08 1977-10-26 Nippon Chemiphar Co Ascorbic acid derivative and pharmaceutical compositions containing the same

Also Published As

Publication number Publication date
WO1980000025A1 (en) 1980-01-10
DK165005B (da) 1992-09-28
DK165005C (da) 1993-02-08
ZA792773B (en) 1981-01-28
HU180199B (en) 1983-02-28
HK76785A (en) 1985-10-18
ES8100283A1 (es) 1980-11-01
AU537177B2 (en) 1984-06-14
PH15720A (en) 1983-03-18
JPS55500473A (de) 1980-07-31
JPS648629B2 (de) 1989-02-14
AU4689279A (en) 1979-12-13
CY1305A (en) 1985-12-06
US4169202A (en) 1979-09-25
DK37580A (da) 1980-01-29
EP0006305B1 (de) 1982-08-11
ES481233A0 (es) 1980-11-01
EP0006305A1 (de) 1980-01-09
CA1118777A (en) 1982-02-23
MY8600277A (en) 1986-12-31

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Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee