CN106070245B - A kind of microbicide compositions - Google Patents
A kind of microbicide compositions Download PDFInfo
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- CN106070245B CN106070245B CN201610674115.8A CN201610674115A CN106070245B CN 106070245 B CN106070245 B CN 106070245B CN 201610674115 A CN201610674115 A CN 201610674115A CN 106070245 B CN106070245 B CN 106070245B
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- lentinan
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- polyene sugar
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
- A01N43/14—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings
- A01N43/16—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings with oxygen as the ring hetero atom
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- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
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- General Health & Medical Sciences (AREA)
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Abstract
The present invention provides a kind of microbicide compositions, the composition includes two kinds of effective constituents As and B, active component A is the structural compounds with formula (I), and active component B is selected from the lentinan of fungicide containing carbohydrate or Portugal's polyene sugar, and the weight ratio between two components is 1:0.01~20.The present invention also provides the Preparation method and uses of the composition.Test result shows that above-mentioned bactericidal composition synergy provided by the invention is apparent, it is often more important that amount of application is reduced, and use cost reduces.The bactericidal composition can effectively prevent certain specific bacteriums or the fungal disease of crop.By compounding the fungicide of different role mechanism and the mode of action, there is good effect for expand fungicidal spectrum and delay fungi, bacterial resistance and improve control effect etc..
Description
Technical field
The invention belongs to agriculture plant protection fields, more particularly to a kind of bactericidal composition for having and improving performance, tool
Say to body it is to be related to a kind of bactericidal composition including benzoisothiazolinone class and halogenated cyanuric acid class.
Background technology
Benzoisothiazolinone class compound is a kind of novel, wide-spectrum bactericide, is mainly used for preventing and treating Cereal
The various bacterias such as crop, veterinary antibiotics, fungal disease.Its bactericidal effect mechanism, main includes destroying germ cell core knot
Structure makes it lose the metabolism of cardia and failure death and interference germ cell, makes its physiologic derangement, eventually leads to dead
Die two aspects.It is not infected in the early stages of disease by pathogen using can effectively protect plant, disease takes the circumstances into consideration to increase after occurring
Dosage can obviously control the sprawling of germ, to the double action for reaching protection and rooting out.
Lentinan (fungous proteoglycan) can generate inhibiting effect to the growth of some germs, influence fungi
Spore germination, hypha form morphs, biochemistry changes in spore for induction.Gene in plant, generation can be excited to have
Chitinase, dextranase, guarantor's element and PR albumen of resistant effect etc., and there is cell activation effect, contribute to aggrieved plant
Restore, promoting root growth strong sprout, enhance the resistance of crop, promotes growth and development of plants.
Portugal's polyene sugar is a kind of excitation of the inducible disease resistance of plant from pathogen in host's cause of disease Interaction
Son is commonly called as " two sugar ", is that a kind of international new bio newly developed lures resistance virucide, activity to be significantly higher than common oligosaccharides
Product.It can effectively be passivated virus, have good control effect to disease caused by a variety of viruses：It can also promote photosynthetic work simultaneously
With the accumulation of increase sugared part and vitamin improves crop autoimmunity and defense response.
Actual pesticide experience have shown that, repeat and a kind of reactive compound of single-minded application prevent harmful fungoid very
The fast selective that will lead to fungal bacterial strain in the case of more, to reduce the danger of refractory fungal bacterial strain selectivity, at present usually
Harmful fungoid is prevented using the mixture of different activities compound.By will have the reactive compound of different role mechanism into
Row combination, can delaying drug resistance generate, reduce amount of application, reduce cost accounting.
Invention content
The purpose of the present invention is being directed to fungicide resistance and pedo relict problem in practical applications, filters out difference and kill
The fungicide of bacterium principle is compounded, and a kind of new microbicide compositions are obtained, to improve bactericidal agent for preventing and treating effect, delaying drug resistance
It generates, reduces amount of application, reduce cost accounting.
It is a further object to provide the preparation method comprising two kinds of effective constituents As and B bactericidal compositions and
Agriculture field prevents the application of corps diseases.
The purpose of the present invention can be achieved by the following measures：
A kind of microbicide compositions with synergistic effect, the composition includes two kinds of active components of A and B, wherein activity
Component A is the structural compounds with formula (I), and active component B is the lentinan of fungicide containing carbohydrate or Portugal's polyene sugar.
In formula (I), R is selected from H or C1~C8Alkyl.
C in the present invention1~C8Alkyl refers to the linear or branched alkyl group containing 1 to 8 carbon atom, it includes C1Alkyl
(such as methyl), C2Alkyl (such as ethyl), C3Alkyl (such as n-propyl, isopropyl), C4Alkyl (such as normal-butyl, isobutyl group, tertiary butyl,
Sec-butyl), C5Alkyl (such as n-pentyl), C6Alkyl, C7Alkyl, C8Alkyl.It includes but not limited to C1~C6Alkyl, C1~C5
Alkyl, C1~C4Alkyl etc..
In a kind of preferred embodiment, R is selected from H or C1~C4Alkyl.
In a kind of preferred scheme, R is selected from H ,-CH3Or-C4H9。
In formula (I), when R is H, A is 1,2-benzisothiazolin-3-one (abbreviation BIT in specification).
In formula (I), when R is CH3When, A is 2- methyl-1s, 2- benzisothiazole-3-ketones (abbreviation MBIT in specification).
In formula (I), when R is C4H9When, A is 2- butyl -1,2-benzisothiazolin-3-one, and " butyl " in the formula is preferred
Normal-butyl (abbreviation BBIT in specification).
Inventor is found by experiment that composition of the invention is for preventing crops bacterium or fungal disease prevention
Synergy is apparent, it is often more important that amount of application is reduced, and reduces use cost.Compound structure type containing component A and component B is not
Together, mechanism of action is different, and the two compounding can expand fungicidal spectrum, and can delay the production of pathogen resistance to a certain extent
Raw and development speed, and no interactions resistance between component A and component B.
The weight ratio between two components in microbicide compositions of the present invention is 1:0.01~20.For the medicine for making between two components
Effect synergistic effect is more notable, and the weight ratio between two component of weight of component A and component B can be advanced optimized to 1：0.02
~15 or 1:0.03~10..
In a kind of preferred scheme, weight ratio between two component of A and B can arbitrarily in the range of following proportionings into
Row adjustment：1：0.1、1：0.2、1：0.3、1：0.4、1：0.5、1：0.6、1：0.7、1：0.8、1：0.9、1：1、2:1、3:1、4:1、
5:1、6:1、7:1、8:1、9:1、10:1、11:1、12:1、13:1、14:1、15:1、16:1、17:1、18:1、19:1、20:1、
21:1、22:1、23:1、24:1、25:1、26:1、27:1、28:1、29:1、30:1、31:1、32:1、33:1、34:1、35:1、
36:1、37:1、38:1、39:1、40:1、41:1、42:1、43:1、44:1、45:1、46:1、47:1、48:1、49:1、50:1、
51:1、52:1、53:1、54:1、55:1、56:1、57:1、58:1、59:1、60:1、61:1、62:1、63:1、64:1、65:1、
66:1、67:1、68:1、69:1、70:1、71:1、72:1、73:1、74:1、75:1、76:1、77:1、78:1、79:1、80:1、
81:1、82:1、83:1、84:1、85:1、86:1、87:1、88:1、89:1、90：1、91：1、92：1、93：1、94：1、95：1、
96：1、97：1、98：1、99：1、100：1, it can also be selected in the range of two proportionings of any of the above are formed, these
Ratio can be understood as weight ratio, can also include molar ratio.
The dosage form allowed on pesticide can be made by active constituent and insecticides adjuvant or auxiliary material in the composition of the present invention.Into one
Step, the composition is made of the active component of 2~80% parts by weight and the insecticides adjuvant of 98~20% parts by weight to be permitted on pesticide
Perhaps dosage form.
The present invention provides the bactericidal compositions comprising component A and component B in terms of agriculture field prevents corps diseases
Purposes, the especially purposes in terms of the fungi or bacterium for preventing certain crops.
Above-mentioned composition specifically may include insecticides adjuvant or auxiliary material, such as carrier, solvent, dispersant, wetting agent, gluing
One or more of agent, thickener, adhesive, surfactant or fertilizer etc..It can be mixed during application common
Auxiliary agent.
Suitable auxiliary agent or auxiliary material can be solid or liquid, they are typically common substance during formulation,
Such as natural or regenerated minerals, solvent, dispersant, wetting agent, adhesive, thickener, adhesive.
The method of administration of the present composition includes that the composition of the present invention is used for the aerial part of plant growth, especially
It is leaf portion or blade face.It can select to soak seed or be applied to controlling object surface.The frequency and amount of application of application depend on pathogen
Biology and weather life condition.The growth place of plant, such as rice field can be soaked with the liquid preparation of composition, or
Composition is applied in soil by person in solid form, and such as in granular form (soil application), composition can be by soil through planting
Object root enters in plant (systemic action).
The composition of the present invention can be prepared into various dosage forms pesticide-acceptable, including but not limited to missible oil, suspension
Agent, wettable powder, water dispersible granules, pulvis, granula, aqua, aqueous emulsion, microemulsion, poison bait, mother liquor, female powder etc., in one kind
In preferred embodiment, dosage form of the invention uses wettable powder, suspending agent, water dispersible granules, aqueous emulsion or microemulsion.According to this
Property and application composition the institute purpose to be achieved and ambient conditions of a little compositions, can select composition to spray,
Atomizing dusts, broadcasts sowing or sprinkles the method application poured or the like.
Can by known method can by the present invention composition be prepared into various dosage forms, can by active ingredient with help
Agent can uniformly mix together with surfactant when needing, grind, be prepared into required dose such as solvent, solid carrier
Type.
Above-mentioned solvent can be selected from aromatic hydrocarbon, preferably contain 8-12 carbon atom, such as xylene mixture or substituted benzene, phthalein
Esters of gallic acid, if Dibutyl phthalate or phthalandione two are sad, fat hydrocarbon, such as thiacyclohexane or paraffin, the ether of alcohol and ethylene glycol and they
And ester, such as ethyl alcohol, ethylene glycol, ethylene glycol monomethyl；Ketone, such as cyclohexanone, highly polar solvent, such as N- methyl -2- pyrrolidines
Ketone, dimethyl sulfoxide (DMSO) or dimethylformamide and vegetable oil or vegetable oil, such as soybean oil.
Above-mentioned solid carrier, such as pulvis and dispersible dose of typically natural mineral fillers, such as talcum, kaolinite
Soil, montmorillonite or atlapulgite.In order to manage the physical property of composition, polymolecularity silicic acid or polymolecularity can also be added
Adsorpting polymerization object carrier, such as granulated adsorptive carriers or non-adsorbed carrier, suitable granulated adsorptive carriers are porous types, it is such as floating
Stone, bentonite or bentonite；Suitable non-adsorbed carrier such as calcite or sand.Further, it is possible to use a large amount of inorganic in nature or having
The prefabricated material to granulate of machine property is as carrier, especially dolomite.
The chemical property of active ingredient in composition according to the present invention, suitable surfactant are sulfomethylated lignin
Acid, naphthalene sulfonic acids, phenolsulfonic acid, alkali salt or amine salt, alkylaryl sulfonates, alkyl sulfate, alkylsulfonate, fat
Alcohol sulfate, aliphatic acid and sulphated fatty alcohol glycol ether, the also condensation product of sulfonated naphthalene and naphthalene derivatives and formaldehyde, naphthalene or
The condensation product of naphthalene sulfonic acids and phenol and formaldehyde, NONIN HS 240, ethoxylated isooctyl-phenol, octyl phenol, nonyl phenol,
Alkylaryl polyglycol ether, tributyl benzene polyglycol ether, three stearyl phenyl polyglycol ethers, alkyl aryl polyether alcohol,
Ethoxylated castor oil, polyoxyethylene alkyl ether, ethylene oxide condensation product, ethoxylation polyoxypropylene, bay acid polyethylene glycol
Ether acetal, sorbitol ester, lignin sulfite waste liquor and methylcellulose.
When preparing liquid or solid dosage forms, can active component A be first dissolved in certain specific alkaline matters, form benzene
And isothiazoline metal salt, suitable alkaline matter include：Alkali carbonate, alkali metal hydroxide (such as sodium hydroxide, hydrogen
Potassium oxide), alkali metal alkoxy carbonate, alkali metal alcoholates or magnesium methoxide.
Two kinds of active ingredients show as synergistic effect in the composition of the present invention, and the activity of the composition is than using individualized
The independent activity of the expected summation of activity and single compound of closing object is more notable.Synergistic effect shows as allowing amount of application
Reduction, broader antifungal control spectrum, quick, more longlasting control effect, by a small number of applying only once or several times more
Good control plant pest fungi and broaden the possible administration interval time.These characteristics are plant epiphyte control practices
It especially needs in the process.
In terms of the microbicide compositions of the present invention can be applied to agriculture field prevention corps diseases, targeted specific disease
Disease include but not limited to wheat diseases (such as：Wheat scab, wheat powdery mildew, wheat rust etc.), rice disease (such as：Rice
Banded sclerotial blight, rice green smut, rice blast, paddy bacterial streak etc.), maize diseases (such as：Smut of maize, corn are big
Pinta, corn southern leaf blight), cucumber disease (such as：The bacillary angle spot of cucumber downy mildew, powdery mildew of cucumber, cucumber anthracnose, cucumber
Disease etc.), tomato disease (such as：Anthracnose of tomato, graw mold of tomato, tomato bacterial angular leaf spot etc.), grape disease (such as：Grape
Downy mildew, grape grey mould, uncinula necator), apple disease (such as ring rot of apple, apple anthracnose), citrus disease (mandarin orange
Tangerine canker, citrus scab simultaneously, citrus anthracnose), tobacco diseases (wildfire) etc..
The other features of the bactericidal composition of the present invention shown are mainly shown as：1, composition mixture of the invention tool
There is apparent synergistic effect；2, since two single dose chemical constitutions of this composition are widely different, the mechanism of action is entirely different, no
There are cross resistances, can delay two single doses that generated resistance problem is used alone；3, composition of the invention to crop safety,
Preventive effect is good.Tests prove that microbicide compositions chemical property of the present invention is stablized, synergy is notable, is shown to controlling object bright
Aobvious synergy and complementation.
Specific implementation mode
In order to make the purpose , technical scheme and advantage of the present invention be clearer, with reference to embodiments, to the present invention
It is further elaborated.It should be appreciated that described herein, specific examples are only used to explain the present invention, is not used to limit
The fixed present invention, any modifications, equivalent replacements and improvementsmade within the spirit and principles of the invention, etc. should be included in
Within protection scope of the present invention.
Percentage is weight percentage in all formulas of following embodiment.The processing work of the various preparations of the present composition
Skill is the prior art, can be varied from according to different situations.
One, dosage form prepares embodiment
(1) processing of water dispersible granules and embodiment
By active constituent activity grouping A and active component B, it is mixed according to the formula uniformly, through gas with auxiliary agent and filler
Stream is ground into wettable powder, adds a certain amount of water mixing extruder grain, and water dispersible granules production is made after dry sieve
Product.
1, isothiazolinone and lentinan prepare water dispersible granules
(1) active component A (BIT) prepares water dispersible granules with active component lentinan
Embodiment 1：25.5%BIT lentinan water dispersible granules
BIT 25%, lentinan 0.5%, benzene sulfonic acid sodium salt 5%, potassium sulfate 5%, aliphatic alcohol sulfate 6%, kaolin
5%, precipitated calcium carbonate complements to 100%.
Embodiment 2：48%BIT lentinan water dispersible granules
BIT 45%, lentinan 3%, methyl naphthalene sulfonate formaldehyde condensate 5%, sodium carboxymethyl starch 5%, xanthans
6%, diatomite complements to 100%.
(2) active component A (MBIT) prepares water dispersible granules with lentinan
Embodiment 3：25.5%MBIT lentinan water dispersible granules
MBIT 25%, lentinan 0.5%, remaining component are prepared according to the method for embodiment 1.
Embodiment 4：48%MBIT lentinan water dispersible granules
MBIT 45%, lentinan 3%, remaining component are prepared according to the method for embodiment 2.
(3) active component A (BBIT) prepares water dispersible granules with lentinan
Embodiment 5：25.5%BBIT lentinan water dispersible granules
BBIT 25%, lentinan 0.5%, remaining component are prepared according to the method for embodiment 1.
Embodiment 6：48%BBIT lentinan water dispersible granules
BBIT 45%, lentinan 3%, remaining component are prepared according to the method for embodiment 2.
2, isothiazolinone and Portugal's polyene sugar prepare water dispersible granules
(1) active component A (BIT) prepares water dispersible granules with Portugal's polyene sugar
Embodiment 7：The Portugals 25.5%BIT polyene syrup dispersible granule
BIT 25%, Portugal's polyene sugar 0.5%, remaining component are prepared according to the method for embodiment 1.
Embodiment 8：The Portugals 48%BIT polyene syrup dispersible granule
BIT 45%, Portugal's polyene sugar 3%, remaining component are prepared according to the method for embodiment 2.
(2) active component A (MBIT) prepares water dispersible granules with Portugal's polyene sugar
Embodiment 9：The Portugals 25.5%MBIT polyene syrup dispersible granule
MBIT 25%, Portugal's polyene sugar 0.5%, remaining component are prepared according to the method for embodiment 1.
Embodiment 10：The Portugals 48%MBIT polyene syrup dispersible granule
MBIT 45%, Portugal's polyene sugar 3%, remaining component are prepared according to the method for embodiment 2.
(3) active component A (BBIT) prepares water dispersible granules with Portugal's polyene sugar
Embodiment 11：The Portugals 25.5%BBIT polyene syrup dispersible granule
BBIT 25%, Portugal's polyene sugar 0.5%, remaining component are prepared according to the method for embodiment 1.
Embodiment 12：The Portugals 48%BBIT polyene syrup dispersible granule
BBIT 45%, Portugal's polyene sugar 3%, remaining component are prepared according to the method for embodiment 2.
(2) processing of suspending agent and embodiment
By active constituent activity grouping A and active component B, with each components such as dispersant, wetting agent, thickener and water by matching
The ratio of side is uniformly mixed, and after sand milling and/or high speed shear, obtains semi-finished product, is mended after analysis and is mixed with water filtering i.e.
Obtain finished product.
1, isothiazolinone and lentinan prepare suspending agent
(1) active component A (BIT) prepares suspending agent with lentinan
Embodiment 13：15.2%BIT lentinan suspending agents
BIT 15%, lentinan 0.2%, calcite 6%, sodium sulfonate 5%, xanthans 5%, ethylene glycol 4%, alkyl virtue
Base sulfate 5%, water complements to 100%.
Embodiment 14：40%BIT lentinan suspending agents
BIT 20%, lentinan 20%, bentonite 6%, propylene glycol 6%, ethylene oxide condensation product 6%, water complements to
100%.
Embodiment 15：21%BIT lentinan suspending agents
BIT 1%, lentinan 20%, diatomite 6%, toluene 5%, sodium lignin sulfonate 5%, lignin sulfite
Waste liquid 4%, water complements to 100%.
(2) active component A (MBIT) prepares suspending agent with lentinan
Embodiment 16：15.2%MBIT lentinan suspending agents
MBIT 15%, lentinan 0.2%, remaining component are prepared according to the method for embodiment 13.
Embodiment 17：40%MBIT lentinan suspending agents
MBIT 20%, lentinan 20%, remaining component are prepared according to the method for embodiment 14.
Embodiment 18：21%MBIT lentinan suspending agents
MBIT 1%, lentinan 20%, remaining component are prepared according to the method for embodiment 15.
(3) active component A (BBIT) prepares suspending agent with lentinan
Embodiment 19：15.2%BBIT lentinan suspending agents
BBIT 15%, lentinan 0.2%, remaining component are prepared according to the method for embodiment 13.
Embodiment 20：40%BBIT lentinan suspending agents
BBIT 20%, lentinan 20%, remaining component are prepared according to the method for embodiment 14.
Embodiment 21：21%BBIT lentinan suspending agents
BBIT 1%, lentinan 20%, remaining component are prepared according to the method for embodiment 15.
2, isothiazolinone and Portugal's polyene sugar suspending agent
(1) active component A (BIT) prepares suspending agent with Portugal's polyene sugar
Embodiment 22：The Portugals 15.2%BIT polyene sugar suspending agent
BIT 15%, Portugal's polyene sugar 0.2%, remaining component are prepared according to the method for embodiment 13.
Embodiment 23：The Portugals 40%BIT polyene sugar suspending agent
BIT 20%, Portugal's polyene sugar 20%, remaining component are prepared according to the method for embodiment 14.
Embodiment 24：The Portugals 21%BIT polyene sugar suspending agent
BIT 1%, Portugal's polyene sugar 20%, remaining component are prepared according to the method for embodiment 15.
(2) active component A (MBIT) prepares suspending agent with Portugal's polyene sugar
Embodiment 25：The Portugals 15.2%MBIT polyene sugar suspending agent
MBIT 15%, Portugal's polyene sugar 0.2%, remaining component are prepared according to the method for embodiment 13.
Embodiment 26：The Portugals 40%MBIT polyene sugar suspending agent
MBIT 20%, Portugal's polyene sugar 20%, remaining component are prepared according to the method for embodiment 14.
Embodiment 27：The Portugals 21%MBIT polyene sugar suspending agent
MBIT 1%, Portugal's polyene sugar 20%, remaining component are prepared according to the method for embodiment 15.
(3) active component A (BBIT) prepares suspending agent with Portugal's polyene sugar
Embodiment 28：The Portugals 15.2%BBIT polyene sugar suspending agent
BBIT 15%, Portugal's polyene sugar 0.2%, remaining component are prepared according to the method for embodiment 13.
Embodiment 29：The Portugals 40%BBIT polyene sugar suspending agent
BBIT 20%, Portugal's polyene sugar 20%, remaining component are prepared according to the method for embodiment 14.
Embodiment 30：The Portugals 21%BBIT polyene sugar suspending agent
BBIT 1%, Portugal's polyene sugar 20%, remaining component are prepared according to the method for embodiment 15.
(3) processing of wettable powder and embodiment
Active components A and B activity ingredient and various auxiliary agents and filler etc. are sufficiently mixed in proportion, through ultrafine crusher powder
Obtained wettable powder after broken.
1, isothiazolinone and lentinan prepare wettable powder
(1) active component A (BIT) prepares wettable powder with lentinan
Embodiment 31:50.5%BIT lentinan wettable powders
BIT 50%, lentinan 0.5%, benzene sulfonic acid potassium 5%, aliphatic alcohol sulfate 6%, bentonite 4%, lightweight carbonic acid
Calcium complements to 100%.
Embodiment 32:31%BIT lentinan wettable powders
BIT 30%, lentinan 1%, pull open powder 5%, potassium lignosulfonate 5%, xanthans 4%, kaolin complements to
100%.
Embodiment 33:80%BIT lentinan wettable powders
BIT 5%, lentinan 75%, alkylsulfonate 5%, methyl naphthalene sulfonate formaldehyde condensate 5%, bentonite
8%, white carbon supply to 100%.
(2) active component A (MBIT) prepares wettable powder with lentinan
Embodiment 34：50.5%MBIT lentinan wettable powders
MBIT 50%, lentinan 0.5%, remaining component are prepared according to the method for embodiment 31.
Embodiment 35：31%MBIT lentinan wettable powders
MBIT 30%, lentinan 1%, remaining component are prepared according to the method for embodiment 32.
Embodiment 36：80%MBIT lentinan wettable powders
MBIT 5%, lentinan 75%, remaining component are prepared according to the method for embodiment 33.
(3) active component A (BBIT) prepares wettable powder with lentinan
Embodiment 37：50.5%BBIT lentinan wettable powders
BBIT 50%, lentinan 0.5%, remaining component are prepared according to the method for embodiment 31.
Embodiment 38：31%BBIT lentinan wettable powders
BBIT 30%, lentinan 1%, remaining component are prepared according to the method for embodiment 32.
Embodiment 39：80%BBIT lentinan wettable powders
BBIT 5%, lentinan 75%, remaining component are prepared according to the method for embodiment 33.
2, isothiazolinone and Portugal's polyene sugar prepare wettable powder
(1) active component A (BIT) prepares wettable powder with Portugal's polyene sugar
Embodiment 40：The Portugals 50.5%BIT polyene sugar wettable powder
BIT 50%, Portugal's polyene sugar 0.5%, remaining component are prepared according to the method for embodiment 31.
Embodiment 41：The Portugals 31%BIT polyene sugar wettable powder
BIT 30%, Portugal's polyene sugar 1%, remaining component are prepared according to the method for embodiment 32.
Embodiment 42：The Portugals 80%BIT polyene sugar wettable powder
BIT 5%, Portugal's polyene sugar 75%, remaining component are prepared according to the method for embodiment 33.
(2) active component A (MBIT) prepares wettable powder with Portugal's polyene sugar
Embodiment 43：The Portugals 50.5%MBIT polyene sugar wettable powder
MBIT 50%, Portugal's polyene sugar 0.5%, remaining component are prepared according to the method for embodiment 31.
Embodiment 44：The Portugals 31%MBIT polyene sugar wettable powder
MBIT 30%, Portugal's polyene sugar 1%, remaining component are prepared according to the method for embodiment 32.
Embodiment 45：The Portugals 80%MBIT polyene sugar wettable powder
MBIT 5%, Portugal's polyene sugar 75%, remaining component are prepared according to the method for embodiment 33.
(3) active component A (BBIT) prepares wettable powder with Portugal's polyene sugar
Embodiment 46：The Portugals 50.5%BBIT polyene sugar wettable powder
BBIT 50%, Portugal's polyene sugar 0.5%, remaining component are prepared according to the method for embodiment 31.
Embodiment 47：The Portugals 31%BBIT polyene sugar wettable powder
BBIT 30%, Portugal's polyene sugar 1%, remaining component are prepared according to the method for embodiment 32.
Embodiment 48：The Portugals 80%BBIT polyene sugar wettable powder
BBIT 5%, Portugal's polyene sugar 75%, remaining component are prepared according to the method for embodiment 33.
Two, drug effect verification test
(1) Assays Example
The incidence that whole strain blade is investigated according to experiment grade scale, calculates disease index and control effect.
Control effect is converted into niqueMin (y), liquid does height (μ g/ml) and is converted into logarithm (x), with least square
Concentration EC50 during method calculates virulence equation and inhibits, the toxicity index grade co-toxicity coefficient (CTC) of medicament is calculated according to Sun Yunpei's Method.
Survey toxicity index (ATI)=(standard agent EC50/ reagent agent EC50) * 100
Percentage composition+B medicament toxicity index * the mixtures of A in theoretical toxicity index (TTI)=A medicament toxicity index * mixtures
The percentage composition of middle B
Co-toxicity coefficient (CTC)=[mixture surveys toxicity index (ATI)/mixtures theoretical toxicity index (TTI)] * 100
CTC≤80, composition show as antagonism, 80 ＜ CTC ＜ 120, and composition shows as summation action, and CTC >=
120, composition shows as synergistic effect.
1, BIT and lentinan compounding test tomato bacterial angular leaf spot toxicity test
Table 1.BIT is compounded with lentinan to tomato bacterial angular leaf spot toxicity test interpretation of result
As a result (table 1) shows that BIT significantly improves the control effect of tomato bacterial angular leaf spot with lentinan compounding,
Illustrate that the two compounding has significant synergistic effect to the prevention of tomato bacterial angular leaf spot.Experiment is found, when BIT and lentinan
Compound proportion not within the scope of the invention when, be difficult with synergistic function to tomato bacterial angular leaf spot.
2, MBIT and lentinan compounding test cucumber downy mildew toxicity test
Table 2.MBIT is compounded with lentinan to cucumber downy mildew toxicity test interpretation of result
| Medicament title | EC50(μg/ml) | ATI | TTI | Co-toxicity coefficient (CTC) |
| MBIT | 11.75 | 100.00 | \ | \ |
| Lentinan | 8.83 | 133.07 | \ | \ |
| MBIT：Lentinan=100:1 | 9.31 | 126.19 | 100.33 | 125.78 |
| MBIT：Lentinan=75:1 | 8.95 | 131.22 | 100.44 | 130.65 |
| MBIT：Lentinan=50:1 | 8.57 | 137.15 | 100.65 | 136.27 |
| MBIT：Lentinan=30:1 | 8.12 | 144.62 | 101.07 | 143.09 |
| MBIT：Lentinan=15:1 | 7.81 | 150.43 | 102.07 | 147.38 |
| MBIT：Lentinan=1:1 | 7.25 | 162.04 | 116.54 | 139.05 |
| MBIT：Lentinan=1:15 | 6.85 | 171.44 | 131.00 | 130.87 |
| MBIT：Lentinan=1:20 | 7.16 | 164.00 | 131.50 | 124.72 |
As a result (table 2) shows that MBIT significantly improves the control effect of cucumber downy mildew with lentinan compounding, illustrates two
Person's compounding has significant synergistic effect to cucumber downy mildew prevention.Experiment find, when the compound proportion of MBIT and lentinan not
When within the scope of the invention, to cucumber downy mildew it is difficult to have synergistic function.
3, BBIT and lentinan test rice sheath blight disease toxicity test
Table 3.BBIT is compounded with lentinan to rice sheath blight disease toxicity test interpretation of result
As a result (table 3) shows that BBIT significantly improves the control effect of rice sheath blight disease with lentinan compounding, illustrates two
Person's compounding has significant synergistic effect to rice sheath blight disease controlling.Experiment find, when the compound proportion of BBIT and lentinan not
When within the scope of the invention, to rice sheath blight disease it is difficult to have synergistic function.
4, BIT and Portugal's polyene sugar compounding test wildfire disease toxicity test
Table 4.BIT is with Portugal's polyene sugar compounding to wildfire toxicity test interpretation of result
| Medicament title | EC50(μg/ml) | ATI | TTI | Co-toxicity coefficient (CTC) |
| BIT | 15.38 | 100.00 | \ | \ |
| Portugal's polyene sugar | 8.63 | 178.22 | \ | \ |
| BIT：Portugal polyene sugar=100:1 | 11.67 | 131.84 | 100.77 | 130.83 |
| BIT：Portugal polyene sugar=75:1 | 10.85 | 141.69 | 101.03 | 140.25 |
| BIT：Portugal polyene sugar=50:1 | 9.96 | 154.34 | 101.53 | 152.01 |
| BIT：Portugal polyene sugar=30:1 | 8.97 | 171.50 | 102.52 | 167.28 |
| BIT：Portugal polyene sugar=15:1 | 8.99 | 171.06 | 104.89 | 163.09 |
| BIT：Portugal polyene sugar=1:1 | 7.38 | 208.36 | 139.11 | 149.78 |
| BIT：Portugal polyene sugar=1:15 | 6.41 | 240.03 | 173.33 | 138.48 |
| BIT：Portugal polyene sugar=1:20 | 6.81 | 225.71 | 174.50 | 129.35 |
As a result (table 4) shows that BIT significantly improves the control effect of wildfire with Portugal's polyene sugar compounding, illustrates two
Person's compounding has significant synergistic effect to wildfire prevention.Experiment is found, when the compound proportion of BIT and Portugal's polyene sugar does not exist
When in the scope of the present invention, to wildfire it is difficult to have synergistic function.
5, MBIT and Portugal's polyene sugar compounding test corn southern leaf blight toxicity test
Table 5.MBIT is with Portugal's polyene sugar compounding to corn southern leaf blight toxicity test interpretation of result
| Medicament title | EC50(μg/ml) | ATI | TTI | Co-toxicity coefficient (CTC) |
| MBIT | 20.54 | 100.00 | \ | \ |
| Portugal's polyene sugar | 12.39 | 165.78 | \ | \ |
| MBIT：Portugal polyene sugar=100:1 | 16.47 | 124.75 | 100.65 | 123.94 |
| MBIT：Portugal polyene sugar=75:1 | 15.74 | 130.48 | 100.87 | 129.36 |
| MBIT：Portugal polyene sugar=50:1 | 15.04 | 136.57 | 101.29 | 134.83 |
| MBIT：Portugal polyene sugar=30:1 | 14.34 | 143.25 | 102.12 | 140.27 |
| MBIT：Portugal polyene sugar=15:1 | 13.95 | 147.23 | 104.11 | 141.42 |
| MBIT：Portugal polyene sugar=1:1 | 11.42 | 179.92 | 132.89 | 135.39 |
| MBIT：Portugal polyene sugar=1:15 | 9.77 | 210.20 | 161.67 | 130.02 |
| MBIT：Portugal polyene sugar=1:20 | 10.15 | 202.45 | 162.65 | 124.47 |
As a result (table 5) shows that MBIT significantly improves the control effect of corn southern leaf blight with Portugal's polyene sugar compounding, illustrates two
Person's compounding has significant synergistic effect to corn southern leaf blight prevention.Experiment finds, when MBIT and Portugal's polyene sugar compound proportion not
When within the scope of the invention, to corn southern leaf blight it is difficult to have synergistic function.
6, BBIT and Portugal's polyene sugar compounding test wheat powdery mildew toxicity test
Table 6.BBIT is with Portugal's polyene sugar compounding to wheat powdery mildew toxicity test interpretation of result
| Medicament title | EC50(μg/ml) | ATI | TTI | Co-toxicity coefficient (CTC) |
| BBIT | 16.29 | 100.00 | \ | \ |
| Portugal's polyene sugar | 9.54 | 170.75 | \ | \ |
| BBIT：Portugal polyene sugar=100:1 | 12.71 | 128.21 | 100.70 | 127.32 |
| BBIT：Portugal polyene sugar=75:1 | 12.19 | 133.63 | 100.93 | 132.40 |
| BBIT：Portugal polyene sugar=50:1 | 11.58 | 140.72 | 101.39 | 138.79 |
| BBIT：Portugal polyene sugar=30:1 | 11.05 | 147.36 | 102.28 | 144.07 |
| BBIT：Portugal polyene sugar=15:1 | 10.66 | 152.76 | 104.42 | 146.29 |
| BBIT：Portugal polyene sugar=1:1 | 8.60 | 189.50 | 135.38 | 139.98 |
| BBIT：Portugal polyene sugar=1:15 | 7.25 | 224.58 | 166.33 | 135.02 |
| BBIT：Portugal polyene sugar=1:20 | 7.54 | 215.90 | 167.38 | 128.99 |
As a result (table 6) shows that BBIT significantly improves the control effect of wheat powdery mildew with Portugal's polyene sugar compounding, illustrates two
Person's compounding has significant synergistic effect to wheat powdery mildew prevention.Experiment finds, when BBIT and Portugal's polyene sugar compound proportion not
When within the scope of the invention, to wheat powdery mildew it is difficult to have synergistic function.
(2) field efficacy verification test
Test method：At the initial stage of a disease, first time spraying is carried out immediately, and second of dispenser is carried out after 7 days, each handles 4
A cell, 20 square meter of each cell.11 days investigation statistics incidences, 5 points of each cell are random before medicine and after second of medicine
Sampling, 5 plants of crops of every investigation, investigates percentage and classification that the lesion area in whole strain per blade accounts for blade area, calculates
Disease index and control effect.
It is expected that preventive effect (%)=X+Y-XY/100 (wherein, X, Y are single dose preventive effect)
Grade scale：
0 grade：Disease-free spot；
1 grade：Leaf spot lesion is less than 5, and length is less than 1cm；
3 grades：Leaf spot lesion 6-10, part scab length is more than 1cm；
5 grades：Leaf spot lesion 11-25, part scab is linked to be piece, and lesion area accounts for the 10-25% of leaf area；
7 grades：Leaf spot lesion 26 or more, scab are linked to be piece, and lesion area accounts for the 26-50% of leaf area；
9 grades：Scab is linked to be piece, lesion area account for 50% of leaf area or more or full leaf it is withered.
1, BIT and lentinan compounding field efficacy experiment
7 BIT of table is with lentinan mixture to wheat scab control effect
Both measurement result (table 7) shows that BIT and the preventive effect of lentinan pairing wheat scab are significantly improved, illustrate
Compounding has significant synergistic effect to wheat scab.
2, MBIT and lentinan compounding field efficacy experiment
8 MBIT of table is with lentinan mixture to pear scab control effect
Measurement result (table 8) shows that MBIT significantly improves the preventive effect of pear scab with lentinan mixture, illustrates two
Person's compounding has significant synergistic effect to pear scab.
3, BBIT and lentinan compounding field efficacy experiment
9 BBIT of table is with lentinan mixture to tomato virus disease control effect
Measurement result (table 9) shows that BBIT significantly improves the preventive effect of tomato virus disease with lentinan mixture, illustrates two
Person's compounding has significant synergistic effect to tomato virus disease.
4, BIT and the compounding field efficacy experiment of Portugal's polyene sugar
10 BIT of table is with Portugal's polyene sugar mixture to radish mosaic disease control effect
Measurement result (table 10) shows that BIT significantly improves the preventive effect of radish mosaic disease with Portugal's polyene sugar mixture, illustrates two
Person's compounding has significant synergistic effect to radish mosaic disease.
5, MBIT and the compounding field efficacy experiment of Portugal's polyene sugar
11 MBIT of table is with Portugal's polyene sugar mixture to canker of apple fruit control effect
Measurement result (table 11) shows that MBIT significantly improves the preventive effect of canker of apple fruit with Portugal's polyene sugar mixture, explanation
The two compounding has significant synergistic effect to canker of apple fruit.
6, BBIT and the compounding field efficacy experiment of Portugal's polyene sugar
12 BBIT of table is with Portugal's polyene sugar mixture to target control effect
Measurement result (table 12) shows that BBIT significantly improves the preventive effect of target with Portugal's polyene sugar mixture, says
Both bright compounding has significant synergistic effect to target.
Claims (10)
1. a kind of microbicide compositions, it is characterised in that the composition includes two kinds of active components of A and B, wherein activearm
It is the structural compounds with formula (I) to divide A, and active component B is selected from the lentinan of fungicide containing carbohydrate or Portugal's polyene sugar, two components
Between weight ratio be 1:0.01~20
In formula (I), R is selected from H or C1~C8Alkyl.
2. microbicide compositions according to claim 1, it is characterised in that in formula (I), R is selected from H or C1~C4Alkyl.
3. microbicide compositions according to claim 1, it is characterised in that in formula (I), R is preferably selected from H ,-CH3Or-
C4H9, corresponding active component A is respectively 1,2-benzisothiazolin-3-one, 2- methyl-1s, 2- benzisothiazole-3-ketones or
2- butyl -1,2- benzisothiazole-3-ketones.
4. microbicide compositions according to claim 1, it is characterised in that the weight ratio of active component A and active component B
It is 1:0.02~15.
5. microbicide compositions according to claim 4, it is characterised in that the weight ratio of active component A and active component B
It is 1:0.03~10.
6. the microbicide compositions according to any one of Claims 1 to 5, it is characterised in that the composition by activity at
Divide and the dosage form allowed on pesticide is made with insecticides adjuvant or auxiliary material.
7. microbicide compositions according to claim 6, it is characterised in that the dosage form is wettable powder, suspending agent
Or water dispersible granules.
8. microbicide compositions according to claim 6, it is characterised in that the composition by 2~80% parts by weight activity
Component and the dosage form allowed on the insecticides adjuvant composition pesticide of 98~20% parts by weight.
9. microbicide compositions according to claim 6, it is characterised in that the insecticides adjuvant or auxiliary material are selected from carrier, molten
One or more of agent, adhesive, thickener and surfactant.
10. the microbicide compositions described in any one of Claims 1 to 5 are in terms of agriculture field prevents corps diseases
Purposes.
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| CN110537542A (en) * | 2018-12-13 | 2019-12-06 | 北京宇悦生物科技有限公司 | Pesticide composition and application thereof |
| CN116138256A (en) * | 2023-03-08 | 2023-05-23 | 陕西康禾立丰生物科技药业有限公司 | Sterilization composition containing glucagons and bromothalonil |
| CN116530517A (en) * | 2023-05-08 | 2023-08-04 | 陕西康禾立丰生物科技药业有限公司 | Sterilization composition containing glucurolactone and isothiabendazole and application thereof |
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| CN103918716A (en) * | 2013-01-10 | 2014-07-16 | 陕西汤普森生物科技有限公司 | Brevibacillus laterosporus-containing efficient pesticide composition |
| CN104798789A (en) * | 2014-01-28 | 2015-07-29 | 中国科学院大连化学物理研究所 | Broad-spectrum oligosaccharide compound bactericide and use thereof |
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| CN103918716A (en) * | 2013-01-10 | 2014-07-16 | 陕西汤普森生物科技有限公司 | Brevibacillus laterosporus-containing efficient pesticide composition |
| CN104798789A (en) * | 2014-01-28 | 2015-07-29 | 中国科学院大连化学物理研究所 | Broad-spectrum oligosaccharide compound bactericide and use thereof |
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