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CN101918074B - 药物混合及注射装置和药物混合方法 - Google Patents

药物混合及注射装置和药物混合方法 Download PDF

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CN101918074B
CN101918074B CN2008801082849A CN200880108284A CN101918074B CN 101918074 B CN101918074 B CN 101918074B CN 2008801082849 A CN2008801082849 A CN 2008801082849A CN 200880108284 A CN200880108284 A CN 200880108284A CN 101918074 B CN101918074 B CN 101918074B
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伊戈·德恩布鲁格
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Abstract

一种混合及注射装置，包括一针头和一针头座、一注射器连接部件和一混合腔连接组装件，所述混合腔连接组装件包括一包围所述针头的针头腔和一第一液体导管部分，从所述针头腔起密封，所述混合腔连接组装件还包括一混合腔连接部分，所述混合腔连接部分包括一与所述第一液体导管部分连通的第二液体导管部分，所述混合腔连接部分被设置成与一混合腔连通，所述注射器连接部件和所述针头座被设置成在当所述注射器连接部件和所述针头座位于所述第一相对连接方位时允许在所述注射器的内部和所述第一液体导管部分之间进行流体连接，以及在当所述注射器连接部件和所述针头座位于所述第二相对连接方位，沿着所述注射轴从所述第一相对方位轴向分离时，用于允许在所述注射器的内部和所述针头之间流体连接。

Description

药物混合及注射装置和药物混合方法
对相关申请的参考引用 
特此引用于2007年9月18日提交的申请号为60/973,180的发明名称为“液体控制装置”的美国临时专利申请，该临时申请的公开内容被引用并结合到本申请中，并且本申请特此根据CFR的37条的1.78a(4)和(5)(i)要求该临时申请的巴黎公约优先权。 
发明领域
本发明一般地涉及液体药物注射装置。 
发明背景 
以下专利文件被认为是代表了本领域技术现状：US5,584,819；US5,746,733；US5,755,696；US5,820,621；US5,827,262；US5,832,971；US5,887,633；US5,919,182；US6,238,372；US6,280,430；US6,524,278；US6,729,370；US2007/0088313；US2007/0167904；US2007/0270778和US2008/0009789。 
发明概述 
本发明旨在提供一种改进的药物混合及注射装置。 
因此，根据本发明的一优选实施例，所提供的药物混合及注射装置包括一注射针头组件、一注射器连接部件和一药物混合腔连接组件，所述注射针头组件包括一沿着一注射轴(injection axis)延伸的针头和一固定所述针头的针头座；所述注射器连接部件在位于沿所述注射轴相互轴向分离的至少第一和第二相对连接方位(engagement orientations)被设置在其第一轴向末端去容纳一无针头注射器以及在其第二轴向末端来连接所述针头座，所述药物混合腔连接组件包括一具有一手动连接部分(hand-engageable portion)的中间部分，所述中间部件包括一包围所述针头的针头腔和一第一液体导管部分，所述中间部件包括一围绕该针头的针头腔室，一从所述针头腔起密封的第一液体导管部分以及所述药物混合腔连接组件还包括一药物混合腔连接部分，所述药物混合腔连接部分包括一与所述第一液体导管部分 连通的第二液体导管部分，且所述药物混合腔连接部分被设置成与一药物混合腔连通，所述注射器连接部件和所述针头座被设置成用于在当所述注射器连接部件和所述针头座位于所述第一相对连接方位时允许在所述无针头注射器的内部和所述第一液体导管部分之间进行流体连接，以及在当所述注射器连接部件和所述针头座位于所述第二相对连接方位，并被沿着所述注射轴从所述第一相对方位轴向分离时，允许在所述无针头注射器的内部和所述针头之间流体连接。 
根据本发明的一优选实施例，药物混合及注射装置操作所述手动连接部分使得所述针头座和所述注射器连接部分从沿着所述注射轴的所述第一相对方位向沿着所述注射轴的所述第二相对方位作相对轴向移动。 
根据本发明一优选实施例，所述中间部分和所述药物混合腔连接部分被制造成独立的部件或一个整体。 
优选地，一种药物混合及注射方法包括提供一药物混合及注射组件，所述药物混合及注射组件包括一沿着一注射轴延伸的针头和一固定所述针头的针头座、一注射器连接部件和一药物混合腔连接组件，所述注射器附件并位于相互地沿着所述注射轴轴向分离的至少第一和第二相对连接方位(engagement orientations)被设置成在其第一轴向末端容纳一无针头注射器和在其第二轴向末端连接所述针头座，将一药物混合腔与所述药物混合腔连接组装件连接，将一注射器连接到所述注射器连接部件，当所述注射器连接部件和所述针头座位于所述第一相对连接方位时混合所述药物混合腔内的药物并抽吸混合的药物进入所述注射器，提供所述针头座和所述注射器连接部件沿着所述注射轴的相对轴向移动，以使得所述注射器连接部件和所述针头座位于所述第二相对连接方位，将所述药物混合腔连接组件从所述注射器连接部件脱离，并从所述注射器通过所述针头注射所述混合药物。 
根据本发明的一优选实施例，所述药物混合腔连接组件包括一包围所述针头的针头腔和一液体导管部分，从所述针头腔起密封，且所述注射器连接部件和所述针头座被配置成用于在当所述注射器连接部件和所述针头座位于所述第一相对连接方位时允许在所述无针头注射器内部和所述第一液体导管部分之间进行流体连接，以及在当所述注射器连接部件和所述针头座位于所述第二相对连接方位，沿着所述注射轴从所述第一相对方位轴向分离时允许在所述无针头注射器内部和所述针头之间进行流体连接。 
根据本发明的一优选实施例，所述药物混合腔连接组件包括一手动连接部分，所述手动连接部分可选择地使所述针头座和所述注射器连接部分从沿着所述注射轴的所述第一相对方 位向沿着所述注射轴的所述第二相对方位作相对轴向移动。 
附图简要说明 
将从以下详细的描述说明来了解并更全面地理解本发明： 
图1和2为根据本发明的一优选实施例构成的和使用中(operative)的药物混合及注射装置的简化透视组装图和简化透视分解图； 
图3A、3B和3C为图1和2中所示装置的注射器连接部件的简化示意图； 
图4A和4B为图3B和3C中沿IVA-IVA线和IVB-IVB线的剖面示意图； 
图5A、5B和5C为图1和2中所示装置的针头座的简化示意图； 
图6A和6B为图5B和5C中沿VIA-VIA线和VIB-VIB线的剖面示意图； 
图7A、7B、7C、7D、7E和7F为图1和2中所示装置的一药物混合腔连接组装件的第一部分的简化示意图； 
图8A和8B为图7C和7D中沿VIIIA-VIIIA线和VIIIB-VIIIB线的剖面示意图； 
图9A、9B和9C为图1和2中所示装置的一药物混合腔连接组装件的第二部分的简化示意图； 
图10A和10B为图9B和9C中沿XA-XA线和XB-XB线的剖面示意图； 
图11A、11B、11C、11D、11E、11F、11G和11H为图1至10B中所示装置的操作状态的各个阶段的简化侧视图； 
图12A为图11A-11E所示的注射器连接部件、针头座和药物混合腔连接组装件的相对方位的剖面示意图； 
图12B为图11F所示的注射器连接部件、针头座和药物混合腔连接组装件的相对方位的剖面示意图； 
图12C为图11G所示的注射器连接部件、针头座和药物混合腔连接组装件的相对方位的剖面示意图； 
图12D为图11H所示注射器连接部件和所述针头的相对方位的剖面示意图、 
发明详述 
现在参照图1-11H，其显示了根据本发明的一优选实施例的构成的和操作的药物混合及注射装置的结构和操作图。 
图1和2显示了根据本发明的一优选实施例的构成的和使用中的药物混合及注射装置的简化透视组装图和简化透视分解图。如图1和2所示，所述药物混合及注射装置优选地包括一注射器连接部件100和一注射针头组件(injection needle assembly)102，所述注射针头组件102包括一沿着一注射轴106延伸的针头104和一通常通过粘合剂固定所述针头的针头座108。 
根据本发明的一优选实施例，所述注射器连接部件100被设置成：位于沿着所述注射轴106相互地轴向分离的至少第一和第二相对连接方位。在其第一轴向末端110容纳一无针头注射器(未图示)，并在其第二轴向末端112连接所述针头底座108。 
所述药物混合及注射装置优选地还包括一药物混合腔连接组件120，所述药物混合腔连接组件120包括一具有一手动连接部分124的第一部分122，该中间部件优选地包括一包围所述针头104的针头腔128和一第一液体导管部分126，所述药物混合腔连接组件120从所述针头腔128起密封，所述药物混合腔连接组装件120还包括药物混合腔连接部分130，所述药物混合腔连接部分130包括一与所述第一液体导管部分126连通的第二液体导管部分132，所述药物混合腔连接部分130被设置成用于与一药物混合腔(未图示)连通，所述药物混合腔可以是例如一小瓶或安瓿并可选择地为任意其它适合的药物混合腔。 
在所述用图说明的实施例中，部分122和130显示为独立的元件，可以理解的是，备选地，它们可被制作成一整体部件。 
根据本发明的一优选实施例，所述注射器连接部件100和所述针头座108被设置成在当所述注射器连接部件100和所述针头座108位于所述第一相对连接方位时允许在所述无针头注射器(未图示)的内部和所述第一液体导管部分122之间进行流体连接，以及在当所述注射器连接部件100和所述针头座108位于所述第二相对连接方位，沿着所述注射轴从所述第一相对方位轴向分离时，允许在所述无针头注射器(未图示)的内部和所述针头104之间进行流体连接，。 
优选地，当所述注射器连接部件100和所述针头座108位于所述第一相对连接方位时，所述无针头注射器(未图示)内部的液体被阻止流到所述针头104，以及当所述注射器连接部件100和所述针头座108位于所述第二相对连接方位，被沿着所述注射轴从所述第一相对方位轴向分离时，所述无针头注射器(未图示)的内部的液体被阻止流到所述第一液体导管部分122。 
图3、3A、3B、4A和4B，显示了注射器连接部件100的一优选实施例。如图3-4B所 示，所述注射器连接部件100是一通常的圆筒状部件，在末端110形成一螺旋栓(Luer lock)，以及在末端110具有一外螺纹150，和一在末端110开口的一般圆锥形的内部管道152(internal passageway)。 
在所述注射器连接部件100的末端112具有第一和第二，通常轴向延伸的，连接片154和156。片154具有一面向内部末端部分158(inwardly facing end portion)，所述面向内部末端部分158具有一通常截短的圆锥形横截面并具有一保持肩形凸出部表面160(retaining shoulder surface)。片156具有一面向内部末端部分162，所述面向内部末端部分162具有一通常截短的圆锥形横截面并具有一保持肩形凸出部表面164。 
管道152的末端具有一分隔壁170，所述分隔壁170具有一一般在中央的孔172和一侧孔174。一般中央孔172局部限定成一带有一通常截短的圆锥形外壁表面176的轴向部分。环绕壁表面176并延伸至末端112是由一一圆筒状壁180表面形成的凹槽178。 
图5、5A、5B、6A和6B显示了针头座108的一优选实施例。如图5-6B所示，所述针头座108优选为一整体部件，通常采用注塑成型，其包括一中心圆筒状部分200，它设有一轴向针头固定孔202，以便沿着注射轴106容纳和固定针头104(未图示)，与一流体连通孔204相连通。 
围绕中心圆筒状部分200的部件是一中间圆筒状部分206，在所述中间圆筒状部分206内具有一环形凹槽208，所述环形凹槽208在边缘连接一壁212的通常是圆锥形壁表面210，壁212的外表面构成了中间圆筒状部分206的外表面圆筒状壁表面214的一部分。圆筒状部分206被配置成一定尺寸和一定形状以便在所述注射器连接部件100和所述针头座108位于所述第二相对连接方位时轴向滑动连接凹槽178。在该方位上，轴向延伸到中间圆筒状部分206以外的中心圆筒状部分200的部分滑动地密封连接所述注射器连接部件的通常的孔172。 
液体导管216从凹槽208起延伸，通常与所述注射轴106平行，并穿过所述中间圆筒状部分206的部分及穿过一座部分222，所述轴向针头固定孔202也延伸穿过所述座部分222。座部分222具有一通常平面肩形凸出部表面224(planar shoulder surface)和一相对的通常平面表面226以及圆锥形边缘表面228和230。 
平行于注射轴106并从通常平面表面226起延伸典型地构成第一和第二并接的圆筒232和234。圆筒232优选以所述注射轴106为中心，且轴向针头固定孔202延伸穿过所述圆筒232。圆筒234具有一通常圆筒状凹槽236，所述通常圆筒状凹槽236与所述液体导管216相连通。 
图7A、7B、7C、7D、7E、7F、8A和8B显示了第一部分122的一优选实施例。所述第一部分122优选为一通常圆筒状部件，优选地包括一第一通常是圆形的圆筒状部分240，它设置成可拆卸的连接所述注射器连接部件100，和一第二通常圆形的圆筒状部分242，所述通常圆形的圆筒状部分242具有一面向外部的圆锥形凸缘243(externally facing conical flange)以便固定所述药物混合腔连接部分130。中间部分240和242是一手动连接部分244，所述手动连接部分244具有被通常平坦壁部分254和256分离的通常相对的表面弯曲的侧壁部分250和252。 
手动连接部分244优选地包括一手动连接手柄260，所述手动连接手柄260可摆动连接通常平坦壁部分254，所述手动连接部分244还包括一可选择定位的保持边262。一般相对手动连接手柄260布置并延伸到通常平坦壁部分256的部分的上面的是一面向内部固定突起部264。 
在手动连接部分244的内部，优选地设置有一壁270，与所述注射轴106平行并延伸，所述壁270末端连接一垂直所述注射轴106延伸的壁272。壁270和272优选地使第一液体导管部分126和针头腔128分开，所述针头腔128被壁270和272与其分隔开。 
图9、9A、9B、10A和10B显示了所述第二部分130的一优选实施例。如图9-10B所示，第二部分130包括一与所述第一液体导管部分126连通的第二液体导管部分132，所述第二部分130被设置成用于与一药物混合腔(未图示)连接，所述药物混合腔可以是例如一小瓶或安瓿，并可选择地为任意其它适合的药物混合腔。 
可以看出第二部分130包括一第一通常圆形的圆筒状部分280和一第二通常圆形的圆筒状部分282，所述第一通常圆形的圆筒状部分280优选地具有一对用于固定所述第一部分122的相对布置的窗口284和286，所述第二通常圆形的圆筒状部分282优选地具有一对相对布置的窗口288和290，和一用于连接一药物混合腔(未图示)的面向内部固定突起部292和294，所述第一通常圆形的圆筒状部分280和一第二通常圆形的圆筒状部分282被一中心具有一空心锥296的分隔壁295分开。使用时，锥296刺穿药物混合腔的弹性密封装置(未图示)，从而使在所述药物混合腔(未图示)与所述注射器内部(未图示)之间通过在锥296前端形成的孔298能够进行流体连通。 
图11A、11B、11C、11D、11E、11F、11G和11H为简化侧视图说明，显示了图1-10B中所示装置的操作状态的各个阶段。图11A显示了将无针头注射器310与注射器连接部件100连接，并将小瓶320插入第二部分130。图11B显示无针头注射器310完全连接注射器 连接部件100和小瓶320完全插入到第二部分130，可以理解的是在小瓶320完全插入到第二部分130后将小瓶320从第二部分130上去掉是非常困难或不可能的。 
图11C显示了来自注射器310的液体被吸入小瓶320。这是由操作者进行操作，将带有已连接的注射器310和小瓶320的如图1所示的装置保持在如图所示的通常垂直的方向，推动所述注射器推杆312。 
图11D显示小瓶320内的已混合的药物和带有已连接的注射器310和小瓶320的如图1所示的装置被转到相反的位置，如图所示。 
图11E显示来自小瓶320的液体被吸入注射器310。这是由操作者进行操作，将带有已连接的注射器310和小瓶320的如图1所示的装置保持在如图所示的通常垂直的方向，拉动所述注射器推杆312。 
图11F显示向内压迫手动连接手柄260。 
图11G显示了通过推动包含小瓶320的所述药物混合腔连接组件120，使注射针头组件102和注射器连接部件100相对轴向移动。 
图11H显示了从图1所示装置上移去包含小瓶320的所述药物混合腔连接组件120。 
图12A、12B、12C和12D是图11A-11H所示的注射器连接部件100、针头座108和药物混合腔连接组件120的剖面示意图。 
图12A是图11A-11E所示的所述注射器连接部件100、所述针头座108和药物混合腔连接组件120的第一相对连接方位的剖面示意图，所述注射器连接部件100、所述针头座108和药物混合腔连接组装件120被配设置成用以允许在所述无针头注射器(未图示)的内部和所述药物混合腔(未图示)之间进行流体连通，所述流体连通经过管道152、侧孔174和所述注射器连接部件100的凹槽178、凹槽208和所述针头座108的液体导管216、第一部分122的第一液体导管部分126和第二部分130的带有孔298的空心锥296。可以看出，手动连接手柄260阻止提供从第一相对连接方位向第二相对连接方位的相对轴向移动，并且面向内部固定突起部264顶着肩形凸出部表面224，防止药物混合腔连接组装件120从针头座108上移去。 
图12B是图11F所示的所述注射器连接部件100、所述针头座108和药物混合腔连接组装件120的第一相对连接方位的剖面示意图，可以看出手动连接手柄260允许通过向内压迫手动连接手柄260而提供从第一相对连接方位向第二相对连接方位的相对轴向移动。 
图12C是图11G所示的所述注射器连接部件100、所述针头座108和药物混合腔连接 组装件120的第二相对连接方位的剖面示意图。所述注射器连接部件100、所述针头座108和药物混合腔连接组装件120被设置成用以允许所述无针头注射器内部(未图示)和针头104之间进行流体连接，所述流体连接通过所述注射器连接部件100的管道152、流体连通孔204和所述针头座108的轴向针头固定孔202。可以看出，中间圆筒状部分206插入到凹槽178用于防止所述无针头注射器内部(未图示)和所述药物混合腔(未图示)之间进行流体连接，并且突起部264允许通过从肩形凸出部表面224向外压迫突起部264将药物混合腔连接组装件120从针头座108上除去。 
图12D为当图1所示装置处于准备用于注射的状态时，图11H所示的所述注射器连接部件100和针头座108的相对方位的剖面示意图。 

Claims (7)

1.药物混合及注射装置，包括：
一注射针头组件，所述注射针头组件包括一沿着一注射轴延伸的针头和一固定所述针头的针头座；
一注射器连接部件，所述注射器连接部件设置成：位于沿着所述注射轴相互地轴向分离的至少第一和第二相对连接方位，在注射器连接部件的第一轴向末端容纳一无针头注射器，并在注射器连接部件的第二轴向末端连接所述针头座；以及
一药物混合腔连接组件，所述药物混合腔连接组件包括：
一具有一手动连接部分的中间部分，所述中间部分有一包围所述针头的针头腔和一第一液体导管部分，第一液体导管部分从所述针头腔起密封；和
一药物混合腔连接部分，所述药物混合腔连接部分包括一与所述第一液体导管部分连通的第二液体导管部分，所述药物混合腔连接部分被设置成用于与一药物混合腔连通；
所述注射器连接部件和所述针头座被设置成用于在当所述注射器连接部件和所述针头座位于所述第一相对连接方位时允许在所述无针头注射器的内部和所述第一液体导管部分之间进行流体连接，以及在当所述注射器连接部件和所述针头座位于所述第二相对连接方位，沿着所述注射轴从所述第一相对连接方位轴向分离时，用于允许在所述无针头注射器的内部和所述针头之间流体连接。
2.根据权利要求1所述的药物混合及注射装置，其中操作所述手动连接部分使得所述针头座和所述注射器连接部件从沿着所述注射轴的所述第一相对连接方位向沿着所述注射轴的所述第二相对连接方位作相对轴向移动。
3.根据权利要求1或2任一项所述的药物混合及注射装置，其中所述中间部分和所述药物混合腔连接部分被制造成独立的部件。
4.根据权利要求1或2任一项所述的药物混合及注射装置，其中所述药物混合腔连接组件被制造成一整体部件。
5.一种药物混合方法，包括：
提供一药物混合及注射组件，所述药物混合及注射组件包括一沿着一注射轴延伸的针头和一固定所述针头的针头座、一注射器连接部件和一药物混合腔连接组件，所述注射器连接部件被设置成：位于相互地沿着所述注射轴轴向分离的至少第一和第二相对连接方位，在注射器连接部件的第一轴向末端能够容纳一无针头注射器，和在注射器连接部件的第二轴向末端连接所述针头座；
将一药物混合腔与所述药物混合腔连接组件连接；
将一无针头注射器连接到所述注射器连接部件；
当所述注射器连接部件和所述针头座位于所述第一相对连接方位时混合所述药物混合腔内的药物并抽吸混合的药物进入所述无针头注射器；
提供所述针头座和所述注射器连接部件沿着所述注射轴的相对轴向移动，以使得所述注射器连接部件和所述针头座位于所述第二相对连接方位；
将所述药物混合腔连接组件从所述注射器连接部件脱离。
6.根据权利要求5所述的一种药物混合方法，其中，所述药物混合腔连接组件包括一包围所述针头的针头腔和一液体导管部分，从所述针头腔起密封，且所述注射器连接部件和所述针头座被设置成在当所述注射器连接部件和所述针头座位于所述第一相对连接方位时允许在所述无针头注射器内部和所述第一液体导管部分之间进行流体连接，以及在当所述注射器连接部件和所述针头座位于所述第二相对连接方位，沿着所述注射轴从所述第一相对连接方位轴向分离时，允许在所述无针头注射器内部和所述针头之间进行流体连接。
7.根据权利要求5或6任一项所述的一种药物混合方法，其中，所述药物混合腔连接组件包括一手动连接部分，所述手动连接部分可选择地使所述针头座和所述注射器连接部件从所述沿着所述注射轴的第一相对连接方位向沿着所述注射轴的所述第二相对连接方位作相对轴向移动。
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Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3108911A1 (en) * 2003-10-30 2016-12-28 Teva Medical Ltd. Safety drug handling device
IL161660A0 (en) 2004-04-29 2004-09-27 Medimop Medical Projects Ltd Liquid drug delivery device
ES2371557T3 (es) 2005-08-11 2012-01-05 Medimop Medical Projects Ltd. Dispositivos de transferencia de fármacos líquidos para un correcto ajuste a presión a prueba de fallos en viales medicinales.
IL182605A0 (en) 2007-04-17 2007-07-24 Medimop Medical Projects Ltd Fluid control device with manually depressed actuator
WO2009038860A2 (en) 2007-09-18 2009-03-26 Medeq Llc Medicament mixing and injection apparatus
IL186290A0 (en) 2007-09-25 2008-01-20 Medimop Medical Projects Ltd Liquid drug delivery devices for use with syringe having widened distal tip
USD712536S1 (en) * 2008-07-25 2014-09-02 Continental Plastic Corp. Biological fluid container
USD641080S1 (en) 2009-03-31 2011-07-05 Medimop Medical Projects Ltd. Medical device having syringe port with locking mechanism
IL201323A0 (en) 2009-10-01 2010-05-31 Medimop Medical Projects Ltd Fluid transfer device for assembling a vial with pre-attached female connector
IL202069A0 (en) 2009-11-12 2010-06-16 Medimop Medical Projects Ltd Fluid transfer device with sealing arrangement
IL202070A0 (en) * 2009-11-12 2010-06-16 Medimop Medical Projects Ltd Inline liquid drug medical device
US8684994B2 (en) 2010-02-24 2014-04-01 Medimop Medical Projects Ltd. Fluid transfer assembly with venting arrangement
JP5709905B2 (ja) 2010-02-24 2015-04-30 メディモップ・メディカル・プロジェクツ・リミテッド ベント付きバイアルアダプタを含む液剤移送デバイス
USD669980S1 (en) 2010-10-15 2012-10-30 Medimop Medical Projects Ltd. Vented vial adapter
IL209102A0 (en) 2010-11-04 2011-01-31 Medimop Medical Projects Ltd Inline liquid drug medical device with handle operated flow control member
IL209290A0 (en) * 2010-11-14 2011-01-31 Medimop Medical Projects Ltd Inline liquid drug medical device having rotary flow control member
US9387150B2 (en) 2011-03-18 2016-07-12 Terumo Kabushiki Kaisha Integrated puncture needle adapter
IL212420A0 (en) 2011-04-17 2011-06-30 Medimop Medical Projects Ltd Liquid drug transfer assembly
FR2975896B1 (fr) * 2011-06-06 2014-06-06 Biocorp Rech Et Dev Dispositif de connexion entre un recipient et un contenant, procede d'assemblage et d'utilisation d'un tel dispositif
US9220660B2 (en) 2011-07-15 2015-12-29 Antares Pharma, Inc. Liquid-transfer adapter beveled spike
AU2012324002C1 (en) * 2011-07-15 2016-03-24 Antares Pharma, Inc. Liquid-transfer adapter beveled spike
IL215699A0 (en) 2011-10-11 2011-12-29 Medimop Medical Projects Ltd Liquid drug reconstitution assemblage for use with iv bag and drug vial
USD720451S1 (en) 2012-02-13 2014-12-30 Medimop Medical Projects Ltd. Liquid drug transfer assembly
USD737436S1 (en) 2012-02-13 2015-08-25 Medimop Medical Projects Ltd. Liquid drug reconstitution assembly
USD674088S1 (en) 2012-02-13 2013-01-08 Medimop Medical Projects Ltd. Vial adapter
IL219065A0 (en) 2012-04-05 2012-07-31 Medimop Medical Projects Ltd Fluid transfer device with manual operated cartridge release arrangement
JP2015521949A (ja) 2012-07-12 2015-08-03 アンタレス・ファーマ・インコーポレーテッド 液体移送アダプタの面取りしたスパイク
US10799423B2 (en) 2012-07-12 2020-10-13 Ferring International Center S.A. Liquid-transfer adapter beveled spike
IL221634A0 (en) 2012-08-26 2012-12-31 Medimop Medical Projects Ltd Universal drug vial adapter
IL221635A0 (en) 2012-08-26 2012-12-31 Medimop Medical Projects Ltd Drug vial mixing and transfer device for use with iv bag and drug vial
WO2014041529A1 (en) 2012-09-13 2014-03-20 Medimop Medical Projects Ltd Telescopic female drug vial adapter
US20150217058A1 (en) 2012-09-24 2015-08-06 Enable Injections, Llc Medical vial and injector assemblies and methods of use
EP2735300A1 (en) 2012-11-26 2014-05-28 Becton Dickinson France Adaptor for multidose medical container
USD734868S1 (en) 2012-11-27 2015-07-21 Medimop Medical Projects Ltd. Drug vial adapter with downwardly depending stopper
CA2892679A1 (en) 2012-12-17 2014-06-26 Unitract Syringe Pty Ltd Vial adapters
US20140257204A1 (en) * 2013-03-05 2014-09-11 Stuart Robert Lessin Apparatus for reconstituting and dispensing drugs for topical application
US10022301B2 (en) 2013-03-15 2018-07-17 Becton Dickinson and Company Ltd. Connection system for medical device components
US9414990B2 (en) 2013-03-15 2016-08-16 Becton Dickinson and Company Ltd. Seal system for cannula
IL225734A0 (en) 2013-04-14 2013-09-30 Medimop Medical Projects Ltd A ready-to-use medicine vial device including a medicine vial closure, and a medicine vial closure for it
WO2014181328A1 (en) 2013-05-10 2014-11-13 Medimop Medical Projects Ltd Medical devices including vial adapter with inline dry drug module
ES2728054T3 (es) 2013-06-18 2019-10-22 Enable Injections Inc Aparato de transferencia e inyección de viales
USD765837S1 (en) 2013-08-07 2016-09-06 Medimop Medical Projects Ltd. Liquid transfer device with integral vial adapter
USD767124S1 (en) 2013-08-07 2016-09-20 Medimop Medical Projects Ltd. Liquid transfer device with integral vial adapter
CN205626622U (zh) 2013-08-07 2016-10-12 麦迪麦珀医疗工程有限公司 与输液容器一起使用的液体转移装置
KR102274424B1 (ko) * 2013-09-19 2021-07-07 가부시키가이샤 유야마 세이사쿠쇼 혼주 장치, 혼주 방법
CN105792793B (zh) 2013-11-06 2020-08-14 贝克顿·迪金森有限公司 带连接器的液体密封转移系统
CA2929473C (en) 2013-11-06 2019-06-04 Becton Dickinson and Company Limited Medical connector having locking engagement
JP6438022B2 (ja) 2013-11-06 2018-12-12 ベクトン ディキンソン アンド カンパニー リミテッド ロッキング部材を含む、流体の密閉された移送のためのシステム
CA2929478C (en) 2013-11-06 2019-07-02 Becton Dickinson and Company Limited Connection apparatus for a medical device
WO2015161047A1 (en) 2014-04-16 2015-10-22 Becton Dickinson and Company Limited Fluid transfer device with axially and rotationally movable portion
ES2948711T3 (es) 2014-04-21 2023-09-18 Becton Dickinson & Co Ltd Adaptador de jeringuilla con movimiento combinado de desacoplamiento
JP6449910B2 (ja) 2014-04-21 2019-01-09 ベクトン ディキンソン アンド カンパニー リミテッド 流体移送デバイスおよびそのパッケージング
EP3398583A1 (en) 2014-04-21 2018-11-07 Becton Dickinson and Company Limited System with adapter for closed transfer of fluids
CA2946549C (en) 2014-04-21 2019-11-12 Becton Dickinson and Company Limited System for closed transfer of fluids
ES2808904T3 (es) 2014-04-21 2021-03-02 Becton Dickinson & Co Ltd Sistema para transferencia cerrada de fluidos y dispositivos de membrana para su uso del mismo
CN106659635B (zh) 2014-04-21 2019-08-13 贝克顿迪金森有限公司 带有可连接的瓶适配器的瓶稳定器基部
ES2925687T3 (es) 2014-04-21 2022-10-19 Becton Dickinson & Co Ltd Adaptador de jeringa con mecanismo de retroalimentación de desconexión
CN106456442B (zh) 2014-04-21 2020-06-12 贝克顿迪金森有限公司 流体传送装置和用于该装置的包装件
USD757933S1 (en) 2014-09-11 2016-05-31 Medimop Medical Projects Ltd. Dual vial adapter assemblage
EP3217944B1 (en) 2015-01-05 2019-04-10 West Pharma. Services IL, Ltd Dual vial adapter assemblages with quick release drug vial adapter for ensuring correct usage
US20180099093A1 (en) * 2015-04-03 2018-04-12 Adrenacard, Inc. Compartmentalized auto-injection system
US10130776B2 (en) * 2015-04-09 2018-11-20 James P. Wire Protective support for needles
US10357429B2 (en) 2015-07-16 2019-07-23 West Pharma. Services IL, Ltd. Liquid drug transfer devices for secure telescopic snap fit on injection vials
US9572555B1 (en) * 2015-09-24 2017-02-21 Ethicon, Inc. Spray or drip tips having multiple outlet channels
USD801522S1 (en) 2015-11-09 2017-10-31 Medimop Medical Projects Ltd. Fluid transfer assembly
US10278897B2 (en) 2015-11-25 2019-05-07 West Pharma. Services IL, Ltd. Dual vial adapter assemblage including drug vial adapter with self-sealing access valve
US10022531B2 (en) 2016-01-21 2018-07-17 Teva Medical Ltd. Luer lock adaptor
IL245803A0 (en) 2016-05-24 2016-08-31 West Pharma Services Il Ltd Devices with two vial adapters include an aerated drug vial adapter and an aerated liquid vial adapter
IL245800A0 (en) 2016-05-24 2016-08-31 West Pharma Services Il Ltd A device with two vial adapters includes two identical vial adapters
IL246073A0 (en) 2016-06-06 2016-08-31 West Pharma Services Il Ltd A fluid transport device for use with a slide-driven piston medicine pump cartridge
IL247376A0 (en) 2016-08-21 2016-12-29 Medimop Medical Projects Ltd Injector assembly
USD832430S1 (en) 2016-11-15 2018-10-30 West Pharma. Services IL, Ltd. Dual vial adapter assemblage
IL249408A0 (en) 2016-12-06 2017-03-30 Medimop Medical Projects Ltd A device for transporting fluids for use with an infusion fluid container and a hand tool similar to a plunger to release a vial from it
IL251458A0 (en) 2017-03-29 2017-06-29 Medimop Medical Projects Ltd Liquid drug delivery devices are user-operated for use in pre-prepared liquid drug delivery assemblies (rtu)
IL254802A0 (en) 2017-09-29 2017-12-31 Medimop Medical Projects Ltd A device with two vial adapters includes two identical perforated vial adapters
USD903864S1 (en) 2018-06-20 2020-12-01 West Pharma. Services IL, Ltd. Medication mixing apparatus
JP1630477S (zh) 2018-07-06 2019-05-07
USD923812S1 (en) 2019-01-16 2021-06-29 West Pharma. Services IL, Ltd. Medication mixing apparatus
JP1648075S (zh) 2019-01-17 2019-12-16
JP7101900B2 (ja) 2019-01-31 2022-07-15 ウェスト・ファーマ・サービシーズ・アイエル・リミテッド 液体移送装置
ES2980865T3 (es) 2019-04-30 2024-10-03 West Pharma Services Il Ltd Dispositivo de transferencia de líquidos con lumen dual con punta IV
USD956958S1 (en) 2020-07-13 2022-07-05 West Pharma. Services IL, Ltd. Liquid transfer device
JP2023546374A (ja) 2020-10-09 2023-11-02 アイシーユー・メディカル・インコーポレーテッド 流体移送デバイスおよびそれのための使用の方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1054374A (zh) * 1990-01-22 1991-09-11 诺沃挪第克公司 一种用于混合和注射药物的方法和装置
CN1132480A (zh) * 1993-09-29 1996-10-02 法马西雅公司 注射管的改进
US5674195A (en) * 1995-02-06 1997-10-07 Truthan; Charles Edwin Syringe apparatus and method of mixing liquid medicants within a syringe

Family Cites Families (342)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US62333A (en) 1867-02-26 Henry holl
US1704817A (en) 1928-01-17 1929-03-12 Okadee Company Locomotive-cylinder cock
US1930944A (en) 1932-12-21 1933-10-17 Jr William L Schmitz Measuring dispenser
US2326490A (en) 1942-06-13 1943-08-10 Harold N Perelson Fluid dispenser
US3059643A (en) 1954-12-10 1962-10-23 Baxter Laboratories Inc Pumping apparatus
US2931668A (en) 1956-04-30 1960-04-05 Bastian Blessing Co Coupling
US2968497A (en) 1958-02-05 1961-01-17 Avro Aircraft Ltd Self-sealing coupling
DE1945279U (de) 1966-07-02 1966-09-01 Gruenenthal Chemie Hilfsgeraet zur herstellung von sterilen loesungen.
FR2029242A5 (en) 1969-01-21 1970-10-16 Alriq Christian Self-perforable plug for bacteriological - culture tubes
DE1913926A1 (de) 1969-03-19 1970-09-24 Hoechst Ag Zweikammerspritze
US3757981A (en) 1969-11-24 1973-09-11 Harris R Valves and valve needle syringes
US3618637A (en) 1970-02-04 1971-11-09 Deseret Pharma Rotary mixing valve
US3826261A (en) 1971-12-27 1974-07-30 Upjohn Co Vial and syringe assembly
US4109670A (en) 1973-05-16 1978-08-29 Slagel Roger D Combination check flow control and selector valve
US3885607A (en) 1973-11-16 1975-05-27 Richard I Peltier Device for providing fluid communication between two sealed vessels
FR2268707B1 (zh) 1974-04-26 1976-12-17 Becton Dickinson France
US3977555A (en) 1974-05-07 1976-08-31 Pharmaco, Inc. Protective safety cap for medicament vial
US3957052A (en) 1974-09-13 1976-05-18 Medical Development Corporation Pumping-syringe
US3993063A (en) 1975-06-16 1976-11-23 Union Carbide Corporation Protective shielding assembly for use in loading a hypodermic syringe with radioactive material
US4051852A (en) 1975-06-26 1977-10-04 The Kendall Company Aspirating device
US4020839A (en) 1976-02-26 1977-05-03 Parke, Davis & Company Medicament-dispensing package
US4210173A (en) 1976-12-06 1980-07-01 American Hospital Supply Corporation Syringe pumping system with valves
US4187848A (en) 1977-07-18 1980-02-12 The Kendall Company Adapter assembly
USD257286S (en) 1978-03-06 1980-10-07 Tronomed International, Inc. Medical valve
US4314586A (en) 1978-08-30 1982-02-09 Tronomed International, Inc. Disposable valve
US4639019A (en) 1979-06-04 1987-01-27 Baxter Travenol Laboratories, Inc. Luer connection
US4296786A (en) 1979-09-28 1981-10-27 The West Company Transfer device for use in mixing a primary solution and a secondary or additive substance
US4253501A (en) 1979-11-09 1981-03-03 Ims Limited Transfer system
US4328802A (en) 1980-05-14 1982-05-11 Survival Technology, Inc. Wet dry syringe package
US4376634A (en) 1980-05-30 1983-03-15 Mallinckrodt, Inc. Assay kit having syringe, dilution device and reagents within sealed container
USD267199S (en) 1980-07-17 1982-12-07 Abbott Laboratories Vial and solution container connecting device
USD271421S (en) 1981-06-12 1983-11-15 Fetterman James W Medical valve
US4493348A (en) 1981-06-29 1985-01-15 Pur/Acc Corporation Method and apparatus for orally dispensing liquid medication
US4434823A (en) 1981-06-29 1984-03-06 American Hospital Supply Corporation Liquid transfer device
US4475915A (en) 1982-05-07 1984-10-09 Sloane Glenn L Holder for a syringe and an ampoule
US4588396A (en) 1982-10-22 1986-05-13 Stroebel Maurice G Apparatus for gravity feed of liquid under constant hydrostatic pressure
USD280018S (en) 1982-10-25 1985-08-06 Commonwealth Industries Syringe loading guide
US4507113A (en) 1982-11-22 1985-03-26 Derata Corporation Hypodermic jet injector
US4505709A (en) 1983-02-22 1985-03-19 Froning Edward C Liquid transfer device
US4676530A (en) 1983-04-07 1987-06-30 Warner-Lambert Company Coupling assembly for use in fluid flow systems
US4778447A (en) 1983-05-20 1988-10-18 Travenol European Research & Development Center Connectors
NZ207354A (en) 1983-05-20 1988-02-29 Bengt Gustavsson Device for transferring fluid without the release of droplets
JPS6026391U (ja) 1983-07-30 1985-02-22 株式会社ハーマン 管接続具
US4532969A (en) 1983-09-21 1985-08-06 Kwaan Hau C Fluid withdrawal and instillation device
USD284603S (en) 1983-11-25 1986-07-08 Loignon Edward G Syphon fitting
US4743243A (en) 1984-01-03 1988-05-10 Vaillancourt Vincent L Needle with vent filter assembly
IT1173370B (it) 1984-02-24 1987-06-24 Erba Farmitalia Dispositivo di sicurezza per collegare una siringa alla imboccatura di un flacone contenente un farmaco o di un tubicino per l'erogazione del farmaco della siringa
US5088996A (en) 1984-04-16 1992-02-18 Kopfer Rudolph J Anti-aerosoling drug reconstitution device
US4697622A (en) 1984-06-01 1987-10-06 Parker Hannifin Corporation Passive filling device
US4588403A (en) 1984-06-01 1986-05-13 American Hospital Supply Corporation Vented syringe adapter assembly
US4604093A (en) 1984-06-12 1986-08-05 I-Flow Corporation Apparatus and method for administering multiple fluid infusions
US5113904A (en) 1984-07-13 1992-05-19 Aslanian Jerry L Flow control device for administration of intravenous fluids
US4607671A (en) 1984-08-21 1986-08-26 Baxter Travenol Laboratories, Inc. Reconstitution device
US4759756A (en) 1984-09-14 1988-07-26 Baxter Travenol Laboratories, Inc. Reconstitution device
US4614437A (en) 1984-11-02 1986-09-30 Dougherty Brothers Company Mixing container and adapter
US4721133A (en) 1985-09-26 1988-01-26 Alcon Laboratories, Inc. Multiple use valving device
US4667927A (en) 1985-11-08 1987-05-26 Rao Medical Devices, Inc. Liquid flow metering device
US4865592A (en) 1986-02-20 1989-09-12 Becton, Dickinson And Company Container and needle assembly
US4834152A (en) 1986-02-27 1989-05-30 Intelligent Medicine, Inc. Storage receptacle sealing and transfer apparatus
US5049129A (en) 1986-05-29 1991-09-17 Zdeb Brian D Adapter for passive drug delivery system
SE461765B (sv) 1986-07-10 1990-03-26 Haessle Ab Anordning foer frisaettning av substans
IT1201801B (it) 1986-08-04 1989-02-02 Pietro Cosmai Caricatore miscelatore per iniettori transcutanei
US4743229A (en) 1986-09-29 1988-05-10 Collagen Corporation Collagen/mineral mixing device and method
US4729401A (en) 1987-01-29 1988-03-08 Burron Medical Inc. Aspiration assembly having dual co-axial check valves
US5041105A (en) 1987-03-03 1991-08-20 Sherwood Medical Company Vented spike connection component
US4787898A (en) 1987-05-12 1988-11-29 Burron Medical Inc. Vented needle with sideport
US4758235A (en) 1987-05-26 1988-07-19 Tu Ho C Cardiopulmonary resuscitation medication assembly
US5178607A (en) 1987-07-31 1993-01-12 Lynn Lawrence A Blood aspiration assembly septum and blunt needle aspirator
IT211830Z2 (it) 1987-09-22 1989-05-25 Farmitalia Carl Erba S P A Dispositivo di sicurezza perl'introduzione ed il prelievo di liquidi in e da flaconi di farmaci e simili.
USD314050S (en) 1987-11-27 1991-01-22 Terumo Kabushiki Kaisha Medical connector
US5211638A (en) 1988-01-25 1993-05-18 Baxter International Inc. Pre-slit injection site
DE3804429A1 (de) 1988-02-12 1989-08-24 Schleicher & Schuell Gmbh Einmalfilter
US5122124A (en) 1988-12-14 1992-06-16 Patco Ventures Ltd. Safety syringe needle device with interchangeable and retractable needle platform
US6344031B1 (en) 1989-03-22 2002-02-05 Laurel A. Novacek Safety syringe needle device with interchangeable and retractable needle platform
US5035686A (en) 1989-01-27 1991-07-30 C. R. Bard, Inc. Catheter exchange system with detachable luer fitting
US5135492A (en) 1989-06-26 1992-08-04 University Of Florida Arterial/venous fluid transfer system
US4967797A (en) 1989-08-16 1990-11-06 Manska Wayne E Tap valve
US5053015A (en) 1989-08-30 1991-10-01 The Kendall Company Locking catheter adapter
US4997430A (en) 1989-09-06 1991-03-05 Npbi Nederlands Produktielaboratorium Voor Bloedtransfusieapparatuur En Infusievloeistoffen B.V. Method of and apparatus for administering medicament to a patient
US5578015A (en) 1989-09-18 1996-11-26 Robb Pascal Patent Limited Safety syringe incorporating automatic needle holder release
US5304163A (en) 1990-01-29 1994-04-19 Baxter International Inc. Integral reconstitution device
US5061248A (en) 1990-04-04 1991-10-29 Sacco John J Injection port safety shield
USRE38996E1 (en) 1990-04-20 2006-02-28 Becton, Dickinson And Company Needle tip cover
US5104387A (en) 1990-05-25 1992-04-14 St. Jude Medical, Inc. Bi-planar fluid control valve
US5045066A (en) 1990-06-07 1991-09-03 Smith & Nephew, Inc. Dental needle with stick resistant protective sleeve
US5203775A (en) 1990-09-18 1993-04-20 Medex, Inc. Needleless connector sample site
US5125908A (en) 1990-10-19 1992-06-30 Cohen Milton J Hypodermic syringe with protective holder
US5201717A (en) 1990-12-05 1993-04-13 Philip Wyatt Safety enclosure
JP3066611B2 (ja) 1991-04-30 2000-07-17 武田薬品工業株式会社 個別密封容器に収容した２種薬剤の無菌保持混合装置
US5183469A (en) 1991-05-10 1993-02-02 Becton, Dickinson And Company Device for the removal and replacement of a needle shield
DE4122221A1 (de) 1991-07-04 1993-03-18 Axel Von Brand Transfer- und entnahmespike
DE4122476A1 (de) 1991-07-06 1993-01-07 Leopold Pharma Gmbh Verfahren und vorrichtung zum ueberleiten von zwei oder mehr sterilen fluessigkeiten im geschlossenen system
US5288290A (en) 1991-09-25 1994-02-22 Alcon Surgical, Inc. Multi-ported valve assembly
WO1993010001A1 (en) 1991-11-21 1993-05-27 Gds Technology, Inc. Fluid transfer device
US5171230A (en) 1991-11-29 1992-12-15 Medex, Inc. Fast flush catheter valve
US5247972A (en) 1991-12-17 1993-09-28 Whittier Medical, Inc. Alignment guide for hypodermic syringe
US5279597A (en) 1992-01-13 1994-01-18 Arrow International Investment Corp. Catheter compression clamp
CA2093560C (en) 1992-04-10 2005-06-07 Minoru Honda Fluid container
US5328474A (en) 1992-04-13 1994-07-12 B. Braun Medical Inc. Tamper resistant syringe cap
JP2605345Y2 (ja) 1992-05-01 2000-07-10 株式会社大塚製薬工場 薬剤容器
JPH05317383A (ja) 1992-05-19 1993-12-03 Nissho Corp 薬剤容器との連通手段を備えた溶解液容器
US5279576A (en) 1992-05-26 1994-01-18 George Loo Medication vial adapter
US5232109A (en) 1992-06-02 1993-08-03 Sterling Winthrop Inc. Double-seal stopper for parenteral bottle
GB9211912D0 (en) 1992-06-04 1992-07-15 Drg Flexpak Ltd Vial connector system
AU4999793A (en) 1992-08-07 1994-03-03 West Company, Incorporated, The Needleless access stopper
US5344417A (en) 1992-09-11 1994-09-06 Becton, Dickinson And Company Universal fitting for inoculation receptacles
US5334163A (en) 1992-09-16 1994-08-02 Sinnett Kevin B Apparatus for preparing and administering a dose of a fluid mixture for injection into body tissue
US5385547A (en) 1992-11-19 1995-01-31 Baxter International Inc. Adaptor for drug delivery
DE69317650T2 (de) 1992-12-15 1998-10-08 Sanofi Sa Vorrichtung zur vorbereitung einer lösung, einer suspension oder einer emulsion einer medizinischen lösung
JPH06239352A (ja) 1993-02-05 1994-08-30 Nissho Corp 溶解液注入セット
US5269768A (en) 1993-02-08 1993-12-14 Smiths Industries Medical Systems, Inc. Valved suction catheter
US5312377A (en) 1993-03-29 1994-05-17 Dalton Michael J Tapered luer connector
US5591143A (en) 1993-04-02 1997-01-07 Medrad Inc. Luer connector with torque indicator
US5607439A (en) 1993-06-24 1997-03-04 Yoon; Inbae Safety penetrating instrument with penetrating member moving during penetration and triggered safety member protrusion
US5445630A (en) 1993-07-28 1995-08-29 Richmond; Frank M. Spike with luer fitting
US5364387A (en) 1993-08-02 1994-11-15 Becton, Dickinson And Company Drug access assembly for vials and ampules
US5397303A (en) 1993-08-06 1995-03-14 River Medical, Inc. Liquid delivery device having a vial attachment or adapter incorporated therein
US5827262A (en) * 1993-09-07 1998-10-27 Debiotech S.A. Syringe device for mixing two compounds
US5509433A (en) 1993-10-13 1996-04-23 Paradis; Joseph R. Control of fluid flow
US5466220A (en) 1994-03-08 1995-11-14 Bioject, Inc. Drug vial mixing and transfer device
US5554128A (en) 1994-03-09 1996-09-10 Joseph K. Andonian Syringe and vial connector
US5520659A (en) 1994-03-09 1996-05-28 Joseph K. Andonian Syringe needle cover and vial connector
US5462317A (en) 1994-03-23 1995-10-31 Keller; Wilhelm A. Adapter for a mixing or dispensing device
DE4414697C2 (de) 1994-04-27 1998-06-18 Caremed Vertriebsgesellschaft Vorrichtung zum Transferieren und Entnehmen von Flüssigkeiten aus Flaschen, Beuteln oder ähnlichen Behältnissen für medizinische Zwecke
US5832971A (en) 1994-05-19 1998-11-10 Becton, Dickinson And Company Syringe filling and delivery device
US5746733A (en) 1994-05-19 1998-05-05 Becton, Dickinson And Company Syringe filling and delivery device
JP4221515B2 (ja) 1994-05-23 2009-02-12 セファロン リミテッド 製剤調製機
US5649637A (en) 1994-06-02 1997-07-22 Automatic Liquid Packaging, Inc. Torque-resistant closure for a hermetically sealed container
US5470319A (en) 1994-06-20 1995-11-28 Critical Device Corporation Needleless injection site
RU2154462C2 (ru) 1994-06-24 2000-08-20 Айку Медикал, Инк. Устройство для перемещения жидкости и способ его применения
EP0692235A1 (en) 1994-07-14 1996-01-17 International Medication Systems (U.K.) Ltd. Mixing & dispensing apparatus
US5526853A (en) 1994-08-17 1996-06-18 Mcgaw, Inc. Pressure-activated medication transfer system
FR2726768A1 (fr) 1994-11-14 1996-05-15 Debiotech Sa Dispositif de seringue fixable sur un flacon
GB9425642D0 (en) 1994-12-20 1995-02-22 Weston Medical Ltd Filling device
US6681810B2 (en) 1994-12-20 2004-01-27 Aradigm Corporation Filling device for a needleless injector cartridge
US5531695A (en) 1994-12-22 1996-07-02 Sherwood Medical Company Tamper evident sleeve
US5653686A (en) 1995-01-13 1997-08-05 Coulter Corporation Closed vial transfer method and system
US5492147A (en) 1995-01-17 1996-02-20 Aeroquip Corporation Dry break coupling
US5647845A (en) 1995-02-01 1997-07-15 Habley Medical Technology Corporation Generic intravenous infusion system
DE19504413A1 (de) 1995-02-10 1996-08-22 Pharmacia Gmbh Überleitungsgerät
US5584819A (en) 1995-03-13 1996-12-17 Kopfer; Rudolph J. Nested blunt/sharp injection assembly
IL114960A0 (en) 1995-03-20 1995-12-08 Medimop Medical Projects Ltd Flow control device
US5651776A (en) 1995-03-22 1997-07-29 Angiodynamics, Inc. Luer-type connector
US5566729A (en) 1995-04-06 1996-10-22 Abbott Laboratories Drug reconstitution and administration system
DE19513666C1 (de) 1995-04-11 1996-11-28 Behringwerke Ag Vorrichtung zum Zusammenführen einer ersten flüssigen und einer zweiten festen oder flüssigen Komponente mittels Unterdruck unter sterilen Bedingungen
SE509950C2 (sv) 1995-05-02 1999-03-29 Carmel Pharma Ab Anordning för administrering av toxisk vätska
US5839715A (en) 1995-05-16 1998-11-24 Alaris Medical Systems, Inc. Medical adapter having needleless valve and sharpened cannula
US5616203A (en) 1995-07-14 1997-04-01 Merit Medical Method of manufacturing a split ring airless rotatable connector
FR2738550B1 (fr) 1995-09-11 1997-11-07 Biodome Dispositif d'obturation d'un recipient lui-meme ferme, ensemble pour dispenser un produit comprenant un tel recipient et un tel dispositif d'obturation
US5611576A (en) 1995-11-24 1997-03-18 Industrie Borla Spa Female coupling element for haemodialysis medical equipment
US5833213A (en) 1995-12-29 1998-11-10 Rymed Technologies, Inc. Multiple dose drug vial adapter for use with a vial having a pierceable septum and a needleless syringe
WO1997025015A1 (en) 1996-01-11 1997-07-17 Duoject Medical Systems Inc. Delivery system for pharmaceuticals packed in pharmaceutical vials
US5893397A (en) 1996-01-12 1999-04-13 Bioject Inc. Medication vial/syringe liquid-transfer apparatus
US5879337A (en) 1997-02-27 1999-03-09 Injectimed, Inc. Needle tip guard for hypodermic needles
US6629959B2 (en) 1996-02-27 2003-10-07 Injectimed, Inc. Needle tip guard for percutaneous entry needles
USD393722S (en) 1996-04-04 1998-04-21 Icu Medical, Inc. Locking blunt cannula
WO1997039720A1 (en) 1996-04-22 1997-10-30 Abbott Laboratories Container closure system
GB9609563D0 (en) 1996-05-08 1996-07-10 Sterimatic Holdings Ltd Venting devices
DE19619026A1 (de) 1996-05-10 1997-11-13 Trinova Gmbh Schnellkupplung
US5873872A (en) 1996-09-17 1999-02-23 Becton Dickinson And Company Multipositional resealable vial connector assembly for efficient transfer of liquid
US5738144A (en) 1996-10-11 1998-04-14 Aeroquip Corporation Luer connecting coupling
US5895383A (en) 1996-11-08 1999-04-20 Bracco Diagnostics Inc. Medicament container closure with recessed integral spike access means
US6004278A (en) 1996-12-05 1999-12-21 Mdc Investment Holdings, Inc. Fluid collection device with retractable needle
FR2756811B1 (fr) 1996-12-06 1999-02-05 Valois Dispositif de distribution de produit fluide du type bicomposant
GB9701413D0 (en) 1997-01-24 1997-03-12 Smithkline Beecham Biolog Novel device
US5954104A (en) 1997-02-28 1999-09-21 Abbott Laboratories Container cap assembly having an enclosed penetrator
US5772652A (en) 1997-05-14 1998-06-30 Comar, Inc. Stab cap for a vial having a puncturable seal
US5755696A (en) 1997-06-30 1998-05-26 Becton, Dickinson And Company Syringe filling and delivery device
US5820621A (en) 1997-07-29 1998-10-13 Becton, Dickinson And Company Medical fluid transfer and delivery device
US7125397B2 (en) 1997-08-20 2006-10-24 B. Braun Melsungen Ag Protective device for an injection needle
IL121605A (en) 1997-08-22 2001-03-19 Medimop Medical Projects Ltd Fluid access assembly and a method for preparing a liquid drug
US5834744A (en) 1997-09-08 1998-11-10 The Rubbright Group Tubular microwave applicator
US5919182A (en) 1997-09-12 1999-07-06 Becton, Dickinson And Company Medical fluid transfer and delivery device
US6090093A (en) 1997-09-25 2000-07-18 Becton Dickinson And Company Connector assembly for a vial having a flexible collar
US5925029A (en) 1997-09-25 1999-07-20 Becton, Dickinson And Company Method and apparatus for fixing a connector assembly onto a vial with a crimp cap
US5944700A (en) 1997-09-26 1999-08-31 Becton, Dickinson And Company Adjustable injection length pen needle
US5902298A (en) 1997-11-07 1999-05-11 Bracco Research Usa Medicament container stopper with integral spike access means
IT236233Y1 (it) 1997-11-26 2000-08-08 Eurospital S P A Dispositivo per il collegamento di un contenitore di prodottofarmaceutico ad una sacca di prodotto liquido per effettuare il
US6019750A (en) 1997-12-04 2000-02-01 Baxter International Inc. Sliding reconstitution device with seal
US6457488B2 (en) 1998-01-08 2002-10-01 George Loo Stopcock having axial port for syringe twist actuation
FR2773735B1 (fr) 1998-01-20 2000-02-25 Becton Dickinson France Dispositif de confinement etanche
US6681946B1 (en) 1998-02-26 2004-01-27 Becton, Dickinson And Company Resealable medical transfer set
US6003566A (en) 1998-02-26 1999-12-21 Becton Dickinson And Company Vial transferset and method
US6080132A (en) 1998-02-27 2000-06-27 Abbott Laboratories Apparatus for altering characteristics of a fluid
US6378714B1 (en) 1998-04-20 2002-04-30 Becton Dickinson And Company Transferset for vials and other medical containers
US6957745B2 (en) 1998-04-20 2005-10-25 Becton, Dickinson And Company Transfer set
US6245044B1 (en) 1998-07-17 2001-06-12 Becton, Dickinson And Company Variable extension combined spinal/epidural needle set and method for its use
US6358236B1 (en) 1998-08-06 2002-03-19 Baxter International Inc. Device for reconstituting medicaments for injection
GB2359754B (en) 2000-03-03 2004-04-28 Nmt Group Plc Needle sheath
US7074216B2 (en) 1998-09-15 2006-07-11 Baxter International Inc. Sliding reconstitution device for a diluent container
US6113583A (en) 1998-09-15 2000-09-05 Baxter International Inc. Vial connecting device for a sliding reconstitution device for a diluent container
US20050137566A1 (en) 2003-12-23 2005-06-23 Fowles Thomas A. Sliding reconstitution device for a diluent container
AR021220A1 (es) 1998-09-15 2002-07-03 Baxter Int DISPOSITIVO DE CONEXIoN PARA ESTABLECER UNA COMUNICACIoN FLUíDA ENTRE UN PRIMER RECIPIENTE Y UN SEGUNDO RECIPIENTE.
USD427308S (en) 1999-01-22 2000-06-27 Medimop Medical Projects Ltd. Vial adapter
FR2789369B1 (fr) 1999-02-10 2001-04-27 Biodome Dispositif de connexion entre un recipient et un contenant et ensemble pret a l'emploi comprenant un tel dispositif
FR2790948B1 (fr) 1999-03-18 2001-06-22 Sedat Dispositif de transfert bidirectionnel d'un liquide entre un flacon et une capsule
US6099511A (en) 1999-03-19 2000-08-08 Merit Medical Systems, Inc. Manifold with check valve positioned within manifold body
US6231552B1 (en) 1999-05-04 2001-05-15 Saf-T-Med, Inc. Threaded latching mechanism
US6156025A (en) 1999-06-17 2000-12-05 Bracco Research Usa Inc. Twist valve
JP2002059570A (ja) * 1999-06-24 2002-02-26 Canon Inc インクジェット記録装置及び該装置用部品
US6348044B1 (en) 1999-10-12 2002-02-19 George D. N. Coletti Method and apparatus for recapping single-use hypodermic needles
AU784838B2 (en) 1999-10-22 2006-07-06 Antares Pharma, Inc. Medical injector and medicament loading system for use therewith
US7198618B2 (en) 1999-11-04 2007-04-03 Tyco Healthcare Group Lp Safety shield for medical needles
US6253804B1 (en) 1999-11-05 2001-07-03 Minimed Inc. Needle safe transfer guard
FR2800713B1 (fr) 1999-11-05 2002-01-04 Biodome Dispositif de connexion entre un recipient et un contenant et ensemble pret a l'emploi comprenant un tel dispositif
US6453956B2 (en) 1999-11-05 2002-09-24 Medtronic Minimed, Inc. Needle safe transfer guard
US6832994B2 (en) 2000-01-24 2004-12-21 Bracco Diagnostics Inc. Table top drug dispensing vial access adapter
US6544246B1 (en) 2000-01-24 2003-04-08 Bracco Diagnostics, Inc. Vial access adapter and vial combination
USD445501S1 (en) 2000-01-24 2001-07-24 Bracco Diagnostics, Inc. Vial access adapter
US7799009B2 (en) 2000-01-24 2010-09-21 Bracco Diagnostics Inc. Tabletop drug dispensing vial access adapter
US6139534A (en) 2000-01-24 2000-10-31 Bracco Diagnostics, Inc. Vial access adapter
US6503240B1 (en) 2000-01-24 2003-01-07 Brocco Diagnostics, Inc. Vial access adapter
US6706031B2 (en) 2000-02-15 2004-03-16 Comar, Inc. Needleless access apparatus and system
ES2223644T3 (es) 2000-02-16 2005-03-01 Haselmeier S.A R.L. Procedimiento de reconstitucion de un liquido de inyeccion, y aparato para llevar a cabo un procedimiento de este tipo.
US6530903B2 (en) 2000-02-24 2003-03-11 Xiping Wang Safety syringe
US6652509B1 (en) 2000-04-03 2003-11-25 Abbott Laboratories Housing capable of connecting a container to a medical device
JP4372310B2 (ja) 2000-04-10 2009-11-25 ニプロ株式会社 混注用アダプター
US6343629B1 (en) 2000-06-02 2002-02-05 Carmel Pharma Ab Coupling device for coupling a vial connector to a drug vial
ES2765665T3 (es) 2000-08-02 2020-06-10 Becton Dickinson Co Sistema de aguja de pluma y pantalla protectora de seguridad
US20030036725A1 (en) 2000-09-21 2003-02-20 Gilad Lavi Reconstitution and injection system
FR2815328B1 (fr) 2000-10-17 2002-12-20 Biodome Dispositif de connexion entre un recipient et un contenant et ensemble pret a l'emploi comprenant un tel dispositif
JP2002177392A (ja) 2000-11-08 2002-06-25 West Pharmaceutical Services Inc 注射器安全装置
US6666852B2 (en) 2000-12-04 2003-12-23 Bracco Diagnostics, Inc. Axially activated vial access adapter
US20020087118A1 (en) 2000-12-29 2002-07-04 Duoject Medical Systems Inc. Pharmaceutical delivery system
US6558365B2 (en) 2001-01-03 2003-05-06 Medimop Medical Projects, Ltd. Fluid transfer device
USD468015S1 (en) 2001-01-22 2002-12-31 Astra Tech Ab Combined connector with valve and non-return valve for medical equipment
US6474375B2 (en) 2001-02-02 2002-11-05 Baxter International Inc. Reconstitution device and method of use
US6503244B2 (en) 2001-03-07 2003-01-07 Micro Therapeutics, Inc. High pressure injection system
US6656433B2 (en) 2001-03-07 2003-12-02 Churchill Medical Systems, Inc. Vial access device for use with various size drug vials
US6581593B1 (en) 2001-04-03 2003-06-24 Darren A. Rubin Universal oxygen connector system
EP1264609B1 (en) 2001-06-06 2006-01-18 Graziano Azzolini High-sterility and high-capacity connector for lines for outflow from bottles
US6745998B2 (en) 2001-08-10 2004-06-08 Alaris Medical Systems, Inc. Valved male luer
FR2829691B1 (fr) 2001-09-17 2004-07-09 Sedat Dispositif de transfert bidirectionnel d'un liquide entre un flacon et une carpule
US7354422B2 (en) 2001-09-26 2008-04-08 B. Braun Melsungen Ag Spring launched needle safety clip
JP4817564B2 (ja) 2001-09-28 2011-11-16 株式会社細川洋行 ニードルケース及び輸液容器
US6715520B2 (en) 2001-10-11 2004-04-06 Carmel Pharma Ab Method and assembly for fluid transfer
WO2003041788A1 (fr) 2001-11-14 2003-05-22 Jms Co., Ltd. Robinet d'arret a trois voies et circuits de transfusion liquide ou sanguine utilisant ce robinet
US6802828B2 (en) 2001-11-23 2004-10-12 Duoject Medical Systems, Inc. System for filling and assembling pharmaceutical delivery devices
EP1557191B2 (en) 2001-11-30 2016-09-07 Novo Nordisk A/S A safety needle assembly
AU2002346711A1 (en) 2001-12-13 2003-06-30 Becton Dickinson And Company Needle closure system removal device
US6875205B2 (en) 2002-02-08 2005-04-05 Alaris Medical Systems, Inc. Vial adapter having a needle-free valve for use with vial closures of different sizes
FR2836129B1 (fr) 2002-02-20 2004-04-02 Biodome Dispositif de connexion entre un recipient et un contenant et ensemble pret a l'emploi comprenant un tel dispositif
JP2003301967A (ja) * 2002-04-10 2003-10-24 Mitsubishi Rayon Co Ltd 洗浄機能付きバルブ
US7867215B2 (en) 2002-04-17 2011-01-11 Carmel Pharma Ab Method and device for fluid transfer in an infusion system
USD472630S1 (en) 2002-04-30 2003-04-01 Sterling Medivations, Inc. Pen needle catheter connector
USD472316S1 (en) 2002-04-30 2003-03-25 Sterling Medivations, Inc. Pen needle catheter connector
USD476733S1 (en) 2002-05-09 2003-07-01 Becton, Dickinson And Company Medical needle assembly
AU2003241481B2 (en) 2002-05-16 2008-09-04 Scott Laboratories, Inc. Drug container entry mechanisms and method
JP4427965B2 (ja) 2002-07-02 2010-03-10 ニプロ株式会社 連通手段付き薬液容器
JP4209642B2 (ja) 2002-07-26 2009-01-14 川澄化学工業株式会社 針カバー及びキャップ付針カバー並びに針カバー付翼付針
US7083600B2 (en) 2002-08-08 2006-08-01 Advanced Medical Sharps, Inc. Safety needle and shield
JP2004097253A (ja) 2002-09-04 2004-04-02 Nipro Corp 液体移注具
US20040073189A1 (en) 2002-10-09 2004-04-15 Phil Wyatt Vial access transfer set
USD483869S1 (en) 2002-10-29 2003-12-16 Pre Holding, Inc. Tubing connector
US20060155257A1 (en) 2002-11-08 2006-07-13 Reynolds David L Pharmaceutical delivery systems and methods for using same
US8100879B2 (en) 2002-11-18 2012-01-24 Nestec S.A. Connector device for enteral administration set
JP4341239B2 (ja) 2002-12-19 2009-10-07 ニプロ株式会社 液体移注具
USD483487S1 (en) 2002-12-19 2003-12-09 Becton Dickinson And Company Stopcock device
ES2397833T3 (es) 2003-03-05 2013-03-11 Csl Behring Gmbh Dispositivo de transferencia
ES2293105T3 (es) 2003-03-06 2008-03-16 Csl Behring Gmbh Dispositivo de transferencia, en particular para fluidos medicinales.
US20040181192A1 (en) 2003-03-11 2004-09-16 Cuppy Michael John Vascular access device and method of using same
US7470265B2 (en) 2003-03-20 2008-12-30 Nxstage Medical, Inc. Dual access spike for infusate bags
US7024968B2 (en) 2003-03-26 2006-04-11 Boston Scientific Scimed, Inc. Luer lock wrench
US7001369B2 (en) 2003-03-27 2006-02-21 Scimed Life Systems, Inc. Medical device
US7040598B2 (en) 2003-05-14 2006-05-09 Cardinal Health 303, Inc. Self-sealing male connector
USD495416S1 (en) 2003-05-30 2004-08-31 Alaris Medical Systems, Inc. Vial access device
JP3883527B2 (ja) 2003-07-17 2007-02-21 ニプロ株式会社 トランスファーニードル
US7488297B2 (en) 2003-07-30 2009-02-10 Patrice Flaherty Blood collecting devices
FR2858931B1 (fr) 2003-08-21 2007-04-13 Becton Dickinson France Dispositif d'administration orale d'un medicament
EP3108911A1 (en) 2003-10-30 2016-12-28 Teva Medical Ltd. Safety drug handling device
US6994315B2 (en) 2004-01-13 2006-02-07 Rymed Technologies, Inc. Swabbable needle-free injection port valve system with neutral fluid displacement
DE102004005435B3 (de) 2004-02-04 2005-09-15 Haindl, Hans, Dr. Medizinisches Transfergerät
EP1735045B1 (en) 2004-03-26 2012-01-11 Cook Medical Technologies LLC Method and apparatus for an improved luer fitting connection
IL161660A0 (en) * 2004-04-29 2004-09-27 Medimop Medical Projects Ltd Liquid drug delivery device
FR2869795B1 (fr) 2004-05-07 2006-08-04 Sedat Sa Dispositif de transfert bidirectionnel
DE202004012714U1 (de) 2004-08-12 2004-11-04 Smiths Medical Deutschland Gmbh Luer-Lock-Verbinder für medizinische Geräte
US7984730B2 (en) 2004-09-03 2011-07-26 Elcam Medical Agricultural Cooperative Association Stopcock
US7731678B2 (en) 2004-10-13 2010-06-08 Hyprotek, Inc. Syringe devices and methods for mixing and administering medication
US7771383B2 (en) 2004-10-22 2010-08-10 Medegen, Inc. Fluid control device with valve and methods of use
US20060089594A1 (en) 2004-10-26 2006-04-27 Sergio Landau Needle-free injection device
US7192423B2 (en) 2004-11-17 2007-03-20 Cindy Wong Dispensing spike assembly with removable indicia bands
US7523967B2 (en) 2004-12-13 2009-04-28 Alcon, Inc. Tubing fitting
US20060135948A1 (en) 2004-12-16 2006-06-22 Medtronic Vascular, Inc., A Delaware Corporation Multi-exchange catheter guide member with improved seal
WO2006085327A1 (en) * 2005-02-14 2006-08-17 Medimop Medical Projects Ltd Medical device for in situ liquid drug reconstitution in medicinal vessels
US20070060904A1 (en) 2005-03-14 2007-03-15 Becton, Dickinson And Company Filling system and method for syringes with short needles
US20060253084A1 (en) 2005-05-03 2006-11-09 Greg Nordgren Outdwelling slit valves and assemblies for medical liquid flow through a cannula and related methods
US20070088293A1 (en) 2005-07-06 2007-04-19 Fangrow Thomas F Jr Medical connector with closeable male luer
EP1909735A1 (en) 2005-08-01 2008-04-16 Medimop Medical Projects Ltd. Liquid drug delivery system
ES2371557T3 (es) 2005-08-11 2012-01-05 Medimop Medical Projects Ltd. Dispositivos de transferencia de fármacos líquidos para un correcto ajuste a presión a prueba de fallos en viales medicinales.
US7882863B2 (en) 2005-10-19 2011-02-08 Cd Solutions, Llc Apparatus and method for mixing and transferring medications
US7611502B2 (en) 2005-10-20 2009-11-03 Covidien Ag Connector for enteral fluid delivery set
PT1951344E (pt) 2005-11-07 2014-09-03 Borla Ind Adaptador de frasco-ampola ventilado de manuseamento seguro
JP2007143813A (ja) 2005-11-28 2007-06-14 Nippon Sherwood Medical Industries Ltd 医療用活栓
US20070191767A1 (en) 2005-12-16 2007-08-16 Medtronic Vascular, Inc. Bifurcated Catheter Joints
US7981101B2 (en) 2005-12-30 2011-07-19 Carefusion 303, Inc. Medical vial adapter with reduced diameter cannula and enlarged vent lumen
EP1820485B1 (de) 2006-02-16 2009-11-11 F.Hoffmann-La Roche Ag System und Vorrichtung zum Entnehmen von Pharmazeutika
IL174352A0 (en) 2006-03-16 2006-08-20 Medimop Medical Projects Ltd Medical devices for use with carpules
JP4769103B2 (ja) 2006-03-17 2011-09-07 日本シャーウッド株式会社 コネクタ
JP4775638B2 (ja) 2006-03-31 2011-09-21 株式会社ジェイ・エム・エス 連通部材、およびそれを用いた医療用容器、並びに輸液調剤用具セット
US7547300B2 (en) 2006-04-12 2009-06-16 Icu Medical, Inc. Vial adaptor for regulating pressure
JP4820703B2 (ja) 2006-04-28 2011-11-24 日本シャーウッド株式会社 液体混注具
JP4871019B2 (ja) 2006-05-15 2012-02-08 日本コヴィディエン株式会社 液体混注具
CA2655804C (en) 2006-06-19 2014-06-10 Nipro Corporation Drug solution preparing kit
JP2008005974A (ja) 2006-06-28 2008-01-17 Nippon Sherwood Medical Industries Ltd ルアー固定フィッティング接続構造
US20090177178A1 (en) 2006-07-21 2009-07-09 Polimoon Medical Packaging A/S Connector device and method for sterile mixing
USD561348S1 (en) 2006-08-17 2008-02-05 Medimop Medical Projects Ltd. Vial adapter
US8167863B2 (en) 2006-10-16 2012-05-01 Carefusion 303, Inc. Vented vial adapter with filter for aerosol retention
US20100030181A1 (en) 2006-11-30 2010-02-04 Kevin Helle Dual-lumen needle
US20100076397A1 (en) 2006-11-30 2010-03-25 Jay Reed Dual-lumen needle with an elongate notch opening
US7758082B2 (en) 2006-12-05 2010-07-20 Nxstage Medical, Inc. Fluid line connector safety device
US8002756B2 (en) 2006-12-08 2011-08-23 Becton, Dickinson And Company Method and apparatus for delivering a therapeutic substance through an injection port
US7900659B2 (en) 2006-12-19 2011-03-08 Carefusion 303, Inc. Pressure equalizing device for vial access
GB2446778A (en) 2007-02-01 2008-08-27 Pa Knowledge Ltd Syringe adaptor
US7883499B2 (en) 2007-03-09 2011-02-08 Icu Medical, Inc. Vial adaptors and vials for regulating pressure
IL182922A0 (en) * 2007-05-02 2007-09-20 Medimop Medical Projects Ltd Automatic liquid drug reconstitution apparatus
US8657803B2 (en) 2007-06-13 2014-02-25 Carmel Pharma Ab Device for providing fluid to a receptacle
JP5506681B2 (ja) 2007-08-21 2014-05-28 ユーコン・メディカル，リミテッド・ライアビリティ・カンパニー バイアルアクセス・注射システム
JP5615176B2 (ja) 2007-08-30 2014-10-29 カルメル ファルマ アクチボラゲット 流体移送装置
WO2009038860A2 (en) 2007-09-18 2009-03-26 Medeq Llc Medicament mixing and injection apparatus
WO2009039022A2 (en) * 2007-09-18 2009-03-26 Hpsn Llc Safety needle device
IL186290A0 (en) 2007-09-25 2008-01-20 Medimop Medical Projects Ltd Liquid drug delivery devices for use with syringe having widened distal tip
USD616090S1 (en) 2007-10-29 2010-05-18 Daikyo Seiko, Ltd. Sealing device for medicine container or medical apparatus
US8870832B2 (en) 2007-11-08 2014-10-28 Elcam Medical A.C.A.L Ltd Vial adaptor and manufacturing method therefor
DE102007061346A1 (de) 2007-12-17 2009-06-18 Bayer Schering Pharma Aktiengesellschaft Spike mit zwei Dornen
JP2011509134A (ja) 2008-01-09 2011-03-24 ノバルティス アーゲー 工場取り付けに適した単一型回収用スパイクユニット
US8287496B2 (en) 2008-01-17 2012-10-16 Custom Medical Applications, Inc. Flow elements for use with flexible spinal needles, needle assemblies and methods therefor
IL188975A0 (en) 2008-01-23 2008-11-03 Medimop Medical Projects Ltd Fluid control device with stopper
WO2009105489A1 (en) 2008-02-18 2009-08-27 Icu Medical, Inc. Vial adaptor
DE102008002800A1 (de) 2008-03-10 2009-09-24 Süddeutsche Feinmechanik GmbH Mischvorrichtung
US7967785B2 (en) 2008-07-14 2011-06-28 Nipro Healthcare Systems, Llc Insulin reservoir detection via magnetic switching
USD595862S1 (en) 2008-07-18 2009-07-07 Hitachi High-Technologies Corporation Adapter for a sample rack
USD595863S1 (en) 2008-07-18 2009-07-07 Hitachi High-Technologies Corporation Adapter for a sample rack
USD595420S1 (en) 2008-07-18 2009-06-30 Hitachi High-Technologies Corporation Adapter for a sample rack
USD595421S1 (en) 2008-07-18 2009-06-30 Hitachi High-Technologies Corporation Adapter for a sample rack
JP5607628B2 (ja) 2008-08-22 2014-10-15 サークル バイオロジクス，インコーポレイテッド 流体管理装置及び流体管理方法
US8512309B2 (en) 2009-01-15 2013-08-20 Teva Medical Ltd. Vial adapter element
US8123736B2 (en) 2009-02-10 2012-02-28 Kraushaar Timothy Y Cap adapters for medicament vial and associated methods
US8864725B2 (en) 2009-03-17 2014-10-21 Baxter Corporation Englewood Hazardous drug handling system, apparatus and method
USD616984S1 (en) 2009-07-02 2010-06-01 Medimop Medical Projects Ltd. Vial adapter having side windows
USD630732S1 (en) 2009-09-29 2011-01-11 Medimop Medical Projects Ltd. Vial adapter with female connector
USD637713S1 (en) 2009-11-20 2011-05-10 Carmel Pharma Ab Medical device adaptor
US8702674B2 (en) 2010-04-27 2014-04-22 Crisi Medical Systems, Inc. Medication and identification information transfer apparatus

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1054374A (zh) * 1990-01-22 1991-09-11 诺沃挪第克公司 一种用于混合和注射药物的方法和装置
CN1132480A (zh) * 1993-09-29 1996-10-02 法马西雅公司 注射管的改进
US5772630A (en) * 1993-09-29 1998-06-30 Pharmacia Ab Injection cartridges
US5674195A (en) * 1995-02-06 1997-10-07 Truthan; Charles Edwin Syringe apparatus and method of mixing liquid medicants within a syringe

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US20100204679A1 (en) 2010-08-12
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WO2009038860A3 (en) 2009-05-22
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