CN106309920A - Traditional Chinese medicine preparation for relieving fatigue and preparation method thereof - Google Patents
Traditional Chinese medicine preparation for relieving fatigue and preparation method thereof Download PDFInfo
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- CN106309920A CN106309920A CN201610892004.4A CN201610892004A CN106309920A CN 106309920 A CN106309920 A CN 106309920A CN 201610892004 A CN201610892004 A CN 201610892004A CN 106309920 A CN106309920 A CN 106309920A
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/638—Ligustrum, e.g. Chinese privet
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
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- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a traditional Chinese medicine preparation for relieving fatigue and a preparation method thereof. The traditional Chinese medicine preparation is prepared from the following components in percent by weight: 10%-40% prepared rehmannia roots, 10%-40% wolfberry fruits, 10%-30% of polygonatum sibiricum, 10%-30% of glossy privet fruits and 10%-30% of American ginseng. The traditional Chinese medicine preparation provided by the invention does not use prepared fleece-flower roots but uses polygonatum sibiricum to replace prepared fleece-flower roots, so that the traditional Chinese medicine preparation is free of toxic or side effect and can be taken for a long time without the need of liver function detection; and the traditional Chinese medicine preparation has a good function of relieving fatigue and also has the functions of strengthening yang and tonifying the kidneys.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation and preparation method thereof, this Chinese medicine preparation can effectively alleviate various fatigue.
Background technology
Chronic fatigue syndrome, is a kind of disease of modern medicine new knowledge.It is weary that this disease cardinal symptom shows as Mental fatigue
Power, insomnia and dreamful sleep, tinnitus are forgetful, sore waist and aching in the waist and the back, alopecia and early whitening of beard and hair etc..Existing general the doing of alleviation confirmed fatigue
Method is exactly directly to massage, have a rest or take the mode of medicine, but these modes often poor effect, and directly take medicine also
Toxic side effect, in the course of time, is also easy to cause other diseases to be shown effect together.In prior art, also there is employing Chinese medicine ingredients system
The functional food of standby food stage is used for fatigue alleviating, and Radix Polygoni Multiflori Preparata has invigorating the liver and kidney, benefiting essence-blood, crow beard and hair, bone and muscle strengthening, is used for
Blood deficiency and yellow complexion, vertigo and tinnitus, early whitening of beard and hair, soreness of the waist and knees, numb limbs and tense tendons etc., so, what is first often to use system in functional food
Crow is as wherein Herba indigoferae Pseudotinctoriae composition.And Radix Polygoni Multiflori eats more than 60g and can cause poisoning, dose is excessive, and producing gastrointestinal stimulates
, there are nausea,vomiting,diarrhea, ophthalmalgia, psychentonia, dysphoria, tachycardia, dyspnea, tic etc. in effect.At present
Have and be excessively used the Case report causing liver injury, also familial allergy (erythra), cause eye pigmentation and upper digestive tract
Hemorrhage grade is reported.Radix Polygoni Multiflori Preparata is the Radix Polygoni Multiflori goods through processing, so, the product containing Radix Polygoni Multiflori composition in the market will
The most periodically go to check liver function.
Summary of the invention
The technical problem to be solved is to overcome the deficiencies in the prior art, it is provided that the Chinese medicine system of a kind of fatigue alleviating
Agent and preparation method thereof.
For solving above technical problem, the present invention adopts the following technical scheme that
A kind of Chinese medicine preparation of fatigue alleviating, weight percentage, described Chinese medicine preparation is composed of the following components: 10% ~
40% Radix Rehmanniae Preparata, 10% ~ 40% Fructus Lycii, 10% ~ 30% Rhizoma Polygonati, 10% ~ 30% Fructus Ligustri Lucidi, 10% ~ 30% Radix Panacis Quinquefolii.
Further, described Chinese medicine preparation by 25% ~ 35% Radix Rehmanniae Preparata, 10% ~ 25% Fructus Lycii, 15% ~ 25% Rhizoma Polygonati, 10% ~
20% Fructus Ligustri Lucidi, 15% ~ 25% Radix Panacis Quinquefolii are made.
Further, described Chinese medicine preparation by 25% ~ 30% Radix Rehmanniae Preparata, 16% ~ 20% Fructus Lycii, 18% ~ 22% Rhizoma Polygonati, 12% ~
16% Fructus Ligustri Lucidi, 18% ~ 22% Radix Panacis Quinquefolii are made.
It is further preferred that described Chinese medicine preparation by 28% Radix Rehmanniae Preparata, 18% Fructus Lycii, 20% Rhizoma Polygonati, 14% Fructus Ligustri Lucidi,
20% Radix Panacis Quinquefolii is made.
The Radix Rehmanniae Preparata that the present invention uses: sweet in the mouth, slightly warm in nature, enters liver, kidney channel.Having nourishing YIN and supplementing blood, benefit essence fills out effect of marrow.
For diseases such as the hepatic and renal YIN deficiency, soreness of the waist and knees, night sweat seminal emissions.
Fructus Lycii: sweet in the mouth is put down, and returns liver, kidney channel.Having nourishing the liver and kidney, replenishing vital essence to improve eyesight, it is bright that research shows that Fructus Lycii has
Aobvious raising resisting fatigue and hypoxia-bearing capability.
Rhizoma Polygonati: boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney tonifying.For Deficiency and coldness of spleen and stomach, fatigue and asthenia, xerostomia lack of appetite, deficiency of the lung cough caused by dryness,
Asthenia of essence and blood, interior-heat are quenched one's thirst.It is clinically used for treating diabetes, leukopenia, coronary heart disease, pulmonary tuberculosis, chronic bronchial
Inflammation, tinea pedis etc..
The pharmacologically active of Rhizoma Polygonati: there is resisting pathogenic microbes (antibacterial, fungus, virus etc.), antitumor, resisting fatigue, resistance to lack
Oxygen, defying age, blood fat reducing, blood sugar lowering, blood pressure lowering, (leukopenia that antagonism cyclophosphamide causes strengthens neutrality to immunostimulant
Granulocyte phagocytosis), radioprotective, antioxidant activity, energy coronary artery dilator, increase coronary flow.
Contained polygonatum polysaccharide can improve body's immunity, promotes lymphocyte quantity, increases lymphocyte and softens, also
Energy anti peroxidation of lipid, has good therapeutic effect to leukopenia and respiratory tract Secondary cases fungal infection.
Fructus Ligustri Lucidi: the mature fruit of Oleaceae plants Fructus Ligustri Lucidi, property is put down, bitter in the mouth, sweet, has replenishing kidney-YIN, nourishing the liver item
Effect.For treating yin asthenia generating intrinsic heat, soreness of the waist and knees, the dizzy disease such as eye, early whitening of beard and hair.
Radix Panacis Quinquefolii: hardship sweet, micro-, cool, GUIXIN, lung, kidney channel.There is the function of boosting qi and nourishing yin, clearing away heat and promoting production of body fluid.Radix Panacis Quinquefolii contains
More than 40 plant the compositions such as saponin, various trace elements and polysaccharide, have obvious resisting fatigue, enhancing immunity and slow down aging etc. and make
With.
The another kind of technical scheme that the present invention takes is: the preparation method of the Chinese medicine preparation of a kind of above-mentioned fatigue alleviating,
Described preparation method comprises the following steps:
(1) by Radix Rehmanniae Preparata, Fructus Lycii, Rhizoma Polygonati, Fructus Ligustri Lucidi, the cleanest system of Radix Panacis Quinquefolii, standby；
(2) take the Radix Panacis Quinquefolii crushed after being dried of 50% weight ratio, cross 100 mesh sieves,60Co irradiation sterilization, obtains Radix Panacis Quinquefolii powder, standby
With；
(3) remain the Radix Panacis Quinquefolii of 50% weight ratio, Rhizoma Polygonati, Fructus Ligustri Lucidi 70% alcohol reflux 1 ~ 3 time, add 7 ~ 9 times amount every time
Ethanol, each 1 ~ 2 hour, filters extracting solution, collects all filtrate and be concentrated to give alcohol extraction clear paste, standby；
(4) by the filtering residue of step (3) and Radix Rehmanniae Preparata, Fructus Lycii boiling 1 ~ 3 time, add 7 ~ 9 times amount water every time, each 1 ~ 2 little
Time, filter decocting liquid, collect all filtrate and be concentrated to give water and carry clear paste, standby；
(5) water that alcohol extraction clear paste step (3) obtained and step (4) obtain carries clear paste and dry, pulverize, and crosses 80 mesh sieves, standby；
(6) step (2) obtained Radix Panacis Quinquefolii powder and dried cream powder mix homogeneously that step (5) obtains, make soft with 85% ethanol
Material, 16 mesh sieves are pelletized, and are dried, 14 mesh sieve granulate.
Further, the baking temperature in step (2) is 55 DEG C ~ 65 DEG C.
Further, the detailed description of the invention preparing alcohol extraction clear paste in step (3) is: by filtrate-0.065 ~-
0.075MPa, decompression recycling ethanol to be concentrated at 60 DEG C survey relative density be 1.30 ~ 1.35 under the conditions of 60 DEG C ~ 70 DEG C.
Further, step (4) prepare water put forward the detailed description of the invention of clear paste and be: by filtrate-0.065 ~-
0.075MPa, to be evaporated at 60 DEG C under the conditions of 70 DEG C ~ 80 DEG C survey relative density be 1.30 ~ 1.35.
Further, being dried as-0.085MPa, the drying under reduced pressure of 65 DEG C in step (5), drying time is 15 ~ 18 little
Time.
Further, being dried in step (6) is 60 DEG C, and drying time is 4 ~ 5 hours.
Due to the enforcement of technique scheme, the present invention compared with prior art has the advantage that
The Chinese medicine preparation of the present invention does not use Radix Polygoni Multiflori Preparata, but uses Rhizoma Polygonati to replace Radix Polygoni Multiflori Preparata, has no side effect, takes for a long time
With being also not required to do Liver function grade, the Chinese medicine preparation of the present invention has good fatigue alleviating function, but also has tonifying YANG, benefit
Renal function.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further detailed explanation, but the present invention is not limited to these enforcement
Example.
Embodiment 1
Thering is provided the Chinese medicine preparation of a kind of fatigue alleviating, weight percentage in this example, formula is as follows:
Radix Rehmanniae Preparata 28%, Fructus Lycii 18%, Rhizoma Polygonati 20%, Fructus Ligustri Lucidi 14%, Radix Panacis Quinquefolii 20%.
Preparation method is as follows:
(1) by Radix Rehmanniae Preparata, Fructus Lycii, Rhizoma Polygonati, Fructus Ligustri Lucidi, the cleanest system of Radix Panacis Quinquefolii, standby；
(2) take 60 DEG C of crushed after being dried of Radix Panacis Quinquefolii of 50% weight ratio, cross 100 mesh sieves,60Co irradiation sterilization, obtains Radix Panacis Quinquefolii powder,
Standby；
(3) remain the Radix Panacis Quinquefolii of 50% weight ratio, Rhizoma Polygonati, Fructus Ligustri Lucidi 70% alcohol reflux 2 times, add 8 times amount ethanol every time,
Each 1.5 hours, filtering extracting solution, collect all filtrate, filtrate is reduced pressure back at-0.065 ~-0.075MPa, under the conditions of 65 DEG C
Receive ethanol and be concentrated at 60 DEG C survey relative density be 1.30 ~ 1.35, obtain alcohol extraction clear paste, standby；
(4) by the filtering residue of step (3) and Radix Rehmanniae Preparata, Fructus Lycii boiling 2 times, add 8 times amount water every time, each 1.5 hours, mistake
Filter decocting liquid, collects all filtrate, filtrate at-0.065 ~-0.075MPa, be evaporated at 60 DEG C under the conditions of 75 DEG C survey relatively
Density is 1.30 ~ 1.35, obtains water and carries clear paste, standby；
(5) water that alcohol extraction clear paste step (3) obtained and step (4) obtain carries clear paste and subtracts at-0.085MPa, under the conditions of 65 DEG C
Pressing dry dry, drying time is 15 ~ 18 hours, pulverizes, and crosses 80 mesh sieves, standby；
(6) by step (2) obtain Radix Panacis Quinquefolii powder and dried cream powder that step (5) obtains mixes 30 minutes, make soft with 85% ethanol
Material, 16 mesh sieves granulations, 60 DEG C are dried 4 ~ 5 hours, 14 mesh sieve granulate.
Embodiment 2
Thering is provided the Chinese medicine preparation of a kind of fatigue alleviating, weight percentage in this example, formula is as follows:
Radix Rehmanniae Preparata 30%, Fructus Lycii 16%, Rhizoma Polygonati 20%, Fructus Ligustri Lucidi 16%, Radix Panacis Quinquefolii 18%.
Preparation method is with embodiment 1.
Embodiment 3
Thering is provided the Chinese medicine preparation of a kind of fatigue alleviating, weight percentage in this example, formula is as follows:
Radix Rehmanniae Preparata 35%, Fructus Lycii 10%, Rhizoma Polygonati 15%, Fructus Ligustri Lucidi 15%, Radix Panacis Quinquefolii 25%.
Preparation method is with embodiment 1.
Embodiment 4
Thering is provided the Chinese medicine preparation of a kind of fatigue alleviating, weight percentage in this example, formula is as follows:
Radix Rehmanniae Preparata 23%, Fructus Lycii 19%, Rhizoma Polygonati 22%, Fructus Ligustri Lucidi 16%, Radix Panacis Quinquefolii 20%.
Preparation method is with embodiment 1.
Embodiment 5
Thering is provided the Chinese medicine preparation of a kind of fatigue alleviating, weight percentage in this example, formula is as follows:
Radix Rehmanniae Preparata 25%, Fructus Lycii 20%, Rhizoma Polygonati 18%, Fructus Ligustri Lucidi 16%, Radix Panacis Quinquefolii 21%.
Preparation method is with embodiment 1.
Clinical trial
The object of observation is outpatient.Taking 6 months, taking trencherman's cardinal symptom is: psychentonia, irritated insomnia, shortness of breath and tired spirit,
Waist soreness, inappetence, hypomnesis, sexual disorder etc..All possess wherein four cardinal symptom persons, all includes test in
Case.
Examination trencherman amount to 100 examples, patient all between 4 ~ 15 weeks, the age between 38 ~ 65 years old, 4 weeks observing times.
Observation item and index
Safety is observed: 1) blood, urine, feces routine test；2) Liver and kidney function inspection；3) chest X-ray；4) B ultrasonic, electrocardiogram
Check.
In addition to checking once before Chest X-rays, B ultrasonic, electrocardiogram medication, before and after remaining index medication, once, result confirms in each inspection
Before and after's indices statistical result of taking medicine there was no significant difference, and illustrates that this fatigue alleviating product safety has no side effect.
Efficacy assessment standard:
Curing: energetic, resourceful, god is sleeping good, honey stomach, and lassitude loin and legs's disease disappears；
Effective: above-mentioned symptom has three improvers；
Effective: above-mentioned symptom has two improvers；
Invalid: none improver of above-mentioned symptom.
After treatment, cure 40 examples (40%), effective 50 examples (50%), effective 8 examples (8%), invalid 2 examples (2%).Visible treatment
Effect is notable.
Above-mentioned outpatient takes the Chinese medicine preparation of embodiment 1 preparation, and directly oral 12 months, result was: cure 60
Example (60%), effective 30 examples (30%), effective 9 examples (9%), invalid 1 example (1%).Take medicine before and after's indices without significant difference.
Above-mentioned outpatient is taken the Chinese medicine preparation using formula as below to prepare: Radix Rehmanniae Preparata 28%, Fructus Lycii 18%, system how
The Radix Polygoni Multiflori 20%, Fructus Ligustri Lucidi 14%, Radix Panacis Quinquefolii 20%.Directly oral 12 months, cure 30 examples (30%), effective 45 examples (45%), effective 22
Example (22%), invalid 3 examples (3%).In period of taking medicine, patient periodically to do Liver function grade, depending on individual physique, and substantially 3
Within about individual month, do Liver function grade.
The Chinese medicine preparation using embodiment 1 preparation carries out clinical trial, direct mouth to the clinical 100 examples worker of staying up late for a long time
Clothes, result is: cure 70 examples (70%), effective 20 examples (20%), effective 9 examples (9%), invalid 1 example (1%).
The construction site workman using the Chinese medicine preparation of embodiment 2 preparation that clinical 100 examples are carried out building operation for a long time enters
Row clinical trial, is directly administered orally, and result is: cure 65 examples (65%), effective 21 examples (21%), effective 12 examples (12%), invalid 2 examples
(2%).
The Chinese medicine preparation using embodiment 3 preparation carries out clinical trial to clinical 100 example university students, is directly administered orally, result
For: cure 61 examples (61%), effective 20 examples (20%), effective 16 examples (16%), invalid 3 examples (3%).
Use the Chinese medicine preparation of preparation of embodiment 1 to occurring that impotence and premature ejaculation is sick, sleep not good enough, the patient of fatigue in both spirit and physical strength
(45 years old, man) carries out clinical trial, is directly administered orally, sleep after month, spirit amelioration, and physical ability strengthens, and function of male becomes hard
By force.
Above the present invention is described in detail, its object is to allow the personage being familiar with this art will appreciate that this
Invention content and be carried out, can not limit the scope of the invention with this, and the invention is not restricted to above-mentioned enforcement
Example, all equivalence changes made according to the spirit of the present invention or modification, all should contain within protection scope of the present invention.
Claims (10)
1. the Chinese medicine preparation of a fatigue alleviating, it is characterised in that weight percentage, described Chinese medicine preparation is by following group
It is grouped into: 10% ~ 40% Radix Rehmanniae Preparata, 10% ~ 40% Fructus Lycii, 10% ~ 30% Rhizoma Polygonati, 10% ~ 30% Fructus Ligustri Lucidi, 10% ~ 30% Radix Panacis Quinquefolii.
The Chinese medicine preparation of fatigue alleviating the most according to claim 1, it is characterised in that: described Chinese medicine preparation is by 25% ~ 35%
Radix Rehmanniae Preparata, 10% ~ 25% Fructus Lycii, 15% ~ 25% Rhizoma Polygonati, 10% ~ 20% Fructus Ligustri Lucidi, 15% ~ 25% Radix Panacis Quinquefolii are made.
The Chinese medicine preparation of fatigue alleviating the most according to claim 2, it is characterised in that: described Chinese medicine preparation is by 25% ~ 30%
Radix Rehmanniae Preparata, 16% ~ 20% Fructus Lycii, 18% ~ 22% Rhizoma Polygonati, 12% ~ 16% Fructus Ligustri Lucidi, 18% ~ 22% Radix Panacis Quinquefolii are made.
The Chinese medicine preparation of fatigue alleviating the most according to claim 3, it is characterised in that: described Chinese medicine preparation is by 28% Radix Rehmanniae Preparata
Huang, 18% Fructus Lycii, 20% Rhizoma Polygonati, 14% Fructus Ligustri Lucidi, 20% Radix Panacis Quinquefolii are made.
5. a preparation method for the Chinese medicine preparation of the fatigue alleviating described in claim any one of claim 1 ~ 4, it is special
Levying and be, described preparation method comprises the following steps:
(1) by Radix Rehmanniae Preparata, Fructus Lycii, Rhizoma Polygonati, Fructus Ligustri Lucidi, the cleanest system of Radix Panacis Quinquefolii, standby；
(2) take the Radix Panacis Quinquefolii crushed after being dried of 50% weight ratio, cross 100 mesh sieves,60Co irradiation sterilization, obtains Radix Panacis Quinquefolii powder, standby；
(3) remain the Radix Panacis Quinquefolii of 50% weight ratio, Rhizoma Polygonati, Fructus Ligustri Lucidi 70% alcohol reflux 1 ~ 3 time, add 7 ~ 9 times amount every time
Ethanol, each 1 ~ 2 hour, filters extracting solution, collects all filtrate and be concentrated to give alcohol extraction clear paste, standby；
(4) by the filtering residue of step (3) and Radix Rehmanniae Preparata, Fructus Lycii boiling 1 ~ 3 time, add 7 ~ 9 times amount water every time, each 1 ~ 2 little
Time, filter decocting liquid, collect all filtrate and be concentrated to give water and carry clear paste, standby；
(5) water that alcohol extraction clear paste step (3) obtained and step (4) obtain carries clear paste and dry, pulverize, and crosses 80 mesh sieves, standby；
(6) step (2) obtained Radix Panacis Quinquefolii powder and dried cream powder mix homogeneously that step (5) obtains, make soft with 85% ethanol
Material, 16 mesh sieves are pelletized, and are dried, 14 mesh sieve granulate.
Preparation method the most according to claim 5, it is characterised in that: the baking temperature in step (2) is 55 DEG C ~ 65 DEG C.
Preparation method the most according to claim 5, it is characterised in that: step (3) prepares being embodied as of alcohol extraction clear paste
Mode is: by filtrate at-0.065 ~-0.075MPa, decompression recycling ethanol be concentrated at 60 DEG C survey under the conditions of 60 DEG C ~ 70 DEG C
Relative density is 1.30 ~ 1.35.
Preparation method the most according to claim 5, it is characterised in that: step (4) prepares water and carries being embodied as of clear paste
Mode is: by filtrate at-0.065 ~-0.075MPa, be evaporated at 60 DEG C under the conditions of 70 DEG C ~ 80 DEG C survey relative density and be
1.30~1.35。
Preparation method the most according to claim 5, it is characterised in that: in step (5) be dried for-0.085MPa, 65 DEG C
Drying under reduced pressure, drying time is 15 ~ 18 hours.
Preparation method the most according to claim 5, it is characterised in that: being dried in step (6) is 60 DEG C, drying time
It it is 4 ~ 5 hours.
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| CN107216979A (en) * | 2017-06-14 | 2017-09-29 | 浙江得恩德制药股份有限公司 | A kind of American ginseng sealwort wine and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101904501A (en) * | 2010-08-02 | 2010-12-08 | 西北大学 | A kind of functional food for alleviating fatigue and its preparation method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101904501A (en) * | 2010-08-02 | 2010-12-08 | 西北大学 | A kind of functional food for alleviating fatigue and its preparation method |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107216979A (en) * | 2017-06-14 | 2017-09-29 | 浙江得恩德制药股份有限公司 | A kind of American ginseng sealwort wine and preparation method thereof |
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