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CY1106910T1 - Διαδικασια για την παρασκευη διυδροξυ εστερων και παραγωγων αυτων - Google Patents

Διαδικασια για την παρασκευη διυδροξυ εστερων και παραγωγων αυτων

Info

Publication number
CY1106910T1
CY1106910T1 CY20071101270T CY071101270T CY1106910T1 CY 1106910 T1 CY1106910 T1 CY 1106910T1 CY 20071101270 T CY20071101270 T CY 20071101270T CY 071101270 T CY071101270 T CY 071101270T CY 1106910 T1 CY1106910 T1 CY 1106910T1
Authority
CY
Cyprus
Prior art keywords
group
divroxy
stars
producers
procedure
Prior art date
Application number
CY20071101270T
Other languages
English (en)
Inventor
Robert Antony Holt
Christopher David Reeve
Andrew John Blacker
Original Assignee
Astrazeneca Uk Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Uk Limited filed Critical Astrazeneca Uk Limited
Publication of CY1106910T1 publication Critical patent/CY1106910T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/03—Preparation of carboxylic acid esters by reacting an ester group with a hydroxy group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/675—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids of saturated hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Παρέχεται μία διαδικασία για την παρασκευή μίας ένωσης του τύπου (5) όπου το R αντιπροσωπεύει μία προαιρετικά υποκατεστημένη υδροκαρβυλ ομάδα και το Χ αντιπροσωπεύει μία υδροκαρβυλ ομάδα σύνδεσης. Η διαδικασία περιλαμβάνει είτε τη στερεοεκλεκτική αναγωγή της κετο ομάδας σε μία διυδροξυ κετο πρόδρομο που ακολουθείται από εκλεκτική εστεροποίηση ενός πρωτοταγούς υδροξέος, ή την εκλεκτική εστεροποίηση ενός πρωτοταγούς υδροξέος μίας διυδροξυ κετο προδρόμου που ακολουθείται από στερεοεκλεκτική αναγωγή της κετο ομάδας.
CY20071101270T 2000-05-09 2007-10-05 Διαδικασια για την παρασκευη διυδροξυ εστερων και παραγωγων αυτων CY1106910T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0011120.3A GB0011120D0 (en) 2000-05-09 2000-05-09 Process
EP06002032A EP1657310B1 (en) 2000-05-09 2001-05-01 Process for the preparation of dihydroxy esters and derivatives thereof

Publications (1)

Publication Number Publication Date
CY1106910T1 true CY1106910T1 (el) 2012-09-26

Family

ID=9891211

Family Applications (3)

Application Number Title Priority Date Filing Date
CY20061101301T CY1105376T1 (el) 2000-05-09 2006-09-12 Διαδικασια για την παρασκευη διυδροξυ εστερων και παραγωγων αυτων
CY20071101270T CY1106910T1 (el) 2000-05-09 2007-10-05 Διαδικασια για την παρασκευη διυδροξυ εστερων και παραγωγων αυτων
CY20101100376T CY1109991T1 (el) 2000-05-09 2010-04-27 Διαδικασια για την παρασκευη διυδροξυ εστερων και παραγωγων αυτων

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CY20061101301T CY1105376T1 (el) 2000-05-09 2006-09-12 Διαδικασια για την παρασκευη διυδροξυ εστερων και παραγωγων αυτων

Family Applications After (1)

Application Number Title Priority Date Filing Date
CY20101100376T CY1109991T1 (el) 2000-05-09 2010-04-27 Διαδικασια για την παρασκευη διυδροξυ εστερων και παραγωγων αυτων

Country Status (34)

Country Link
US (4) US7157255B2 (el)
EP (3) EP1282719B1 (el)
JP (1) JP4733901B2 (el)
KR (2) KR100996977B1 (el)
CN (1) CN1196793C (el)
AR (2) AR028074A1 (el)
AT (3) ATE369437T1 (el)
AU (2) AU2001252383B2 (el)
BR (1) BR0110667A (el)
CA (2) CA2408004C (el)
CY (3) CY1105376T1 (el)
CZ (3) CZ302675B6 (el)
DE (3) DE60120685T2 (el)
DK (3) DK1657310T3 (el)
EE (1) EE05062B1 (el)
ES (3) ES2264981T3 (el)
GB (1) GB0011120D0 (el)
HK (3) HK1051708A1 (el)
HU (1) HUP0302216A3 (el)
IL (4) IL152608A0 (el)
IS (1) IS2290B (el)
MX (1) MXPA02010955A (el)
MY (1) MY127751A (el)
NO (1) NO20025377L (el)
NZ (1) NZ522407A (el)
PL (3) PL208379B1 (el)
PT (3) PT1657310E (el)
RU (1) RU2266961C2 (el)
SI (3) SI1282719T1 (el)
SK (2) SK287524B6 (el)
TW (1) TWI240753B (el)
UA (1) UA73774C2 (el)
WO (1) WO2001085975A1 (el)
ZA (1) ZA200208937B (el)

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CN108530416B (zh) * 2017-11-02 2020-05-12 江苏阿尔法药业有限公司 一种瑞舒伐他汀中间体的制备方法
CN109574830B (zh) * 2019-01-04 2021-04-13 浙江宏元药业股份有限公司 一种瑞舒伐他汀钙中间体及其制备方法和应用
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Also Published As

Publication number Publication date
DE60129865T2 (de) 2008-05-08
PL208359B1 (pl) 2011-04-29
IS6609A (is) 2002-11-07
EE05062B1 (et) 2008-08-15
SI1657310T1 (sl) 2007-12-31
CN1440461A (zh) 2003-09-03
KR100996977B1 (ko) 2010-11-26
SK287524B6 (sk) 2011-01-04
PL208379B1 (pl) 2011-04-29
PL208377B1 (pl) 2011-04-29
AR070946A2 (es) 2010-05-19
CN1196793C (zh) 2005-04-13
EE200200628A (et) 2004-04-15
IL193405A (en) 2010-04-29
DK1282719T3 (da) 2006-10-02
EP1657310A1 (en) 2006-05-17
US7732171B2 (en) 2010-06-08
DE60141424D1 (de) 2010-04-08
CA2408004C (en) 2010-04-13
ATE369437T1 (de) 2007-08-15
NZ522407A (en) 2004-06-25
US20100209984A1 (en) 2010-08-19
US7157255B2 (en) 2007-01-02
BR0110667A (pt) 2003-03-25
CY1105376T1 (el) 2010-04-28
HUP0302216A2 (hu) 2003-10-28
HK1096998A1 (en) 2007-06-15
ES2340190T3 (es) 2010-05-31
IL152608A (en) 2009-05-04
SI1726658T1 (sl) 2010-05-31
HUP0302216A3 (en) 2011-03-28
DE60129865D1 (de) 2007-09-20
AU5238301A (en) 2001-11-20
CY1109991T1 (el) 2014-09-10
EP1282719A1 (en) 2003-02-12
AU2001252383B2 (en) 2005-04-14
CZ20023675A3 (cs) 2003-02-12
US7888083B2 (en) 2011-02-15
DE60120685T2 (de) 2007-06-14
EP1282719B1 (en) 2006-06-14
US20060194297A1 (en) 2006-08-31
WO2001085975A1 (en) 2001-11-15
CZ302675B6 (cs) 2011-08-24
KR20030032949A (ko) 2003-04-26
CA2408004A1 (en) 2001-11-15
TWI240753B (en) 2005-10-01
EP1726658A2 (en) 2006-11-29
MXPA02010955A (es) 2003-05-27
PL359336A1 (en) 2004-08-23
SK15892002A3 (sk) 2003-04-01
DK1657310T3 (da) 2007-10-29
SI1282719T1 (sl) 2006-10-31
IL193405A0 (en) 2009-02-11
ATE458823T1 (de) 2010-03-15
UA73774C2 (en) 2005-09-15
EP1726658B1 (en) 2010-02-24
US7416865B2 (en) 2008-08-26
US20030134900A1 (en) 2003-07-17
AR028074A1 (es) 2003-04-23
PT1726658E (pt) 2010-04-15
GB0011120D0 (en) 2000-06-28
ATE330020T1 (de) 2006-07-15
KR20080042129A (ko) 2008-05-14
DK1726658T3 (da) 2010-05-17
MY127751A (en) 2006-12-29
US20080280336A1 (en) 2008-11-13
NO20025377L (no) 2003-01-07
EP1726658A3 (en) 2008-12-24
ES2289722T3 (es) 2008-02-01
PT1282719E (pt) 2006-09-29
ZA200208937B (en) 2003-08-28
IS2290B (is) 2007-10-15
IL152608A0 (en) 2003-06-24
KR100914675B1 (ko) 2009-08-28
NO20025377D0 (no) 2002-11-08
ES2264981T3 (es) 2007-02-01
PT1657310E (pt) 2007-09-26
RU2266961C2 (ru) 2005-12-27
HK1051708A1 (en) 2003-08-15
CA2677945A1 (en) 2001-11-15
JP2003532427A (ja) 2003-11-05
JP4733901B2 (ja) 2011-07-27
CZ302632B6 (cs) 2011-08-10
DE60120685D1 (de) 2006-07-27
HK1090090A1 (en) 2006-12-15
SK286746B6 (sk) 2009-04-06
EP1657310B1 (en) 2007-08-08
CZ302674B6 (cs) 2011-08-24
IL193404A0 (en) 2009-02-11
IL193404A (en) 2010-04-29

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