CN114259453A - Sensitive muscle relieving and repairing spray and preparation method and application thereof - Google Patents
Sensitive muscle relieving and repairing spray and preparation method and application thereof Download PDFInfo
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- 210000003205 muscle Anatomy 0.000 title claims abstract description 22
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 230000008439 repair process Effects 0.000 claims abstract description 28
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims abstract description 27
- 229910052805 deuterium Inorganic materials 0.000 claims abstract description 27
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- SSISHJJTAXXQAX-ZETCQYMHSA-N L-ergothioneine Chemical compound C[N+](C)(C)[C@H](C([O-])=O)CC1=CNC(=S)N1 SSISHJJTAXXQAX-ZETCQYMHSA-N 0.000 claims abstract description 11
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
Abstract
The invention relates to the technical field of cosmetics, and particularly relates to a sensitive muscle soothing and repairing spray as well as a preparation method and application thereof. The spray disclosed by the invention adopts saffron and trehalose to quickly supplement energy and nutrients for skin, can relieve stimulation, reduce the release of inflammatory factors and protect the skin from external stimulation; ergothioneine and hydrolyzed sodium hyaluronate cooperate with deuterium-depleted water to help reduce oxidative stress generated by inflammatory injury, remove redundant free radicals and help repair sensitive muscles more quickly. The carboxymethyl beta glucan sodium has the functions of improving the immune protection capability of skin cells and increasing the cell repair capability. The composition can improve the skin barrier repair effect by cooperating with fibronectin and phosphoryl oligosaccharide calcium, and improve the skin hydration function and state; the spray disclosed by the invention is simple in components and clear in effect, and can be used for simultaneously moisturizing and relieving sensitive skin, regulating immune balance, enhancing skin immunity, inhibiting inflammation, reducing oxidative stress reaction and reducing free radical multiple aspects to quickly repair sensitive skin.
Description
Technical Field
The invention relates to the technical field of cosmetics, and particularly relates to a sensitive muscle soothing and repairing spray as well as a preparation method and application thereof.
Background
Sensitive skin is mainly characterized in that the barrier function of the skin is damaged, the skin is easily affected by external stimulation, the skin is caused to generate some inflammatory reactions, the skin shows symptoms such as redness, swelling and pain, burning and the like, and the skin cells and the barrier of the skin are continuously damaged. In response to these problems, many cosmetic products are also on the market, which are claimed to have the effect of repairing sensitive skin. The sensitive skin is repaired by moisturizing and relieving the sensitive skin, regulating immune balance, enhancing skin immunity, inhibiting inflammation and the like.
Sensitive muscles continuously express inflammatory reaction and skin injury, generate oxidative stress, and skin cells can continuously release free radicals and repeatedly release inflammatory factors to trigger skin inflammatory reaction. However, the existing cosmetics do not consider oxidative stress generated by injury and are not beneficial to quick repair of sensitive muscles.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provides a sensitive muscle soothing repair spray as well as a preparation method and application thereof. The invention provides a spray for rapidly repairing sensitive muscles by adjusting the balance of free radicals and antioxidant capacity, reducing oxidative stress and free radicals.
In order to achieve the purpose, the invention adopts the technical scheme that: providing a sensitive muscle soothing repair spray comprising phase a, phase B and phase C materials;
the phase A raw material comprises the following components: glycerol; allantoin; 1, 2-pentanediol; trehalose; deuterium-depleted water;
the phase B raw material comprises the following components: hydrolyzing sodium hyaluronate; calcium phosphoryl oligosaccharide; ergothioneine; sodium carboxymethyl β -glucan;
the C-phase raw material comprises the following components: saffron extract; fibronectin; s. Minuisorba/radish root fermentation product filtrate.
Fibronectin in the spray of the invention is the major non-collagenous glycoprotein in the extracellular matrix and basement membrane. Plays a central role in cell adhesion and regulates cell polarity, differentiation and growth. Fibronectin promotes ceramide synthesis by fibroblasts and epidermal cells. Promoting the secretion of hyaluronic acid by basal layer cells and fibroblasts, and repairing skin barrier.
The hydrolyzed hyaluronic acid sodium in the spray has ultrahigh biological activity, has extremely low molecular weight (less than or equal to 5K Da), can quickly penetrate through epidermis to reach dermis, removes free radicals, reduces the activity of inflammatory factors, inhibits inflammatory reaction, repairs damaged cells, and resists skin inflammation and sensitivity caused by various stimuli.
The phosphoryl oligosaccharide calcium in the spray is innovative bioactive calcium, can improve the production of ceramide and sterol in skin, enhance the barrier function of the skin and improve the hydration function of the skin.
The carboxymethyl beta glucan sodium in the spray is a water-soluble glucan derivative with high activity extracted from saccharomycetes, and has the functions of improving the immune protection capability of skin cells and increasing the cell repair capability.
The ergothioneine in the spray is a natural antioxidant, can protect cells in a human body, is an important active substance in a body, can remove high-concentration free radicals generated by the human body, regulates oxidation-reduction reaction in the cells, and has multiple functions of participating in energy regulation in the cells, cell physiological protective agents and the like.
The deuterium-depleted water in the spray disclosed by the invention is 50-115ppm, has the functions of improving the basic metabolism level of an organism, delaying senescence and the like, has the effects of beautifying and protecting skin, is embodied in that the deuterium-depleted water acts on skin cells, and has the effects of resisting oxidation, inhibiting melanin and repairing.
As a preferred embodiment of the sensitive muscle soothing repair spray of the present invention, the phase a raw material comprises the following components in percentage by weight: glycerol: 5.0 to 15.0 percent; allantoin: 0.1 to 0.4 percent; 1, 2-pentanediol: 0.2 to 1.0 percent; trehalose: 1.0-5.0%; deuterium-depleted water: the balance;
the phase B raw material comprises the following components in percentage by weight: hydrolysis of sodium hyaluronate: 0.02-1.0%; phosphoryl oligo-saccharide calcium: 0.1 to 1.0 percent; ergothioneine: 0.01-1%; carboxymethyl β -glucan sodium: 0.02-0.2%;
the C-phase raw material comprises the following components in percentage by weight: saffron extract: 0.5 to 5.0 percent; s. aureus/radish root fermentation product filtrate: 1.5 to 3.0 percent.
As a preferred embodiment of the sensitive muscle soothing repair spray of the present invention, the deuterium depleted water has a deuterium content of 50-115 ppm.
Water existing in nature is composed of 2 hydrogen atoms and 1 oxygen atom, and hydrogen elements have 3 stable isotopes with different masses, i.e., hydrogen (H), deuterium (D, deuterium), and tritium (deuterium) with atomic weights of 1,2, and 3, respectively. Ordinary water having deuterium content of about 150ppm and water having deuterium content of less than 150ppm is called deuterium-depleted water. Research shows that deuterium is harmful to the survival development and reproduction of living bodies, water with low deuterium content has a plurality of benefits to human health and has important significance to human health, and the effect is better when the deuterium content is lower.
As a preferred embodiment of the sensitive muscle soothing repair spray of the present invention, the phase a raw material comprises the following components in percentage by weight: glycerol: 8.00 percent; allantoin: 0.20 percent; 1, 2-pentanediol: 1.50 percent; trehalose: 3.00 percent; deuterium-depleted water: the balance;
the phase B raw material comprises the following components in percentage by weight: hydrolysis of sodium hyaluronate: 0.20 percent; phosphoryl oligo-saccharide calcium: 1.00 percent; ergothioneine: 0.050%; carboxymethyl β -glucan sodium: 0.10 percent;
the C-phase raw material comprises the following components in percentage by weight: saffron extract: 3.00 percent; fibronectin: 2.0 percent; s. aureus/radish root fermentation product filtrate: 2.00 percent.
As a preferred embodiment of the sensitive muscle soothing repair spray of the present invention, the deuterium depleted water has a deuterium content of 70 ppm.
The invention also provides a preparation method of the sensitive muscle soothing and repairing spray, which comprises the following steps: heating the phase A raw material to dissolve, cooling, adding the phase B raw material, continuously cooling, adding the phase C raw material, and uniformly stirring to obtain the product.
As a preferred embodiment of the preparation method of the present invention, the preparation method specifically comprises the steps of:
s1, heating the phase A raw material to 75-80 ℃, stirring until the phase A raw material is completely dissolved, and then cooling;
s2, when the temperature is reduced to 45-50 ℃, sequentially adding the phase B raw materials, and continuously stirring and cooling;
and S3, cooling to below 45 ℃, sequentially adding the C-phase raw materials, and uniformly stirring.
The invention has the beneficial effects that:
(1) the spray disclosed by the invention adopts saffron and trehalose to quickly supplement energy and nutrients for skin, can relieve stimulation, reduce the release of inflammatory factors and protect the skin from external stimulation; ergothioneine and hydrolyzed sodium hyaluronate cooperate with deuterium-depleted water to help reduce oxidative stress generated by inflammatory injury, remove redundant free radicals and help repair sensitive muscles more quickly. The carboxymethyl beta glucan sodium has the functions of improving the immune protection capability of skin cells and increasing the cell repair capability. The composition can improve the skin barrier repair effect by cooperating with fibronectin and phosphoryl oligosaccharide calcium, and improve the skin hydration function and state;
(2) the spray disclosed by the invention is simple in components and clear in effect, can be used for simultaneously moisturizing and relieving sensitive skin, regulating immune balance, enhancing skin immunity, inhibiting inflammation, reducing oxidative stress reaction, reducing free radical multiple aspects, rapidly repairing sensitive skin, and is particularly suitable for repairing sensitive skin in sensitive red swelling.
Detailed Description
To more clearly illustrate the technical solutions of the present invention, the following embodiments are further described, but the present invention is not limited thereto, and these embodiments are only some examples of the present invention.
Example 1
The raw material formulations for samples 1,2, 3 are given in table 1.
TABLE 1 spray raw material formulation
To demonstrate the importance of the feedstock of the present invention, several groups of controls were provided:
control 1: control 1 was identical to sample 2 for other starting materials, lacking only component 7 (calcium phosphoryl oligosaccharide);
control 2: control 2 was identical in other raw material content compared to sample 2, lacking only component 8 (ergothioneine);
control 3: control 3 was identical in content to the other starting materials compared to sample 2, lacking only component 11 (fibronectin).
Example 2 preparation of the spray
The preparation method of the spray comprises the following steps:
(1) heating the phase A raw material to 75-80 ℃ in a stirring pot, stirring until the phase A raw material is completely dissolved, and then cooling;
(2) when the temperature is reduced to 45-50 ℃, sequentially adding the phase B raw materials, and continuously stirring and cooling;
(3) cooling to below 45 deg.C, sequentially adding C phase raw materials, and stirring;
(4) and (5) detecting, discharging and filling to obtain a finished product.
Example 3 anti-inflammatory repair test comparison
Sprays for sensitive skin and a conventional anti-sensitive spray on the market were prepared according to the raw materials in the examples, and human use tests were performed to evaluate the anti-inflammatory and repairing effects of the products, and the specific test methods were as follows:
test samples: example sample 2 spray for sensitive skin, a commercially available anti-sensitivity spray;
testing an instrument: cutommieter dual MPA580 skin tester;
testing parts: an upper arm of the human body;
the test method comprises the following steps: SDS (sodium dodecyl sulfate) with the concentration of 2% is prepared, non-woven fabrics for human body tests are attached to a tested part, 2g of SDS is taken to evenly soak the non-woven fabrics, 2g of SDS is added every 2 hours, and the skin is stimulated for 4 hours, so that the tested part generates erythema. After the tested part generating the erythema is simply washed by purified water (to avoid the interference influence of excessive operation on the erythema), the concentration of the red pigment is respectively 0.03g/cm2Examples of spray density and commercially available anti-sensitivity sprays to alleviate erythema. And the skin Erythem value was tested before stimulation of the skin, after stimulation of the skin and 2 hours, 4 hours after application of the spray.
And (4) judging the standard: the lower the Erythem value, the whiter the skin.
Table 2 anti-inflammatory repair test results for sprays of the invention and commercially available anti-allergy sprays
And (3) testing results: the test data prove that the spray for sensitive skin provided by the sample 2 has excellent repairing effect on a model with damaged skin barrier function caused by the surfactant, and the repairing effect and the recovery speed are obviously superior to those of the commercially available anti-sensitive spray.
Example 4 skin Barrier function repair test comparison
Spray samples 1,2, 3 for sensitive skin and controls 1,2, 3 were prepared according to the raw materials in example 1 and tested for human use to evaluate the repair of skin barrier function by testing the skin TEWL values. The specific test method is as follows:
test samples: sprays prepared for samples 1-3 and controls 1-3;
testing an instrument: cutommieter dual MPA580 skin tester;
selecting 60 female volunteers, wherein each group of test subjects have no systemic diseases and other skin diseases, other skin care products are not used within 2-3 days, and the female is not in the gestation period or the lactation period and participates in the test in the whole course of voluntary; the spray prepared from samples 1-3 and controls 1-3 was applied to 60 subjects randomly in 6 groups of 10 subjects, twice daily, once in the morning and evening, for 28 consecutive days, and the TEWL values before and after use at 20 and 28 days were measured for each group of subjects, with the results shown in table 3 below.
And (3) testing environment: the test is carried out in a room with the temperature of 22-25 ℃ and the relative humidity of 35-45%, and each group of testees enter a test room to rest for 30 minutes and then start the test.
TABLE 3 skin TEWL values versus changes
As can be seen from Table 3, the skin TEWL values of the subjects in each group before use were mostly 20g/hm2As mentioned above, it is indicated that the skin barrier is damaged to different degrees, and after using the skin-care spray of the present invention samples 1-3 for 28 days, the skin barrier function of each group of subjects is significantly enhanced compared to that before using, and the skin TEWL value of each group of subjects is stabilized at 11-12 g/hm2Meanwhile, the skin barrier function is good, which indicates that the spray sample in the example 1 has a repairing effect on the skin barrier function; and the control substances 1-3 lack phosphoryl oligocalcium or ergothioneine or fibronectin in spray, so that the skin barrier repair effect is not ideal compared with that of a sample, and the components in the example 1 achieve a synergistic effect in the aspect of skin barrier repair.
Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting the protection scope of the present invention, and although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.
Claims (7)
1. A sensitive muscle soothing repair spray, comprising phase a, phase B and phase C raw materials;
the phase A raw material comprises the following components: glycerol; allantoin; 1, 2-pentanediol; trehalose; deuterium-depleted water;
the phase B raw material comprises the following components: hydrolyzing sodium hyaluronate; calcium phosphoryl oligosaccharide; ergothioneine; sodium carboxymethyl β -glucan;
the C-phase raw material comprises the following components: saffron extract; fibronectin; s. Minuisorba/radish root fermentation product filtrate.
2. Sensitive muscle soothing repair spray according to claim 1,
the phase A raw material comprises the following components in percentage by weight: glycerol: 5.0 to 15.0 percent; allantoin: 0.1 to 0.4 percent; 1, 2-pentanediol: 0.2 to 1.0 percent; trehalose: 1.0-5.0%; deuterium-depleted water: the balance;
the phase B raw material comprises the following components in percentage by weight: hydrolysis of sodium hyaluronate: 0.02-1.0%; phosphoryl oligo-saccharide calcium: 0.1 to 1.0 percent; ergothioneine: 0.01-1%; carboxymethyl β -glucan sodium: 0.02-0.2%;
the C-phase raw material comprises the following components in percentage by weight: saffron extract: 0.5 to 5.0 percent; fibronectin: 0.5 to 5.0 percent; s. aureus/radish root fermentation product filtrate: 1.5 to 3.0 percent.
3. The sensitive muscle soothing repair spray of claim 2, wherein the deuterium depleted water has a deuterium content of 50-115 ppm.
4. Sensitive muscle soothing repair spray according to claim 2,
the phase A raw material comprises the following components in percentage by weight: glycerol: 8.00 percent; allantoin: 0.20 percent; 1, 2-pentanediol: 1.50 percent; trehalose: 3.00 percent; deuterium-depleted water: the balance;
the phase B raw material comprises the following components in percentage by weight: hydrolysis of sodium hyaluronate: 0.20 percent; phosphoryl oligo-saccharide calcium: 1.00 percent; ergothioneine: 0.050%; carboxymethyl β -glucan sodium: 0.10 percent;
the C-phase raw material comprises the following components in percentage by weight: saffron extract: 3.00 percent; s. aureus/radish root fermentation product filtrate: 2.00 percent.
5. The sensitive muscle soothing repair spray of claim 4, wherein the deuterium depleted water has a deuterium content of 70 ppm.
6. A method of preparing a sensate muscle soothing repair spray according to any of claims 1 to 5, wherein the method of preparation comprises: heating the phase A raw material to dissolve, cooling, adding the phase B raw material, continuously cooling, adding the phase C raw material, and uniformly stirring to obtain the product.
7. The preparation method according to claim 6, comprising the following steps:
s1, heating the phase A raw material to 75-80 ℃, stirring until the phase A raw material is completely dissolved, and then cooling;
s2, when the temperature is reduced to 45-50 ℃, sequentially adding the phase B raw materials, and continuously stirring and cooling;
and S3, cooling to below 45 ℃, sequentially adding the C-phase raw materials, and uniformly stirring.
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