CN114632045B - Anti-aging composition, preparation method and application - Google Patents
Anti-aging composition, preparation method and application Download PDFInfo
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- CN114632045B CN114632045B CN202210404291.5A CN202210404291A CN114632045B CN 114632045 B CN114632045 B CN 114632045B CN 202210404291 A CN202210404291 A CN 202210404291A CN 114632045 B CN114632045 B CN 114632045B
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- MWLSOWXNZPKENC-SSDOTTSWSA-N zileuton Chemical compound C1=CC=C2SC([C@H](N(O)C(N)=O)C)=CC2=C1 MWLSOWXNZPKENC-SSDOTTSWSA-N 0.000 description 1
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/14—Liposomes; Vesicles
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- A—HUMAN NECESSITIES
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
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- A—HUMAN NECESSITIES
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- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
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- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/82—Preparation or application process involves sonication or ultrasonication
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
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Abstract
The invention discloses an anti-aging composition, a preparation method and application thereof, wherein the anti-aging composition comprises nano-liposome and an active component loaded on the nano-liposome, the active component comprises diglucosyl gallic acid, glucosyl hesperidin, spilanthum extract, biotin and caffeine, and the invention also discloses application of the anti-aging composition in preparation of cosmetics. The anti-aging composition can promote the proliferation of human skin fibroblasts, promote the generation of collagen, and improve the transdermal absorption capacity of the anti-aging composition, thereby improving wrinkles, improving skin color, repairing damaged skin and improving xerosis cutis.
Description
Technical Field
The invention belongs to the field of cosmetics, relates to an anti-aging composition, and in particular relates to an anti-aging composition, a preparation method and application thereof.
Background
The skin surface layer tissues and cells of the human body can protect the human body from external invasion through the surface barrier, and can play a role in delaying skin tissue aging through a water retention or moisturizing action mechanism and the like for preventing the volatilization of skin tissue moisture. Both barrier construction of the skin epidermis tissue and moisturizing and anti-aging effects of the skin epidermis tissue are critical and essential for living and tissue protection. The skin tissue cells are the same as other cell types of a human body, aging and decline of structures, compositions, functions and the like can occur with the time and the age of the body, and various metabolic wastes, inactivation, aging cells and subcellular structures can not be effectively removed, and the normal state and steady state of physiological cells are continuously unbalanced to accelerate skin aging and skin diseases.
Aging is a process in which after the body passes through a sexual maturation period, the self-renewal and repair ability of cells is weakened, the structure and function of tissues and organs are degenerated, and death is finally progressed, and is characterized by reduced stress capability, broken equilibrium state and increased risk of suffering from diseases. As the global population ages, a variety of senile degenerative diseases and the consequent enormous medical costs have become increasingly serious social problems. Maintaining the health of elderly people is a key element in reducing the social and economic burden of aging people. Therefore, the method has the advantages of simple and easy exploration, economy, effectiveness, high safety and great significance in the measures and methods for intervening the aging and the aging-related diseases, which are suitable for popularization.
The most common anti-aging way to date is to use anti-aging drugs. Most of clinically used anti-aging medicines are synthetic medicines, such as vitamin E can promote cell division and inhibit oxygen free radical generation, procaine preparation can prolong cell life, amipirone can delay brain aging and the like; aspirin delays the decline in body function caused by aging by combating oxidative stress.
Skin aging is a phenomenon of skin aging caused by natural or unnatural factors. The skin tissue of the human after birth is developed gradually, the functions are active gradually, the skin begins to degenerate when the human reaches a certain age, and the skin aging is usually performed unknowingly and slowly. The growth period of skin tissue generally ends around 25 years old, which is generally called "skin corner", and from then on, the skin elastic fiber gradually thickens and reaches the initial age of 40-50 years old, and the skin aging is slow and obvious, but the aging degree varies from person to person. As the skin ages, the skin becomes thinner with atrophy, subcutaneous fat decreases, and skin elasticity and tension are lost due to changes in spandex and collagen fibers, thereby further causing skin sagging and wrinkles to occur.
In the current medical beauty anti-aging field, except for skin pulling operation and micro-whole operation of buried wire lifting, other methods usually adopt the functions of supplementing collagen, elastin and hyaluronic acid in skin, or stimulating the activities of fiber bud cells, such as photoelectrical treatment of heat, agate, injection of hand, and the like, are to stimulate cells by light and high-frequency electric waves to promote the generation of collagen, but the activities of the stimulated cells are required to be slightly burnt to stimulate the operation of the fiber bud cells, the burned place is mainly recovered by the fiber bud cells, and the fiber bud cells are regenerated, the cultured fiber bud cells are directly injected into dermis of the skin, the regenerated cells are directly supplemented, the cell number is increased, the division speed is improved, the skin of the patient is enabled to continuously generate substances such as collagen, the skin is enabled to be recovered to a young state, the effect is durable and natural, and the skin can also be continuously cultured and used.
With age, the number of fibroblasts is decreasing, so that this type of anti-aging medical treatment requires multiple injections or skin pulling or line embedding on the skin surface of the human body.
However, in the present market, there are some drawbacks and problems in practical application, such as that the effective components are difficult to penetrate the skin to exert their biological effects, absorption is difficult, anti-wrinkle reaction is slow, and the effects are not obvious.
There is thus a need for a composition or a product comprising the composition which promotes fibroblast proliferation and collagen production in human skin.
Disclosure of Invention
In order to solve the above problems, the first aspect of the present invention provides an anti-aging composition, which can promote fibroblast proliferation of human skin, promote collagen production, and improve transdermal absorption capacity of the anti-aging composition, thereby improving wrinkles, improving skin color, repairing damaged skin, and improving skin dryness.
The second aspect of the invention also provides a method for preparing the anti-aging composition.
The third aspect of the present invention also provides the use of the above anti-aging composition.
In order to achieve the above purpose, the present invention adopts the following technical scheme:
In a first aspect, the present invention provides an anti-aging composition comprising nanoliposomes and an active ingredient loaded on the nanoliposomes, the active ingredient comprising: diglucosyl gallic acid, glucosyl hesperidin, spilanthol extract, biotin and caffeine.
In the invention, alpha-glucosidase can be generated in the microbial layer of human skin, and the diglucosyl gallate is acted by the alpha-glucosidase, so that the glucose bond of the diglucosyl gallate is cut off, the trihydroxybenzoic acid is generated, and the diglucosyl gallate rapidly acts on a target spot, thereby reducing the generation of melanin; the trihydroxybenzoic acid has good effects in reducing free radicals, inhibiting the activity of the aminopeptidase and the like, can inhibit the expression of enzymes which are converted into melanin and inhibit the transfer of skin melanin to the skin surface, can inhibit the transfer of skin melanin, and can reduce the melanin of the skin. The diglucosyl gallate can effectively inhibit tyrosinase activity and prevent melanin transfer, thereby obviously reducing color spots, brightening skin and improving skin whiteness; in addition, the diglucosyl gallic acid also has excellent anti-free radical effect and anti-aging effect.
Glucosyl hesperidin: glucosyl hesperidin is a natural bioflavonoid extracted from citrus peel, and is a derivative of water-soluble hesperidin. It can promote blood circulation, improve skin darkness by stimulating skin surface circulation, and flavonoid compounds in glucosyl hesperidin can resist oxidation, absorb ultraviolet rays and remove free radicals, and can also effectively strengthen collagen structure.
The spilanthum extract can stimulate collagen production and laminin production in skin, and can be used to reduce muscle contraction of facial muscles, reduce and/or prevent facial fine lines or wrinkles, reduce dynamic facial wrinkles and forehead wrinkles (e.g., facial wrinkles) due to repeated facial muscle contraction, increase collagen production, reduce matrix metalloproteinases, tighten skin and/or reduce the appearance of loose, sagging and sagging skin.
Biotin is also called vitamin H and coenzyme R, is water-soluble vitamin, and also belongs to vitamin B group and B7. It is an essential substance for the synthesis of vitamin C, an essential substance for the normal metabolism of fats and proteins. Is a necessary nutrient for maintaining natural growth and development of human body and normal human body function health. The biotin has excellent cosmetic effect and can keep skin tender and white.
Caffeine, white powder, characteristic smell, and caffeine have effects of stimulating cellular metabolism and accelerating local microcirculation.
The active components formed by compounding caffeine, biotin, spilanthol extract, glucosyl hesperidin and diglucosyl gallic acid can be effectively absorbed by skin, can effectively reduce melanin deposition, resist external invasion and free radicals, effectively inhibit the activity of inflammatory factors and reduce the loss of skin moisture, thereby effectively relieving and removing dark circles, delaying skin aging and improving skin luster.
And the nano liposome is used for loading the active components, so that the stability is good, the mildness is good, the skin irritation is low, and the damage to the structure of the active components in the preparation process is avoided.
As a preferred embodiment of the present invention, the anti-aging composition comprises, in weight percent: 0.011% -1.1% of diglucosyl gallic acid, 0.01% -1.5% of glucosyl hesperidin, 0.01% -0.8% of spilanthol extract, 0.00001% -0.0005% of biotin, 0.00001% -0.0005% of caffeine, 0.6% -2.6% of cholesterol, 0.1% -1.5% of behenyl alcohol, 6% -6.5% of hydrogenated lecithin and the balance of deionized water.
As a preferred embodiment of the present invention, the anti-aging composition comprises, in weight percent: 0.011% -0.5% of diglucosyl gallic acid, 0.01% -0.5% of glucosyl hesperidin, 0.0447% -0.6% of spilanthol extract, 0.00001% -0.0005% of biotin, 0.00001% -0.0005% of caffeine, 0.6% -2.6% of cholesterol, 0.1% -1.5% of behenyl alcohol, 6% -6.5% of hydrogenated lecithin and the balance of deionized water.
As a preferred embodiment of the present invention, the anti-aging composition comprises, in weight percent: 0.011% of diglucosyl gallic acid, 0.5% of glucosyl hesperidin, 0.0447% of spilanthus extract, 0.0001% of biotin, 0.0001% of caffeine, 0.6% -2.6% of cholesterol, 0.1% -1.5% of behenyl alcohol, 6% -6.5% of hydrogenated lecithin and the balance of deionized water.
As a preferable mode of the invention, the particle size of the nanoliposome is 100-250nm.
The second aspect of the present invention provides a method for preparing the above anti-aging composition, comprising the steps of:
a) Dissolving the active component and the nano liposome to obtain a mixed solution;
b) Evaporating and removing the solvent in the mixed solution in the step a), adding deionized water at 40-60 ℃, and carrying out ultrasonic treatment for 15-20min with the ultrasonic frequency of 15-35Hz; filtering after ultrasonic treatment to obtain the anti-aging composition.
In a third aspect, the invention provides the use of an anti-aging composition as described above in the preparation of a cosmetic product comprising a emollient water, a mask, an essence, an eye cream, an eye mask, a skin care gel, a skin care lotion, a cream or a spray.
As a preferred scheme of the invention, the cosmetic further comprises auxiliary materials, wherein the auxiliary materials comprise at least one of solvents, thickening agents, preservatives, pH regulators, moisturizers, emollients, chelating agents, emulsifying agents, essential oils, essence and pigments.
As a preferred embodiment of the present invention, the cosmetic is an eye cream comprising, in parts by weight: 0.01-60 parts of an anti-aging composition, 0.1-0.8 part of hydrogenated rapeseed oil alcohol, 5-10 parts of diisostearyl malic acid, 5-10 parts of 1, 3-propanediol, 3-12 parts of cocoyl alcohol-caprylate, 0.01-0.1 part of plant zipraline macadamia nut oleate, 0.01-2 parts of retinol palmitate, 0.01-0.5 part of hesperidin methyl chalcone and 50-80 parts of deionized water.
As a preferred embodiment of the present invention, the method for preparing the eye cream comprises the steps of:
1) Adding hydrogenated rapeseed oil alcohol, diisostearyl malic acid, retinol palmitate, cocoyl alcohol-caprylate, plant-catalpol macadamia nut oleate and hesperidin methyl chalcone, stirring uniformly, heating to 50-90 ℃, and stirring uniformly to obtain an oil phase;
2) Mixing the anti-aging composition, water and 1, 3-propylene glycol, and stirring to obtain water phase;
3) Mixing the oil phase obtained in the step 1) with the water phase obtained in the step 2), adding the obtained mixture into a reaction kettle of supercritical equipment, pumping carbon dioxide, adjusting the temperature in the reaction kettle of the supercritical equipment to 45-65 ℃, setting the pressure to 12-15Mpa, performing pressure release for 30-45min, releasing carbon dioxide, and cooling to room temperature to obtain eye cream.
Compared with the prior art, the invention has the following beneficial effects:
1) The active component is compounded by caffeine, biotin, spilanthol extract, glucosyl hesperidin and diglucosyl gallic acid, and the active component is loaded by nano liposome, so that the active component has good stability, good mildness and low skin irritation, the damage to the structure of the active component in the preparation process is avoided, the active component can be effectively absorbed by skin, the melanin deposition can be effectively reduced, the external invasion and free radicals are resisted, the activity of inflammatory factors is effectively inhibited, the loss of skin moisture is reduced, and therefore, the dark eye circles are effectively relieved and removed, the skin aging is delayed, and the skin luster is improved;
2) The anti-aging composition can promote the proliferation of fibroblasts of human skin and promote the generation of collagen, thereby improving wrinkles, improving skin color, repairing damaged skin and improving xerosis cutis.
Drawings
FIG. 1 is a graph showing the results of the promotion of cell proliferation according to the present invention.
FIG. 2 is a graph showing the results of collagen production according to the present invention.
Detailed Description
Furthermore, in the following detailed description, numerous specific details are set forth in order to provide a better illustration of the invention. It will be understood by those skilled in the art that the present invention may be practiced without some of these specific details. In other instances, well known methods, procedures, means, equipment and steps have not been described in detail so as not to obscure the present invention.
It should be noted that: in the present specification, the use of the meaning of "can" or "can" includes both the meaning of performing a certain process and the meaning of not performing a certain process. In the present specification, a numerical range expressed by "numerical value a-numerical value B" means a range including the end point numerical value A, B.
Unless otherwise indicated, all units used in the present invention are international standard units, and numerical values, ranges of values, appearing in the present invention should be understood to include errors permitted in industrial production.
In the present invention, raw materials used are, for example: diglucosylglucosac acid, glucosylglucoside, spilanthol extract, biotin, caffeine are commercially available.
Spilanthol extract Acmella oleracea extract the spilanthol extract used is a water-alcohol extract, wherein the solvent comprises a liquid mixture of water, ethanol and 1, 3-propanediol, and ethanol is removed from the resulting extracted liquid.
In the present invention, the auxiliary materials used in cosmetics may be auxiliary materials commonly used in the existing cosmetic market, such as solvents, thickeners, preservatives, pH adjusters, moisturizers, emollients, chelating agents, emulsifiers, essential oils, fragrances, pigments.
Example 1
The embodiment provides an anti-aging composition, which comprises nano-liposome and active components loaded on the nano-liposome, wherein the anti-aging composition comprises the following components in percentage by weight: 0.011% diglucosyl gallic acid, 0.5% glucosyl hesperidin, 0.0447% spilanthol extract, 0.0001% biotin, 0.0001% caffeine, 1.8% cholesterol, 1.2% behenyl alcohol, 6.3% hydrogenated lecithin, the balance deionized water.
The preparation method of the anti-aging composition comprises the following steps:
a) Dissolving diglucosyl gallic acid, glucosyl hesperidin, spilanthol extract, biotin, caffeine, cholesterol, behenyl alcohol and hydrogenated lecithin in absolute ethanol according to a ratio to obtain a mixed solution;
b) Evaporating and removing absolute ethyl alcohol in the mixed solution in the step a), adding deionized water at 40 ℃, and carrying out ultrasonic treatment for 15min, wherein the ultrasonic frequency is 15Hz; filtering after ultrasonic treatment to obtain the anti-aging composition.
Example 2
The embodiment provides an anti-aging composition, which comprises nano-liposome and active components loaded on the nano-liposome, wherein the anti-aging composition comprises the following components in percentage by weight: 1.1% diglucosyl gallic acid, 1.5% glucosyl hesperidin, 0.8% spilanthol extract, 0.0005% biotin, 0.0005% caffeine, 2.6% cholesterol, 1.5% behenyl alcohol, 6.5% hydrogenated lecithin, the balance being deionized water.
The preparation method of the anti-aging composition comprises the following steps:
a) Dissolving diglucosyl gallic acid, glucosyl hesperidin, spilanthol extract, biotin, caffeine, cholesterol, behenyl alcohol and hydrogenated lecithin in absolute ethanol according to a ratio to obtain a mixed solution;
b) Evaporating and removing absolute ethyl alcohol in the mixed solution in the step a), adding deionized water at 50 ℃, and carrying out ultrasonic treatment for 18min, wherein the ultrasonic frequency is 25Hz; filtering after ultrasonic treatment to obtain the anti-aging composition.
Example 3
The embodiment provides an anti-aging composition, which comprises nano-liposome and active components loaded on the nano-liposome, wherein the anti-aging composition comprises the following components in percentage by weight: 0.011% diglucosyl gallic acid, 0.01% glucosyl hesperidin, 0.01% spilanthol extract, 0.00001% biotin, 0.00001% caffeine, 0.6% cholesterol, 0.1% behenyl alcohol, 6% hydrogenated lecithin, the balance deionized water.
The preparation method of the anti-aging composition comprises the following steps:
a) Dissolving diglucosyl gallic acid, glucosyl hesperidin, spilanthol extract, biotin, caffeine, cholesterol, behenyl alcohol and hydrogenated lecithin in absolute ethanol according to a ratio to obtain a mixed solution;
b) Evaporating and removing absolute ethyl alcohol in the mixed solution in the step a), adding deionized water at 60 ℃, and carrying out ultrasonic treatment for 15-20min with the ultrasonic frequency of 15-35Hz; filtering after ultrasonic treatment to obtain the anti-aging composition.
Example 4
The embodiment provides an anti-aging composition, which comprises nano-liposome and active components loaded on the nano-liposome, wherein the anti-aging composition comprises the following components in percentage by weight: 0.011% diglucosyl gallic acid, 1.2% glucosyl hesperidin, 0.6% spilanthol extract, 0.0002% biotin, 0.000078% caffeine, 1.8% cholesterol, 0.9% behenyl alcohol, 6.2% hydrogenated lecithin, the balance deionized water.
The preparation method of the anti-aging composition comprises the following steps:
a) Dissolving diglucosyl gallic acid, glucosyl hesperidin, spilanthol extract, biotin, caffeine, cholesterol, behenyl alcohol and hydrogenated lecithin in absolute ethanol according to a ratio to obtain a mixed solution;
b) Evaporating and removing the solvent in the mixed solution in the step a), adding deionized water at 45 ℃, and carrying out ultrasonic treatment for 20min with the ultrasonic frequency of 15Hz; filtering after ultrasonic treatment to obtain the anti-aging composition.
Example 5
The embodiment provides an anti-aging composition, which comprises nano-liposome and active components loaded on the nano-liposome, wherein the anti-aging composition comprises the following components in percentage by weight: 0.43% of diglucosyl gallic acid, 1.12% of glucosyl hesperidin, 0.0447% of spilanthol extract, 0.0001% of biotin, 0.0004% of caffeine, 0.9% of cholesterol, 1.1% of behenyl alcohol, 6% of hydrogenated lecithin and the balance of deionized water.
The preparation method of the anti-aging composition comprises the following steps:
a) Dissolving diglucosyl gallic acid, glucosyl hesperidin, spilanthol extract, biotin, caffeine, cholesterol, behenyl alcohol and hydrogenated lecithin in absolute ethanol according to a ratio to obtain a mixed solution;
b) Evaporating and removing absolute ethyl alcohol in the mixed solution in the step a), adding deionized water at 55 ℃, and carrying out ultrasonic treatment for 15min, wherein the ultrasonic frequency is 35Hz; filtering after ultrasonic treatment to obtain the anti-aging composition.
Example 6
The embodiment provides an anti-wrinkle eye cream, which comprises the following components in parts by weight: 12.5 parts of the anti-aging composition prepared in example 1, 0.5 part of hydrogenated rapeseed oil, 5 parts of diisostearyl malate, 10 parts of 1, 3-propanediol, 10 parts of cocoyl-caprylate, 0.05 part of plant-based zizanol macadamia nut oleate, 0.5 part of retinol palmitate, 0.2 part of hesperidin methyl chalcone and 80 parts of deionized water.
The preparation method of the anti-wrinkle eye cream comprises the following steps:
1) Hydrogenated rapeseed oil alcohol, diisostearyl malate, retinol palmitate, cocoyl-caprylate, plant zileuton oleate (PHYTOSTERYL MACADAMIATE, available from Aoke new materials technology (Shanghai) limited) and hesperidin methyl chalcone (hesperidin methyl chalcone is a commercially available compound from a variety of sources (see International cosmetic ingredient dictionary and handbook, 12 th edition, volume 1, page 1146 (2008), incorporated herein by reference) were added. In one aspect, the ingredient may be obtained by using a SEDERMA SAS (French) mixture sold under the trade name EYELISSTM, which is a combination of water, glycerol, hesperidin methyl chalcone, steareth-20, dipeptide-2 (valyl-tryptophan) and palmitoyl tetrapeptide-7 (Pal-GQPR). ) Stirring uniformly, heating to 50 ℃, and stirring uniformly to obtain an oil phase;
2) Mixing the anti-aging composition, water and 1, 3-propylene glycol, and stirring to obtain water phase;
3) Mixing the oil phase obtained in the step 1) with the water phase obtained in the step 2), adding the obtained mixture into a reaction kettle of supercritical equipment, pumping carbon dioxide, adjusting the temperature in the reaction kettle of the supercritical equipment to 55 ℃, setting the pressure to 12Mpa, releasing the carbon dioxide after 30min, and cooling to room temperature to obtain eye cream.
Example 7
The embodiment provides an anti-wrinkle eye cream, which comprises the following components in parts by weight: 25 parts of the anti-aging composition prepared in example 1, 0.8 part of hydrogenated rapeseed oil, 10 parts of diisostearyl malate, 5 parts of 1, 3-propanediol, 3 parts of cocoyl-caprylate, 0.01 part of plant-based zizanol oleate, 0.01 part of retinol palmitate, 0.01 part of hesperidin methyl chalcone and 50 parts of deionized water.
The preparation method of the anti-wrinkle eye cream comprises the following steps:
1) Adding hydrogenated rapeseed oil alcohol, diisostearyl malic acid, retinol palmitate, cocoyl alcohol-caprylate, plant-catalpol macadamia nut oleate and hesperidin methyl chalcone, uniformly stirring, heating to 90 ℃, and uniformly stirring to obtain an oil phase;
2) Mixing the anti-aging composition, water and 1, 3-propylene glycol, and stirring to obtain water phase;
3) Mixing the oil phase obtained in the step 1) with the water phase obtained in the step 2), adding the obtained mixture into a reaction kettle of supercritical equipment, pumping carbon dioxide, adjusting the temperature in the reaction kettle of the supercritical equipment to 65 ℃, setting the pressure to 14Mpa for 30min, releasing the pressure to release the carbon dioxide, and cooling to room temperature to obtain eye cream.
Example 8
The embodiment provides an anti-wrinkle eye cream, which comprises the following components in parts by weight: 50 parts of the anti-aging composition prepared in example 1, 0.1 part of hydrogenated rapeseed oil, 5 parts of diisostearyl malate, 7 parts of 1, 3-propanediol, 12 parts of cocoyl-caprylate, 0.1 part of plant-based zizanol oleate, 2 parts of retinol palmitate, 0.5 part of hesperidin methyl chalcone and 75 parts of deionized water.
The preparation method of the anti-wrinkle eye cream comprises the following steps:
1) Adding hydrogenated rapeseed oil alcohol, diisostearyl malic acid, retinol palmitate, cocoyl alcohol-caprylate, plant-catalpol macadamia nut oleate and hesperidin methyl chalcone, uniformly stirring, heating to 80 ℃, and uniformly stirring to obtain an oil phase;
2) Mixing the anti-aging composition, water and 1, 3-propylene glycol, and stirring to obtain water phase;
3) Mixing the oil phase obtained in the step 1) with the water phase obtained in the step 2), adding the obtained mixture into a reaction kettle of supercritical equipment, pumping carbon dioxide, adjusting the temperature in the reaction kettle of the supercritical equipment to 45 ℃, setting the pressure to 15Mpa, performing pressure release to release carbon dioxide for 40min, and cooling to room temperature to obtain eye cream.
Example 9
The embodiment provides an anti-wrinkle eye cream, which comprises the following components in parts by weight: 100 parts of the anti-aging composition prepared in example 1, 0.1 part of hydrogenated rapeseed oil, 5 parts of diisostearyl malate, 7 parts of 1, 3-propanediol, 12 parts of cocoyl-caprylate, 0.1 part of plant-based zizanol oleate, 2 parts of retinol palmitate, 0.5 part of hesperidin methyl chalcone and 75 parts of deionized water.
The preparation method of the anti-wrinkle eye cream comprises the following steps:
1) Adding hydrogenated rapeseed oil alcohol, diisostearyl malic acid, retinol palmitate, cocoyl alcohol-caprylate, plant-catalpol macadamia nut oleate and hesperidin methyl chalcone, uniformly stirring, heating to 80 ℃, and uniformly stirring to obtain an oil phase;
2) Mixing the anti-aging composition, water and 1, 3-propylene glycol, and stirring to obtain water phase;
3) Mixing the oil phase obtained in the step 1) with the water phase obtained in the step 2), adding the obtained mixture into a reaction kettle of supercritical equipment, pumping carbon dioxide, adjusting the temperature in the reaction kettle of the supercritical equipment to 45 ℃, setting the pressure to 15Mpa, performing pressure release to release carbon dioxide for 40min, and cooling to room temperature to obtain eye cream.
The anti-aging composition prepared in example 1 was subjected to a cell proliferation promoting effect test and a collagen production effect test.
Blank, no anti-aging composition was added.
The cells used were normal human skin fibroblasts.
The test method of the cell proliferation promoting effect comprises the following steps:
1) The proliferated cells were dispersed in Dulbecco's MEM medium containing FBS and inoculated in 96-well plates. The cells were then cultured in a CO 2 incubator (37 ℃ C.).
2) The next day after sowing, the medium was replaced with Dulbecco's MEM medium containing FBS and a blank group of Dulbecco's MEM medium containing FBS to which the anti-aging composition prepared in example 1 was added (12.5%, 25%,50%,100% by mass, respectively), followed by culturing in a CO 2 incubator.
3) On the last day of incubation, the medium in the dish was discarded and MTT solution was prepared in Dulbecco's MEM with FBS, added and incubated in a CO 2 incubator. Thereafter, dissolved in the extract and microparticles, absorbance was measured with a rate reader and used as a value representing the number of cells. The measurement results were control, converted to 100, and the results of the significant difference test by Student's test were shown in FIG. 1, as required.
Referring to fig. 1, the increase of human skin fibroblasts is significantly promoted at the contents of 25% and 50%. But there was no significant difference between the contents of 12.5% and 100%.
The test method for promoting collagen production comprises the following steps:
1) The proliferated cells were dispersed in Dulbecco's MEM medium containing FBS and inoculated in 96-well culture plates. The cells were then cultured in a CO 2 incubator (37 ℃ C.).
2) The next day after sowing, the medium was replaced with Dulbecco's MEM medium containing FBS to which the anti-aging composition prepared in example 1 was added (12.5%, 25%,50% by mass, respectively) and a blank group were added, followed by culturing in a CO 2 incubator.
3) Thereafter, the supernatant was collected and the amount of type I collagen was measured by ELISA. The amount of type I collagen per unit protein after collecting the supernatant was calculated by lysing the cells, and the results were calculated and evaluated as shown in FIG. 2.
Referring to FIG. 2, eye creams containing anti-aging compositions were added to the medium, and the amount of type I collagen per unit protein was increased in comparison to the blank, and a significant difference was observed when 25% was added.
Therefore, the anti-aging composition has the effect of promoting proliferation of normal human skin fibroblasts, and has the effect of promoting collagen production, and the type I collagen has obvious relation with the elasticity and strength of skin, so that the anti-aging composition is added into a product for use, and has the effects of improving the elastic elasticity of skin and improving wrinkles.
While the invention has been described with respect to preferred embodiments thereof, it will be understood by those skilled in the art that various modifications and additions may be made without departing from the scope of the invention. Equivalent embodiments of the present invention will be apparent to those skilled in the art having the benefit of the teachings disclosed herein, when considered in the light of the foregoing disclosure, and without departing from the spirit and scope of the invention; meanwhile, any equivalent changes, modifications and evolution of the above embodiments according to the essential technology of the present invention still fall within the scope of the technical solution of the present invention.
Claims (5)
1. An anti-aging composition comprising nanoliposomes and an active ingredient loaded on the nanoliposomes, the active ingredient comprising: diglucosyl gallic acid, glucosyl hesperidin, spilanthol extract, biotin and caffeine; the anti-aging composition comprises the following components in percentage by weight: 0.011% of diglucosyl gallic acid, 0.5% of glucosyl hesperidin, 0.0447% of spilanthol extract, 0.0001% of biotin, 0.0001% of caffeine, 0.6% -2.6% of cholesterol, 0.1% -1.5% of behenyl alcohol, 6% -6.5% of hydrogenated lecithin and the balance of deionized water;
The preparation method of the anti-aging composition comprises the following steps:
a) Dissolving the active component and the nano liposome to obtain a mixed solution;
b) Evaporating and removing the solvent in the mixed solution in the step a), adding deionized water at 40-60 ℃, and carrying out ultrasonic treatment for 15-20min with the ultrasonic frequency of 15-35Hz; filtering after ultrasonic treatment to obtain an anti-aging composition; the particle size of the nano liposome is 100-250nm.
2. Use of an anti-aging composition according to claim 1, for the preparation of a cosmetic product comprising a emollient water, a mask, an essence, an eye cream, an eye mask, a skin care gel, a skin care emulsion, a cream or a spray.
3. The use of an anti-aging composition according to claim 2, wherein the cosmetic further comprises an auxiliary material comprising at least one of a solvent, a thickener, a preservative, a pH adjuster, a humectant, a emollient, a chelating agent, an emulsifier, an essential oil, a fragrance, a pigment.
4. Use of an anti-aging composition according to claim 3, wherein the cosmetic product is an eye cream comprising, in parts by weight: 12.5-100 parts of an anti-aging composition, 0.1-0.8 part of hydrogenated rapeseed oil alcohol, 5-10 parts of diisostearyl malic acid, 5-10 parts of 1, 3-propanediol, 3-12 parts of cocoyl-caprylate, 0.01-0.1 part of plant zipranol macadamia nut oleate, 0.01-2 parts of retinol palmitate, 0.01-0.5 part of hesperidin methyl chalcone and 50-80 parts of deionized water.
5. The use of an anti-aging composition according to claim 4, wherein the method of preparing the eye cream comprises the steps of:
1) Adding hydrogenated rapeseed oil alcohol, diisostearyl malic acid, retinol palmitate, cocoyl alcohol-caprylate, plant-catalpol macadamia nut oleate and hesperidin methyl chalcone, stirring uniformly, heating to 50-90 ℃, and stirring uniformly to obtain an oil phase;
2) Mixing the anti-aging composition, water and 1, 3-propylene glycol, and stirring to obtain water phase;
3) Mixing the oil phase obtained in the step 1) with the water phase obtained in the step 2), adding the obtained mixture into a reaction kettle of supercritical equipment, pumping carbon dioxide, adjusting the temperature in the reaction kettle of the supercritical equipment to 45-65 ℃, setting the pressure to 12-15Mpa, performing pressure release for 30-45min, releasing carbon dioxide, and cooling to room temperature to obtain eye cream.
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| JP2022079212A JP7357400B1 (en) | 2022-04-18 | 2022-05-13 | Anti-aging composition, manufacturing method and application |
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| CN114632045A (en) | 2022-06-17 |
| JP7357400B1 (en) | 2023-10-06 |
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Denomination of invention: An anti-aging composition, preparation method, and application Granted publication date: 20240531 Pledgee: Hangzhou Bank Co.,Ltd. Zhejiang Free Trade Zone Hangzhou Jiangnan Branch Pledgor: Coq Biotechnology (Hangzhou) Co.,Ltd. Registration number: Y2024330001933 |