CN108653093A - A kind of cosmetic composition with whitening skin lightening - Google Patents
A kind of cosmetic composition with whitening skin lightening Download PDFInfo
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- CN108653093A CN108653093A CN201810731674.7A CN201810731674A CN108653093A CN 108653093 A CN108653093 A CN 108653093A CN 201810731674 A CN201810731674 A CN 201810731674A CN 108653093 A CN108653093 A CN 108653093A
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/23—Sulfur; Selenium; Tellurium; Compounds thereof
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- A—HUMAN NECESSITIES
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61K8/676—Ascorbic acid, i.e. vitamin C
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
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- A61K8/9783—Angiosperms [Magnoliophyta]
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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Abstract
The present invention relates to cosmetic fields, and in particular to a kind of cosmetic composition with whitening skin lightening.The composition includes niacinamide 1 3%, whitening compound 1 4%, 41 10PPM of citrus bark extract 0.5 1.5%, ursin 0.1 0.5% and oligopeptides etc..Wherein the ingredient of whitening compound is water, butanediol, ursin, citric acid, sodium sulfite, Acetyl Tyrosine, aaron's beard extract, peony root extractive, aminopropanol ascorbic acid phosphoric acid esters, radix scutellariae root extract, glutathione, hydrolysis mirabalan.It it is characteristic of the invention that in the selected raw material with synergy of each whitening node, can inhibit tyrosinase activity, inhibit melanin transfer, energy bright color again, it can also jointly act synergistically in each node in whitening path simultaneously, be finally reached safety, effective and stable whitening effect.
Description
Technical field
The present invention relates to a kind of cosmetics, belong to daily skin care item product technical field, espespecially a kind of to have whitening skin lightening
The cosmetic composition of effect.
Background technology
Our East Asia women are from ancient times with Bai Weimei, in order to which whitening has used many methods.Such as milk is taken a shower.Even with
Many virose substances, such as the lead mercury surface application of early stage, until eighties of last century is also used in someone.
Since modern age, many whitening agents have been selected in people's exploitation.Currently, one of the active matter of most effective skin whitening is
Quinhydrones, but quinhydrones molecular weight is small, destroys melanocyte, and may induce inflammation.So quinhydrones is most of in the world
Country is limited by stringent legislation, is prohibited to be used as components of cosmetics.
Rhododendrol was once the leading whitening active object of a Japanese famous cosmetics company.It is produced behind but excessively
The problem of whitening.Later the said firm apologizes in view of this problem to client.
Azelaic acid is a kind of aliphatic acid of naturally occurring medium chain.It is a kind of important skin-whitening agents, there is suppression
The effect of tyrosinase processed.But application when there is also some technologies and formula in terms of the problem of.First, azelaic acid must be
It is just effective when high concentration.Azelaic acid is insoluble at high concentrations, keeps the cosmetics quality of preparation poor, and especially very thick system is very
Difficulty is smeared out.Secondly, the fusing point of azelaic acid is higher, and ordinary circumstance is prepared more difficult.
L-AA and its derivative and licorice are all easy discoloration, and stability still has no small ask
Topic is also to require special attention when in use.
Some present illegal businessman add glucocorticoid for short-term profit in the cosmetics such as facial mask.It can be short
The tender effect compacted in vain is generated in phase, but is used for a long time and very serious consequence is generated to the skin of people.
With the development of modern science and technology, people are more and more deep to the understanding of colour of skin system.The depth of skin color
Regulated and controled by many factors, but the main content for still depending on melanin and distribution.Melanin is generated by melanocyte.It is black
Plain cell is one of important composition cell of skin, is in dendrite, and the melanin formed into the cell is transported by dendrite
Into corneocyte.It is with 1：36 ratios constitute an epidermis unit with keratinocyte, are present in basal layer of epidermis, black
Plain cell determines the skin color depth, while absorbable ultraviolet light by synthesis of melanin, makes damage of the body from ultraviolet light.
The specific forming process of melanin is as follows：When ultraviolet light irradiate skin when, horn cell be stimulated generate inflammation secretion inflammation because
Son and histamine etc., while DNA is damaged and generates free radicals.Melanocyte is broken up by stimulations such as inflammatory factor, free radicals
Accelerate.Internal tyrosinase activity increases, and tyrosine is converted into DOPA under the catalytic action of tyrosinase, is further converted to
DOPA quinone, DOPA quinone are finally translated into melanin through radical reaction.Melanosome is transmitted to horn cell through dendron.Most
The calmness of pigment in skin is caused eventually.
Since in the recent period, many companies develop some lightening compositions, are more some effect simple superposition in fact
Product, it is difficult to achieve the desired results.
How to develop skin care item scheme that is efficient, safe and stablizing and having effects that whitening skin lightening becomes present cosmetics
Where one difficult point of industry.
Invention content
Insufficient existing for above-mentioned technology in order to make up, the object of the present invention is to provide a kind of changes with collaboration whitening effect
Cosmetic compositions can not only inhibit, emphasis effect in terms of melanin transfer in tyrosinase, but also can cooperate with work in other respects
With can not only reach whitening effect outstanding but also can be with equilibrium coordination without causing negative-feedback phenomenon.
Present invention employs technical solutions below：
A kind of cosmetic composition, by mass percentage, including following components：
Preferably, by mass percentage, which includes following components：
Preferably, by mass percentage, which selects excipient matrix by one or more below
Component is constituted：
As further preferably, by mass percentage, which selects excipient matrix by below a kind of or several
Kind component is constituted：
Niacinamide used by the cosmetic composition is high-purity raw, and Nicotinic Acid Content is less than 100PPM.It is pressing down
Melanosome transfer processed, effect protrudes in terms of accelerating damaged dna reparation.When niacinamide content is less than in the cosmetic composition
When 1%, after tested, whole whitening effect weakens very much.When niacinamide content is more than 3%, tested through cell in vitro, cell
Toxicity is too big.Therefore 1-3% is selected.
The whitening compound that the composition uses is water, butanediol, ursin, citric acid, sodium sulfite, acetyl junket ammonia
Acid, aaron's beard extract, peony root extractive, aminopropanol ascorbic acid phosphoric acid esters, radix scutellariae root extract, gluathione
Peptide, hydrolysis mirabalan.The ratio of wherein each component is about：Water 40-50%, butanediol 40-50%, ursin 0.3-0.8%,
Citric acid 0.3-0.6%, sodium sulfite 0.4-0.6%, Acetyl Tyrosine 0.1-0.3%, aaron's beard extract 0.01-
0.3%, peony root extractive 0.01-0.2%, aminopropanol ascorbic acid phosphoric acid esters 0.001-0.1%, radix scutellariae root extract
0.01-0.1%, glutathione 0.001-0.1%, hydrolysis mirabalan 0.01-0.6%.
In the whitening compound：
Absorb ultraviolet light --- ursin, radix scutellariae root extract；
Inhibit inflammatory factor activity --- radix scutellariae root extract, peony root extractive；
Inhibit tyrosinase activity --- ursin；
The polymerization of melanin autoxidation and reduction melanin is inhibited to be formed --- aaron's beard extract, scutellariae,radix
Extract, aminopropanol ascorbic acid phosphoric acid esters；
Repair UV-induced DNA damage --- aaron's beard extract；
Promote synthesis brown-black element rather than eumelanin --- glutathione；
Tyrosinase --- Acetyl Tyrosine is competed with tyrosine；
Promote hyperplasia and cutin update --- aminopropanol ascorbic acid phosphoric acid esters, citric acid；
Melanin is inhibited to be annexed by horn cell --- hydrolysis mirabalan.
By the research and experimental analysis to above-mentioned mechanism, in this cosmetic composition, when this whitening compound dosage
When less than 1%, this cosmetic composition whitening effect unobvious.When this whitening compound dosage is higher than 4%, this cosmetics group
The heat-resisting light fastness stability for closing object is deteriorated.Therefore select dosage for 1-4%.
Effect of the citrus bark extract in this cosmetic composition, which is collaboration other components, keeps skin brighter and cleaner bright.And
Its general flavone amount and type are a standards of its quality.The citrus bark extract used in this cosmetic composition uses dioxy
Change carbon supercritical extraction technique, the orange peel extractive total flavone content of this technology extraction can be more than 2.5%, hence it is evident that than other
The content that mode is extracted wants high.And there is environmental-friendly, energy saving advantage.In the experiment of this cosmetic composition, orange peel
For the content of extract when less than 0.2%, role is small, and when its content is more than 1.5%, this cosmetic composition exists
Illumination and 45 DEG C it is heat-resisting when be easy discoloration, therefore select 0.5-1.5%.
It is the cosmetics-stage raw material that content surpasses 98% that ursin is selected in this cosmetic composition, has and inhibits melanin
The ability of key enzyme-tyrosinase activity in generating process also has the effect of absorbing ultraviolet light.Since ursin is in structure
Upper and tyrosine has similitude, therefore can be with tyrosine competitive binding tyrosine during tyrosine synthesis of melanin
Enzyme, to reduce the effect of tyrosinase catalysis tyrosine synthesis of melanin.The content of ursin is low in this cosmetic composition
When 0.1%, risen whitening effect very little；When its content is more than 0.8%, this cosmetic composition is variable during storage
It is red.Therefore selection 0.1-0.5%.
A kind of oligopeptides -4 selected in cosmetic composition of the present invention, biotechnology raw material based on plant, can protect
Active oxygen (ROS), Matrix Metalloproteinase-9 (MMP-9) and tumor necrosis factor (TNFa) of the Skin Cell from radiation-actuate
Caused by inflammation and light aging multifunctional protein.In addition, she can reduce superficial melanin content, help uniformly highlights skin
Color.
Solvent in cosmetic composition of the present invention is deionized water；
Moisturizer in cosmetic composition of the present invention is including but not limited to glycerine, propylene glycol, 1,3- propylene glycol, fourth two
Alcohol, hexylene glycol, 1,2- pentanediols, pungent glycol, sorbierite and hexyl glycerine, trehalose, glycine betaine, Sodium Hyaluronate, carbohydrate
Isomer, urea, allantoin, panthenol, glyceryl acrylate/acrylic copolymer, glucan and combinations thereof；
Thickener in cosmetic composition of the present invention is including but not limited to xanthans, carbomer, cellulose and its modification
Object, gellan gum, polyacrylamide, sodium acrylate/sodium acryloyldimethyl taurate copolymers, hydroxy-ethyl acrylate/acryloyl
Dimethyltaurine sodium copolymer, polyacrylate -13, acrylamide/acrylic amine copolymer, hydroxy-ethyl acrylate/propylene
Acyl dimethyltaurine sodium copolymer, acryloyldimethyl taurine ammonia/VP copolymers and combinations thereof；
Emulsifier in cosmetic composition of the present invention is including but not limited to cetostearyl alcohol, hexadecanol, stearyl alcohol, 20
Glycol, arachidic alcohol, docosyl alcohol, stearine, Cetyl Phosphate potassium, methyl sesquistearate, PEG-20 methyl
Glucose sesquistearate, hydrolecithin, cetostearyl alcohol olive oleate, Sorbitan fatty acid esters class, polysorbate
Class, alkyl glucosides glycoside, sucrose-fatty esters, stearoyl-glutamic acid sodium, polyglyceryl fatty acid ester class, polyethylene glycol stearic acid
Esters, poly alkyl alcohol ethers, polyethylene glycol are polysiloxane-based and combinations thereof；
Emollient in cosmetic composition of the present invention is including but not limited to vegetable fat, animal fat, Synthetic Oil, mine
Object grease and combinations thereof；Ultra-violet absorber is including but not limited to BHT, TINOGARD TT, VE, sun-screening agent and combinations thereof；
Skin conditioning agent is including but not limited to agent of releiving, anti-sensitizer and combinations thereof；
Chelating agent in cosmetic composition of the present invention is including but not limited to EDTA-2NA, EDTA-4NA and combinations thereof；
Preservative is including but not limited to Phenoxyethanol, parabens, organic acid, imidazolidinyl ureas and combinations thereof.
Cosmetic composition of the present invention is by adopting the above-described technical solution, can be to avoid skin because of some whitening node
Signal the phenomenon that enhancing obtains negative-feedback signal (melanin reduce, need mass production melanin) suddenly.It both can be
Act synergistically prominent whitening effect in several whitening key points, and can be controlled on the node of entire whitening chain so that human body
The generation of the reduction melanin of integumentary system harmony is transmitted to reach whitening skin lightening result.It is demonstrated experimentally that the present composition
Synergy on whitening function protrudes.
Specific implementation mode
A part of specific embodiment is set forth below, and the present invention will be described, these examples are served only for making into one the present invention
The explanation of step is not used to limit the present invention, does not represent limiting the scope of the invention.Other people make according to the present invention
Some it is nonessential modification and adjustment still fall within protection scope of the present invention.Unless otherwise instructed, percentage (%) below
It is mass percentage.
The present invention can absorb ultraviolet light, inhibit inflammatory factor, repair damaged dna, remove free radical, inhibit tyrosine
Enzyme restores melanin, inhibits melanin to be shifted by phagocytosis, and then achieve the purpose that whitening.The present invention both can be in tyrosinase
Inhibit, emphasis effect in terms of melanin transfer, and can act synergistically in other respects, can both reach whitening effect outstanding
It again can be with equilibrium coordination without causing negative-feedback phenomenon.
Embodiment 1-3
Face cream, raw material components proportioning, reference examples raw material is made in a kind of cosmetic composition with whitening skin lightening
The content of component proportion and blank example component proportion, as shown in table 1 below.
1 embodiment 1-3 of table, reference examples 1-5 and blank example (unit：Quality %)
The process for making of face cream is made in this cosmetic composition, can be expressed as follows：
1, water phase pot, agitating and heating is added in deionized water, DETA-2NA, butanediol, allantoin, stearoyl-glutamic acid sodium
To 75-80 DEG C, it is dispersed with stirring uniformly, as A phases；
2, oil is added in monoglyceride, cetostearyl alcohol, caprylic/capric triglyceride, isopropyl myristate, shea butter
Phase pot is stirred and heated to 75-80 DEG C, and stirring and dissolving is uniform, as B phases；
3, it is pumped into when A, B is identical in emulsification pot, emulsifying 6 minutes, by the scattered xanthan gum of glycerine and polypropylene
Acid esters -13 (and) polyisobutene (and) polysorbate -20, emulsification pot is added, homogeneous 6 minutes keeps the temperature 20 minutes, opens cooling
Water；
4, niacinamide, ursin is solvent with suitable aqua sterilisa, for use；
5, when expecting that body cools to 40 DEG C or less in pot, essence, solubilizer, preservative, whitening compound, orange peel are carried
It takes object, solvent niacinamide, oligopeptides -4 and ursin to be added in emulsification pot, stirs evenly；
Ingredient 9- whitening compounds therein, raw material components formula and content are as shown in table 2 below.
The raw material components formula of 2 whitening compound of table
1, tester：80 people's healthy womens (25~45 years old) are divided into 8 groups, and every group is respectively 10 people；Every group uses formula of the same race
Product.
2, test zone：Face's (left face blank sample, right face reference examples sample or embodiment sample)；
3, it uses：Sooner or later twice daily, it persistently uses 4 weeks
4, test equipment：DelfinSkinColorCatch (Finland)
5, effectiveness indicator：Measure variation (the Δ L of colour brightness*), ITA degree, the present invention in L*It is worth (brightness), ITA degree (face
Color individual type angle), it is primarily used to index.
Equation (1)：ΔL*=[L*(reference examples or embodiment product carry out after testing 1 month)-L*(carry out on-test
Before)]-[L*(after blank product carries out experiment 1 month)-L*(before carrying out on-test)]；
(2)：ITA degree (represents coloration entire change situation, ITA ° of value is bigger, and the colour of skin is more shallow.)
| ITA ° of range | Skin color is classified |
| 55–90 | Very light are very shallow |
| 41–54 | Light is shallow |
| 28–40 | Intermediate is medium |
| 10–27 | Tanned is tanned |
| -30–9 | Brown brown |
| -90–-29 | - 29Dark is dark-coloured |
5, test effect is as shown in table 3 below：
Find out, lightening compositions of the present invention, by the synergistic effect between component, have than more significant by the result of table 3
Whitening, the effect of bright color, the effect than single whitening composition becomes apparent from.
Embodiment 4
A kind of lightening compositions are made frost, raw material components proportioning, content of the reference examples raw material components with when blank example,
As shown in table 4 below.
4 embodiment 4 of table, the skin whitener (unit of reference examples 5-14 and blank example：Quality %)
The process for making of the present composition (frost) is same as above.
Ingredient 16- whitening compounds therein, raw material components formula and content are as shown in table 5.
The raw material components formula of 5 whitening compound of table
Compliance test result test example (whitening evaluation)
1, tester：77 people's healthy womens (25~45 years old) are divided into 11 groups, and every group is respectively 7 people, and every group uses formula of the same race
Product.
2, test zone：Face's (left face blank sample, right face reference examples sample or embodiment sample)；
3, it uses：Sooner or later twice daily, it persistently uses 4 weeks；
4, test equipment：DelfinSkinColorCatch (Finland)；
5, effectiveness indicator：Measure the variation (Δ L*) of variation, the ITA degree of colour brightness, L* values (brightness) in the present invention,
ITA degree (color individual type angle), is primarily used to index.
Equation (1)：ΔL*=[L*(reference examples or embodiment product carry out after testing 1 month)-L*(carry out on-test
Before)]-[L*(after blank product carries out experiment 1 month)-L*(before carrying out on-test)]；
(2)：ITA degree (represents coloration entire change situation, ITA ° of value is bigger, and the colour of skin is more shallow.)
6, test effect is as shown in table 6 below：
Find out, the present composition, by the synergistic effect between component, have relatively significant more beautiful by the result of table 6
In vain, the effect of bright color becomes apparent from than two kinds, three kinds or four kinds at the whitening effect of subassembly.
Security test
1, number is tested：Totally 30 people, male 3 people, 27 people of female；Minimal ages：24 years old, max age：45
Year；35.73 ± 7.15 years old aspiration inclusion criteria of average age.
2, test method：Embodiment 1-4 does patch test.Qualified spot is selected to try device, in enclosed type patch test method,
Tested material about 0.020~0.025mL is placed in spot examination device, external application medical adhesive tape is pasted on subject back, is gone after 24 hours
Except tested material, observation dermoreaction in 0.5,24,48 hour, is pressed after removing patch《Cosmetics safety technical specification》
Dermoreaction grade scale records its result in (version in 2015).
3, evaluation criteria such as the following table 7：
7 skin adverse reaction grade scale of table
The result of table 7 is shown：Human skin enclosed type patch test results show that 0 positive reaction, root occurs in 30 people
According to《Cosmetics safety technical specification》Regulation, the tested material will not cause skin bad this batch subject in (version in 2015)
Reaction.
Stability test
1, stability test sample：3 product of embodiment.
2, test method：Inner quality standard (illumination 1 month, high/low temperature are tested 3 months), higher than national standard, professional standard.
3, test result is as follows table 8
The result of table 8 is shown：The present composition has good stability on products application.
The above described is only a preferred embodiment of the present invention, be not intended to limit the present invention in any form, therefore
It is every without departing from technical solution of the present invention content, simply repaiied to any made by above example according to the technical essence of the invention
Change, equivalent variations and modification, in the range of still falling within technical solution of the present invention.
Claims (10)
1. a kind of cosmetic composition with whitening skin lightening, which is characterized in that each comprising following mass percent meter
Component：
2. the cosmetic composition with whitening skin lightening according to claim 1, which is characterized in that include following matter
Measure each component of percentages：
3. the cosmetic composition with whitening skin lightening according to claim 1 or 2, it is characterised in that：The combination
Object selects excipient matrix to be made of one or more of components below：
4. the cosmetic composition with whitening skin lightening according to claim 3, it is characterised in that：The composition is selected auxiliary
Material matrix is made of component below：
5. the cosmetic composition with whitening skin lightening according to claim 1 or 2, it is characterised in that：It uses
Niacinamide is the cosmetic material that Nicotinic Acid Content is less than 100PPM.
6. the cosmetic composition with whitening skin lightening according to claim 1 or 2, which is characterized in that described in it
Whitening compound includes that the ratio of each component is：
Water 40-50%, butanediol 40-50%, ursin 0.3-0.8%, citric acid 0.3-0.6%, sodium sulfite 0.4-
0.6%, Acetyl Tyrosine 0.1-0.3%, aaron's beard extract 0.01-0.3%, peony root extractive 0.01-0.2%,
Aminopropanol ascorbic acid phosphoric acid esters 0.001-0.1%, radix scutellariae root extract 0.01-0.1%, glutathione 0.001-0.1%,
Hydrolyze mirabalan 0.01-0.6%.
7. the cosmetic composition with whitening skin lightening according to claim 1 or 2, it is characterised in that：The mandarin orange
Orange peel extract uses carbon dioxide supercritical extraction technology；
The ursin is the cosmetics-stage raw material that content surpasses 98%；
The oligopeptides -4 is the product of the high pure protein Transient Expression based on plant.
8. the cosmetic composition with whitening skin lightening according to claim 4, it is characterised in that：The present invention combines
Moisturizer in object is selected from：Glycerine, propylene glycol, 1,3- propylene glycol, butanediol, hexylene glycol, 1,2- pentanediols, pungent glycol, sorb
Alcohol and hexyl glycerine, trehalose, glycine betaine, Sodium Hyaluronate, carbohydrate isomer, urea, allantoin, panthenol, glycerine
It is one or more in acrylate/acrylic copolymer, glucan and combinations thereof；
The thickener is selected from：Xanthans, carbomer, cellulose and its modifier, gellan gum, polyacrylamide, sodium acrylate/
Sodium acryloyldimethyl taurate copolymers, hydroxy-ethyl acrylate/sodium acryloyldimethyl taurate copolymers, polyacrylic acid
Ester -13, acrylamide/acrylic amine copolymer, hydroxy-ethyl acrylate/sodium acryloyldimethyl taurate copolymers, acryloyl
It is one or more in dimethyltaurine ammonia/VP copolymers and combinations thereof；
The emulsifier is selected from：Cetostearyl alcohol, hexadecanol, stearyl alcohol, docosanol, arachidic alcohol, docosyl alcohol, glycerol stearate
Ester, Cetyl Phosphate potassium, methyl sesquistearate, PEG-20 methyls sesquistearate, hydrolecithin, whale
Wax stearyl alcohol olive oleate, Sorbitan fatty acid esters class, polysorbate esters, alkyl glucosides glycoside, sucrose-fatty esters,
Stearoyl-glutamic acid sodium, polyglyceryl fatty acid ester class, polyethylene glycol stearate class, poly alkyl alcohol ethers, the poly- silicon of polyethylene glycol
It is one or more in oxygen alkanes and combinations thereof；
The emollient is selected from：One kind or more in vegetable fat, animal fat, Synthetic Oil, mineral grease and combinations thereof
Kind；
The ultra-violet absorber is selected from：It is one or more in BHT, TINOGARD TT, VE, sun-screening agent and combinations thereof；
The skin conditioning agent is selected from：It releives one or more in agent, anti-sensitizer and combinations thereof；
The chelating agent is selected from：It is one or more in EDTA-2NA, EDTA-4NA and combinations thereof；
The preservative is selected from：One in Phenoxyethanol, parabens, organic acid, imidazolidinyl ureas and combinations thereof
Kind is a variety of.
9. a kind of cosmetics, this is used for cosmetic in whitening, bright color, it is characterised in that：The cosmetics include claim 1 or
A kind of cosmetic composition described in 2.
10. cosmetics according to claim 9, it is characterised in that：The cosmetics are that face cream, facial treatment milk, skin care are solidifying
Glue, facial treatment essence or surfactant.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810731674.7A CN108653093B (en) | 2018-07-05 | 2018-07-05 | Cosmetic composition with whitening and skin brightening effects |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810731674.7A CN108653093B (en) | 2018-07-05 | 2018-07-05 | Cosmetic composition with whitening and skin brightening effects |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108653093A true CN108653093A (en) | 2018-10-16 |
| CN108653093B CN108653093B (en) | 2020-03-24 |
Family
ID=63773609
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810731674.7A Active CN108653093B (en) | 2018-07-05 | 2018-07-05 | Cosmetic composition with whitening and skin brightening effects |
Country Status (1)
| Country | Link |
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| CN (1) | CN108653093B (en) |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109381358A (en) * | 2018-12-13 | 2019-02-26 | 上海尚颜进出口贸易有限公司 | A kind of replenishing water and preserving moisture facial mask liquor manufacture method |
| CN109431823A (en) * | 2018-12-13 | 2019-03-08 | 济南豪瑞生物技术有限公司 | Hyaluronic acid derivatives and preparation method thereof |
| CN109568203A (en) * | 2018-12-18 | 2019-04-05 | 诺斯贝尔化妆品股份有限公司 | A kind of cosmetic composition with whitening skin lightening |
| CN111700853A (en) * | 2020-07-22 | 2020-09-25 | 广州澳希亚实业有限公司 | Cosmetic composition with anti-allergy repairing effect and application thereof |
| CN112891278A (en) * | 2021-03-19 | 2021-06-04 | 河南董欣生物科技有限公司 | Whitening composition, preparation method and application |
| CN113332205A (en) * | 2021-07-19 | 2021-09-03 | 上海新高姿化妆品有限公司 | Composition and cosmetic composition with effects of whitening and brightening skin color |
| CN113768818A (en) * | 2021-10-12 | 2021-12-10 | 上海新高姿化妆品有限公司 | Whitening and anti-aging composition, cosmetic and preparation method thereof |
| CN113848099A (en) * | 2021-09-03 | 2021-12-28 | 三立慧评(北京)检测技术有限公司 | Matrix composition for evaluating safety of cosmetic raw materials and preparation method and application thereof |
| CN113893184A (en) * | 2021-10-28 | 2022-01-07 | 安徽瀚海博兴生物技术有限公司 | Polypeptide whitening and freckle removing composition, skin care product and preparation method |
| CN115177565A (en) * | 2022-07-27 | 2022-10-14 | 广州环亚化妆品科技股份有限公司 | Whitening and skin-brightening composition and application thereof in cosmetics |
| CN115554194A (en) * | 2022-09-30 | 2023-01-03 | 广州欧兰化妆品有限公司 | Whitening and freckle-removing cream and preparation method thereof |
| CN116077411A (en) * | 2023-01-09 | 2023-05-09 | 康博士日化集团有限公司 | Whitening composition and preparation method and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105411931A (en) * | 2015-12-09 | 2016-03-23 | 上海新高姿化妆品有限公司 | Whitening cosmetic composition |
| WO2017102589A1 (en) * | 2015-12-14 | 2017-06-22 | Dsm Ip Assets B.V. | Composition comprising niacinamide and alpha-arbutin for skin lightening |
-
2018
- 2018-07-05 CN CN201810731674.7A patent/CN108653093B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105411931A (en) * | 2015-12-09 | 2016-03-23 | 上海新高姿化妆品有限公司 | Whitening cosmetic composition |
| WO2017102589A1 (en) * | 2015-12-14 | 2017-06-22 | Dsm Ip Assets B.V. | Composition comprising niacinamide and alpha-arbutin for skin lightening |
Non-Patent Citations (1)
| Title |
|---|
| 无: "短氨基酸序列可用作无毒美白配方", 《中国化妆品（行业）》 * |
Cited By (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109381358A (en) * | 2018-12-13 | 2019-02-26 | 上海尚颜进出口贸易有限公司 | A kind of replenishing water and preserving moisture facial mask liquor manufacture method |
| CN109431823A (en) * | 2018-12-13 | 2019-03-08 | 济南豪瑞生物技术有限公司 | Hyaluronic acid derivatives and preparation method thereof |
| CN109568203A (en) * | 2018-12-18 | 2019-04-05 | 诺斯贝尔化妆品股份有限公司 | A kind of cosmetic composition with whitening skin lightening |
| CN109568203B (en) * | 2018-12-18 | 2021-12-10 | 诺斯贝尔化妆品股份有限公司 | Cosmetic composition with whitening and skin brightening effects |
| CN111700853A (en) * | 2020-07-22 | 2020-09-25 | 广州澳希亚实业有限公司 | Cosmetic composition with anti-allergy repairing effect and application thereof |
| CN112891278A (en) * | 2021-03-19 | 2021-06-04 | 河南董欣生物科技有限公司 | Whitening composition, preparation method and application |
| CN113332205A (en) * | 2021-07-19 | 2021-09-03 | 上海新高姿化妆品有限公司 | Composition and cosmetic composition with effects of whitening and brightening skin color |
| CN113332205B (en) * | 2021-07-19 | 2022-06-07 | 上海新高姿化妆品有限公司 | Composition and cosmetic composition with effects of whitening and brightening skin color |
| CN113848099A (en) * | 2021-09-03 | 2021-12-28 | 三立慧评(北京)检测技术有限公司 | Matrix composition for evaluating safety of cosmetic raw materials and preparation method and application thereof |
| CN113768818A (en) * | 2021-10-12 | 2021-12-10 | 上海新高姿化妆品有限公司 | Whitening and anti-aging composition, cosmetic and preparation method thereof |
| CN113768818B (en) * | 2021-10-12 | 2022-09-13 | 上海新高姿化妆品有限公司 | Whitening and anti-aging composition, cosmetic and preparation method thereof |
| CN113893184A (en) * | 2021-10-28 | 2022-01-07 | 安徽瀚海博兴生物技术有限公司 | Polypeptide whitening and freckle removing composition, skin care product and preparation method |
| CN115177565A (en) * | 2022-07-27 | 2022-10-14 | 广州环亚化妆品科技股份有限公司 | Whitening and skin-brightening composition and application thereof in cosmetics |
| CN115177565B (en) * | 2022-07-27 | 2023-09-26 | 广州环亚化妆品科技股份有限公司 | Whitening and skin brightening composition and application thereof in cosmetics |
| CN115554194A (en) * | 2022-09-30 | 2023-01-03 | 广州欧兰化妆品有限公司 | Whitening and freckle-removing cream and preparation method thereof |
| CN116077411A (en) * | 2023-01-09 | 2023-05-09 | 康博士日化集团有限公司 | Whitening composition and preparation method and application thereof |
| CN116077411B (en) * | 2023-01-09 | 2024-05-28 | 康博士日化集团有限公司 | Whitening composition and preparation method and application thereof |
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| CN108653093B (en) | 2020-03-24 |
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