Nothing Special   »   [go: up one dir, main page]

CY1113209T1 - Νεα παραγωγα πυρρολο [3,2-d] πυριμιδιν-4-ονης και η χρηση τους στη θεραπεια - Google Patents

Νεα παραγωγα πυρρολο [3,2-d] πυριμιδιν-4-ονης και η χρηση τους στη θεραπεια

Info

Publication number
CY1113209T1
CY1113209T1 CY20121100939T CY121100939T CY1113209T1 CY 1113209 T1 CY1113209 T1 CY 1113209T1 CY 20121100939 T CY20121100939 T CY 20121100939T CY 121100939 T CY121100939 T CY 121100939T CY 1113209 T1 CY1113209 T1 CY 1113209T1
Authority
CY
Cyprus
Prior art keywords
therapy
new
pyrolol
producers
pyrimidin
Prior art date
Application number
CY20121100939T
Other languages
English (en)
Inventor
Anders Bögevig
Yvonne Lo-Alfredsson
Donald Pivonka
Anna-Karin Tidén
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36578191&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1113209(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from SE0402972A external-priority patent/SE0402972D0/sv
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of CY1113209T1 publication Critical patent/CY1113209T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/12—Mucolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Αποκαλύπτονται νέες ενώσεις του τύπου (I), όπου τα R1, R12, L, Χ και Υ είναι όπως ορίζονται στην περιγραφή, και φαρμακευτικώς αποδεκτά άλατα αυτών, μαζί με διεργασίες για την παρασκευή τους, συνθέσεις που τα περιέχουν και η χρήση τους στη θεραπεία. Οι ενώσεις είναι αναστολείς του ενζύμου ΜΡΟ και συνεπώς είναι ιδιαιτέρως χρήσιμες στη θεραπευτική αγωγή ή προφύλαξη νευροφλεγμονωδών διαταραχών, καρδιαγγειακών διαταραχών και αναπνευστικών διαταραχών.
CY20121100939T 2004-12-06 2012-10-10 Νεα παραγωγα πυρρολο [3,2-d] πυριμιδιν-4-ονης και η χρηση τους στη θεραπεια CY1113209T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0402972A SE0402972D0 (sv) 2004-12-06 2004-12-06 Novel compounds
SE0501093 2005-05-13
EP05812036A EP1824855B1 (en) 2004-12-06 2005-12-05 Novel pyrrolo [3, 2-d]pyrimidin-4-one derivatives and their use in therapy

Publications (1)

Publication Number Publication Date
CY1113209T1 true CY1113209T1 (el) 2016-04-13

Family

ID=36578191

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20121100939T CY1113209T1 (el) 2004-12-06 2012-10-10 Νεα παραγωγα πυρρολο [3,2-d] πυριμιδιν-4-ονης και η χρηση τους στη θεραπεια

Country Status (30)

Country Link
US (3) US7829707B2 (el)
EP (1) EP1824855B1 (el)
JP (1) JP5028270B2 (el)
KR (3) KR101412939B1 (el)
CN (1) CN101072778B (el)
AR (1) AR051698A1 (el)
AU (1) AU2005312388B2 (el)
BR (1) BRPI0518846B1 (el)
CA (1) CA2591314C (el)
CY (1) CY1113209T1 (el)
DK (1) DK1824855T3 (el)
ES (1) ES2390888T3 (el)
HK (1) HK1110859A1 (el)
HR (1) HRP20120781T1 (el)
IL (1) IL183182A (el)
ME (1) ME01486B (el)
MX (1) MX2007006497A (el)
MY (1) MY140748A (el)
NO (1) NO20072399L (el)
NZ (1) NZ555046A (el)
PL (1) PL1824855T3 (el)
PT (1) PT1824855E (el)
RS (1) RS52490B (el)
RU (2) RU2577858C2 (el)
SA (1) SA05260385B1 (el)
SI (1) SI1824855T1 (el)
TW (1) TWI365189B (el)
UA (1) UA89968C2 (el)
UY (1) UY29246A1 (el)
WO (1) WO2006062465A1 (el)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR039385A1 (es) 2002-04-19 2005-02-16 Astrazeneca Ab Derivados de tioxantina como inhibidores de la mieloperoxidasa
MY140748A (en) 2004-12-06 2010-01-15 Astrazeneca Ab Novel pyrrolo [3,2-d] pyrimidin-4-one derivatives and their use in therapy
AU2007217349B9 (en) * 2006-02-21 2013-06-27 Teva Pharmaceutical Industries, Ltd. Use of rasagiline for the treatment of Multiple System Atrophy
US20090286813A1 (en) * 2006-04-13 2009-11-19 Astrazeneca Ab Thioxanthine Derivatives and Their Use as Inhibitors of MPO
TW200806667A (en) * 2006-04-13 2008-02-01 Astrazeneca Ab New compounds
TW200804383A (en) 2006-06-05 2008-01-16 Astrazeneca Ab New compounds
US20090054468A1 (en) * 2007-08-23 2009-02-26 Astrazeneca Ab New Use 938
JP5201063B2 (ja) * 2008-04-15 2013-06-05 信越化学工業株式会社 付加硬化型シリコーン組成物及びその硬化物
SI2411393T1 (sl) 2009-03-23 2014-03-31 Glenmark Pharmaceuticals S.A. Kondenzirani pirimidin-dionski derivati kot TRPA 1 modulatorji
GB0913345D0 (en) 2009-07-31 2009-09-16 Astrazeneca Ab New combination 802
WO2011061527A1 (en) 2009-11-17 2011-05-26 Astrazeneca Ab Combinations comprising a glucocorticoid receptor modulator for the treatment of respiratory diseases
TWI515187B (zh) * 2010-12-16 2016-01-01 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之吲哚類
TWI527814B (zh) 2010-12-16 2016-04-01 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之氮雜苯并咪唑類
TWI501967B (zh) 2010-12-16 2015-10-01 Janssen R&D Ireland 作為呼吸道融合病毒抗病毒劑之氮雜吲哚類
WO2012088266A2 (en) 2010-12-22 2012-06-28 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3
GB201021992D0 (en) 2010-12-23 2011-02-02 Astrazeneca Ab Compound
GB201021979D0 (en) 2010-12-23 2011-02-02 Astrazeneca Ab New compound
EA027324B1 (ru) 2011-11-11 2017-07-31 Пфайзер Инк. 2-тиопиримидиноны
WO2013150115A1 (en) * 2012-04-05 2013-10-10 Basf Se N- substituted hetero - bicyclic compounds and derivatives for combating animal pests
AR091424A1 (es) 2012-06-13 2015-02-04 Incyte Corp Compuestos triciclicos sustituidos como inhibidores de receptores del factor de crecimiento del fibroplasto (fgfr)
SI2864323T1 (sl) 2012-06-15 2017-08-31 Janssen Sciences Ireland Uc Derivati 1,3-dihidro-2h-benzimidazol-2-ona substituirani s heterocikli, kot protivirusna zdravila respiratornega sincicijskega virusa
WO2014026125A1 (en) 2012-08-10 2014-02-13 Incyte Corporation Pyrazine derivatives as fgfr inhibitors
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
MY181497A (en) 2013-04-19 2020-12-23 Incyte Holdings Corp Bicyclic heterocycles as fgfr inhibitors
US9920075B2 (en) 2014-09-11 2018-03-20 Bristol-Myers Squibb Company Triazolopyridine and triazolopyrimidine inhibitors of myeloperoxidase
US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
US9616063B2 (en) * 2014-12-01 2017-04-11 Astrazeneca Ab 1-[2-(aminomethyl)benzyl]-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-ones as inhibitors of myeloperoxidase
EP3259269B9 (en) 2015-02-20 2020-03-04 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
WO2016134294A1 (en) 2015-02-20 2016-08-25 Incyte Corporation Bicyclic heterocycles as fgfr4 inhibitors
MA41551A (fr) 2015-02-20 2017-12-26 Incyte Corp Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
CN107531647A (zh) 2015-05-05 2018-01-02 辉瑞大药厂 2‑硫代嘧啶酮类
US10214527B2 (en) * 2015-09-03 2019-02-26 Bristol-Myers Squibb Company Triazolopyridine inhibitors of myeloperoxidase
WO2017040449A1 (en) * 2015-09-03 2017-03-09 Bristol-Myers Squibb Company Triazolopyridine inhibitors of myeloperoxidase
WO2017160632A1 (en) * 2016-03-14 2017-09-21 Bristol-Myers Squibb Company Triazolopyridine inhibitors of myeloperoxidase
AR111960A1 (es) 2017-05-26 2019-09-04 Incyte Corp Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
US11246870B2 (en) * 2017-07-17 2022-02-15 Astrazenca Ab MPO inhibitors for use in medicine
US10781226B2 (en) 2017-10-19 2020-09-22 Texas State University Photoactivatable cancer prodrug
AU2019262579B2 (en) 2018-05-04 2024-09-12 Incyte Corporation Salts of an FGFR inhibitor
DK3788047T3 (da) 2018-05-04 2024-09-16 Incyte Corp Faste former af en FGFR-inhibitor og fremgangsmåder til fremstilling deraf
WO2020021300A1 (en) 2018-07-24 2020-01-30 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of myeloperoxidase (mpo) inhibitors for the treatment of chemoresistant acute myeloid leukemia (aml)
US11628162B2 (en) 2019-03-08 2023-04-18 Incyte Corporation Methods of treating cancer with an FGFR inhibitor
WO2021007269A1 (en) 2019-07-09 2021-01-14 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
WO2021013942A1 (en) 2019-07-24 2021-01-28 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of myeloperoxidase inhibitors for the treatment of cardiovascular diseases in patients suffering from myeloproliferative neoplasms
WO2021067374A1 (en) 2019-10-01 2021-04-08 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
JP2022552324A (ja) 2019-10-14 2022-12-15 インサイト・コーポレイション Ｆｇｆｒ阻害剤としての二環式複素環
WO2021076728A1 (en) 2019-10-16 2021-04-22 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
BR112022010664A2 (pt) 2019-12-04 2022-08-16 Incyte Corp Derivados de um inibidor de fgfr
US11897891B2 (en) 2019-12-04 2024-02-13 Incyte Corporation Tricyclic heterocycles as FGFR inhibitors
WO2021146424A1 (en) 2020-01-15 2021-07-22 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
KR20220149709A (ko) * 2020-03-05 2022-11-08 바이오하벤 테라퓨틱스 리미티드 골수 세포형과산화효소 저해제를 사용한 근위축성 측삭 경화증의 치료 방법
US20230192700A1 (en) 2020-03-06 2023-06-22 Bayer Aktiengesellschaft Pyrazolopyrazines acting on cancers via inhibition of cdk12
EP4146219A4 (en) * 2020-05-06 2024-05-22 Biohaven Therapeutics Ltd. PROCESS FOR PREPARING VERDIPERSTAT
TW202304459A (zh) 2021-04-12 2023-02-01 美商英塞特公司 包含ｆｇｆｒ抑制劑及ｎｅｃｔｉｎ－４靶向劑之組合療法
CN115403584B (zh) * 2021-05-26 2024-04-02 长春金赛药业有限责任公司 2-硫代-2,3-二氢嘧啶-4-酮衍生物、药物组合物及其制备方法和应用
EP4352059A1 (en) 2021-06-09 2024-04-17 Incyte Corporation Tricyclic heterocycles as fgfr inhibitors
WO2024038131A1 (en) 2022-08-18 2024-02-22 Astrazeneca Ab Inhibitors of myeloperoxidase
WO2024120457A1 (zh) * 2022-12-09 2024-06-13 深圳信立泰药业股份有限公司 一种吡咯并[3,2-d]嘧啶-4-酮类衍生物及其制备方法和医药用途

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3135753A (en) * 1961-05-10 1964-06-02 Burroughs Wellcome Co Alkylthiopurines and method
US3652579A (en) 1969-06-26 1972-03-28 Hoffmann La Roche 1-methyl-2-substituted 5-nitroimidazoles
SE7810947L (sv) 1978-10-20 1980-04-21 Draco Ab 3-alkylxanthines
US4710503A (en) 1985-02-07 1987-12-01 Euroceltique S.A. 6-thioxanthine derivatives
JPH03501731A (ja) 1987-12-31 1991-04-18 スミスクライン・ベックマン・コーポレイション ４‐アラルキル‐５‐置換‐１，２，４‐トリアゾール‐５‐チオール類
DK440989A (da) 1988-09-12 1990-03-13 Smithkline Beecham Corp Dopamin-beta-hydroxylase inhibitorer
JPH02160235A (ja) 1988-12-13 1990-06-20 Konica Corp ハロゲン化銀カラー写真画像の形成方法
EP0430300A3 (en) 1989-12-01 1992-03-25 Takeda Chemical Industries, Ltd. Xanthine derivatives, their production and use
US5100906A (en) 1990-04-19 1992-03-31 Merrell Dow Pharmaceuticals Inc. 5-aryl-4-alkyl-3h-1,2,4-triazole-3-thiones useful as memory enhancers
FR2665636B1 (fr) * 1990-08-10 1994-10-07 Adir Utilisation d'un derive de la trimethyl-1,3,7 xanthine pour le traitement des troubles de la memoire, des troubles intellectuels de la senescence et de la maladie d'alzheimer.
US6046019A (en) * 1991-07-09 2000-04-04 Goumeniouk; Alexander P. Diagnostic kits and methods for making granulocyte cell counts
US5281209A (en) 1992-06-30 1994-01-25 The Procter & Gamble Company Absorbent article having tucked flaps
RU94046387A (ru) 1992-04-21 1996-09-27 Биокрист Фармасьютикалз Производные пиримидина, способ их получения, фармацевтическая композиция, ее применение и промежуточные продукты
US6469017B1 (en) 1998-01-16 2002-10-22 Cell Therapeutics, Inc. Method of inhibiting interleukin-12 signaling
GB9312853D0 (en) 1993-06-22 1993-08-04 Euro Celtique Sa Chemical compounds
CZ283564B6 (cs) * 1993-11-26 1998-05-13 Pfizer Inc. 3-Aryl-2-isoxazolin-5-hydroxamové kyseliny a farmaceutické prostředky na jejich bázi
US5489598A (en) * 1994-06-08 1996-02-06 Warner-Lambert Company Cytoprotection utilizing aryltriazol-3-thiones
WO1996018399A1 (en) * 1994-12-13 1996-06-20 Euro-Celtique, S.A. Aryl thioxanthines
WO1996018400A1 (en) 1994-12-13 1996-06-20 Euro-Celtique, S.A. Trisubstituted thioxanthines
US6025361A (en) * 1994-12-13 2000-02-15 Euro-Celtique, S.A. Trisubstituted thioxanthines
US5756511A (en) * 1995-04-03 1998-05-26 Cell Therapeutics, Inc. Method for treating symptoms of a neurodegenerative condition
US6294541B1 (en) * 1996-06-06 2001-09-25 Euro-Celtique S.A. Purine derivatives having phosphodiesterase IV inhibition activity
GB9626643D0 (en) 1996-12-21 1997-02-12 Astra Pharma Prod Compounds
US5976823A (en) * 1997-03-19 1999-11-02 Integrated Biomedical Technology, Inc. Low range total available chlorine test strip
EP1016407B1 (en) 1997-09-05 2006-05-10 Kyowa Hakko Kogyo Co., Ltd. Xanthine derivatives for treating brain ischemia
AU9297798A (en) 1997-09-16 1999-04-05 G.D. Searle & Co. Substituted 1,2,4-triazoles useful for inhibiting cholesteryl ester transfer protein activity
AR013669A1 (es) 1997-10-07 2001-01-10 Smithkline Beecham Corp Compuestos y metodos
US6187777B1 (en) 1998-02-06 2001-02-13 Amgen Inc. Compounds and methods which modulate feeding behavior and related diseases
US6319928B1 (en) * 1998-11-30 2001-11-20 Euro-Celtique, S.A. Purine derivatives having phosphodiesterase IV inhibition activity
DZ3019A1 (fr) 1999-03-01 2005-05-20 Smithkline Beecham Corp Utilisation d'un inhibiteur de pde4 dans la préparation d'un médicament contre la copd.
HUP0200938A2 (en) 1999-04-02 2002-10-28 Euro Celtique Sa Purine derivatives having phosphodiesterase iv inhibition activity and medicaments containing them
GB2362101A (en) * 2000-05-12 2001-11-14 Astrazeneca Ab Treatment of chronic obstructive pulmonary disease
FR2811989A1 (fr) 2000-07-18 2002-01-25 Sanofi Synthelabo Derives de polyfluoroalkytriazole, leur preparation et leur application en therapeutique
EP1305328A2 (en) 2000-07-21 2003-05-02 Mark B. Lyles Materials and methods for binding nucleic acids to surfaces
GB0100623D0 (en) 2001-01-10 2001-02-21 Vernalis Res Ltd Chemical compounds IV
GB0100620D0 (en) 2001-01-10 2001-02-21 Vernalis Res Ltd Chemical cokpounds V
FR2819723B1 (fr) * 2001-01-23 2006-11-17 Arnaud Mainnemare Composition halogene, son procede de preparation et ses utilisations
WO2002066447A1 (en) 2001-02-21 2002-08-29 Ono Pharmaceutical Co., Ltd. 4h-1,2,4-triazole-3(2h)-thione deratives as sphingomyelinase inhibitors
ATE346951T1 (de) 2001-05-08 2006-12-15 Astrazeneca Ab Test zum nachweis von inhibitoren des enzyms myeloperokidase
SE0103766D0 (sv) * 2001-11-09 2001-11-09 Astrazeneca Ab Novel assay
ES2193839B1 (es) * 2001-06-22 2005-02-16 Almirall Prodesfarma, S.A. Nuevos derivados de 6-fenildihidropirrolpirimidindiona.
PT2260850T (pt) 2002-01-28 2018-10-24 Kyowa Hakko Kogyo Kk Antagonistas do recetor de a2a para utilização no tratamento de distúrbios de movimento
ES2208063B1 (es) 2002-04-01 2005-10-01 Almirall Prodesfarma, S.A. Nuevos derivados de la 4-(pirrolopirimidin-6-il)bencenosulfonamida.
AR039385A1 (es) * 2002-04-19 2005-02-16 Astrazeneca Ab Derivados de tioxantina como inhibidores de la mieloperoxidasa
SE0301232D0 (sv) 2003-04-25 2003-04-25 Astrazeneca Ab Novel use
SE0302756D0 (sv) * 2003-10-17 2003-10-17 Astrazeneca Ab Novel Compounds
BRPI0415888A (pt) * 2003-10-31 2007-01-09 Cv Therapeutics Inc antagonistas do receptor de adenosina a2b
SG157242A1 (en) 2004-02-14 2009-12-29 Smithkline Beecham Corp Medicaments with hm74a receptor agonist activity
WO2006045564A1 (en) 2004-10-22 2006-05-04 Smithkline Beecham Corporation Xanthine derivatives with hm74a receptor activity
SE0402591D0 (sv) 2004-10-25 2004-10-25 Astrazeneca Ab Novel use
MY140748A (en) 2004-12-06 2010-01-15 Astrazeneca Ab Novel pyrrolo [3,2-d] pyrimidin-4-one derivatives and their use in therapy
TW200806667A (en) 2006-04-13 2008-02-01 Astrazeneca Ab New compounds
JP2009539829A (ja) 2006-06-05 2009-11-19 アストラゼネカ・アクチエボラーグ ミエロペルオキシダーゼ阻害剤としてのピロロ［３，２−ｄ］ピリミジン−４−オン誘導体
TW200804383A (en) 2006-06-05 2008-01-16 Astrazeneca Ab New compounds
AR066936A1 (es) 2007-06-13 2009-09-23 Astrazeneca Ab 3 - (2r - tetrahidrofuril - metil) - 2 - tioxantina. composiciones farmaceuticas.
US20090054468A1 (en) 2007-08-23 2009-02-26 Astrazeneca Ab New Use 938

Also Published As

Publication number Publication date
RS52490B (en) 2013-02-28
IL183182A (en) 2012-02-29
CN101072778B (zh) 2011-06-15
CN101072778A (zh) 2007-11-14
WO2006062465A1 (en) 2006-06-15
MX2007006497A (es) 2007-06-22
NO20072399L (no) 2007-08-24
AU2005312388A1 (en) 2006-06-15
KR20070090178A (ko) 2007-09-05
US20110059996A1 (en) 2011-03-10
TW200626601A (en) 2006-08-01
SA05260385B1 (ar) 2009-02-25
BRPI0518846B1 (pt) 2022-04-05
CA2591314A1 (en) 2006-06-15
UY29246A1 (es) 2006-08-31
ES2390888T3 (es) 2012-11-19
RU2409578C2 (ru) 2011-01-20
MY140748A (en) 2010-01-15
RU2010139806A (ru) 2012-04-10
HRP20120781T1 (hr) 2012-10-31
US9580429B2 (en) 2017-02-28
JP2008522968A (ja) 2008-07-03
AR051698A1 (es) 2007-01-31
HK1110859A1 (en) 2008-07-25
DK1824855T3 (da) 2012-10-15
KR20130037236A (ko) 2013-04-15
EP1824855B1 (en) 2012-08-08
KR101557715B1 (ko) 2015-10-06
CA2591314C (en) 2011-06-21
US20080221136A1 (en) 2008-09-11
IL183182A0 (en) 2007-09-20
RU2007119307A (ru) 2009-01-20
EP1824855A1 (en) 2007-08-29
PL1824855T3 (pl) 2012-11-30
NZ555046A (en) 2010-08-27
KR20140010177A (ko) 2014-01-23
EP1824855A4 (en) 2010-12-08
AU2005312388B2 (en) 2009-10-29
US7829707B2 (en) 2010-11-09
RU2577858C2 (ru) 2016-03-20
ME01486B (me) 2014-04-20
US20150099769A1 (en) 2015-04-09
UA89968C2 (uk) 2010-03-25
TWI365189B (en) 2012-06-01
KR101412786B1 (ko) 2014-06-30
PT1824855E (pt) 2012-10-09
BRPI0518846A2 (pt) 2008-12-09
US8859568B2 (en) 2014-10-14
JP5028270B2 (ja) 2012-09-19
KR101412939B1 (ko) 2014-06-26
SI1824855T1 (sl) 2012-11-30

Similar Documents

Publication Publication Date Title
CY1113209T1 (el) Νεα παραγωγα πυρρολο [3,2-d] πυριμιδιν-4-ονης και η χρηση τους στη θεραπεια
NO2020031I1 (no) kobimetinib, inklusive farmasøytisk akseptable salter og solvater, særlig kobimetinib hemifumarat
CA2603830A1 (en) PYRIDINE [2,3-B] PYRAZINONES
BG108269A (en) Pyrazolopyrimidines as therapeutic agents
MY177111A (en) Substituted amide derivatives and methods of use
BG108268A (en) Pyrazolopyrimidines as therapeutic agents
EA200501009A1 (ru) Замещённые пирролопиразольные производные в качестве ингибиторов киназы
MY142988A (en) Novel aminobenzophenone compounds
CY1106130T1 (el) Παραγωγα 2-πυριδονης ως αναστολεις της ουδετepοφιλης ελαστασης
GEP20084551B (en) 4-phenylamino-quinazolin-6-yl-amides
MY167135A (en) Fused heterocyclic derivatives and methods of use
TW200700392A (en) Novel compounds
CY1115227T1 (el) Νεοι καταστολεις φωσφοδιεστερασης (phosphodiesterase)
TW200504012A (en) Ethynylproline derivatives
CY1108894T1 (el) Νεα παραγωγα βενζιμιδαζολης
TW200639156A (en) New compounds
TW200630374A (en) Thiazolyldihydroindazoles
SE0302756D0 (sv) Novel Compounds
TW200616977A (en) Enantiomers of selected fused heterocyclics and uses thereof
BR0318521A (pt) arilindenopiridinas e arilindenopirimidinas e métodos terapêuticos e profiláticos relacionados
MY141583A (en) Novel fused heterocycles and uses thereof
MXPA03010205A (es) Derivados de acido oxalico.
MY134079A (en) Derivatives of phenoxy-n-'4-(isothiazolidin-1,1-dioxid-2yl)pheny]-valerian-acid amide and other compounds as inhibitors of the coagulation factor xa in the treatment of thromboembolic diseases and tumors
SG171472A1 (en) Substituted aniline derivatives
DE60210981D1 (de) Heteroarylheteroalkylamin derivate und deren verwendung als inhibitoren der stickoxidsynthase