CA1059128A - Piperazinyl pyrazines - Google Patents

Piperazinyl pyrazines

Info

Publication number: CA1059128A
Authority: CA; Canada
Prior art keywords: pyrazine; piperazinyl; chloro; compound; formula
Prior art date: 1975-04-21
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

CA250,732A

Other languages

English (en)

French (fr)

Inventor

Walfred S. Saari

William C. Lumma (Jr.)

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Merck and Co Inc

Original Assignee

Merck and Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1975-04-21

Filing date

1976-04-14

Publication date

1979-07-24

1976-04-14 Application filed by Merck and Co Inc filed Critical Merck and Co Inc

1979-07-24 Application granted granted Critical

1979-07-24 Publication of CA1059128A publication Critical patent/CA1059128A/en

Status Expired legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Child & Adolescent Psychology (AREA)
Hematology (AREA)
Obesity (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Diabetes (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

CA250,732A 1975-04-21 1976-04-14 Piperazinyl pyrazines Expired CA1059128A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US57005275A	1975-04-21	1975-04-21

Publications (1)

Publication Number	Publication Date
CA1059128A true CA1059128A (en)	1979-07-24

Family

ID=24277994

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA250,732A Expired CA1059128A (en)	1975-04-21	1976-04-14	Piperazinyl pyrazines

Country Status (36)

Country	Link
JP (1)	JPS51136688A (pt)
AR (1)	AR210349A1 (pt)
AT (1)	AT353795B (pt)
AU (1)	AU496854B2 (pt)
BE (1)	BE840904A (pt)
BG (1)	BG34185A3 (pt)
CA (1)	CA1059128A (pt)
CH (1)	CH619462A5 (pt)
CS (1)	CS195726B2 (pt)
CY (1)	CY1090A (pt)
DD (1)	DD124599A5 (pt)
DE (1)	DE2617205C3 (pt)
DK (1)	DK143899C (pt)
EG (1)	EG12387A (pt)
ES (4)	ES447150A1 (pt)
FI (1)	FI62666C (pt)
FR (1)	FR2308367A1 (pt)
GB (1)	GB1492528A (pt)
GR (1)	GR59900B (pt)
HK (1)	HK60380A (pt)
HU (1)	HU172684B (pt)
IE (1)	IE42979B1 (pt)
IL (1)	IL49391A (pt)
KE (1)	KE3088A (pt)
LU (1)	LU74795A1 (pt)
MY (1)	MY8100225A (pt)
NL (1)	NL167692C (pt)
NO (1)	NO146599C (pt)
PH (1)	PH12274A (pt)
PL (1)	PL99664B1 (pt)
PT (1)	PT65027B (pt)
RO (1)	RO73278A (pt)
SE (1)	SE421695B (pt)
SU (1)	SU638260A3 (pt)
YU (1)	YU100676A (pt)
ZA (1)	ZA762320B (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4091098A (en) *	1977-04-25	1978-05-23	Merck & Co., Inc.	3-(1-PIPERAZINYL)-1,2,4-BENZOTRIAZINES AND N-oxides
US4163849A (en)	1978-03-17	1979-08-07	Merck & Co., Inc.	Piperazinylpyrazines
US4252816A (en) *	1979-12-03	1981-02-24	Merck & Co., Inc.	Tetrahydro-1H-1,4-diazepino(1,7-a)benzimidazoles useful as analgesic agents
US4339579A (en)	1980-12-29	1982-07-13	American Home Products Corporation	2,6-Bis-(pyrrolopyrazinyl)pyrazines
EP0094498A3 (en) *	1982-05-06	1985-04-03	American Cyanamid Company	Antiatherosclerotic 1-piperazine derivatives
US4547505A (en) *	1983-03-25	1985-10-15	Degussa Aktiengesellschaft	N-Phenyl-N-'-cycloalkylalkanoylpiperazine useful as analgetics and process for its production
US4788290A (en) *	1987-12-11	1988-11-29	American Home Products Corporation	Serotonergic pyrazine derivatives
EP0580465A1 (fr) *	1992-06-25	1994-01-26	Sanofi	Nouvelle utilisation thérapeutique d'hétérocyclyl-pipérazines comme 5-HT3 agonistes et nouveaux dérivés
EE04588B1 (et) *	1997-10-27	2006-02-15	Neurosearch A/S	Heteroarüüldiasatsükloalkaanid kui atsetüülkoliini nikotiinretseptorite kolinergilised ligandid, nende kasutamine ravimitena ning neid sisaldav farmatseutiline kompositsioon
NZ514021A (en)	1999-04-26	2001-09-28	Neurosearch As	Heteroaryl diazacycloalkanes, their preparation and use
CZ20022739A3 (cs) *	2000-02-16	2003-02-12	Neurogen Corporation	Substituované arylpyraziny
US6825198B2 (en) *	2001-06-21	2004-11-30	Pfizer Inc	5-HT receptor ligands and uses thereof
SE0202287D0 (sv) *	2002-07-19	2002-07-19	Biovitrum Ab	New compounds
AU2003243101B2 (en) *	2002-07-19	2010-05-13	Biovitrum Ab (Publ)	Novel piperazinyl-pyrazinone derivatives for the treatment of 5-HT2A receptor-related disorders

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2606906A (en) *	1948-10-14	1952-08-12	American Cyanamid Co	1-(2-pyridyl) piperazine and process of preparing same

1976
- 1976-04-07 SE SE7604093A patent/SE421695B/xx not_active IP Right Cessation
- 1976-04-07 EG EG76205A patent/EG12387A/xx active
- 1976-04-07 DK DK164476A patent/DK143899C/da not_active IP Right Cessation
- 1976-04-08 NO NO761207A patent/NO146599C/no unknown
- 1976-04-09 NL NL7603800A patent/NL167692C/xx not_active IP Right Cessation
- 1976-04-09 FI FI760978A patent/FI62666C/fi not_active IP Right Cessation
- 1976-04-12 IL IL49391A patent/IL49391A/xx unknown
- 1976-04-13 AU AU12966/76A patent/AU496854B2/en not_active Expired
- 1976-04-13 GR GR50538A patent/GR59900B/el unknown
- 1976-04-13 PH PH18329A patent/PH12274A/en unknown
- 1976-04-14 CA CA250,732A patent/CA1059128A/en not_active Expired
- 1976-04-14 FR FR7610958A patent/FR2308367A1/fr active Granted
- 1976-04-15 CY CY1090A patent/CY1090A/xx unknown
- 1976-04-15 DD DD192399A patent/DD124599A5/xx unknown
- 1976-04-15 GB GB15644/76A patent/GB1492528A/en not_active Expired
- 1976-04-16 CS CS762549A patent/CS195726B2/cs unknown
- 1976-04-19 JP JP51043763A patent/JPS51136688A/ja active Granted
- 1976-04-19 ES ES447150A patent/ES447150A1/es not_active Expired
- 1976-04-20 SU SU762346054A patent/SU638260A3/ru active
- 1976-04-20 BG BG032968A patent/BG34185A3/xx unknown
- 1976-04-20 LU LU74795A patent/LU74795A1/xx unknown
- 1976-04-20 BE BE166282A patent/BE840904A/xx not_active IP Right Cessation
- 1976-04-20 CH CH492676A patent/CH619462A5/de not_active IP Right Cessation
- 1976-04-20 AR AR262930A patent/AR210349A1/es active
- 1976-04-20 YU YU01006/76A patent/YU100676A/xx unknown
- 1976-04-20 ZA ZA762320A patent/ZA762320B/xx unknown
- 1976-04-20 AT AT288376A patent/AT353795B/de not_active IP Right Cessation
- 1976-04-20 DE DE2617205A patent/DE2617205C3/de not_active Expired
- 1976-04-20 RO RO7685688A patent/RO73278A/ro unknown
- 1976-04-20 PL PL1976188912A patent/PL99664B1/pl unknown
- 1976-04-21 HU HU76ME00001967A patent/HU172684B/hu unknown
- 1976-04-21 IE IE828/76A patent/IE42979B1/en unknown
- 1976-04-21 PT PT65027A patent/PT65027B/pt unknown
1977
- 1977-06-01 ES ES459405A patent/ES459405A1/es not_active Expired
- 1977-06-01 ES ES459406A patent/ES459406A1/es not_active Expired
- 1977-06-01 ES ES459407A patent/ES459407A1/es not_active Expired
1980
- 1980-10-02 KE KE3088A patent/KE3088A/xx unknown
- 1980-10-30 HK HK603/80A patent/HK60380A/xx unknown
1981
- 1981-12-30 MY MY225/81A patent/MY8100225A/xx unknown

Also Published As

Publication number	Publication date
FR2308367B1 (pt)	1979-09-21
IE42979L (en)	1976-10-21
DK143899B (da)	1981-10-26
FI760978A (pt)	1976-10-22
FR2308367A1 (fr)	1976-11-19
DK164476A (da)	1976-10-22
FI62666C (fi)	1983-02-10
AR210349A1 (es)	1977-07-29
PL99664B1 (pl)	1978-07-31
LU74795A1 (pt)	1977-02-07
DD124599A5 (pt)	1977-03-02
HU172684B (hu)	1978-11-28
JPS5522475B2 (pt)	1980-06-17
CS195726B2 (en)	1980-02-29
ES447150A1 (es)	1977-09-16
AU496854B2 (en)	1978-11-02
GR59900B (en)	1978-03-16
NO761207L (pt)	1976-10-22
NL7603800A (nl)	1976-10-25
JPS51136688A (en)	1976-11-26
KE3088A (en)	1980-11-07
DK143899C (da)	1982-04-13
CH619462A5 (en)	1980-09-30
PT65027A (en)	1976-05-01
NL167692C (nl)	1982-01-18
NO146599C (no)	1982-11-03
ATA288376A (de)	1979-05-15
MY8100225A (en)	1981-12-31
IE42979B1 (en)	1980-11-19
ES459406A1 (es)	1978-08-16
DE2617205B2 (de)	1980-05-08
NO146599B (no)	1982-07-26
IL49391A (en)	1979-09-30
ES459405A1 (es)	1978-08-16
PT65027B (en)	1978-04-03
CY1090A (en)	1980-12-27
ES459407A1 (es)	1978-08-16
AT353795B (de)	1979-12-10
ZA762320B (en)	1977-11-30
BG34185A3 (en)	1983-07-15
EG12387A (en)	1978-12-31
AU1296676A (en)	1977-10-20
BE840904A (fr)	1976-08-16
DE2617205C3 (de)	1981-01-29
SU638260A3 (ru)	1978-12-15
YU100676A (en)	1982-08-31
HK60380A (en)	1980-11-07
NL167692B (nl)	1981-08-17
SE421695B (sv)	1982-01-25
IL49391A0 (en)	1976-06-30
RO73278A (ro)	1982-09-09
SE7604093L (sv)	1976-10-22
FI62666B (fi)	1982-10-29
DE2617205A1 (de)	1976-10-28
GB1492528A (en)	1977-11-23
PH12274A (en)	1978-12-12

Publication	Publication Date	Title
CA1059128A (en)	1979-07-24	Piperazinyl pyrazines
US6599905B2 (en)	2003-07-29	Pyrazine compounds
SU1340589A3 (ru)	1987-09-23	Способ получени 2-(4-замещенных пиперазино-4-амино-6,7-диметокси)хинолинов или их гидрохлоридов
US4081542A (en)	1978-03-28	Piperazinylpyrazines
US3300494A (en)	1967-01-24	Pyrazinamidoguanidine products
JPH0224821B2 (pt)	1990-05-30
US4082844A (en)	1978-04-04	6-chloro-2-(1-piperazinyl)pyrazine
US4118561A (en)	1978-10-03	7-(Substituted)-7H-pyrrolo[3,2-f]quinazoline-1,3-diamines
US6503909B1 (en)	2003-01-07	Pyrazine compounds
US4379160A (en)	1983-04-05	Carbazole compounds and medicinal use thereof
US4242344A (en)	1980-12-30	Piperazinyl-imidazo[1,2-a]pyrazines
JP2002505999A (ja)	2002-02-26	新規な四環化合物、その製造方法およびこれらの化合物を含有する医薬製剤
JP3038064B2 (ja)	2000-05-08	インドール誘導体およびこれを有効成分とする抗潰瘍薬
JPS59216877A (ja)	1984-12-06	置換フエニル−２−（１ｈ）−ピリミジノン
US4144338A (en)	1979-03-13	N-pyrimidinyl-N-dialkylaminoalkyl ureas
JPS63192778A (ja)	1988-08-10	β−アドレナリン受容体遮断薬としてのピペラジニルピリミジン類
US4302455A (en)	1981-11-24	2-(4-Aminopiperidino)pyrazines
US5290933A (en)	1994-03-01	Phenylpyrimidone derivatives
US4011323A (en)	1977-03-08	Bi-4-[1-(quinazolinyl-4)piperidyls] and bis{4-[1-(quinazolinyl-4)piperidyl]alkanes}
CA1293251C (en)	1991-12-17	Pyrazine derivative, a process for preparation thereof and pharmaceutical composition therefrom
US3708484A (en)	1973-01-02	Amino and substituted amino-s-triazolo-(4,3-b)-pyridazines
CA1093555A (en)	1981-01-13	7-(substituted)-7h-pyrrolo¬3,2-f\| quinazoline-1,3- diamines
KR790001500B1 (ko)	1979-10-24	피페라지닐 피라진 화합물의 제법
US4874763A (en)	1989-10-17	Pharmaceutically efficacious pteridine derivatives
US4029788A (en)	1977-06-14	2,3-Bis(4-alkyl-1-piperazinyl)quinoxalines