CN101904501B - Functional food for relieving fatigue and preparation method thereof - Google Patents

Abstract

The invention relates to a functional food for relieving fatigue and a preparation method thereof. The functional food for relieving fatigue comprises 10-60% by weight of rehmannia glutinosa, 10-60% of medlar, 10-60% of Radix Polygoni Multiflori, 15% -50% Ligustrum lucidum and 5-30% American ginseng. The invention provides a fatigue-relieving functional food capable of rapidly relieving fatigue, having no toxic and side effects and remarkable effect and a preparation method thereof.

Description

A kind of functional food for alleviating fatigue and its preparation method

technical field

The invention belongs to the field of food, and in particular relates to a functional food for relieving fatigue and a preparation method thereof.

Background technique

At present, the number of chronic fatigue syndromes caused by various reasons is large, and it is increasing year by year all over the world. The problems in life and work caused by it are also increasing, and it has become a social problem. The general way to relieve chronic fatigue is to directly massage, rest or take medicine directly, but these methods are often ineffective, and when using medicine treatment, there are often toxic side effects, and over time, it is easy to cause other diseases to attack together. According to domestic and foreign literature, there are still few compound foods that can quickly relieve fatigue. Therefore, it is imminent to provide a functional food that can quickly and effectively relieve or relieve physical and mental fatigue.

Contents of the invention

In order to solve the above-mentioned technical problems in the background technology, the present invention provides a fatigue-relieving functional food that can rapidly relieve fatigue, has no toxic and side effects, and has a significant effect and a preparation method thereof.

The technical solution of the present invention is: the present invention provides a functional food for relieving fatigue, which is special in that: the functional food for relieving fatigue includes 10-60% rehmannia glutinosa, Lycium barbarum fruit, 10-60% Radix Polygoni Multiflori, 15-50% Ligustrum lucidum and 5-30% American ginseng are prepared.

The aforementioned functional food for relieving fatigue comprises 15-40% rehmannia glutinosa, 13-35% medlar, 15-30% Radix Polygoni Multiflori, 16-30% Ligustrum lucidum and 6-25% American ginseng. come.

The above-mentioned functional food for relieving fatigue comprises 20-33% rehmannia glutinosa, 15-30% medlar, 16.5-30% Radix Polygoni Multiflori, 18-28.5% Ligustrum lucidum and 7-24% American ginseng. come.

The aforementioned functional food for relieving fatigue comprises 22.4-30% by weight of Rehmannia glutinosa, 16.7-28.2% of Lycium barbarum, 16.8-26% of Polygonum multiflorum, 18.5-27.8% of Ligustrum lucidum and 7.8-22.4% of American ginseng. come.

A method for preparing a functional food for relieving fatigue, which is special in that: the method includes the following steps:

1) Clean rehmannia glutinosa, medlar, Radix Polygoni Multiflori, Ligustrum lucidum and American ginseng separately, and set aside;

2) take American ginseng with a weight ratio of 50%, dry it, grind it, pass through a 100-mesh sieve, sterilize it by irradiation, and set it aside;

3) Take the remaining Radix Polygoni Multiflori and Ligustrum lucidum and extract them with ethanol for 1-4 times, adding 7-10 times the amount of solvent each time for 1-3 hours each time, collecting all the filtrates and concentrating them into an alcohol-extracted clear paste for later use ;

4) Take Rehmannia glutinosa, Lycium barbarum fruit and the alcohol-extracted medicinal residue obtained in step 3), add water to decoct 1-3 times, add 7-10 times the amount of water each time, and collect all the filtrate and concentrate to Water extraction cream, set aside;

5) drying the alcohol-extracted clear paste and water-extracted clear paste obtained in step 3) and step 4), pulverized, and passed through an 80-mesh sieve to obtain dry paste powder;

6) Mix the dry paste powder obtained in step 2) with the western ginseng obtained in step 5), use 85% ethanol to make a soft material, granulate with a 16-mesh sieve, dry at 60°C, and granulate with a 14-mesh sieve to obtain the finished product .

The condition of irradiation sterilization in the above step 2) is irradiation sterilization with ⁶⁰ Co.

The above step 3) to obtain the alcohol extraction paste is to concentrate the filtrate to an alcohol extraction paste with a relative density of 1.30-1.35 at 60°C at -0.065 to -0.075Mpa and 65°C.

Above-mentioned step 4) the condition that obtains the water extracting clear cream is that the filtrate is concentrated under reduced pressure under the condition of 75 DEG C,-0.065～-0.075Mpa to the water extracting clear cream that the relative density is 1.30-1.35 at 60 DEG C.

The above step 5) is to dry the alcohol-extracted paste and the water-extracted paste at 65°C and -0.085Mpa under reduced pressure, pulverize them, and pass through a 80-mesh sieve to obtain dry paste powder.

The advantages of the present invention are:

The present invention provides a functional food capable of rapidly relieving fatigue and a preparation method thereof. The functional food capable of rapidly relieving fatigue prepared by the preparation method provided by the present invention is made of Rehmannia glutinosa, Lycium barbarum, Polygonum multiflorum, Pure natural raw materials such as Ligustrum lucidum and American ginseng, among them, rehmannia glutinosa nourishes yin and blood, nourishes essence and fills marrow, wolfberry fruit and Ligustrum lucidum nourishes liver and kidney, makes Shouwu tonify essence and strengthen bones, American ginseng nourishes qi and nourishes yin, clears heat and promotes body fluid, and achieves Nourishes the liver and kidneys, nourishes qi and blood, regulates the physiological state of the human body, plays a very good role in relieving physical fatigue, and can quickly relieve fatigue. Simultaneously, because the pure natural food raw material that the present invention adopts or the raw material that the country permits to be used in functional food, the usage amount is strictly limited to a certain range, so the safety is guaranteed, the long-term use has no toxic and side effects, and the use effect is very remarkable.

Detailed ways

The invention provides a functional food for relieving fatigue and a preparation method thereof based on formulas selected according to the theory of traditional Chinese medicine diet therapy and recuperation and clinical experience.

A functional food for relieving fatigue, which comprises 10-60% by weight of rehmannia glutinosa, 10-60% of medlar, 10-60% of Polygonum multiflorum, and 15-50% of Ligustrum lucidum and 5-30% American ginseng, and can also include 15-40% rehmannia glutinosa, 13-35% medlar, 15-30% Polygonum multiflorum, 16-30% Ligustrum lucidum and Prepared from 6-25% American ginseng; especially including rehmannia glutinosa 20-33% by weight, 15-30% medlar, 16.5-30% Radix Polygoni Multiflori, 18-28.5% Ligustrum lucidum and 7- 24% American ginseng is prepared, preferably including 22.4-30% rehmannia glutinosa, 16.7-28.2% medlar, 16.8-26% Radix Polygoni Multiflori, 18.5-27.8% Ligustrum lucidum and 7.8-22.4% by weight % American ginseng is prepared.

The Chinese medicine prescription that the present invention adopts is:

Rehmannia glutinosa: sweet in taste, slightly warm in nature, enters the liver and kidney channels. It has the effects of nourishing yin and enriching blood, benefiting essence and filling marrow. For liver and kidney yin deficiency, soreness of the waist and knees, night sweats and nocturnal emission embolisms. Rehmannia glutinosa contains carbohydrates, a variety of amino acids, a variety of trace elements, and also contains catalpol, mannitol, rehmanthin, and vitamin A-like substances. Many experiments have shown that Rehmannia glutinosa extract has obvious effects on the anti-fatigue ability of mice in swimming and scavenging free radicals.

Lycium barbarum: flat in nature, sweet in taste, enters the liver and kidney channels. It has the functions of nourishing liver and kidney, benefiting energy and improving eyesight. The main active ingredient of Lycium barbarum is Lycium barbarum polysaccharides. Research shows that Lycium barbarum can significantly improve the ability to resist fatigue and hypoxia.

Radix Polygoni Multiflori: Bitter, sweet, astringent, warm, returns to liver, heart, kidney meridian and has the effect of nourishing liver and kidney, benefiting essence and blood, strengthening muscles and bones. Experiments have shown that in addition to anti-fatigue and improving immunity, Radix Polygoni Multiflori also has the effect of lowering blood fat.

Ligustrum lucidum: sweet, bitter, cool. Return liver, kidney meridian, have the effect of nourishing liver and kidney, improving eyesight and black hair. For dizziness and tinnitus, soreness of the waist and knees, premature graying of the beard and hair, and blindness. Experimental studies have shown that salidroside and polysaccharides contained in it have obvious anti-fatigue and anti-oxidation effects.

American ginseng: sweet, slightly bitter, cool, homecoming, lung, kidney meridian. It has the functions of invigorating qi and nourishing yin, clearing away heat and promoting body fluid. American ginseng contains more than 40 kinds of saponins, various trace elements and polysaccharides, which have obvious effects of anti-fatigue, enhancing immunity and delaying aging.

After long-term practice, the inventors have obtained the following proportioning examples (in weight percent), according to which the beneficial effects mentioned in the present invention can be realized.

A method for preparing a functional food for relieving fatigue, the method comprising the following steps:

1) Clean rehmannia glutinosa, medlar, Radix Polygoni Multiflori, Ligustrum lucidum and American ginseng separately, and set aside;

2) take American ginseng with a weight ratio of 50%, dry it, pulverize it, pass through a 100-mesh sieve, sterilize it with ⁶⁰ Co radiation, and set it aside;

3) Take the remaining Radix Polygoni Multiflori and Ligustrum lucidum and extract them with ethanol for 1-4 times, adding 7-10 times the amount of solvent each time for 1-3 hours each time, collecting all the filtrates and concentrating them into an alcohol-extracted clear paste for later use , the condition of the alcohol extraction paste is to concentrate the filtrate at -0.065～-0.075Mpa, 65°C to an alcohol extraction paste with a relative density of 1.30-1.35 at 60°C;

4) Take Rehmannia glutinosa, medlar and alcohol extraction dregs and decoct 1-3 times, add 7-10 times the amount of water each time, 1-3 hours each time, collect all the filtrates and concentrate them into a water-extracted clear paste for later use The condition for obtaining the water extraction paste is to concentrate the filtrate under reduced pressure at 75°C and -0.065～-0.075Mpa to a water extraction paste with a relative density of 1.30-1.35 at 60°C;

5) Dry the alcohol-extracted clear paste and water-extracted clear paste obtained in step 3) and step 4), dry at 65°C and -0.085Mpa under reduced pressure, pulverize, and pass through a 80-mesh sieve to obtain a dry paste powder;

6) Mix the dry paste powder obtained in step 2) with the western ginseng obtained in step 5), use 85% ethanol to make a soft material, granulate with a 16-mesh sieve, dry at 60°C, and granulate with a 14-mesh sieve to obtain the finished product .

Some experimental data of the present invention:

According to the above ratios, multiple groups of medicinal material ratios were selected to conduct safety and toxicology, animal feeding, efficacy and other tests. The results are as follows:

1 safety and toxicology test data

1.1 Acute oral toxicity test in mice

Table 1 Acute toxicity test results on mice

As can be seen from Table 1, after the sample of the maximum dosage (dose is 30000mg/kg BW) was given to mice for gavage, the animals grew well, and no body weight was affected. None of the tested mice had symptoms of poisoning, and no animal died after 14 days of observation. At the end of the test, the animal was dissected and observed in general. There were no obvious abnormal changes in major organs such as liver, kidney, spleen, heart, lung, stomach, and intestine. According to the acute toxicity classification standard, the acute oral toxicity of the sample was non-toxic.

1.2 Genetic toxicity test

The results of three genetic toxicity tests (Ames, mouse bone marrow cell micronucleus test, and mouse sperm abnormality test) were all negative.

Table 2 Ames test results (first time)

Table 3 Ames test results (second time)

As can be seen from Table 2 and Table 3, to TA97a, TA98, TA100, TA102 four kinds of test bacterial strains, no matter whether add S _-9 , the number of back-changing colonies of each dosage group of the sample is not more than twice of the number of spontaneous back-changing colonies, also There is no dose-response relationship, indicating that the mutagenesis test result of the test substance is negative.

1.3 Mouse bone marrow micronucleus test

Table 4 Effects on the incidence of bone marrow micronuclei in mice

As can be seen from Table 4, the micronucleus rate of each dose group of the sample is compared with the negative control group, and the difference is all insignificant (P＞0.05), while the cyclophosphamide positive control group and the negative control group have a very significant difference (P＜0.05). 0.01). The sample was not found to have any damage to the bone marrow cells of the mice.

1.4 Mouse sperm abnormality test

Table 5 Effects on the Incidence Rate of Sperm Deformity in Mice

As can be seen from Table 5, the sample does not produce significant changes to the incidence of sperm deformity in mice. Compared with the negative control group, the sperm deformity rate of each dose group of the sample has no significant difference (P>0.05), while the cyclophosphamide positive control group Compared with the negative control group, the difference was extremely significant (P<0.01). The sample was not found to have a distortion effect on mouse sperm.

2 Rat 30-day feeding test

2.1 General performance of animals: During the experiment, the animals in each group grew and developed well, no abnormal behavior and poisoning performance were found in the animals, and no animals in each group died.

2.2 The influence of the sample on the body weight and food utilization rate of rats: the results are shown in Table 6~Table 7. Sushan Leli Capsules of 4000, 3000, and 2000 mg/kg BW were given to rats by gavage for 30 days. During the experiment, the samples The weekly body weight, weight gain, weekly food intake and total food intake, weekly food utilization rate and total food utilization rate of male and female mice in each dosage group were compared with those of the control group, and there was no significant difference (P>0.05), indicating that the The samples had no significant effect on body weight gain and food utilization in rats.

Table 6 Effects on Rat Body Weight

Note: There is no significant difference between each dosage group in the table and the negative control group (P>0.05).

Table 7 on the impact of total food utilization in rats

Note: There is no significant difference between each dosage group in the table and the negative control group (P>0.05).

2.3 Effect of samples on blood routine indicators in rats

Table 8 30-day feeding test results of blood routine index inspection of rats

Note: There is no significant difference between each dosage group in the table and the negative control group (P>0.05).

Table 9 Result of blood routine index inspection of rats at the end of 30-day feeding test

Note: There is no significant difference between each dosage group in the table and the negative control group (P>0.05).

As can be seen from Table 8 and Table 9, with 4000, 3000, 2000mg/kg BW dosage, rats were given intragastric administration for 30 days, the hemoglobin, total number of red blood cells, total number of white blood cells and their classification, platelet count of each dosage group of samples The numerical values were all within the normal range, and compared with the control group, there was no significant difference (P>0.05), indicating that the sample had no obvious influence on the blood routine indexes of the rats.

2.4 Effect of samples on blood biochemical indicators of rats

The results are shown in Table 10 and Table 11. The Sushan brand Leli Capsules of 4000, 3000, and 2000 mg/kg BW doses were administered to rats for 30 days, and the serum aspartate aminotransferase and alanine aminotransferase of female and male rats in each dosage group were sampled. , blood urea nitrogen, creatinine, cholesterol, triglycerides, total protein, albumin, and blood sugar were all within the normal range, and compared with the control group, there was no significant difference (P>0.05), indicating that the sample had no significant effect on large There was no obvious effect on the blood biochemical indexes of the mice.

Table 10 30-day feeding test ended rat blood biochemical index inspection results

Note: There is no significant difference between each dosage group in the table and the negative control group (P>0.05).

Table 11 30-day feeding test results of blood biochemical indicators in rats

Note: There is no significant difference between each dosage group in the table and the negative control group (P>0.05).

Conclusion: After administration of the sample with the maximum dose (30000mg/kg BW) to the mice, no symptoms of poisoning and death were observed in the animals, and the acute oral toxicity was non-toxic. The results of three genetic toxicity tests (Ames test, mouse bone marrow cell micronucleus test, and mouse sperm abnormality test) were all negative. In the 30-day feeding test, 3 doses of 4000, 3000, and 2000 mg/kg BW (respectively equivalent to 100, 75, and 50 times the recommended dosage for the human body) were continuously administered to rats for 30 days. During the experiment, the animals grew and developed well. The body weight, weight gain, food intake, food utilization rate, blood routine index, blood biochemical index, organ weight and organ/body weight ratio of rats in the dose group were not significantly affected; gross anatomical observation and histopathological examination were not significantly affected. See Unusual Changes Related to Samples. It is suggested that feeding the sample for 30 days has no toxic and side effects on the observed indicators of rats.

3 Function test data

Oral administration of 215, 420, and 840 mg/kg BW (respectively equivalent to 5, 10, and 20 times the recommended human dose) of Shenyuan Capsules to mice for 30 consecutive days can prolong the weight-bearing swimming time of mice , increase the reserve of liver glycogen in mice, reduce the serum urea nitrogen content of mice after exercise, and have no significant effect on the weight gain of mice and the blood lactic acid content of fatigued mice, suggesting that this sample has the function of alleviating physical fatigue.

3.1 Effects of samples on weight-bearing swimming time of mice

Table 12 Weight-bearing swimming time of mice in each group

As can be seen from Table 12, the weight-bearing (5%) swimming time of the mice in each dose group of the sample is all longer than that of the negative control group, and the differences between the high and middle dose groups and the negative control group are all significant (P＜0.05), indicating that This sample has the effect of prolonging the weight-bearing swimming time of mice.

3.2 Effect of samples on serum urea levels in mice after exercise

As can be seen from Table 13, the serum urea content of the mice in the high and middle dose groups of the sample is all lower than that of the control group, and there is significant difference compared with the negative control group (P < 0.05), indicating that the sample can significantly reduce the serum urea of the fatigued mice. generation.

Table 13 The results of serum urea determination after exercise in each group of mice

3.3 Effects of samples on liver glycogen content of mice

Table 14 Determination results of liver glycogen content in each group of mice

As can be seen from Table 14, the liver glycogen content of the mice in each dose group of the sample was higher than that of the negative control group, and the difference between the high and middle dose groups and the negative control group was significant (P＜0.01 and P＜0.05 respectively), It shows that the sample has the effect of promoting liver glycogen storage in mice.

3.4 Effect of samples on blood lactic acid value of mice after exercise

Table 15 Area under the curve of blood lactic acid (mg/L) after exercise in each group of mice

As can be seen from Table 15, the area under the blood lactic acid curve at 3 time points of each dose of the sample is close to that of the negative control group, and there is no significant difference between each dose group and the negative control group (P>0.05), indicating that the sample has no effect on the mice after exercise. The area under the curve of blood lactate had no significant effect.

3.5 Clinical trials

The functional food for relieving fatigue made by the present invention is carried out following clinical trials according to the optimal proportioning:

The observed patients were all outpatients. Time of taking: March 2009 to October 2009. The main symptoms of the users are: nervousness, irritability, insomnia, shortness of breath, fatigue, sore waist and legs, loss of appetite, memory loss, sexual dysfunction, etc. Anyone with four of the main symptoms was included in the test cases.

A total of 100 food testers were randomly divided into a treatment group and a control group. There were 50 cases in each treatment group and control group. The course of disease was between 4-15 weeks, and the age ranged from 38 to 65 years. The distribution of gender and age of the two groups was roughly balanced and comparable. The treatment group took products for relieving physical fatigue, and the control group took placebo, and the observation time was 4 weeks.

Observation items and indicators

3.5.1 Safety observation

1) Blood, urine, and stool routine tests; 2) Liver and kidney function tests; 3) Chest X-ray examination;

4) B-ultrasound and electrocardiogram examination.

In addition to the chest X-ray, B-ultrasound, and electrocardiogram, the other indicators were checked before and after the treatment. The results confirmed that there was no significant difference in the statistical results of the indicators before and after treatment in the treatment group (P>0.05), indicating that the product for relieving fatigue is safe. toxic side effect.

3.5.2 Curative effect observation

Efficacy evaluation criteria:

1) Healing: full of energy, quick thinking, good sleep, strong appetite, and the symptoms of sore waist and legs disappear;

2) Significant effect: three of the above symptoms have improved;

3) Effective: two of the above symptoms improved: 4) Ineffective: none of the above symptoms improved.

3.5.3 Curative Effect Observation Result Table

16 Table of curative effect comparison between the treatment group and the control group

group cure Significantly effective efficient invalid Total effective rate% therapy group 18 twenty three 8 1 98.0 ^**△△ control group 1 2 3 44 12

Note: **, compared with the control group, P>0.01, compared with before and after △△ self-symptom scores, P>0.01.

Compared with the two groups, the curative effect of the treatment group was significantly higher than that of the control group, and the self-symptom scores were compared before and after, and the treatment group was significantly improved.

The clinical data of the products prepared according to different ratios are as follows:

Embodiment one:

Take Rehmannia glutinosa 10% (weight ratio), wolfberry fruit 57.5%, Polygonum multiflorum 11%, Ligustrum lucidum 15% and American ginseng 6.5% to prepare functional food for relieving fatigue. After 3-6 hours of exercise in 200 clinical cases, directly Orally, the results are shown in the table below:

Table 17 embodiment one treatment group and control group curative effect comparative table

group cure Significantly effective efficient invalid Total effective rate% Treatment group 100 people 65 twenty four 7 4 96.0 ^**△△ 100 people in the control group 3 5 5 87 13

Note: **, compared with the control group, P>0.01, compared with before and after △△ self-symptom scores, P>0.01.

Embodiment two:

Take Rehmannia glutinosa 16% (by weight), medlar 10%, Polygonum multiflorum 27%, Ligustrum lucidum 30% and American ginseng 5.5% to prepare a functional food for relieving fatigue. Clinical trials were carried out on 153 long-term workers who stayed up late for a long time. Orally, the results are shown in the table below:

Table 18 embodiment two treatment group and control group curative effect comparative table

group cure Significantly effective efficient invalid Total effective rate% 81 people in the treatment group 51 twenty one 6 3 96.3 ^**△△ 72 people in the control group 1 3 3 65 9.6

Note: **, compared with the control group, P>0.01, compared with before and after △△ self-symptom scores, P>0.01.

Embodiment three:

Take Rehmannia glutinosa 18% (by weight), Lycium barbarum 13.6%, Radix Polygoni Multiflori 11.4%, Ligustrum lucidum 50% and American ginseng 7% to prepare functional food for relieving fatigue. 78 clinical cases of construction site workers who have been doing construction work for a long time were tested. Clinical trials, direct oral administration, the results are shown in the table below:

Table 18 embodiment three treatment groups and control group curative effect comparative table

group cure Significantly effective efficient invalid Total effective rate% 39 people in the treatment group twenty four 10 4 1 97.4 ^**△△ 39 people in the control group 1 1 2 35 10.2

Note: **, compared with the control group, P>0.01, compared with before and after △△ self-symptom scores, P>0.01.

Embodiment four:

Take Rehmannia glutinosa 22% (by weight), Lycium barbarum 15%, Polygonum multiflorum 12%, Ligustrum lucidum 21% and American ginseng 20% to prepare a functional food for relieving fatigue. Clinical trials were conducted on 164 cases of college students, and they were directly orally administered. See the table below for the results:

Table 19 embodiment four treatment group and control group curative effect comparative table

group cure Significantly effective efficient invalid Total effective rate% 82 people in the treatment group 48 14 15 5 94.5 ^**△△ 82 people in the control group 2 4 3 73 11

Note: **, compared with the control group, P>0.01, compared with before and after △△ self-symptom scores, P>0.01.

Claims (7)

1. A functional food for relieving fatigue, characterized in that: the functional food for relieving fatigue is composed of 10-60% rehmannia glutinosa, 10-60% medlar, 10-60% Polygonum multiflorum, 15% by weight. -50% Ligustrum lucidum and 5-30% American ginseng. 2. The functional food for relieving fatigue according to claim 1, characterized in that: the functional food for relieving fatigue consists of 15-40% rehmannia glutinosa, 13-35% medlar, 15-30% Prepared from Polygonum multiflorum, 16-30% Ligustrum lucidum and 6-25% American ginseng. 3. The functional food for relieving fatigue according to claim 2, characterized in that: the functional food for relieving fatigue consists of 20-33% rehmannia glutinosa, 15-30% medlar, 16.5- 30% Radix Polygoni Multiflori, 18-28.5% Ligustrum lucidum and 7-24% American Ginseng are prepared. 4. The functional food for relieving fatigue according to claim 3, characterized in that: the functional food for relieving fatigue consists of rehmannia glutinosa of 22.4-30% by weight, wolfberry of 16.7-28.2% 4% American ginseng prepared. 5. A method for preparing the fatigue-relieving functional food according to any one of claims 1-4, characterized in that: the method comprises the following steps: 1) Clean rehmannia glutinosa, medlar, Radix Polygoni Multiflori, Ligustrum lucidum, and American ginseng separately, and set aside; 2) Take American ginseng with 50% by weight, dry it, crush it, pass through a 100-mesh sieve, sterilize it by irradiation, and set it aside; 3) Take the remaining Radix Polygoni Multiflori and Ligustrum lucidum, extract with ethanol for 1-4 times under reflux, add 7-10 times the amount of solvent each time, and collect all the filtrates and concentrate them into alcohol-extracted clear paste for later use ; 4) Take Rehmannia glutinosa, Lycium barbarum fruit and the alcohol-extracted medicinal residue obtained in step 3), add water to decoct 1-2 times, add 7-10 times the amount of water each time, 1-3 hours each time, collect all the filtrate and concentrate to Water extraction cream, for later use; 5) Drying the alcohol-extracted clear paste and water-extracted clear paste obtained in step 3) and step 4), crushed, and passed through a 80-mesh sieve to obtain dry paste powder; 6) Mix the dry cream powder obtained in step 2) with Xiyangginseng obtained in step 5), use 85% ethanol to make a soft material, granulate with a 16-mesh sieve, dry at 60°C, and granulate with a 14-mesh sieve to obtain the finished product . 6. The method for preparing a fatigue-relieving functional food according to claim 5, characterized in that: the condition of irradiation sterilization in the step 2) is irradiation sterilization. 7. The method for preparing a fatigue-relieving functional food according to claim 6, characterized in that: the condition for obtaining the alcohol extraction cream in the step 3) is to put the filtrate at -0.065～-0.075Mpa, 65°C, 30-1.35的粉量液油。 And concentrated to the relative density of 1.30-1.35 alcohol extraction paste at 60 ° C.