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CR8288A - 6-[ (sustituido) fenil] triazolopirimidinas como agentes anticancer - Google Patents

6-[ (sustituido) fenil] triazolopirimidinas como agentes anticancer

Info

Publication number
CR8288A
CR8288A CR8288A CR8288A CR8288A CR 8288 A CR8288 A CR 8288A CR 8288 A CR8288 A CR 8288A CR 8288 A CR8288 A CR 8288A CR 8288 A CR8288 A CR 8288A
Authority
CR
Costa Rica
Prior art keywords
phenyl
replaced
triazolopirimidinas
anticancer agents
compounds
Prior art date
Application number
CR8288A
Other languages
English (en)
Inventor
Zhang Nan
Kaloustian Semiramis
Hiep Nguyen Thai
Tong Wei
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of CR8288A publication Critical patent/CR8288A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Esta invencion se relaciona con algunos compuestos de 6-[ (SUSTITUIDO) FENIL] TRIAZOLOPIRIMIDINAS o de sales farmaceuticamente aceptables de los mismos y con composiciones que coentienen estos compuestos o las sales farmaceuticamente aceptables de los mismos, en donde estos compuestos son agentes anti-cancer utiles para el tratamiento de cancer en mamiferos.
CR8288A 2003-09-24 2006-03-14 6-[ (sustituido) fenil] triazolopirimidinas como agentes anticancer CR8288A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US50554403P 2003-09-24 2003-09-24

Publications (1)

Publication Number Publication Date
CR8288A true CR8288A (es) 2006-10-04

Family

ID=34393032

Family Applications (1)

Application Number Title Priority Date Filing Date
CR8288A CR8288A (es) 2003-09-24 2006-03-14 6-[ (sustituido) fenil] triazolopirimidinas como agentes anticancer

Country Status (31)

Country Link
US (1) US7507739B2 (es)
EP (1) EP1680425B1 (es)
JP (1) JP2007506744A (es)
KR (1) KR20060098368A (es)
CN (1) CN100519559C (es)
AR (1) AR045810A1 (es)
AU (1) AU2004276240A1 (es)
BR (1) BRPI0414700A (es)
CA (1) CA2539252A1 (es)
CO (1) CO5690598A2 (es)
CR (1) CR8288A (es)
CY (1) CY1106392T1 (es)
DE (1) DE602004004295T8 (es)
DK (1) DK1680425T3 (es)
EC (1) ECSP066458A (es)
ES (1) ES2279452T3 (es)
GT (1) GT200400190A (es)
HK (1) HK1090374A1 (es)
IL (1) IL174281A0 (es)
MX (1) MXPA06003206A (es)
NO (1) NO20061318L (es)
PA (1) PA8613301A1 (es)
PE (1) PE20050433A1 (es)
PL (1) PL1680425T3 (es)
PT (1) PT1680425E (es)
RU (1) RU2006107579A (es)
SA (1) SA04250302A (es)
SI (1) SI1680425T1 (es)
TW (1) TW200512211A (es)
WO (1) WO2005030775A1 (es)
ZA (1) ZA200602387B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
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US6255309B1 (en) * 1999-03-19 2001-07-03 American Cyanomid Co. Fungicidal trifluoromethylalkylamino-triazolopyrimidines
SK18412002A3 (sk) * 2000-06-30 2003-06-03 Wyeth Použitie substituovaných triazolopyrimidínových derivátov a farmaceutický prostriedok s ich obsahom
US7419982B2 (en) * 2003-09-24 2008-09-02 Wyeth Holdings Corporation Crystalline forms of 5-chloro-6-{2,6-difluoro-4-[3-(methylamino)propoxy]phenyl}-N-[(1S)-2,2,2-trifluoro-1-methylethyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine salts
JP2007506744A (ja) 2003-09-24 2007-03-22 ワイス・ホールディングズ・コーポレイション 抗癌剤としての６−［（置換）フェニル］トリアゾロピリミジン類
MY179926A (en) * 2003-12-08 2020-11-19 Wyeth Corp Process for the preparation of tubulin inhibitors
CN101193884A (zh) 2005-06-13 2008-06-04 惠氏公司 微管蛋白抑制剂和其制备方法
WO2006138180A1 (en) * 2005-06-13 2006-12-28 Wyeth Tubulin inhibitor and process for its preparation
BRPI0612676A2 (pt) * 2005-06-27 2016-11-29 Basf Ag processo para preparar compostos, compostos, e, uso de compostos
CA2633962A1 (en) * 2005-12-16 2007-07-05 Wyeth Dimers and adducts of 6-[(substituted) phenyl] triazolopyrimidines useful as anticancer agents
AR058361A1 (es) * 2005-12-16 2008-01-30 Wyeth Corp Composiciones lifolizadas de un compuesto de triazolopirimidina
CN101600350A (zh) * 2007-01-08 2009-12-09 巴斯夫欧洲公司 唑并嘧啶在防治植物病原性有害真菌中的用途
EP2903436B1 (en) * 2012-09-19 2019-07-17 The Trustees Of The University Of Pennsylvania Heterocyclic compounds and their use for the treatment of neurodegenerative tauopathies
WO2019169111A1 (en) 2018-03-02 2019-09-06 The Trustees Of The University Of Pennsylvania [1,2,4]triazolo[1,5-a]pyrimidine compounds and use in stabilizing microtubules
CN114369098B (zh) * 2022-01-06 2023-03-10 苏州大学 一种三唑并嘧啶醇类化合物及其制备方法和应用

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US5593996A (en) * 1991-12-30 1997-01-14 American Cyanamid Company Triazolopyrimidine derivatives
TW224044B (es) 1991-12-30 1994-05-21 Shell Internat Res Schappej B V
JP2794510B2 (ja) 1992-03-27 1998-09-10 富士写真フイルム株式会社 ハロゲン化銀写真感光材料
IL108731A (en) * 1993-03-04 1997-03-18 Shell Int Research 6, N-DISUBSTITUTED-£1, 2, 4| TRIAZOLO-£1, 5-a| PYRIMIDINE- 7-AMINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS FUNGICIDES
IL108747A (en) 1993-03-04 1999-03-12 Shell Int Research Mushroom-killing preparations containing a history of 6 metamorphoses of 5 - 7 Dihalo - 1, 2 - 4 Triazlo [A-1,5] Pyrimidine Certain such new compounds and their preparation
RU2147584C1 (ru) 1995-10-27 2000-04-20 Американ Цианамид Компани Способ получения дигалоидазолопиримидинов и способ получения дигидроксиазолопиримидинов
US5817663A (en) * 1996-10-07 1998-10-06 American Cyanamid Company Pentafluorophenylazolopyrimidines
US5750766A (en) * 1997-03-18 1998-05-12 American Cyanamid Company Process for the preparation of arylmalonates
DE69810924T2 (de) 1997-03-18 2003-09-04 Basf Ag Verfahren zur herstellung von arylmalonaten
US6117876A (en) * 1997-04-14 2000-09-12 American Cyanamid Company Fungicidal trifluorophenyl-triazolopyrimidines
US5948783A (en) * 1997-04-14 1999-09-07 American Cyanamid Company Fungicidal trifluoromethylalkylamino-triazolopyrimidines
TW460476B (en) 1997-04-14 2001-10-21 American Cyanamid Co Fungicidal trifluoromethylalkylamino-triazolopyrimidines
US6255309B1 (en) * 1999-03-19 2001-07-03 American Cyanomid Co. Fungicidal trifluoromethylalkylamino-triazolopyrimidines
TWI252231B (en) 1997-04-14 2006-04-01 American Cyanamid Co Fungicidal trifluorophenyl-triazolopyrimidines
US5994360A (en) * 1997-07-14 1999-11-30 American Cyanamid Company Fungicidal 5-alkyl-triazolopyrimidines
US6020338A (en) * 1998-02-11 2000-02-01 American Cyanamid Company Fungicidal 7-alkyl-triazolopyrimidines
BR9907863A (pt) 1998-02-11 2000-10-24 American Cyanamid Co Composto, processo para a preparação do mesmo, composição fungicida, processo para combater fungo em um local, e, uso do composto ou da composição
JPH11322517A (ja) 1998-03-17 1999-11-24 American Cyanamid Co トリアゾロピリミジン類の効力の増進
US6124301A (en) * 1998-03-17 2000-09-26 American Cyanamid Company Enhancement of the efficacy of triazolopyrimidines
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US5985883A (en) * 1998-09-25 1999-11-16 American Cyanamid Company Fungicidal trichlorophenyl-triazolopyrimidines
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CZ20011057A3 (cs) 1998-09-25 2002-05-15 Basf Aktiengesellschaft Nevodný suspenzní koncentrát
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US6242451B1 (en) * 1998-09-25 2001-06-05 Klaus-Juergen Pees Fungicidal trihalophenyl-triazolopyrimidines
US6521628B1 (en) * 1999-01-29 2003-02-18 Basf Aktiengesellschaft Fungicidal mixtures
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SK18412002A3 (sk) * 2000-06-30 2003-06-03 Wyeth Použitie substituovaných triazolopyrimidínových derivátov a farmaceutický prostriedok s ich obsahom
HUP0300808A3 (en) * 2000-08-25 2005-10-28 Basf Ag Fungicidal formulation containing triazolopyridine derivative
US6459602B1 (en) * 2000-10-26 2002-10-01 O2 Micro International Limited DC-to-DC converter with improved transient response
JP2004513170A (ja) 2000-11-13 2004-04-30 ビーエーエスエフ　アクチェンゲゼルシャフト ７−（ｒ）−アミノトリアゾロピリミジン類、それらの製造及び植物病原性真菌を防除するためのそれらの使用
JP2004515502A (ja) 2000-12-06 2004-05-27 ビーエーエスエフ アクチェンゲゼルシャフト 殺真菌性を有する６−（トリフルオロメチル−フェニル）−トリアゾロピリミジン類
DE10063115A1 (de) * 2000-12-18 2002-06-27 Bayer Ag Triazolopyrimidine
WO2002067679A1 (en) 2001-02-19 2002-09-06 Basf Aktiengesellschaft Fungicidal mixtures
ATE287405T1 (de) 2001-04-11 2005-02-15 Wyeth Corp 5-halogen-6-phenyl-7-fluoroalkylamino- triazolopyrimidine als fungizide
DE10124208A1 (de) * 2001-05-18 2002-11-21 Bayer Ag Verwendung von Triazolopyrimidin-Derivaten als Mikrobizide
JP2005504743A (ja) 2001-07-18 2005-02-17 ビーエーエスエフ アクチェンゲゼルシャフト 殺菌薬としての置換された６−（２−メトキシ−フェニル）−トリアゾロピリミジン
JP2007506744A (ja) 2003-09-24 2007-03-22 ワイス・ホールディングズ・コーポレイション 抗癌剤としての６−［（置換）フェニル］トリアゾロピリミジン類

Also Published As

Publication number Publication date
DK1680425T3 (da) 2007-03-19
DE602004004295D1 (de) 2007-02-22
ECSP066458A (es) 2006-09-18
IL174281A0 (en) 2006-08-01
AR045810A1 (es) 2005-11-16
AU2004276240A1 (en) 2005-04-07
TW200512211A (en) 2005-04-01
EP1680425B1 (en) 2007-01-10
PL1680425T3 (pl) 2007-05-31
SA04250302A (ar) 2005-12-03
DE602004004295T8 (de) 2007-09-20
NO20061318L (no) 2006-04-21
ZA200602387B (en) 2008-11-26
WO2005030775A1 (en) 2005-04-07
PT1680425E (pt) 2007-02-28
EP1680425A1 (en) 2006-07-19
ES2279452T3 (es) 2007-08-16
SI1680425T1 (sl) 2007-04-30
GT200400190A (es) 2005-05-02
HK1090374A1 (en) 2006-12-22
MXPA06003206A (es) 2006-06-23
CN100519559C (zh) 2009-07-29
CY1106392T1 (el) 2011-10-12
CN1867569A (zh) 2006-11-22
DE602004004295T2 (de) 2007-06-06
CO5690598A2 (es) 2006-10-31
US20050090508A1 (en) 2005-04-28
KR20060098368A (ko) 2006-09-18
BRPI0414700A (pt) 2006-11-14
US7507739B2 (en) 2009-03-24
RU2006107579A (ru) 2007-10-27
PE20050433A1 (es) 2005-07-21
CA2539252A1 (en) 2005-04-07
PA8613301A1 (es) 2005-11-25
JP2007506744A (ja) 2007-03-22

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Legal Events

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FA Abandonment or withdrawal (granting procedure)