CN111956557A - Composition and cosmetic with whitening and spot-fading effects and preparation method thereof - Google Patents
Composition and cosmetic with whitening and spot-fading effects and preparation method thereof Download PDFInfo
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- CN111956557A CN111956557A CN202010974853.0A CN202010974853A CN111956557A CN 111956557 A CN111956557 A CN 111956557A CN 202010974853 A CN202010974853 A CN 202010974853A CN 111956557 A CN111956557 A CN 111956557A
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- composition
- whitening
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- 238000002360 preparation method Methods 0.000 title claims abstract description 22
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
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- A61K8/67—Vitamins
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Abstract
The invention discloses a composition with whitening and spot-fading effects, a cosmetic and a preparation method thereof, wherein the composition mainly comprises the following components in parts by weight: nicotinamide: 2-8 parts of glutathione: 1-5 parts, alpha-arbutin: 1-5 parts, phenethyl resorcinol: 1-5 parts of vitamin C polypeptide: 1-5 parts of a deciduous rooted leaf extract: 1-5 parts. The composition and its cosmetic can prevent melanin aggregation and transfer, and reduce and decolorize melanin; inhibiting tyrosinase activity, scavenging oxygen free radicals to alter melanin production pathway; thereby preventing melanin generation and further realizing the effects of whitening and lightening spots.
Description
Technical Field
The invention relates to the technical field of cosmetics, and particularly relates to a composition with whitening and spot-fading effects, a cosmetic and a preparation method of the composition.
Background
The production of melanin is related to visceral dysfunction, endocrine disorder, ultraviolet irradiation, mental stress, skin injury, dietetic malnutrition, and poor cosmetic quality, and diseases caused by melanin include: freckle, chloasma, melanosis and the like cause a great trouble to modern people, and are also the main contents of research in the beauty treatment industry.
At present, many compounds for whitening, brightening and removing stains exist, such as: vitamin C, beta-arbutin, kojic acid and the like, but the stability and safety of a plurality of raw materials with whitening efficacy are not good. For example, vitamin C is easily broken by light irradiation and decomposed, and is not stable enough and easily oxidized. The beta-arbutin has strict requirements on the pH value of the product, is only suitable for the pH 6-7 of the product, and has a tendency of decomposition when the pH value is too high or too low. Kojic acid can weaken the skin barrier, has poor stability to light, is easily oxidized and discolored, and can cause the whitening product to turn yellow in the using process.
Disclosure of Invention
Based on the above, there is a need for a composition, a cosmetic and a preparation method thereof, which are more direct and effective, are purely natural and are not easy to oxidize and have the effects of whitening and lightening spots.
In order to solve the technical problems and achieve the purpose, the invention adopts the following specific technical scheme:
the composition with the effects of whitening and fading the spots mainly comprises the following components in parts by weight:
nicotinamide: 2-8 parts of (by weight),
glutathione: 1-5 parts of (A) a stabilizer,
alpha-arbutin: 1-5 parts of (A) a stabilizer,
phenethyl resorcinol: 1-5 parts of (A) a stabilizer,
a vitamin C polypeptide: 1-5 parts of (A) a stabilizer,
extract of the leaves of the Fall Potentilla Laciniana: 1-5 parts.
Preferably, the composition consists essentially of the following components in parts by weight:
nicotinamide: 5-8 parts of (by weight),
glutathione: 1-5 parts of (A) a stabilizer,
alpha-arbutin: 1-5 parts of (A) a stabilizer,
phenethyl resorcinol: 1-5 parts of (A) a stabilizer,
a vitamin C polypeptide: 1-5 parts of (A) a stabilizer,
extract of the leaves of the Fall Potentilla Laciniana: 2-3 parts.
Preferably, the glutathione is grape ferment-glutathione.
Preferably, the present invention also provides a cosmetic comprising the composition having the whitening and spot-lightening effects according to the embodiment of the present invention.
Preferably, the cosmetic consists essentially of the following components in percentage by weight:
the composition is as follows: 10 to 15 weight percent of the total weight of the composition,
glycerol: 30 to 40 weight percent of the total weight of the alloy,
propylene glycol: 35 to 45 weight percent of the total weight of the alloy,
betaine: 0 to 2 wt% of a catalyst,
p-hydroxyacetophenone: 0.5 wt% of the total weight of the alloy,
1, 2-hexanediol: 0.5 wt% of the total weight of the alloy,
deionized water: and (4) the balance.
Preferably, the cosmetic also comprises the following components in percentage by weight:
hyaluronic acid: 0 to 0.1 wt% of a catalyst,
allantoin: 0 to 0.2 wt% of a catalyst,
sodium acrylate/sodium acryloyldimethyl taurate copolymer: 0 to 2 wt% of a catalyst,
d-panthenol: 0 to 0.5 wt%.
Preferably, the cosmetic also comprises the following components in percentage by weight:
acrylic/C10-30 alkanol acrylate crosspolymer: 0 to 0.2 wt% of a catalyst,
disodium ethylene diamine tetraacetate: 0 to 0.02 weight percent of,
cetostearyl alcohol: 0 to 1.5 wt% of a catalyst,
tocopherol acetate: 0 to 0.5 wt% of a catalyst,
caprylic/capric triglyceride: 0 to 2.5 wt% of a catalyst,
isononyl isononanoate: 0 to 2.5 wt% of a catalyst,
pentaerythritol tetrakis (bis-tert-butylhydroxyhydrocinnamate): 0 to 0.05 weight percent,
A165：0-1.5wt％，
MONTANOV 68：0-0.5wt％，
EG：0-1wt％，
triethanolamine: 0 to 0.2 wt% of a catalyst,
essence: 0 to 0.1 wt%.
The invention also provides a preparation method of the cosmetic, which comprises the following preparation steps:
step 1: putting the component A into an emulsifying pot, stirring, heating to 80-85 deg.C, stirring, maintaining the temperature for 30min to completely dissolve and disperse, slowly stirring, defoaming, and cooling;
step 2: when the temperature is reduced to 42-45 ℃ by stirring, adding the component B into the mixture, and uniformly stirring to completely dissolve the component B;
and step 3: cooling to 38-40 deg.C under stirring, and checking to obtain cosmetic;
the component A comprises deionized water, glycerol, propylene glycol and p-hydroxyacetophenone;
the component B comprises the composition with the whitening and spot-lightening efficacy of the embodiment of the invention and 1, 2-hexanediol.
Preferably, a method for preparing a cosmetic, comprising the steps of:
step 1: putting the component A into an emulsifying pot, stirring, heating to 80-85 deg.C, stirring, maintaining the temperature for 30min to completely dissolve and disperse, slowly stirring, defoaming, and cooling;
step 2: when the temperature is reduced to 42-45 ℃ by stirring, adding the component B into the mixture, and uniformly stirring to completely dissolve the component B;
and step 3: cooling to 38-40 deg.C under stirring, and checking to obtain cosmetic;
the component A comprises deionized water, glycerol, propylene glycol, betaine, hyaluronic acid, p-hydroxyacetophenone, allantoin and sodium acrylate/sodium acryloyldimethyl taurate copolymer;
the component B comprises D-panthenol, the composition with the whitening and spot-lightening efficacy provided by the embodiment of the invention and 1, 2-hexanediol.
Preferably, a method for preparing a cosmetic, comprising the steps of:
step 1: putting the component A into a water phase pot, stirring and heating to 80-85 ℃;
step 2: putting the component C into an oil phase pot, heating to 80-85 ℃, and keeping the temperature until the dissolution is finished;
and step 3: heating the component C to 80-85 deg.C to dissolve, adding into the component A, homogenizing at low speed, and stirring for 10 min;
and 4, step 4: cooling to 65-70 deg.C, adding EG, homogenizing at high speed and stirring for 5 min;
and 5: when the temperature is reduced to 55-60 ℃ by stirring, adding triethanolamine and stirring uniformly;
step 6: when the temperature is reduced to 42-45 ℃ by stirring, adding the component B;
and 7: cooling to 38-40 deg.C under stirring, and checking to obtain cosmetic;
the component A comprises deionized water, glycerol, propylene glycol, betaine, hyaluronic acid, p-hydroxyacetophenone, allantoin, sodium acrylate/sodium acryloyldimethyl taurate copolymer, acrylic acid (acrylate)/C10-30 alkanol acrylate cross-linked polymer and disodium ethylene diamine tetraacetate;
the component B comprises D-panthenol, the composition with the whitening and spot-fading effects, 1, 2-hexanediol and essence;
component C includes cetearyl alcohol, caprylic/capric triglyceride, isononyl isononanoate, tocopheryl acetate, pentaerythritol tetrakis (di-tert-butyl hydroxyhydrocinnamate), A165 and MONTANOV 68.
The composition with the effects of whitening and fading spots comprises nicotinamide, glutathione, alpha-arbutin, phenethyl resorcinol, vitamin C polypeptide and a deciduous root leaf extract. For reasons of skin darkening and color spot induction, the nicotinamide can inhibit the migration of melanosomes to the skin surface so as to prevent pigments from appearing on the skin surface; glutathione has strong reducing effect, and can reduce melanin in cells into pale pigment to inhibit formation of mottle; the alpha-arbutin inhibits tyrosinase activity so as to reduce the generation of melanin, and has no toxicity, irritation or sensitization; the phenethyl resorcinol can effectively inhibit the activity of B16V cells for synthesizing melanin, improve uneven skin color and reduce skin coloration caused by ultraviolet irradiation on the skin; the vitamin C polypeptide can be conveniently added into cosmetics, keeps the activity of the vitamin C for a long time and is not easy to be oxidized; the extract of the leaves of the plant Fall rooted comprises antioxidant components, and has antioxidant effect and can reduce the probability of the attack of intercellular keratinocyte lipid by free radicals. The composition and cosmetic containing the 6 components with skin whitening and speckle reducing effects can prevent melanin aggregation and transfer, and reduce and decolorize melanin; inhibiting tyrosinase activity, scavenging oxygen free radicals to alter melanin production pathway; thereby preventing melanin generation and further realizing the effects of whitening and lightening spots.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the structures shown in the drawings without creative efforts.
FIG. 1 is a graph showing the results of inhibition of melanin by nicotinamide based on fluorescence detection in an experimental example;
FIG. 2 is a graph showing the results of reducing pigmentation on 3D artificial epidermis by niacinamide in one experimental example;
FIG. 3 is a graph showing the results of the niacinamide vs. age spots test in an experimental example;
FIG. 4 is a graph showing the results of an experiment of inhibition of tyrosinase activity by glucanase-glutathione in an experimental example;
FIG. 5 is a graph showing the results of an example of the deposition assay using Glutamine ferment-glutathione;
FIG. 6 is a graph showing the effect of glucosidase on pigmentation in an experimental example;
FIG. 7 is a graph showing the results of an experiment for inhibiting tyrosinase activity by α -arbutin in an experimental example;
FIG. 8 is a graph showing the results of an experiment of inhibiting melanin by α -arbutin in an experimental example;
FIG. 9 is a graph showing whitening test effects of phenylethyl resorcinol in an experimental example;
FIG. 10 is a graph showing the effect of the vitamin C polypeptide in the skin lightening test in an experimental example.
The implementation, functional features and advantages of the objects of the present invention will be further explained with reference to the accompanying drawings.
Detailed Description
To better illustrate the objects, technical solutions and advantages of the present invention, the present invention will be further described with reference to specific embodiments.
The experimental procedures in the following examples are conventional unless otherwise specified. Test materials, reagents and the like used in the following examples are commercially available unless otherwise specified. In the quantitative tests in the following examples, three replicates were set, and the data are the mean or the mean ± standard deviation of the three replicates.
The embodiment of the invention provides a composition with whitening and spot-lightening effects, which mainly comprises the following components in parts by weight:
nicotinamide: 2-8 parts of (by weight),
glutathione: 1-5 parts of (A) a stabilizer,
alpha-arbutin: 1-5 parts of (A) a stabilizer,
phenethyl resorcinol: 1-5 parts of (A) a stabilizer,
a vitamin C polypeptide: 1-5 parts of (A) a stabilizer,
extract of the leaves of the Fall Potentilla Laciniana: 1-5 parts.
Preferably, the composition consists essentially of the following components in parts by weight:
nicotinamide: 5-8 parts of (by weight),
glutathione: 1-5 parts of (A) a stabilizer,
alpha-arbutin: 1-5 parts of (A) a stabilizer,
phenethyl resorcinol: 1-5 parts of (A) a stabilizer,
a vitamin C polypeptide: 1-5 parts of (A) a stabilizer,
extract of the leaves of the Fall Potentilla Laciniana: 2-3 parts.
Preferably, the glutathione is grape ferment-glutathione.
In one embodiment, the composition with the whitening and spot-lightening effects consists of the following components in parts by weight:
nicotinamide: 2 parts of (a) to (b),
grape ferment-glutathione: 1 part of (A) and (B),
alpha-arbutin: 1 part of (A) and (B),
phenethyl resorcinol: 5 parts of (a) a mixture of (b),
a vitamin C polypeptide: 1 part of (A) and (B),
extract of the leaves of the Fall Potentilla Laciniana: 5 parts of the raw materials.
In one embodiment, the composition with the whitening and spot-lightening effects consists of the following components in parts by weight:
nicotinamide: 2 parts of (a) to (b),
grape ferment-glutathione: 5 parts of (a) a mixture of (b),
alpha-arbutin: 5 parts of (a) a mixture of (b),
phenethyl resorcinol: 1 part of (A) and (B),
a vitamin C polypeptide: 1 part of (A) and (B),
extract of the leaves of the Fall Potentilla Laciniana: 1 part.
In one embodiment, the composition with the whitening and spot-lightening effects consists of the following components in parts by weight:
nicotinamide: 5 parts of (a) a mixture of (b),
grape ferment-glutathione: 1 part of (A) and (B),
alpha-arbutin: 1 part of (A) and (B),
phenethyl resorcinol: 1 part of (A) and (B),
a vitamin C polypeptide: 5 parts of (a) a mixture of (b),
extract of the leaves of the Fall Potentilla Laciniana: and 2 parts.
In one embodiment, the composition with the whitening and spot-lightening effects consists of the following components in parts by weight:
nicotinamide: 8 parts of (a) a mixture of (b),
grape ferment-glutathione: 1 part of (A) and (B),
alpha-arbutin: 1 part of (A) and (B),
phenethyl resorcinol: 1 part of (A) and (B),
a vitamin C polypeptide: 1 part of (A) and (B),
extract of the leaves of the Fall Potentilla Laciniana: and 3 parts.
The nicotinamide of the invention is prepared by oxidizing beta-picoline into nicotinic acid by air, reacting the nicotinic acid with ammonium hydroxide, and heating and dehydrating. Nicotinamide is a derivative of vitamin B3, is involved in the transport of melanin and accelerates the rate of melanosome movement in melanocytes, and has regulatory effects on calcium pump, the expression of the cell motor protein Dynein and melanosome movement, and the concentration of nicotinamide is an important regulatory factor. Niacinamide prevents the appearance of pigments on the skin surface, and in particular inhibits the migration of melanosomes to the skin surface. The topical niacinamide can improve dark yellow and dull skin due to aging. By insisting on using the nicotinamide stock solution, the skin texture is obviously improved, fine lines and wrinkles are obviously reduced, the skin becomes rich in elasticity, pigmentation and erythema are obviously reduced, dark yellow is obviously reduced, and the skin is rich in luster.
The glutathione of the present invention was purchased from japan pill company. Glutathione is small molecular peptide combined by glutamic acid, cysteine and glycine, has strong reducing effect, can reduce melanin in cells into light pigment, and can inhibit the formation of color spots.
The grape ferment-glutathione is obtained by compounding ferment fermented grape juice and glutathione. The grape ferment in the grape ferment-glutathione can activate dermal cells and promote the osmotic absorption of glutathione, thereby not only greatly solving the technical application problem of the glutathione, but also having the inhibition effect on tyrosinase and promoting metabolism.
The alpha-arbutin is obtained by fermenting natural active substances derived from green plants. Alpha-arbutin is white needle-shaped crystal or powder, which directly inhibits tyrosinase activity instead of inhibiting cell growth or tyrosinase gene expression to reduce melanin generation. The arbutin is a natural active substance derived from green plants, integrates the green plants, the safe and reliable and the efficient decoloration into a whole, can quickly permeate into the skin, can effectively inhibit the activity of tyrosinase in the skin and block the formation of melanin while not influencing the cell proliferation concentration, and accelerates the decomposition and excretion of the melanin by directly combining the arbutin with the tyrosinase, thereby reducing the skin pigmentation, removing color spots and freckles, and generating no toxic, irritant, sensitizing and other side effects on the melanocyte. The melanin inhibiting effect of alpha-arbutin is about 10 times stronger than that of beta-arbutin, and the whitening effect and safety of alpha-arbutin are higher than those of beta-arbutin.
The phenethyl resorcinol is prepared by carrying out Friedel-Crafts alkylation reaction on 1, 3-benzenediol and styrene to generate a phenethyl resorcinol crude product, and carrying out purification steps of cleaning, distilling, crystallizing and the like on the reaction crude product to obtain a final product. The phenethyl resorcinol is a novel efficient skin whitening agent, has good stability and safety, can improve uneven skin color and reduce skin coloring caused by ultraviolet irradiation on the skin. The phenethyl resorcinol is one of tyrosinase inhibitors with the highest activity, the activity of inhibiting the tyrosinase is 22 times that of kojic acid, the activity of inhibiting the B16V cell from synthesizing melanin is 210 times that of the kojic acid and 32 times that of arbutin, and the antioxidant activity of the phenethyl resorcinol is better than that of conventional antioxidants VE, VC and BHT.
The preparation of the vitamin C polypeptide comprises the following steps: the temperature is raised to 37 to 40 ℃ in a suitable stainless steel fermenter, the freshly harvested citrus fruit is first cut to very small pieces and the ascorbic acid synthesis reaction is then carried out with the ascorbic acid-conjugated citrus fruit and bioflavonoids until the reaction is stopped when no free ascorbic acid is detectable in the fermenter, which usually takes 4 to 6 hours. Then, filtering the remaining solid matter, washing the remaining slurry, wherein the washing liquid already contains the initial extraction component, then making the washing liquid into a concentrated solution by vacuumizing or under the protection of nitrogen, and finally, spraying the concentrated solution to free flowing white or cream powder to obtain the vitamin C polypeptide. The vitamin C polypeptide is a stable and non-discoloring vitamin C derivative containing a plurality of short peptides, can be conveniently added into cosmetics, can keep the activity of the vitamin C for a long time, and is not easy to be oxidized.
The invention relates to an extraction method of a fallen rhizogenesis leaf extract, which comprises the following steps: screening raw materials, crushing, sieving, fermenting, centrifuging, separating supernatant, and performing supercritical extraction to obtain the extract of the leaves of the rhizomes fallen to the ground. The extract of the fallen rhizomes leaf is also called raw Sichuan lotus and large-size yellow chicken claw in the fallen rhizomes of Taiwan area, and the effective components of the extract comprise: ferulic acid, syringic acid, caffeic acid, p-coumaric acid, friedelin, kaempferol, garcinia camomila flavin, quercetin, campesterol, stigmasterol, taraxasterol, mucinol, kaempferol-3-rhamnoside. The effective components in the extract of the leaves of the rhizomes fallen onto the ground can effectively prevent the skin from being oxidized.
In order to verify the whitening effects of the raw material components of the composition having the whitening and spot-lightening effects according to the present invention and the whitening effects of the composition having the whitening and spot-lightening effects, the following experiments of experimental examples 1 to 7 were performed.
Experimental example 1 Nicotinamide whitening and Spot-lightening efficacy measurement
1. Assay for inhibition of melanin by nicotinamide
Blank control group: a keratinocyte and melanocyte combined culture system;
experimental group 1: adding nicotinamide (1mmol/L) into a combined culture system of keratinocytes and melanocytes (melanocyte strain 560);
experimental group 2: nicotinamide (1mmol/L) was added to a combined culture system of keratinocytes and melanocytes (melanocyte strain: 660).
The result of inhibiting melanin transfer rate by niacinamide in the 3-cell co-culture system by fluorescence labeling is shown in fig. 1, and the inhibition of melanin migration by niacinamide can be as high as 68%.
2. Nicotinamide assay for reduction of pigmentation
Blank group: no skin care product is used;
PTU group: adding a completely controlled amount of PTU into the daily skin care product;
a PC group: the daily skin care product is added with nicotinamide PC with a completely controlled amount.
Skin pigmentation changes were measured on 3D artificial epidermis for 13 days using Minolta chromameter CR 300. The measurements are referenced in units of lightness [ L (D65) ] and white (L100). Results of niacinamide to reduce pigmentation figure 2 shows that niacinamide is significantly effective after 13 days on 3D artificial epidermis.
3. Nicotinamide assay for reducing age spots
With age, the skin becomes dark yellow and dull, which can be improved by topical niacinamide. The test result of studying senile plaque by external nicotinamide is shown in figure 3, and when the nicotinamide stock solution is used 2 times a day, the skin texture is obviously improved and fine lines and wrinkles are obviously reduced at the 8 th week; the skin became elastic at week 12, with a marked reduction in pigmentation and erythema, a marked reduction in dark yellow and a shiny appearance.
Experimental example 2 whitening and spot-lightening efficacy assay of grape ferment-glutathione
1. Determination of tyrosinase inhibition by grape ferment-glutathione
The results of the tyrosinase activity inhibition experiment by grape ferment-glutathione are shown in fig. 4, and the grape ferment-glutathione has an inhibition effect on the tyrosinase activity and can promote metabolism.
2. Determination of pigmentation by grape ferment-glutathione
And (3) testing a sample: 100% grape ferment-glutathione;
and (3) reference sample: 30% of 1, 3-butanediol.
The detection method comprises the following steps: the test specimens were used 2 times a day for 7 days in 6 volunteers.
The test results are shown in fig. 5 and 6, where o is less pigmented than the reference; delta pigmentation as for the reference; x pigmentation was higher than the reference. After 7 days, most people used grape ferment-glutathione with less pigmentation effect than the control.
Experimental example 3 whitening and Spot-lightening efficacy assay of alpha-arbutin
1. Determination of alpha-arbutin inhibition tyrosinase
The results of the experiments on the inhibition of the activity of alpha-arbutin and beta-arbutin with different concentrations on tyrosinase are shown in fig. 7, and the results show that the inhibition rate of alpha-arbutin on tyrosinase at a lower concentration exceeds 30%, and the inhibition rate is superior to that of beta-arbutin at the same concentration.
2. Determination of alpha-arbutin for inhibiting melanin
The results of experiments on the inhibition of melanin in B16 cells by alpha-arbutin and beta-arbutin with different concentrations are shown in fig. 8, and the results show that both alpha-arbutin and beta-arbutin can effectively inhibit the expression of melanin in B16 cells, and the inhibition rate of alpha-arbutin on melanin is significantly higher than that of beta-arbutin.
Experimental example 4 determination of whitening and Spot-lightening efficacy of Phenylethylresorcinol
The results of the measurement of the melanin phosphate buffer containing 1.0% kojic acid and 0.1% kojic acid and the melanin phosphate buffer containing 0.1% phenethyl resorcinol and 0.01% phenethyl resorcinol, respectively, are shown in fig. 9, in which the melanin phosphate buffer containing 0.1% kojic acid inhibits melanin by 2%, while the melanin phosphate buffer containing 0.1% phenethyl resorcinol inhibits melanin by 95%, and phenethyl resorcinol inhibits melanin significantly.
Experimental example 5 measurement of whitening and Spot-lightening efficacy of vitamin C polypeptide
The vitamin C polypeptide essence with the content of 1% is externally applied, the test result is shown in figure 10, and the whitening and spot-lightening effect is obvious after the vitamin C polypeptide essence is used for 28 days.
Experimental example 6 determination of whitening and spot-lightening efficacy of extract of the root-growing leaves of the rehmannia glutinosa
1. Analysis of antioxidant component of extract of leaves of Farfarae
In this example, the antioxidant component of the extract of the leaves of the rhizomes of fallen flowers was analyzed, and the analysis results are shown in table 1.
TABLE 1 Main antioxidant ingredient list of extract of Salvia miltiorrhiza leaves
Polyphenols: phenolic compounds are the largest group of phytochemicals and are believed to have anti-radical and anti-aging effects.
Flavonoid: flavonoids, the largest group of polyphenols, are believed to have a strong antioxidant capacity, which is two to three times that of red wine or green tea, and can capture free radicals and chelate magnesium-contacting metal ions required for peroxidation, especially for some dark chocolates containing the flavonoid epicatechin.
Anthocyanins: anthocyanins, also known as anthocyanidins, are water-soluble natural pigments, which are one of the bioflavonoids, and are believed to have very strong antioxidant and anti-inflammatory properties, and are capable of resisting free radicals and delaying aging.
Antioxidant principle of the extract of the leaves of the rhizomes fallen to the ground: the lipid will generate free radicals during the oxidation process, and the free radicals will combine with the oil to generate more free radicals, so as to further scavenge the free radicals in the environment by the antioxidant, and stop the continuous reaction of peroxidation, i.e. scavenge the free radicals to provide the antioxidant effect.
2. Method for measuring oxidation resistance
DPPH radical scavenging capacity: DPPH is a violet-black radical solution having the highest absorbance at a wavelength of 517nm, and after reacting with hydrogen ions or electrons, its color becomes pale yellow, so that the absorbance becomes lower and lower, and thus is often used in the measurement of antioxidant ability.
ABTS+The determination and analysis method comprises the following steps: ABTS in proper location, also known as total antioxidant capacity determinationABTS oxidized into green under the action of oxidant+ABTS in the presence of antioxidants+Can be suppressed. Ability to chelate ferrous ions, Fe2+(ferrous ion) is the most influential pro-oxidant, which promotes lipid oxidation, to Fe2+The chelating ability of (ferrous ions) is often closely related to its resistance to oxidation.
3. Determination of antioxidant Capacity of extract of Fall-Poa-Dichotoma
The antioxidant efficacy of the extract of the leaves rooted on the ground was verified by free radical scavenging test, the test results are shown in table 2 below.
TABLE 2 measurement of antioxidant capacity of extracts of deciduous rooted leaves
The test results prove that the extract of the leaves of the rhizosphere of the fallen leaves contains antioxidant components, has antioxidant effect and can reduce the probability of the lipid among corneocytes being attacked by free radicals.
Specifically, the compositions of examples 1 to 4 of the present invention and the compositions of comparative examples 1 to 12 were prepared in the same manner except that the contents of the respective raw material components of the compositions of examples 1 to 4 and comparative examples 1 to 12 were different.
TABLE 3 raw Material composition Table of the composition
The compositions of examples 1 to 4 of the present invention and the methods for preparing the compositions of comparative examples 1 to 12 were as follows: mixing nicotinamide, grape ferment-glutathione, alpha-arbutin, phenethyl resorcinol, vitamin C polypeptide and the extract of the leaves of the rhizomes fallen to the ground with different contents, and stirring and dissolving the mixture completely at 45 ℃.
The composition with the whitening and spot-lightening effects can be prepared into gel, spray, cream, ointment, cream, gel, lotion, skin lotion, facial mask, essential oil or facial cleanser. The acceptable carrier for the daily necessities can be: water (refined water, hot spring water, deep water, etc.), oil agent, humectant, antioxidant, surfactant, alcohol, gelling agent, alcohol, water-soluble polymer, powder, pH regulator, involucra forming agent, resin, ultraviolet ray protective agent, coating compound, antibacterial agent, perfume, deodorant, salt, and algefacient can be mixed with matrix components such as animal, microorganism extract, plant extract, blood circulation promoter, collecting agent, fat leakage preventing agent, active oxygen scavenger, cell activator, keratinocyte dissolving agent, enzyme, hormone, and vitamins. As other preferable schemes, the composition of the invention can also be prepared into powder, soap, oil, dry powder, liquid foundation or wet powder, etc., which is convenient for use.
Preferably, the cosmetic consists essentially of the following components in percentage by weight:
the composition is as follows: 10 to 15 weight percent of the total weight of the composition,
glycerol: 30 to 40 weight percent of the total weight of the alloy,
propylene glycol: 35 to 45 weight percent of the total weight of the alloy,
betaine: 0 to 2 wt% of a catalyst,
p-hydroxyacetophenone: 0.5 wt% of the total weight of the alloy,
1, 2-hexanediol: 0.5 wt% of the total weight of the alloy,
deionized water: and (4) the balance.
Preferably, the cosmetic also comprises the following components in percentage by weight:
hyaluronic acid: 0 to 0.1 wt% of a catalyst,
allantoin: 0 to 0.2 wt% of a catalyst,
sodium acrylate/sodium acryloyldimethyl taurate copolymer: 0 to 2 wt% of a catalyst,
d-panthenol: 0 to 0.5 wt%.
Preferably, the cosmetic also comprises the following components in percentage by weight:
acrylic/C10-30 alkanol acrylate crosspolymer: 0 to 0.2 wt% of a catalyst,
disodium ethylene diamine tetraacetate: 0 to 0.02 weight percent of,
cetostearyl alcohol: 0 to 1.5 wt% of a catalyst,
tocopherol acetate: 0 to 0.5 wt% of a catalyst,
caprylic/capric triglyceride: 0 to 2.5 wt% of a catalyst,
isononyl isononanoate: 0 to 2.5 wt% of a catalyst,
pentaerythritol tetrakis (bis-tert-butylhydroxyhydrocinnamate): 0 to 0.05 weight percent,
A165：0-1.5wt％，
MONTANOV 68：0-0.5wt％，
EG：0-1wt％，
triethanolamine: 0 to 0.2 wt% of a catalyst,
essence: 0 to 0.1 wt%.
The invention also provides a preparation method of the cosmetic, which comprises the following preparation steps:
step 1: putting the component A into an emulsifying pot, stirring, heating to 80-85 deg.C, stirring, maintaining the temperature for 30min to completely dissolve and disperse, slowly stirring, defoaming, and cooling;
step 2: when the temperature is reduced to 42-45 ℃ by stirring, adding the component B into the mixture, and uniformly stirring to completely dissolve the component B;
and step 3: cooling to 38-40 deg.C under stirring, and checking to obtain cosmetic;
the component A comprises deionized water, glycerol, propylene glycol and p-hydroxyacetophenone;
the component B comprises the composition with the whitening and spot-lightening efficacy of the embodiment of the invention and 1, 2-hexanediol.
Preferably, a method for preparing a cosmetic, comprising the steps of:
step 1: putting the component A into an emulsifying pot, stirring, heating to 80-85 deg.C, stirring, maintaining the temperature for 30min to completely dissolve and disperse, slowly stirring, defoaming, and cooling;
step 2: when the temperature is reduced to 42-45 ℃ by stirring, adding the component B into the mixture, and uniformly stirring to completely dissolve the component B;
and step 3: cooling to 38-40 deg.C under stirring, and checking to obtain cosmetic;
the component A comprises deionized water, glycerol, propylene glycol, betaine, hyaluronic acid, p-hydroxyacetophenone, allantoin and sodium acrylate/sodium acryloyldimethyl taurate copolymer;
the component B comprises D-panthenol, the composition with the whitening and spot-lightening efficacy provided by the embodiment of the invention and 1, 2-hexanediol.
Preferably, a method for preparing a cosmetic, comprising the steps of:
step 1: putting the component A into a water phase pot, stirring and heating to 80-85 ℃;
step 2: putting the component C into an oil phase pot, heating to 80-85 ℃, and keeping the temperature until the dissolution is finished;
and step 3: heating the component C to 80-85 deg.C to dissolve, adding into the component A, homogenizing at low speed, and stirring for 10 min;
and 4, step 4: cooling to 65-70 deg.C, adding EG, homogenizing at high speed and stirring for 5 min;
and 5: when the temperature is reduced to 55-60 ℃ by stirring, adding triethanolamine and stirring uniformly;
step 6: when the temperature is reduced to 42-45 ℃ by stirring, adding the component B;
and 7: cooling to 38-40 deg.C under stirring, and checking to obtain cosmetic;
the component A comprises deionized water, glycerol, propylene glycol, betaine, hyaluronic acid, p-hydroxyacetophenone, allantoin, sodium acrylate/sodium acryloyldimethyl taurate copolymer, acrylic acid (acrylate)/C10-30 alkanol acrylate cross-linked polymer and disodium ethylene diamine tetraacetate;
the component B comprises D-panthenol, the composition with the whitening and spot-fading effects, 1, 2-hexanediol and essence;
component C includes cetearyl alcohol, caprylic/capric triglyceride, isononyl isononanoate, tocopheryl acetate, pentaerythritol tetrakis (di-tert-butyl hydroxyhydrocinnamate), A165 and MONTANOV 68.
The deionized water is a solvent of cosmetics; glycerin and propylene glycol are main moisturizers of cosmetics; the deionized water, the glycerol and the propylene glycol are mainly used for dispersing and dissolving the extract of the leaves of the rhizomes fallen into the ground.
The betaine, the hyaluronic acid and the D-panthenol are used as an auxiliary moisturizing agent of cosmetics, wherein the D-panthenol has the effects of moisturizing and repairing the skin.
The p-hydroxyacetophenone, the hexanediol and the 1, 2-hexanediol are used as bacteriostatic agents of cosmetics and have bacteriostatic and bactericidal effects.
The allantoin, the tocopherol acetate and the pentaerythritol tetra (di-tert-butyl hydroxy hydrocinnamate) ester are antioxidants of cosmetics, wherein the allantoin has an anti-allergic effect besides an anti-oxidation effect.
The sodium acrylate/sodium acryloyldimethyl taurate copolymer, the acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer and EG are thickeners for cosmetics, wherein the EG comprises the sodium acrylate/sodium acryloyldimethyl taurate copolymer, isohexadecane, polysorbate-80 and sorbitan oleate.
The disodium ethylene diamine tetraacetate is a chelating agent of cosmetics.
The caprylic/capric triglyceride and isononyl isononanoate are cosmetic emollients.
The cetearyl alcohol, the A165 and the MONTANOV68 are cosmetic emulsifiers, wherein the A165 comprises TG100 stearate and glycerol stearate, and the MONTANOV68 comprises cetearyl alcohol and cetearyl glucoside.
The triethanolamine is a pH regulator of cosmetics.
The essence is an aromatic of cosmetics.
The following describes the application of the composition with whitening and spot-lightening effects in the preparation of cosmetics with reference to specific application examples.
Application example 1 preparation of essence water with whitening and spot-fading effects
1. The components and the proportion of the essence water
The application example provides essence water with whitening and spot-fading effects, which consists of the following components in percentage by weight:
the composition with the whitening and spot-lightening effects comprises the following components: 10 wt% of the total weight of the composition,
glycerol: 30 percent by weight of the total weight of the components,
propylene glycol: 35 percent by weight of the total weight of the composition,
betaine: 1 percent by weight of the total amount of the catalyst,
p-hydroxyacetophenone: 0.5 wt% of the total weight of the alloy,
hexanediol: 0.5 wt% of the total weight of the alloy,
deionized water: and (4) the balance.
2. Preparation of essence water
A preparation method of essence water with whitening and spot-fading effects comprises the following steps:
step 1: putting deionized water, glycerol, propylene glycol, betaine and p-hydroxyacetophenone into an emulsifying pot, stirring, heating to 80-85 deg.C, stirring, maintaining the temperature for 30min to completely dissolve and disperse, slowly stirring, defoaming, and cooling;
step 2: when the temperature is reduced to 45 ℃ by stirring, the composition with the whitening and spot-fading effects and the hexanediol are sequentially added, and the mixture is uniformly stirred to be completely dissolved;
and step 3: when the mixture is stirred and cooled to 40 ℃, the essence water with the whitening and spot-fading effects is obtained after the inspection is qualified.
Application example 2 preparation of essence with whitening and spot-lightening effects
1. The components and the proportion of the essence
The application example provides essence with whitening and spot-fading effects, which consists of the following components in percentage by weight:
the composition with the whitening and spot-lightening effects comprises the following components: 15 percent by weight of the total weight of the composition,
glycerol: 30 percent by weight of the total weight of the components,
propylene glycol: 35 percent by weight of the total weight of the composition,
hyaluronic acid: 0.1 wt% of the total weight of the alloy,
d-panthenol: 0.5 wt% of the total weight of the alloy,
p-hydroxyacetophenone: 0.5 wt% of the total weight of the alloy,
hexanediol: 0.5 wt% of the total weight of the alloy,
allantoin: 0.2 wt% of the total weight of the alloy,
sodium acrylate/sodium acryloyldimethyl taurate copolymer: 2 percent by weight of a catalyst,
deionized water: and (4) the balance.
2. Preparation of essence
A preparation method of essence with whitening and spot-fading effects comprises the following steps:
step 1: putting deionized water, glycerol, propylene glycol, hyaluronic acid, p-hydroxyacetophenone, allantoin, and sodium acrylate/sodium acryloyldimethyl taurate copolymer into an emulsifying pot, stirring, heating to 80-85 deg.C, stirring, maintaining the temperature for 30min for complete dissolution and dispersion, slowly stirring, defoaming, and cooling;
step 2: when the temperature is reduced to 45 ℃ by stirring, sequentially adding the D-panthenol, the composition with the whitening and spot-fading effects and the hexanediol, and uniformly stirring to completely dissolve the D-panthenol, the composition with the whitening and spot-fading effects and the hexanediol;
and step 3: when the mixture is stirred and cooled to 40 ℃, the essence with the whitening and spot-fading effects is obtained after the inspection is qualified.
Application example 3 preparation of cream with whitening and spot-fading effects
1. The components and the proportion of the cream
The application example provides a cream with whitening and spot-fading effects, which consists of the following components in percentage by weight:
the composition with the whitening and spot-lightening effects comprises the following components: 15 percent by weight of the total weight of the composition,
glycerol: 30 percent by weight of the total weight of the components,
propylene glycol: 35 percent by weight of the total weight of the composition,
betaine: 2 percent by weight of a catalyst,
p-hydroxyacetophenone: 0.5 wt% of the total weight of the alloy,
1, 2-hexanediol: 0.5 wt% of the total weight of the alloy,
allantoin: 0.2 wt% of the total weight of the alloy,
tocopherol acetate: 0.5 wt% of the total weight of the alloy,
pentaerythritol tetrakis (bis-tert-butylhydroxyhydrocinnamate): 0.05 wt% of the total weight of the alloy,
acrylic/C10-30 alkanol acrylate crosspolymer: 0.2 wt% of the total weight of the alloy,
EG：1wt％，
cetostearyl alcohol: 1.5 wt% of a catalyst,
A165：1.5wt％，
MONTANOV 68：0.5wt％，
caprylic/capric triglyceride: 2.5 percent by weight of a catalyst,
isononyl isononanoate: 2.5 percent by weight of a catalyst,
disodium ethylene diamine tetraacetate: 0.02 wt% of the total weight of the alloy,
triethanolamine: 0.2 wt% of the total weight of the alloy,
essence: 0.1 wt% of the total weight of the alloy,
deionized water: and (4) the balance.
2. Preparation of cream
A preparation method of a cream with whitening and spot-fading effects comprises the following steps:
step 1: adding component A (deionized water, glycerol, propylene glycol, betaine, p-hydroxyacetophenone, allantoin, acrylic acid (acrylate)/C10-30 alkanol acrylate cross-linked polymer, and disodium ethylene diamine tetraacetate) into water phase pot, stirring and heating to 85 deg.C;
step 2: putting the component C (tocopheryl acetate, pentaerythritol tetra (di-tert-butyl hydroxy hydrocinnamate), cetostearyl alcohol, A165, MONTANOV68, caprylic/capric triglyceride and isononyl isononanoate) into an oil phase pot, heating to 85 ℃, and keeping the temperature until the dissolution is completed;
and step 3: heating the component C to 85 ℃ to dissolve the component C, adding the component C into the component A, and homogenizing and stirring at a low speed for 10 min;
and 4, step 4: cooling to 70 deg.C, adding EG, homogenizing at high speed and stirring for 5 min;
and 5: when the temperature is reduced to 60 ℃ by stirring, adding triethanolamine and stirring uniformly;
step 6: when the mixture is stirred and cooled to 45 ℃, 1, 2-hexanediol, the composition with the whitening and spot-fading effects and essence are sequentially added;
and 7: when the mixture is stirred and cooled to 40 ℃, the cream with the whitening and spot-fading effects is obtained after the inspection is qualified.
In order to verify the whitening and spot-lightening efficacy of the cosmetic of the present invention, the following experimental example 7 was performed.
First, experiment purpose
The whitening and spot-lightening effects of the cosmetics prepared in the above application examples 1 to 3 were evaluated by comparative analysis.
Second, Experimental methods
Test samples:
experimental groups: the liquid containing the essence of examples 1 to 4 was set as experiment 1, the essence containing examples 1 to 4 was set as experiment 2, and the cream containing examples 1 to 4 was set as experiment 3.
Blank group: the blank 1 is the essence containing no composition with the whitening and spot-lightening efficacy, the blank 2 is the essence containing no composition with the whitening and spot-lightening efficacy, and the blank 3 is the cream containing no composition with the whitening and spot-lightening efficacy.
Control group: the essence containing the comparison examples 1-12 is set as a comparison group 1, the essence containing the comparison examples 1-12 is set as a comparison group 2, the cream containing the comparison examples 1-12 is set as a comparison group 3, and the essence, the essence and the cream with the whitening and spot-fading effects are sold in the market.
Test objects: 30 middle-aged women, 30-40 years old, healthy, no dermatosis and anaphylaxis history, non-sensitive skin, use cosmetics according to the regulation, have certain expression ability, can really feed back the feeling after using.
And (3) testing and analyzing: in the cheek area, the composition is applied once a day in the morning and evening for 6 weeks. The test subjects were tested by using a Visia skin tester and evaluated for whitening and lightening effects before and after 6 weeks of use.
Third, evaluation of Effect
Table 4 evaluation of the effects of serum, serum and cream
As shown in table 4, the comparison of the data of the experimental group 1, the control group 1, the blank group 1 and the commercial essence lotion shows that the whitening and spot-fading effects of the experimental group 1 containing the examples 1 to 4 are significantly better than those of the control group 1 containing the control examples 1 to 12, the blank group 1 and the commercial essence lotion. Among them, the control group 1 containing the control examples 1 to 12 lacks some components of the composition having the whitening and spot-lightening effect, and the whitening and spot-lightening effect is lower than that of the experimental group 1 containing the examples 1 to 4, which indicates that the composition having the whitening and spot-lightening effect of the present invention is not indispensable.
The comparison of the data of the experimental group 2, the control group 2, the blank group 2 and the commercial essence shows that the whitening and spot-lightening effect of the experimental group 2 containing the examples 1 to 4 is obviously better than that of the control group 2, the blank group 2 and the commercial essence 2 containing the control examples 1 to 12. Among them, the control group 2 containing the control examples 1 to 12 lacks some components of the composition having the whitening and spot-lightening effects, and the whitening and spot-lightening effects are lower than those of the experimental group 2 containing the examples 1 to 4, which indicates that the composition having the whitening and spot-lightening effects of the present invention is not indispensable.
The comparison of the data of the experimental group 3, the control group 3, the blank group 3 and the commercial cream shows that the whitening and spot-fading effects of the experimental group 3 containing the examples 1 to 4 are obviously better than those of the control group 3 and the blank group 3 containing the control examples 1 to 12 and the commercial essence water. Among them, the control group 3 containing the control examples 1 to 12 lacks some components of the composition having the whitening and spot-lightening effects, and the whitening and spot-lightening effects are lower than those of the experimental group 3 containing the examples 1 to 4, which indicates that the composition having the whitening and spot-lightening effects of the present invention is not indispensable.
In summary, the components of the composition with whitening effect in the invention are synergistic, but none of them is sufficient, that is, the composition containing 6 components of niacinamide, grape ferment-glutathione, alpha-arbutin, phenethyl resorcinol, vitamin C polypeptide and ragged rooted leaf extract has the best whitening and spot-fading effect, and the whitening and spot-fading effects of the cosmetic containing the composition are obviously higher than those of the cosmetics sold in the market.
The composition containing the 6 components with skin whitening and speckle reducing effects can prevent melanin aggregation and transfer, and reduce and decolorize melanin; inhibiting tyrosinase activity, scavenging oxygen free radicals to alter melanin production pathway; thereby preventing melanin generation and further realizing the effects of whitening and lightening spots.
The cosmetic containing the composition with the whitening and spot-fading effects has the whitening and spot-fading effects superior to those of the commercially available cosmetics, and can effectively whiten the skin and fade spots.
The above description is of the preferred embodiment of the invention. It is to be understood that the invention is not limited to the particular embodiments described above, wherein technical parameters and raw material components which are not described in detail in the invention are changed within the range of the listed parameters, and the technical effects which are the same as or similar to the above-mentioned examples can be obtained, and still belong to the protection scope of the invention.
Finally, it is to be understood that those skilled in the art, on the basis of the method and technical disclosure disclosed above, may make numerous changes and modifications to the technical disclosure of the present invention, or may modify equivalent embodiments to equivalent variations, without departing from the scope of the technical disclosure of the present invention. Therefore, any simple modification, equivalent change and modification of the above embodiments, or the application of the above technical solutions to other related technical fields directly or indirectly by using the equivalent technical parameters, equivalent raw material components or equivalent process flow transformation performed in the present specification without departing from the technical solution of the present invention, shall still fall within the protection scope of the technical solution of the present invention.
Claims (10)
1. The composition with the effects of whitening and fading the spots is characterized by mainly comprising the following components in parts by weight:
nicotinamide: 2-8 parts of (by weight),
glutathione: 1-5 parts of (A) a stabilizer,
alpha-arbutin: 1-5 parts of (A) a stabilizer,
phenethyl resorcinol: 1-5 parts of (A) a stabilizer,
a vitamin C polypeptide: 1-5 parts of (A) a stabilizer,
extract of the leaves of the Fall Potentilla Laciniana: 1-5 parts.
2. The composition of claim 1, wherein the composition consists essentially of, in parts by weight:
nicotinamide: 5-8 parts of (by weight),
glutathione: 1-5 parts of (A) a stabilizer,
alpha-arbutin: 1-5 parts of (A) a stabilizer,
phenethyl resorcinol: 1-5 parts of (A) a stabilizer,
a vitamin C polypeptide: 1-5 parts of (A) a stabilizer,
extract of the leaves of the Fall Potentilla Laciniana: 2-3 parts.
3. The composition of any one of claims 1 or 2, wherein the glutathione is glucerase-glutathione.
4. A cosmetic comprising the composition according to any one of claims 1 to 3.
5. The cosmetic according to claim 4, wherein the cosmetic consists essentially of, by weight:
the composition is as follows: 10 to 15 weight percent of the total weight of the composition,
glycerol: 30 to 40 weight percent of the total weight of the alloy,
propylene glycol: 35 to 45 weight percent of the total weight of the alloy,
betaine: 0 to 2 wt% of a catalyst,
p-hydroxyacetophenone: 0.5 wt% of the total weight of the alloy,
1, 2-hexanediol: 0.5 wt% of the total weight of the alloy,
deionized water: and (4) the balance.
6. The cosmetic according to claim 5, further comprising the following components in percentage by weight:
hyaluronic acid: 0 to 0.1 wt% of a catalyst,
allantoin: 0 to 0.2 wt% of a catalyst,
sodium acrylate/sodium acryloyldimethyl taurate copolymer: 0 to 2 wt% of a catalyst,
d-panthenol: 0 to 0.5 wt%.
7. The cosmetic according to claim 6, further comprising the following components in weight percent:
acrylic/C10-30 alkanol acrylate crosspolymer: 0 to 0.2 wt% of a catalyst,
disodium ethylene diamine tetraacetate: 0 to 0.02 weight percent of,
cetostearyl alcohol: 0 to 1.5 wt% of a catalyst,
tocopherol acetate: 0 to 0.5 wt% of a catalyst,
caprylic/capric triglyceride: 0 to 2.5 wt% of a catalyst,
isononyl isononanoate: 0 to 2.5 wt% of a catalyst,
pentaerythritol tetrakis (bis-tert-butylhydroxyhydrocinnamate): 0 to 0.05 weight percent,
A165：0-1.5wt％，
MONTANOV 68：0-0.5wt％，
EG：0-1wt％，
triethanolamine: 0 to 0.2 wt% of a catalyst,
essence: 0 to 0.1 wt%.
8. A preparation method of cosmetics is characterized by comprising the following preparation steps:
step 1: putting the component A into an emulsifying pot, stirring, heating to 80-85 deg.C, stirring, maintaining the temperature for 30min to completely dissolve and disperse, slowly stirring, defoaming, and cooling;
step 2: when the temperature is reduced to 42-45 ℃ by stirring, adding the component B into the mixture, and uniformly stirring to completely dissolve the component B;
and step 3: cooling to 38-40 deg.C under stirring, and checking to obtain cosmetic;
the component A comprises deionized water, glycerol, propylene glycol and p-hydroxyacetophenone;
the component B comprises the composition as claimed in any of claims 1 to 3 and 1, 2-hexanediol.
9. A method for producing a cosmetic according to claim 6, comprising the steps of:
step 1: putting the component A into an emulsifying pot, stirring, heating to 80-85 deg.C, stirring, maintaining the temperature for 30min to completely dissolve and disperse, slowly stirring, defoaming, and cooling;
step 2: when the temperature is reduced to 42-45 ℃ by stirring, adding the component B into the mixture, and uniformly stirring to completely dissolve the component B;
and step 3: cooling to 38-40 deg.C under stirring, and checking to obtain cosmetic;
the component A comprises deionized water, glycerol, propylene glycol, betaine, hyaluronic acid, p-hydroxyacetophenone, allantoin and sodium acrylate/sodium acryloyldimethyl taurate copolymer;
said component B comprising D-panthenol, said composition and 1, 2-hexanediol.
10. A method for producing a cosmetic according to claim 7, comprising the steps of:
step 1: putting the component A into a water phase pot, stirring and heating to 80-85 ℃;
step 2: putting the component C into an oil phase pot, heating to 80-85 ℃, and keeping the temperature until the dissolution is finished;
and step 3: heating the component C to 80-85 deg.C to dissolve, adding into the component A, homogenizing at low speed, and stirring for 10 min;
and 4, step 4: cooling to 65-70 deg.C, adding EG, homogenizing at high speed and stirring for 5 min;
and 5: when the temperature is reduced to 55-60 ℃ by stirring, adding triethanolamine and stirring uniformly;
step 6: when the temperature is reduced to 42-45 ℃ by stirring, adding the component B;
and 7: cooling to 38-40 deg.C under stirring, and checking to obtain cosmetic;
the component A comprises deionized water, glycerol, propylene glycol, betaine, hyaluronic acid, p-hydroxyacetophenone, allantoin, sodium acrylate/sodium acryloyldimethyl taurate copolymer, acrylic acid (acrylate)/C10-30 alkanol acrylate cross-linked polymer and disodium ethylene diamine tetraacetate;
the component B comprises D-panthenol, the composition, 1, 2-hexanediol and essence;
component C includes cetearyl alcohol, caprylic/capric triglyceride, isononyl isononanoate, tocopheryl acetate, pentaerythritol tetrakis (di-tert-butyl hydroxyhydrocinnamate), A165 and MONTANOV 68.
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| CN114588054A (en) * | 2022-03-11 | 2022-06-07 | 广东丸美生物技术股份有限公司 | Whitening and moisturizing composition and preparation method and application thereof |
| CN114588054B (en) * | 2022-03-11 | 2023-11-21 | 广东丸美生物技术股份有限公司 | Whitening and moisturizing composition and preparation method and application thereof |
| CN117017869A (en) * | 2023-09-15 | 2023-11-10 | 名宇(广东)化妆品科技有限公司 | Whitening and freckle-removing cream and preparation method thereof |
| CN117017869B (en) * | 2023-09-15 | 2024-01-30 | 名宇(广东)化妆品科技有限公司 | Whitening and freckle-removing cream and preparation method thereof |
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