CN106070245A - A kind of microbicide compositions - Google Patents
A kind of microbicide compositions Download PDFInfo
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- CN106070245A CN106070245A CN201610674115.8A CN201610674115A CN106070245A CN 106070245 A CN106070245 A CN 106070245A CN 201610674115 A CN201610674115 A CN 201610674115A CN 106070245 A CN106070245 A CN 106070245A
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- portugal
- lentinan
- active component
- polyene sugar
- mbit
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
- A01N43/14—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings
- A01N43/16—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings with oxygen as the ring hetero atom
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- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
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- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention provides a kind of microbicide compositions, said composition comprises two kinds of effective constituents A and B, active component A is to have the structural compounds of formula I, and active component B is selected from sugary series bactericidal agent lentinan or Portugal's polyene sugar, and the weight ratio between two components is 1:0.01～20.Present invention also offers the Preparation method and use of said composition.Result of the test shows, the above-mentioned bactericidal composition potentiation that the present invention provides is obvious, it is often more important that amount of application reduces, and use cost reduces.This bactericidal composition can effectively prevent and treat some specific antibacterial or fungal disease of crop.By the antibacterial of different mechanism of action and model of action is compounded, for expanding fungicidal spectrum and delaying the aspects such as fungus, bacterial resistance and raising prevention effect to have well effect.
Description
Technical field
The invention belongs to agriculture plant protection field, particularly relate to a kind of bactericidal composition having and improving performance, tool
Say body and relate to a kind of bactericidal composition comprising BIT class and halogeno-cyanogen uric acid class.
Background technology
BIT compounds is a kind of novel, wide-spectrum bactericide, is mainly used in preventing and treating and treatment Cereal
The various bacteria such as crop, veterinary antibiotics, fungal disease.Its bactericidal action mechanism, mainly includes destroying pathogenic bacteria nucleus knot
Structure so that it is lose cardia and exhaustion is dead and the metabolism of interference pathogenic bacteria cell so that it is physiologic derangement, ultimately results in dead
Die two aspects.Using can effectively protect plant not infected by pathogen at disease early period of origination, disease takes the circumstances into consideration to increase after occurring
Dosage can substantially control spreading of pathogenic bacteria, thus reaches protection and the dual function rooted out.
Lentinan (fungous proteoglycan) can produce inhibitory action to the growth of some pathogenic bacterias, affects fungus
Spore germination, induction hypha form morphs, biochemistry changes in spore.Can excite gene in plant, generation has
The chitinase of resistant effect, glucanase, guarantor's element and PR albumen etc., and there is cell activation effect, contribute to the plant that is injured
Recover, promote root strong sprout, strengthen the resistance of crop, promote growth and development of plants.
Portugal's polyene sugar is a kind of the exciting of induced disease resistance of plant from pathogen in host's cause of disease Interaction
Son, is commonly called as " two sugar ", is that international a kind of new bio newly developed lures resistance antiviral, and activity is significantly higher than common oligosaccharide
Product.It can effectively be passivated virus, and the disease causing multiple virus has good prevention effect: can also promote light cooperation simultaneously
With, increase sugar part and the accumulation of vitamin, improve crop autoimmunity and defense response.
Actual pesticide experience have shown that, repeats and single-minded one reactive compound of using is to prevent and treat harmful fungoid very
The fast selective of fungal bacterial strain will be caused in the case of Duo, the most dangerous, the most generally for reducing refractory fungal bacterial strain
The mixture using different activities compound prevents and treats harmful fungoid.By the reactive compound with the different mechanism of action is entered
Row combination, delaying drug resistance can produce, reduces amount of application, reduce cost accounting.
Summary of the invention
It is an object of the invention to, for antibacterial resistance in actual applications and pedo relict problem, filter out difference and kill
The antibacterial of bacterium principle compounds, and obtains new a kind of microbicide compositions, to improve bactericidal agent for preventing and treating effect, delaying drug resistance
Produce, reduce amount of application, reduce cost accounting.
It is a further object to provide comprise two kinds of effective constituents A and the preparation method of B bactericidal composition and
The application of agriculture field preventing and treating corps diseases.
The purpose of the present invention can be reached by following measures:
A kind of microbicide compositions with potentiation, said composition comprises two kinds of active components of A and B, wherein activity
Component A is to have the structural compounds of formula I, and active component B is sugary series bactericidal agent lentinan or Portugal's polyene sugar.
In formula I, R is selected from H or C1～C8Alkyl.
C in the present invention1～C8Alkyl refers to the straight or branched alkyl containing 1 to 8 carbon atom, and it includes C1Alkyl
(such as methyl), C2Alkyl (such as ethyl), C3Alkyl (such as n-pro-pyl, isopropyl), C4Alkyl (as normal-butyl, isobutyl group, the tert-butyl group,
Sec-butyl), C5Alkyl (such as n-pentyl etc.), C6Alkyl, C7Alkyl, C8Alkyl.It includes but not limited to C1～C6Alkyl, C1～C5
Alkyl, C1～C4Alkyl etc..
In a kind of preferred version, R is selected from H or C1～C4Alkyl.
In a kind of preferred scheme, R is selected from H ,-CH3Or-C4H9。
In formula I, when R is H, A is BIT (being called for short BIT in description).
In formula I, when R is CH3Time, A is 2-methyl isophthalic acid, and 2-benzisothiazole-3-ketone (is called for short MBIT) in description.
In formula I, when R is C4H9Time, A is 2-butyl-BIT, and " butyl " in this formula is preferred
Normal-butyl (is called for short BBIT) in description.
Inventor is found by experiment that, the compositions of the present invention is for preventing and treating crops antibacterial or fungal disease preventing and treating
Potentiation is obvious, it is often more important that amount of application reduces, and reduces use cost.Compound structure type containing component A and component B is not
With, mechanism of action is different, and both are compounding can expand fungicidal spectrum, and can delay the product of pathogen resistance to a certain extent
No interactions resistance between life and development speed, and component A and component B.
The weight ratio between two components in microbicide compositions of the present invention is 1:0.01～20.For making the medicine between two components
Effect potentiation is the most notable, and the weight ratio between weight two component of component A and component B can be optimized to 1:0.02 further
～15 or 1:0.03～10..
In a kind of preferably scheme, the weight ratio between A and B two component can at random be entered in the range of following proportioning
Row sum-equal matrix: 1:0.1,1:0.2,1:0.3,1:0.4,1:0.5,1:0.6,1:0.7,1:0.8,1:0.9,1:1,2:1,3:1,4:1,
5:1、6:1、7:1、8:1、9:1、10:1、11:1、12:1、13:1、14:1、15:1、16:1、17:1、18:1、19:1、20:1、
21:1、22:1、23:1、24:1、25:1、26:1、27:1、28:1、29:1、30:1、31:1、32:1、33:1、34:1、35:1、
36:1、37:1、38:1、39:1、40:1、41:1、42:1、43:1、44:1、45:1、46:1、47:1、48:1、49:1、50:1、
51:1、52:1、53:1、54:1、55:1、56:1、57:1、58:1、59:1、60:1、61:1、62:1、63:1、64:1、65:1、
66:1、67:1、68:1、69:1、70:1、71:1、72:1、73:1、74:1、75:1、76:1、77:1、78:1、79:1、80:1、
81:1,82:1,83:1,84:1,85:1,86:1,87:1,88:1,89:1,90:1,91:1,92:1,93:1,94:1,95:1,
96:1,97:1,98:1,99:1,100:1, it is also possible to select in the range of two proportionings of any of the above are formed, these
Ratio can be understood as weight ratio, it is also possible to includes mol ratio.
The compositions of the present invention can be made, by active component and insecticides adjuvant or adjuvant, the dosage form allowed on pesticide.Enter one
Step, said composition by 2～80% weight portion active component with 98～20% the insecticides adjuvant of weight portion form on pesticide fair
The dosage form permitted.
The invention provides the bactericidal composition comprising component A and component B in terms of agriculture field preventing and treating corps diseases
Purposes, the particularly purposes in terms of preventing and treating the fungus of some crop or antibacterial.
Above-mentioned composition specifically can comprise insecticides adjuvant or adjuvant, such as carrier, solvent, dispersant, wetting agent, gluing
One or more in agent, thickening agent, binding agent, surfactant or fertilizer etc..Can mix conventional during using
Auxiliary agent.
Suitably auxiliary agent or adjuvant can be solid or liquid, the material that they are conventional during being typically formulation,
Mineral that is the most natural or that regenerate, solvent, dispersant, wetting agent, adhesive, thickening agent, binding agent.
The application process of the present composition includes the aerial parts that the compositions of the present invention is used for plant growing, especially
It is leaf portion or blade face.Seed soaking can be selected or be applied in controlling object surface.Frequency and the amount of application used depend on pathogen
Biology and weather conditions of existence.The growth place of plant, such as rice field, can be soaked with the liquid preparation of compositions, or
Compositions is applied in soil by person in solid form, and as in granular form (soil application), compositions can be by soil through planting
Thing root enters in plant (systemic action).
The compositions of the present invention can be prepared as acceptable various dosage forms on pesticide, includes but not limited to cream, suspension
Agent, wettable powder, water dispersible granules, powder, granule, water preparation, aqueous emulsion, microemulsion, poison bait, mother solution, female powder etc., in one
In preferred version, the dosage form of the present invention uses wettable powder, suspending agent, water dispersible granules, aqueous emulsion or microemulsion.According to this
The character of a little compositionss and use compositions purpose to be reached and ambient conditions, can select compositions to spray,
Atomizing, dust, broadcast sowing or sprinkle the method watered or the like and use.
The compositions of the present invention can be prepared as various dosage form by available known method, can by effective ingredient with help
Agent, such as solvent, solid carrier, can uniformly mix together with surfactant when needing, grind, be prepared as required agent
Type.
Above-mentioned solvent is selected from aromatic hydrocarbon, preferably containing 8-12 carbon atom, such as xylene mixture or substituted benzene, phthalein
Esters of gallic acid, such as Dibutyl phthalate or phthalandione two octanoic acid, fat hydrocarbon, such as thiacyclohexane or paraffin, alcohol and ethylene glycol and their ether
And ester, such as ethanol, ethylene glycol, ethylene glycol monomethyl；Ketone, such as cyclohexanone, highly polar solvent, such as N-methyl-2-pyrrolidine
Ketone, dimethyl sulfoxide or dimethylformamide, and vegetable oil or vegetable oil, such as soybean oil.
Above-mentioned solid carrier, as powder and the typically natural mineral fillers, such as Talcum, kaolinite that dispersible agent
Soil, montmorillonite or active hargil.In order to manage the physical property of compositions, it is also possible to add polymolecularity silicic acid or polymolecularity
Adsorpting polymerization thing carrier, such as granulated adsorptive carriers or non-adsorbed carrier, suitable granulated adsorptive carriers is porous type, as floating
Stone, Bentonite or bentonite；Suitably non-adsorbed carrier such as calcite or sand.Further, it is possible to use substantial amounts of inorganic in nature or have
Machine character be prefabricated into granular material as carrier, particularly dolomite.
According to the chemical property of the effective ingredient in the compositions of the present invention, suitable surfactant is sulfomethylated lignin
Acid, LOMAR PWA EINECS 246-676-2, phenolsulfonic acid, alkali salt or amine salt, alkylaryl sulfonates, alkyl sulfate, alkylsulfonate, fat
Alcohol sulfate, fatty acid and sulphated fatty alcohol glycol ether, the also condensation substance of sulfonated naphthalene and naphthalene derivatives and formaldehyde, naphthalene or
LOMAR PWA EINECS 246-676-2 and phenol and the condensation substance of formaldehyde, NONIN HS 240, ethoxylated isooctyl-phenol, octyl phenol, nonyl phenol,
Alkylaryl polyglycol ether, tributyl benzene polyglycol ether, three stearyl phenyl polyglycol ethers, alkyl aryl polyether alcohol,
Ethoxylated castor oil, polyoxyethylene alkyl ether, ethylene oxide condensation substance, ethoxylation polyoxypropylene, lauric acid Polyethylene Glycol
Ether acetal, sorbitol ester, lignin sulfite waste liquor and methylcellulose.
When preparing liquid or solid dosage form, first active component A can be dissolved in some specific alkaline matter, form benzene
And isothiazoline slaine, suitable alkaline matter includes: alkali carbonate, alkali metal hydroxide are (such as sodium hydroxide, hydrogen
Potassium oxide), alkali metal alkoxyl carbonate, alkali metal alcoholates or Bis(methoxy)magnesium.
In the compositions of the present invention, two kinds of effective ingredient show as synergistic effect, and the specific activity of said composition uses individualized
The activity expection summation of compound, and the independent activity of individualized compound is the most notable.Synergistic effect shows as allowing amount of application
Reduce, broader antifungal controls spectrum, instant effect, more longlasting prevention effect, pass through only once or minority is used more several times
Good controls plant pest fungus and broadens the possible administration interval time.These characteristics are that plant epiphyte controls practice
During especially need.
The microbicide compositions of the present invention can be applicable to agriculture field preventing and treating corps diseases aspect, and targeted is concrete sick
Disease includes but not limited to wheat diseases (such as: wheat scab, wheat powdery mildew, wheat rust etc.), rice disease (such as: Oryza sativa L.
Banded sclerotial blight, rice green smut, rice blast, paddy bacterial streak etc.), maize diseases (such as: smut of maize, Semen Maydis are big
Pinta, corn southern leaf blight), cucumber disease (such as: cucumber downy mildew, powdery mildew of cucumber, cucumber anthracnose, Fructus Cucumidis sativi bacillary angle speckle
Sick etc.), tomato disease (such as: anthracnose of tomato, graw mold of tomato, tomato bacterial angular leaf spot etc.), grape disease (such as: Fructus Vitis viniferae
Downy mildew, grape grey mould, uncinula necator), apple disease (such as ring rot of apple, apple anthracnose etc.), citrus disease (Citrus chachiensis Hort.
Fructus Citri tangerinae Peptic Ulcers, Citrus scab also, citrus anthracnose), tobacco diseases (wildfire) etc..
Other feature shown of the bactericidal composition of the present invention mainly shows themselves in that 1, the compositions mixture of present invention tool
There is obvious potentiation；2, widely different due to two single dose chemical constitutions of this compositions, the mechanism of action is entirely different, no
There is cross resistance, two single doses can be delayed to be used alone produced resistance problem；3, the compositions of the present invention to crop safety,
Preventive effect is good.Tests prove that, microbicide compositions stable chemical nature of the present invention, potentiation is notable, shows controlling object bright
Aobvious potentiation and complementary action.
Detailed description of the invention
In order to make the purpose of the present invention, technical scheme and advantage clearer, below in conjunction with embodiment, to the present invention
It is further elaborated.Should be appreciated that specific embodiment described herein, only in order to explain the present invention, is not used to limit
Determine the present invention, all any amendment, equivalent and improvement etc. made within the spirit and principles in the present invention, should be included in
Within protection scope of the present invention.
In all formula of following example, percentage ratio is all weight percentage.The processing work of the various preparation of the present composition
Skill is prior art, can be varied from according to different situations.
One, dosage form prepares embodiment
(1) processing of water dispersible granules and embodiment
By active component activity packet A and active component B, mix homogeneously in the ratio of formula, through gas with auxiliary agent and filler
Stream is ground into wettable powder, adds a certain amount of water mixing extruder grain, prepares water dispersible granules and produce after drying screening
Product.
1, isothiazolinone and lentinan prepare water dispersible granules
(1) active component A (BIT) and active component lentinan prepare water dispersible granules
Embodiment 1:25.5%BIT lentinan water dispersible granules
BIT 25%, lentinan 0.5%, benzene sulfonic acid sodium salt 5%, potassium sulfate 5%, aliphatic alcohol sulfate 6%, Kaolin
5%, precipitated calcium carbonate complements to 100%.
Embodiment 2:48%BIT lentinan water dispersible granules
BIT 45%, lentinan 3%, methyl naphthalene sulfonate formaldehyde condensate 5%, carboxymethyl starch sodium 5%, xanthan gum
6%, kieselguhr complements to 100%.
(2) active component A (MBIT) and lentinan prepare water dispersible granules
Embodiment 3:25.5%MBIT lentinan water dispersible granules
MBIT 25%, lentinan 0.5%, remaining component is prepared according to the method for embodiment 1.
Embodiment 4:48%MBIT lentinan water dispersible granules
MBIT 45%, lentinan 3%, remaining component is prepared according to the method for embodiment 2.
(3) active component A (BBIT) and lentinan prepare water dispersible granules
Embodiment 5:25.5%BBIT lentinan water dispersible granules
BBIT 25%, lentinan 0.5%, remaining component is prepared according to the method for embodiment 1.
Embodiment 6:48%BBIT lentinan water dispersible granules
BBIT 45%, lentinan 3%, remaining component is prepared according to the method for embodiment 2.
2, water dispersible granules prepared by isothiazolinone and Portugal's polyene sugar
(1) water dispersible granules prepared by active component A (BIT) and Portugal's polyene sugar
Embodiment 7:25.5%BIT Portugal polyene sucrose solution dispersible granule
BIT 25%, Portugal's polyene sugar 0.5%, remaining component is prepared according to the method for embodiment 1.
Embodiment 8:48%BIT Portugal polyene sucrose solution dispersible granule
BIT 45%, Portugal's polyene sugar 3%, remaining component is prepared according to the method for embodiment 2.
(2) water dispersible granules prepared by active component A (MBIT) and Portugal's polyene sugar
Embodiment 9:25.5%MBIT Portugal polyene sucrose solution dispersible granule
MBIT 25%, Portugal's polyene sugar 0.5%, remaining component is prepared according to the method for embodiment 1.
Embodiment 10:48%MBIT Portugal polyene sucrose solution dispersible granule
MBIT 45%, Portugal's polyene sugar 3%, remaining component is prepared according to the method for embodiment 2.
(3) water dispersible granules prepared by active component A (BBIT) and Portugal's polyene sugar
Embodiment 11:25.5%BBIT Portugal polyene sucrose solution dispersible granule
BBIT 25%, Portugal's polyene sugar 0.5%, remaining component is prepared according to the method for embodiment 1.
Embodiment 12:48%BBIT Portugal polyene sucrose solution dispersible granule
BBIT 45%, Portugal's polyene sugar 3%, remaining component is prepared according to the method for embodiment 2.
(2) processing of suspending agent and embodiment
By active component activity packet A and active component B, with each component such as dispersant, wetting agent, thickening agent and water by joining
The ratio mix homogeneously of side, after sand milling and/or high speed shear, obtains semi-finished product, adds water mix homogeneously and filter i.e. after analysis
Obtain finished product.
1, isothiazolinone and lentinan prepare suspending agent
(1) active component A (BIT) and lentinan prepare suspending agent
Embodiment 13:15.2%BIT lentinan suspending agent
BIT 15%, lentinan 0.2%, calcite 6%, sodium sulfonate 5%, xanthan gum 5%, ethylene glycol 4%, alkyl virtue
Base sulfate 5%, water complements to 100%.
Embodiment 14:40%BIT lentinan suspending agent
BIT 20%, lentinan 20%, Bentonite 6%, propylene glycol 6%, ethylene oxide condensation substance 6%, water complements to
100%.
Embodiment 15:21%BIT lentinan suspending agent
BIT 1%, lentinan 20%, kieselguhr 6%, toluene 5%, sodium lignin sulfonate 5%, lignin sulfite
Waste liquid 4%, water complements to 100%.
(2) active component A (MBIT) and lentinan prepare suspending agent
Embodiment 16:15.2%MBIT lentinan suspending agent
MBIT 15%, lentinan 0.2%, remaining component is prepared according to the method for embodiment 13.
Embodiment 17:40%MBIT lentinan suspending agent
MBIT 20%, lentinan 20%, remaining component is prepared according to the method for embodiment 14.
Embodiment 18:21%MBIT lentinan suspending agent
MBIT 1%, lentinan 20%, remaining component is prepared according to the method for embodiment 15.
(3) active component A (BBIT) and lentinan prepare suspending agent
Embodiment 19:15.2%BBIT lentinan suspending agent
BBIT 15%, lentinan 0.2%, remaining component is prepared according to the method for embodiment 13.
Embodiment 20:40%BBIT lentinan suspending agent
BBIT 20%, lentinan 20%, remaining component is prepared according to the method for embodiment 14.
Embodiment 21:21%BBIT lentinan suspending agent
BBIT 1%, lentinan 20%, remaining component is prepared according to the method for embodiment 15.
2, isothiazolinone and Portugal's polyene sugar suspending agent
(1) suspending agent prepared by active component A (BIT) and Portugal's polyene sugar
Embodiment 22:15.2%BIT Portugal polyene sugar suspending agent
BIT 15%, Portugal's polyene sugar 0.2%, remaining component is prepared according to the method for embodiment 13.
Embodiment 23:40%BIT Portugal polyene sugar suspending agent
BIT 20%, Portugal's polyene sugar 20%, remaining component is prepared according to the method for embodiment 14.
Embodiment 24:21%BIT Portugal polyene sugar suspending agent
BIT 1%, Portugal's polyene sugar 20%, remaining component is prepared according to the method for embodiment 15.
(2) suspending agent prepared by active component A (MBIT) and Portugal's polyene sugar
Embodiment 25:15.2%MBIT Portugal polyene sugar suspending agent
MBIT 15%, Portugal's polyene sugar 0.2%, remaining component is prepared according to the method for embodiment 13.
Embodiment 26:40%MBIT Portugal polyene sugar suspending agent
MBIT 20%, Portugal's polyene sugar 20%, remaining component is prepared according to the method for embodiment 14.
Embodiment 27:21%MBIT Portugal polyene sugar suspending agent
MBIT 1%, Portugal's polyene sugar 20%, remaining component is prepared according to the method for embodiment 15.
(3) suspending agent prepared by active component A (BBIT) and Portugal's polyene sugar
Embodiment 28:15.2%BBIT Portugal polyene sugar suspending agent
BBIT 15%, Portugal's polyene sugar 0.2%, remaining component is prepared according to the method for embodiment 13.
Embodiment 29:40%BBIT Portugal polyene sugar suspending agent
BBIT 20%, Portugal's polyene sugar 20%, remaining component is prepared according to the method for embodiment 14.
Embodiment 30:21%BBIT Portugal polyene sugar suspending agent
BBIT 1%, Portugal's polyene sugar 20%, remaining component is prepared according to the method for embodiment 15.
(3) processing of wettable powder and embodiment
Active components A is sufficiently mixed, through ultrafine crusher powder with various auxiliary agents and filler etc. in proportion with B activity composition
Wettable powder is prepared after broken.
1, isothiazolinone and lentinan prepare wettable powder
(1) active component A (BIT) and lentinan prepare wettable powder
Embodiment 31:50.5%BIT lentinan wettable powder
BIT 50%, lentinan 0.5%, benzenesulfonic acid potassium 5%, aliphatic alcohol sulfate 6%, bentonite 4%, lightweight carbonic acid
Calcium complements to 100%.
Embodiment 32:31%BIT lentinan wettable powder
BIT 30%, lentinan 1%, pull open powder 5%, lignin sulfonic acid potassium 5%, xanthan gum 4%, Kaolin complements to
100%.
Embodiment 33:80%BIT lentinan wettable powder
BIT 5%, lentinan 75%, alkylsulfonate 5%, methyl naphthalene sulfonate formaldehyde condensate 5%, bentonite
8%, white carbon complements to 100%.
(2) active component A (MBIT) and lentinan prepare wettable powder
Embodiment 34:50.5%MBIT lentinan wettable powder
MBIT 50%, lentinan 0.5%, remaining component is prepared according to the method for embodiment 31.
Embodiment 35:31%MBIT lentinan wettable powder
MBIT 30%, lentinan 1%, remaining component is prepared according to the method for embodiment 32.
Embodiment 36:80%MBIT lentinan wettable powder
MBIT 5%, lentinan 75%, remaining component is prepared according to the method for embodiment 33.
(3) active component A (BBIT) and lentinan prepare wettable powder
Embodiment 37:50.5%BBIT lentinan wettable powder
BBIT 50%, lentinan 0.5%, remaining component is prepared according to the method for embodiment 31.
Embodiment 38:31%BBIT lentinan wettable powder
BBIT 30%, lentinan 1%, remaining component is prepared according to the method for embodiment 32.
Embodiment 39:80%BBIT lentinan wettable powder
BBIT 5%, lentinan 75%, remaining component is prepared according to the method for embodiment 33.
2, wettable powder prepared by isothiazolinone and Portugal's polyene sugar
(1) wettable powder prepared by active component A (BIT) and Portugal's polyene sugar
Embodiment 40:50.5%BIT Portugal polyene sugar wettable powder
BIT 50%, Portugal's polyene sugar 0.5%, remaining component is prepared according to the method for embodiment 31.
Embodiment 41:31%BIT Portugal polyene sugar wettable powder
BIT 30%, Portugal's polyene sugar 1%, remaining component is prepared according to the method for embodiment 32.
Embodiment 42:80%BIT Portugal polyene sugar wettable powder
BIT 5%, Portugal's polyene sugar 75%, remaining component is prepared according to the method for embodiment 33.
(2) wettable powder prepared by active component A (MBIT) and Portugal's polyene sugar
Embodiment 43:50.5%MBIT Portugal polyene sugar wettable powder
MBIT 50%, Portugal's polyene sugar 0.5%, remaining component is prepared according to the method for embodiment 31.
Embodiment 44:31%MBIT Portugal polyene sugar wettable powder
MBIT 30%, Portugal's polyene sugar 1%, remaining component is prepared according to the method for embodiment 32.
Embodiment 45:80%MBIT Portugal polyene sugar wettable powder
MBIT 5%, Portugal's polyene sugar 75%, remaining component is prepared according to the method for embodiment 33.
(3) wettable powder prepared by active component A (BBIT) and Portugal's polyene sugar
Embodiment 46:50.5%BBIT Portugal polyene sugar wettable powder
BBIT 50%, Portugal's polyene sugar 0.5%, remaining component is prepared according to the method for embodiment 31.
Embodiment 47:31%BBIT Portugal polyene sugar wettable powder
BBIT 30%, Portugal's polyene sugar 1%, remaining component is prepared according to the method for embodiment 32.
Embodiment 48:80%BBIT Portugal polyene sugar wettable powder
BBIT 5%, Portugal's polyene sugar 75%, remaining component is prepared according to the method for embodiment 33.
Two, drug effect checking test
(1) Assays Example
Investigate the incidence of whole strain blade according to test grade scale, calculate disease index and prevention effect.
Prevention effect is converted into probability value (y), and medicinal liquid is done height (μ g/ml) and is converted into logarithm value (x), with least square
Method calculates concentration EC50 in virulence equation and suppression, calculates toxicity index level co-toxicity coefficient (CTC) of medicament according to the abundant method of Sun Yun.
Actual measurement toxicity index (ATI)=(standard agent EC50/ reagent agent EC50) * 100
Percentage composition+B medicament toxicity index * the mixture of A in theoretical toxicity index (TTI)=A medicament toxicity index * mixture
The percentage composition of middle B
Co-toxicity coefficient (CTC)=[mixture actual measurement toxicity index (ATI)/mixture theory toxicity index (TTI)] * 100
CTC≤80, compositions shows as antagonism, 80 ＜ CTC ＜ 120, and compositions shows as summation action, CTC >=
120, compositions shows as potentiation.
1, BIT is compounding with lentinan tests tomato bacterial angular leaf spot toxicity test
Table 1.BIT is compounding with lentinan to tomato bacterial angular leaf spot toxicity test interpretation of result
Result (table 1) shows, BIT prevention effect to tomato bacterial angular leaf spot compounding with lentinan significantly improves,
Illustrate that the two compounding prevents and treats tomato bacterial angular leaf spot has significant potentiation.Experiment finds, when BIT and lentinan
Compound proportion not within the scope of the invention time, tomato bacterial angular leaf spot is difficult to have synergistic function.
2, MBIT is compounding with lentinan tests cucumber downy mildew toxicity test
Table 2.MBIT is compounding with lentinan to cucumber downy mildew toxicity test interpretation of result
| Medicament title | EC<sub>50</sub>(μg/ml) | ATI | TTI | Co-toxicity coefficient (CTC) |
| MBIT | 11.75 | 100.00 | \ | \ |
| Lentinan | 8.83 | 133.07 | \ | \ |
| MBIT: lentinan=100:1 | 9.31 | 126.19 | 100.33 | 125.78 |
| MBIT: lentinan=75:1 | 8.95 | 131.22 | 100.44 | 130.65 |
| MBIT: lentinan=50:1 | 8.57 | 137.15 | 100.65 | 136.27 |
| MBIT: lentinan=30:1 | 8.12 | 144.62 | 101.07 | 143.09 |
| MBIT: lentinan=15:1 | 7.81 | 150.43 | 102.07 | 147.38 |
| MBIT: lentinan=1:1 | 7.25 | 162.04 | 116.54 | 139.05 |
| MBIT: lentinan=1:15 | 6.85 | 171.44 | 131.00 | 130.87 |
| MBIT: lentinan=1:20 | 7.16 | 164.00 | 131.50 | 124.72 |
Result (table 2) shows, MBIT prevention effect to cucumber downy mildew compounding with lentinan significantly improves, and illustrates two
Person is compounding has significant potentiation to cucumber downy mildew preventing and treating.Experiment finds, when MBIT and lentinan compound proportion not
Time within the scope of the invention, cucumber downy mildew is difficult to have synergistic function.
3, rice sheath blight disease toxicity test is tested by BBIT with lentinan
Table 3.BBIT is compounding with lentinan to rice sheath blight disease toxicity test interpretation of result
Result (table 3) shows, BBIT prevention effect to rice sheath blight disease compounding with lentinan significantly improves, and illustrates two
Person is compounding significant potentiation to rice sheath blight disease controlling.Experiment finds, when BBIT and lentinan compound proportion not
Time within the scope of the invention, rice sheath blight disease is difficult to have synergistic function.
4, BIT is compounding with Portugal's polyene sugar to wildfire virus power determination test
Table 4.BIT is compounding with Portugal's polyene sugar to wildfire toxicity test interpretation of result
| Medicament title | EC<sub>50</sub>(μg/ml) | ATI | TTI | Co-toxicity coefficient (CTC) |
| BIT | 15.38 | 100.00 | \ | \ |
| Portugal's polyene sugar | 8.63 | 178.22 | \ | \ |
| BIT: Portugal's polyene sugar=100:1 | 11.67 | 131.84 | 100.77 | 130.83 |
| BIT: Portugal's polyene sugar=75:1 | 10.85 | 141.69 | 101.03 | 140.25 |
| BIT: Portugal's polyene sugar=50:1 | 9.96 | 154.34 | 101.53 | 152.01 |
| BIT: Portugal's polyene sugar=30:1 | 8.97 | 171.50 | 102.52 | 167.28 |
| BIT: Portugal's polyene sugar=15:1 | 8.99 | 171.06 | 104.89 | 163.09 |
| BIT: Portugal's polyene sugar=1:1 | 7.38 | 208.36 | 139.11 | 149.78 |
| BIT: Portugal's polyene sugar=1:15 | 6.41 | 240.03 | 173.33 | 138.48 |
| BIT: Portugal's polyene sugar=1:20 | 6.81 | 225.71 | 174.50 | 129.35 |
Result (table 4) shows, BIT prevention effect to wildfire compounding with Portugal's polyene sugar significantly improves, and illustrates two
Person is compounding has significant potentiation to wildfire preventing and treating.Experiment finds, when the compound proportion of BIT with Portugal's polyene sugar does not exists
Time in the scope of the present invention, wildfire is difficult to have synergistic function.
5, MBIT is compounding with Portugal's polyene sugar tests corn southern leaf blight toxicity test
Table 5.MBIT is compounding with Portugal's polyene sugar to corn southern leaf blight toxicity test interpretation of result
| Medicament title | EC<sub>50</sub>(μg/ml) | ATI | TTI | Co-toxicity coefficient (CTC) |
| MBIT | 20.54 | 100.00 | \ | \ |
| Portugal's polyene sugar | 12.39 | 165.78 | \ | \ |
| MBIT: Portugal's polyene sugar=100:1 | 16.47 | 124.75 | 100.65 | 123.94 |
| MBIT: Portugal's polyene sugar=75:1 | 15.74 | 130.48 | 100.87 | 129.36 |
| MBIT: Portugal's polyene sugar=50:1 | 15.04 | 136.57 | 101.29 | 134.83 |
| MBIT: Portugal's polyene sugar=30:1 | 14.34 | 143.25 | 102.12 | 140.27 |
| MBIT: Portugal's polyene sugar=15:1 | 13.95 | 147.23 | 104.11 | 141.42 |
| MBIT: Portugal's polyene sugar=1:1 | 11.42 | 179.92 | 132.89 | 135.39 |
| MBIT: Portugal's polyene sugar=1:15 | 9.77 | 210.20 | 161.67 | 130.02 |
| MBIT: Portugal's polyene sugar=1:20 | 10.15 | 202.45 | 162.65 | 124.47 |
Result (table 5) shows, MBIT prevention effect to corn southern leaf blight compounding with Portugal's polyene sugar significantly improves, and illustrates two
Person is compounding has significant potentiation to corn southern leaf blight preventing and treating.Experiment finds, when MBIT and Portugal polyene sugar compound proportion not
Time within the scope of the invention, corn southern leaf blight is difficult to have synergistic function.
6, BBIT is compounding with Portugal's polyene sugar tests wheat powdery mildew toxicity test
Table 6.BBIT is compounding with Portugal's polyene sugar to wheat powdery mildew toxicity test interpretation of result
| Medicament title | EC<sub>50</sub>(μg/ml) | ATI | TTI | Co-toxicity coefficient (CTC) |
| BBIT | 16.29 | 100.00 | \ | \ |
| Portugal's polyene sugar | 9.54 | 170.75 | \ | \ |
| BBIT: Portugal's polyene sugar=100:1 | 12.71 | 128.21 | 100.70 | 127.32 |
| BBIT: Portugal's polyene sugar=75:1 | 12.19 | 133.63 | 100.93 | 132.40 |
| BBIT: Portugal's polyene sugar=50:1 | 11.58 | 140.72 | 101.39 | 138.79 |
| BBIT: Portugal's polyene sugar=30:1 | 11.05 | 147.36 | 102.28 | 144.07 |
| BBIT: Portugal's polyene sugar=15:1 | 10.66 | 152.76 | 104.42 | 146.29 |
| BBIT: Portugal's polyene sugar=1:1 | 8.60 | 189.50 | 135.38 | 139.98 |
| BBIT: Portugal's polyene sugar=1:15 | 7.25 | 224.58 | 166.33 | 135.02 |
| BBIT: Portugal's polyene sugar=1:20 | 7.54 | 215.90 | 167.38 | 128.99 |
Result (table 6) shows, BBIT prevention effect to wheat powdery mildew compounding with Portugal's polyene sugar significantly improves, and illustrates two
Person is compounding has significant potentiation to wheat powdery mildew preventing and treating.Experiment finds, when BBIT and Portugal polyene sugar compound proportion not
Time within the scope of the invention, wheat powdery mildew is difficult to have synergistic function.
(2) field efficacy checking test
Test method: at the initial stage of a disease, carries out immediately spraying for the first time, carries out second time dispenser, each process 4 after 7 days
Individual community, each community 20 square meter.11 days investigation statistics incidences before medicine and after second time medicine, 5, each community is random
Sampling, every some investigation 5 strain crops, investigate the lesion area of every blade in whole strain and account for percentage rate the classification of blade area, calculate
Disease index and prevention effect.
Expection preventive effect (%)=X+Y-XY/100 (wherein, X, Y are single dose preventive effect)
Grade scale:
0 grade: without scab；
1 grade: leaf spot lesion is less than 5, length is less than 1cm；
3 grades: leaf spot lesion 6-10, part scab length is more than 1cm；
5 grades: leaf spot lesion 11-25, part scab is linked to be sheet, and lesion area accounts for the 10-25% of leaf area；
7 grades: leaf spot lesion more than 26, scab is linked to be sheet, and lesion area accounts for the 26-50% of leaf area；
9 grades: scab is linked to be sheet, more than the 50% or full leaf that lesion area accounts for leaf area is withered.
1, BIT and lentinan compound field efficacy experiment
Table 7 BIT and lentinan mixture are to wheat scab prevention effect
Measurement result (table 7) shows, BIT significantly improves with the preventive effect of lentinan pairing wheat scab, and the two is described
Compounding have significant potentiation to wheat scab.
2, MBIT and lentinan compound field efficacy experiment
Table 8 MBIT and lentinan mixture are to pear scab prevention effect
Measurement result (table 8) shows, the preventive effect of pear scab is significantly improved by MBIT with lentinan mixture, illustrates two
Person is compounding significant potentiation to pear scab.
3, BBIT and lentinan compound field efficacy experiment
Table 9 BBIT and lentinan mixture are to tomato virus disease prevention effect
Measurement result (table 9) shows, the preventive effect of tomato virus disease is significantly improved by BBIT with lentinan mixture, illustrates two
Person is compounding significant potentiation to tomato virus disease.
4, BIT and Portugal's polyene sugar compound field efficacy experiment
Table 10 BIT and Portugal's polyene sugar mixture are to radish mosaic disease prevention effect
Measurement result (table 10) shows, the preventive effect of radish mosaic disease is significantly improved by BIT with Portugal's polyene sugar mixture, illustrates two
Person is compounding significant potentiation to radish mosaic disease.
5, MBIT and Portugal's polyene sugar compound field efficacy experiment
Table 11 MBIT and Portugal's polyene sugar mixture are to canker of apple fruit prevention effect
Measurement result (table 11) shows, the preventive effect of canker of apple fruit is significantly improved by MBIT with Portugal's polyene sugar mixture, explanation
The two compounds significant potentiation to canker of apple fruit.
6, BBIT and Portugal's polyene sugar compound field efficacy experiment
Table 12 BBIT and Portugal's polyene sugar mixture are to target prevention effect
Measurement result (table 12) shows, the preventive effect of target is significantly improved by BBIT with Portugal's polyene sugar mixture, says
Compounding both bright have significant potentiation to target.
Claims (10)
1. a microbicide compositions, it is characterised in that described compositions comprises two kinds of active components of A and B, wherein activity group
Dividing A is the structural compounds with formula I, and active component B is selected from sugary series bactericidal agent lentinan or Portugal's polyene sugar, two components
Between weight ratio be 1:0.01～20
In formula I, R is selected from H or C1～C8Alkyl.
Microbicide compositions the most according to claim 1, it is characterised in that in formula I, R is selected from H or C1～C4Alkyl.
Microbicide compositions the most according to claim 1, it is characterised in that in formula I, R is preferably selected from H ,-CH3Or-
C4H9, corresponding active component A is respectively BIT, 2-methyl isophthalic acid, 2-benzisothiazole-3-ketone or
2-butyl-1,2-benzisothiazole-3-ketone.
Microbicide compositions the most according to claim 1, it is characterised in that active component A and the weight ratio of active component B
For 1:0.02～15.
Microbicide compositions the most according to claim 4, it is characterised in that active component A and the weight ratio of active component B
For 1:0.03～10.
6. according to the microbicide compositions described in any one in Claims 1 to 5, it is characterised in that said composition is become by activity
Divide and make, with insecticides adjuvant or adjuvant, the dosage form allowed on pesticide.
Microbicide compositions the most according to claim 6, it is characterised in that described dosage form is wettable powder, suspending agent
Or water dispersible granules.
Microbicide compositions the most according to claim 6, it is characterised in that said composition is by 2～80% activity of weight portion
Component with 98～20% weight portion insecticides adjuvant composition pesticide on allow dosage form.
Microbicide compositions the most according to claim 6, it is characterised in that described insecticides adjuvant or adjuvant are selected from carrier, molten
One or more in agent, dispersant, wetting agent, adhesive, thickening agent, binding agent, surfactant or fertilizer.
10. in Claims 1 to 5 microbicide compositions described in any one in terms of agriculture field preventing and treating corps diseases
Purposes.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106922683A (en) * | 2017-03-21 | 2017-07-07 | 江苏辉丰农化股份有限公司 | Composition pesticide containing BIT and Thidiazuron |
| CN110537542A (en) * | 2018-12-13 | 2019-12-06 | 北京宇悦生物科技有限公司 | Pesticide composition and application thereof |
| CN116138256A (en) * | 2023-03-08 | 2023-05-23 | 陕西康禾立丰生物科技药业有限公司 | Sterilization composition containing glucagons and bromothalonil |
| CN116530517A (en) * | 2023-05-08 | 2023-08-04 | 陕西康禾立丰生物科技药业有限公司 | Sterilization composition containing glucurolactone and isothiabendazole and application thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103918716A (en) * | 2013-01-10 | 2014-07-16 | 陕西汤普森生物科技有限公司 | Brevibacillus laterosporus-containing efficient pesticide composition |
| CN104798789B (en) * | 2014-01-28 | 2018-11-27 | 中国科学院大连化学物理研究所 | A kind of broad spectrum activity oligosaccharides composite bactericide and its application |
-
2016
- 2016-08-15 CN CN201610674115.8A patent/CN106070245B/en active Active
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106922683A (en) * | 2017-03-21 | 2017-07-07 | 江苏辉丰农化股份有限公司 | Composition pesticide containing BIT and Thidiazuron |
| CN110537542A (en) * | 2018-12-13 | 2019-12-06 | 北京宇悦生物科技有限公司 | Pesticide composition and application thereof |
| CN116138256A (en) * | 2023-03-08 | 2023-05-23 | 陕西康禾立丰生物科技药业有限公司 | Sterilization composition containing glucagons and bromothalonil |
| CN116530517A (en) * | 2023-05-08 | 2023-08-04 | 陕西康禾立丰生物科技药业有限公司 | Sterilization composition containing glucurolactone and isothiabendazole and application thereof |
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