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NO20061318L - 6-[-(substituerte) fenyl] Triazolopyrimidiner somanticancer midler - Google Patents

6-[-(substituerte) fenyl] Triazolopyrimidiner somanticancer midler

Info

Publication number
NO20061318L
NO20061318L NO20061318A NO20061318A NO20061318L NO 20061318 L NO20061318 L NO 20061318L NO 20061318 A NO20061318 A NO 20061318A NO 20061318 A NO20061318 A NO 20061318A NO 20061318 L NO20061318 L NO 20061318L
Authority
NO
Norway
Prior art keywords
compounds
pharmaceutically acceptable
acceptable salts
mammal
treating
Prior art date
Application number
NO20061318A
Other languages
English (en)
Inventor
Semiramis Ayral-Kaloustian
Nan Zhang
Yanzhong Wu
Thai Hiep Nguyen
Wei Tong
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of NO20061318L publication Critical patent/NO20061318L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Foreliggende oppfinnelse angår visse 6-[(substituert)fenyl]-triazolpyrimidin-forbindelser eller farmasøytisk akseptable salter derav, og preparater som inneholder de nevnte forbindelser eller farmasøytisk akseptable salter derav, hvor de nevnte forbindelser er antikreftmidler som er anvendelige for behandling av kreft hos pattedyr. Foreliggende oppfinnelse angår videre en metode for behandling eller hemming av veksten av cancerøse tumorceller og relaterte sykdommer hos et pattedyr, og tilveiebringer videre en metode for behandling eller forebygging av cancerøse tumorer som oppviser multiresistens (MDR) eller er resistente på grunn av MDR, hos et pattedyr med behov for dette, hvor metoden omfatter å administrere til nevnte pattedyr en effektiv mengde av de nevnte forbindelser eller farmasøytisk akseptable salter derav. Foreliggende oppfinnelse angår en metode for behandling eller hemming av veksten av cancerøse tumorceller og relaterte sykdommer hos et pattedyr med behov for dette, ved å fremme mikrotubuli-polymerisering, som omfatter å administrere til nevnte pattedyr en effektiv mengde av de nevnte forbindelser og farmasøytisk akseptable salter derav. Foreliggende oppfinnelse angår visse 6-[(substituert)fenyl]-triazolpyrimidin-forbindelser eller farmasøytisk akseptable salter derav, og preparater som inneholder de nevnte forbindelser eller farmasøytisk akseptable salter derav, hvor de nevnte forbindelser er antikreftmidler som er anvendelige for behandling av kreft hos pattedyr. Foreliggende oppfinnelse angår videre en metode for behandling eller hemming av veksten av cancerøse tumorceller og relaterte sykdommer hos et pattedyr, og tilveiebringer videre en metode for behandling eller forebygging av cancerøse tumorer som oppviser multiresistens (MDR) eller er resistente på grunn av MDR, hos et pattedyr med behov for dette, hvor metoden omfatter å administrere til nevnte pattedyr en effektiv mengde av de nevnte forbindelser eller farmasøytisk akseptable salter derav. Foreliggende oppfinnelse angår en metode for behandling eller hemming av veksten av cancerøse tumorceller og relaterte sykdommer hos et pattedyr med behov for dette, ved å fremme mikrotubuli-polymerisering, som omfatter å administrere til nevnte pattedyr en effektiv mengde av de nevnte forbindelser og farmasøytisk akseptable salter derav.
NO20061318A 2003-09-24 2006-03-23 6-[-(substituerte) fenyl] Triazolopyrimidiner somanticancer midler NO20061318L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50554403P 2003-09-24 2003-09-24
PCT/US2004/030515 WO2005030775A1 (en) 2003-09-24 2004-09-17 6-[(substituted)phenyl]triazolopyrimidines as anticancer agents

Publications (1)

Publication Number Publication Date
NO20061318L true NO20061318L (no) 2006-04-21

Family

ID=34393032

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20061318A NO20061318L (no) 2003-09-24 2006-03-23 6-[-(substituerte) fenyl] Triazolopyrimidiner somanticancer midler

Country Status (31)

Country Link
US (1) US7507739B2 (no)
EP (1) EP1680425B1 (no)
JP (1) JP2007506744A (no)
KR (1) KR20060098368A (no)
CN (1) CN100519559C (no)
AR (1) AR045810A1 (no)
AU (1) AU2004276240A1 (no)
BR (1) BRPI0414700A (no)
CA (1) CA2539252A1 (no)
CO (1) CO5690598A2 (no)
CR (1) CR8288A (no)
CY (1) CY1106392T1 (no)
DE (1) DE602004004295T8 (no)
DK (1) DK1680425T3 (no)
EC (1) ECSP066458A (no)
ES (1) ES2279452T3 (no)
GT (1) GT200400190A (no)
HK (1) HK1090374A1 (no)
IL (1) IL174281A0 (no)
MX (1) MXPA06003206A (no)
NO (1) NO20061318L (no)
PA (1) PA8613301A1 (no)
PE (1) PE20050433A1 (no)
PL (1) PL1680425T3 (no)
PT (1) PT1680425E (no)
RU (1) RU2006107579A (no)
SA (1) SA04250302A (no)
SI (1) SI1680425T1 (no)
TW (1) TW200512211A (no)
WO (1) WO2005030775A1 (no)
ZA (1) ZA200602387B (no)

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SK18412002A3 (sk) * 2000-06-30 2003-06-03 Wyeth Použitie substituovaných triazolopyrimidínových derivátov a farmaceutický prostriedok s ich obsahom
US7419982B2 (en) * 2003-09-24 2008-09-02 Wyeth Holdings Corporation Crystalline forms of 5-chloro-6-{2,6-difluoro-4-[3-(methylamino)propoxy]phenyl}-N-[(1S)-2,2,2-trifluoro-1-methylethyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine salts
JP2007506744A (ja) 2003-09-24 2007-03-22 ワイス・ホールディングズ・コーポレイション 抗癌剤としての６−［（置換）フェニル］トリアゾロピリミジン類
MY179926A (en) * 2003-12-08 2020-11-19 Wyeth Corp Process for the preparation of tubulin inhibitors
CN101193884A (zh) 2005-06-13 2008-06-04 惠氏公司 微管蛋白抑制剂和其制备方法
WO2006138180A1 (en) * 2005-06-13 2006-12-28 Wyeth Tubulin inhibitor and process for its preparation
BRPI0612676A2 (pt) * 2005-06-27 2016-11-29 Basf Ag processo para preparar compostos, compostos, e, uso de compostos
CA2633962A1 (en) * 2005-12-16 2007-07-05 Wyeth Dimers and adducts of 6-[(substituted) phenyl] triazolopyrimidines useful as anticancer agents
AR058361A1 (es) * 2005-12-16 2008-01-30 Wyeth Corp Composiciones lifolizadas de un compuesto de triazolopirimidina
CN101600350A (zh) * 2007-01-08 2009-12-09 巴斯夫欧洲公司 唑并嘧啶在防治植物病原性有害真菌中的用途
EP2903436B1 (en) * 2012-09-19 2019-07-17 The Trustees Of The University Of Pennsylvania Heterocyclic compounds and their use for the treatment of neurodegenerative tauopathies
WO2019169111A1 (en) 2018-03-02 2019-09-06 The Trustees Of The University Of Pennsylvania [1,2,4]triazolo[1,5-a]pyrimidine compounds and use in stabilizing microtubules
CN114369098B (zh) * 2022-01-06 2023-03-10 苏州大学 一种三唑并嘧啶醇类化合物及其制备方法和应用

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JP2007506744A (ja) 2003-09-24 2007-03-22 ワイス・ホールディングズ・コーポレイション 抗癌剤としての６−［（置換）フェニル］トリアゾロピリミジン類

Also Published As

Publication number Publication date
DK1680425T3 (da) 2007-03-19
DE602004004295D1 (de) 2007-02-22
ECSP066458A (es) 2006-09-18
IL174281A0 (en) 2006-08-01
AR045810A1 (es) 2005-11-16
AU2004276240A1 (en) 2005-04-07
TW200512211A (en) 2005-04-01
EP1680425B1 (en) 2007-01-10
PL1680425T3 (pl) 2007-05-31
SA04250302A (ar) 2005-12-03
DE602004004295T8 (de) 2007-09-20
ZA200602387B (en) 2008-11-26
WO2005030775A1 (en) 2005-04-07
PT1680425E (pt) 2007-02-28
EP1680425A1 (en) 2006-07-19
ES2279452T3 (es) 2007-08-16
SI1680425T1 (sl) 2007-04-30
GT200400190A (es) 2005-05-02
HK1090374A1 (en) 2006-12-22
MXPA06003206A (es) 2006-06-23
CN100519559C (zh) 2009-07-29
CY1106392T1 (el) 2011-10-12
CN1867569A (zh) 2006-11-22
DE602004004295T2 (de) 2007-06-06
CO5690598A2 (es) 2006-10-31
CR8288A (es) 2006-10-04
US20050090508A1 (en) 2005-04-28
KR20060098368A (ko) 2006-09-18
BRPI0414700A (pt) 2006-11-14
US7507739B2 (en) 2009-03-24
RU2006107579A (ru) 2007-10-27
PE20050433A1 (es) 2005-07-21
CA2539252A1 (en) 2005-04-07
PA8613301A1 (es) 2005-11-25
JP2007506744A (ja) 2007-03-22

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