Nothing Special   »   [go: up one dir, main page]

BRPI0720218A2 - Anticorpos monoclonais contra angptl3 - Google Patents

Anticorpos monoclonais contra angptl3

Info

Publication number
BRPI0720218A2
BRPI0720218A2 BRPI0720218-0A2A BRPI0720218A BRPI0720218A2 BR PI0720218 A2 BRPI0720218 A2 BR PI0720218A2 BR PI0720218 A BRPI0720218 A BR PI0720218A BR PI0720218 A2 BRPI0720218 A2 BR PI0720218A2
Authority
BR
Brazil
Prior art keywords
monoclonal antibodies
antibodies against
against angptl3
angptl3
monoclonal
Prior art date
Application number
BRPI0720218-0A2A
Other languages
English (en)
Inventor
E-Chiang Lee
Gregory Landes
Seokjoo Hong
Urvi Desai
David Powell
Xiao Feng
Original Assignee
Lexicon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lexicon Pharmaceuticals Inc filed Critical Lexicon Pharmaceuticals Inc
Publication of BRPI0720218A2 publication Critical patent/BRPI0720218A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
BRPI0720218-0A2A 2006-12-08 2007-12-06 Anticorpos monoclonais contra angptl3 BRPI0720218A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87383406P 2006-12-08 2006-12-08
PCT/US2007/025080 WO2008073300A2 (en) 2006-12-08 2007-12-06 Monoclonal antibodies against angptl3

Publications (1)

Publication Number Publication Date
BRPI0720218A2 true BRPI0720218A2 (pt) 2013-12-24

Family

ID=39512267

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0720218-0A2A BRPI0720218A2 (pt) 2006-12-08 2007-12-06 Anticorpos monoclonais contra angptl3

Country Status (21)

Country Link
US (2) US7935796B2 (pt)
EP (1) EP2121751B1 (pt)
JP (1) JP5484063B2 (pt)
KR (1) KR101503937B1 (pt)
CN (1) CN101855241B (pt)
AR (1) AR064205A1 (pt)
AU (1) AU2007332855B2 (pt)
BR (1) BRPI0720218A2 (pt)
CA (1) CA2672049C (pt)
DK (1) DK2121751T3 (pt)
EA (1) EA019661B1 (pt)
ES (1) ES2618830T3 (pt)
HU (1) HUE033960T2 (pt)
IL (1) IL199216A (pt)
MX (1) MX2009006082A (pt)
NO (1) NO20092215L (pt)
PL (1) PL2121751T3 (pt)
PT (1) PT2121751T (pt)
TW (1) TW200846364A (pt)
WO (1) WO2008073300A2 (pt)
ZA (1) ZA200904022B (pt)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA019661B1 (ru) * 2006-12-08 2014-05-30 Лексикон Фармасьютикалз, Инк. Моноклональные антитела против angptl3
US8802646B2 (en) 2008-10-08 2014-08-12 Trustees Of Dartmouth College Method for selectively inhibiting the activity of ACAT1 in the treatment of alzheimer's disease
US9388413B2 (en) 2008-10-08 2016-07-12 Trustees Of Dartmouth College Method for selectively inhibiting ACAT1 in the treatment of neurodegenerative diseases
WO2010042292A1 (en) * 2008-10-08 2010-04-15 Trustees Of Dartmouth College Method for selectively inhibiting the activity of acat1 in the treatment of alzheimer's disease
US9388414B2 (en) 2008-10-08 2016-07-12 Trustees Of Dartmouth College Method for selectively inhibiting ACAT1 in the treatment of neurodegenerative diseases
US9149492B2 (en) 2008-10-08 2015-10-06 Trustees Of Dartmouth College Method for selectively inhibiting ACAT1 in the treatment of alzheimer's disease
US20130064834A1 (en) 2008-12-15 2013-03-14 Regeneron Pharmaceuticals, Inc. Methods for treating hypercholesterolemia using antibodies to pcsk9
CN101852805B (zh) * 2009-03-31 2015-04-01 浙江大学 Angptl3作为卵巢癌的诊断标记物的用途
AU2015200969A1 (en) * 2010-01-08 2015-03-19 Ionis Pharmaceuticals, Inc. Modulation of angiopoietin-like 3 expression
CN111700901A (zh) * 2010-01-08 2020-09-25 Ionis制药公司 血管生成素样3表达的调节
ME03447B (me) 2010-03-04 2020-01-20 Macrogenics Inc Anтitela reakтivna sa b7-нз, njihovi imunološki akтivni fragmenтi i upotreba
US8802091B2 (en) 2010-03-04 2014-08-12 Macrogenics, Inc. Antibodies reactive with B7-H3 and uses thereof
US11644471B2 (en) 2010-09-30 2023-05-09 Ablynx N.V. Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains
ES2683953T3 (es) * 2011-02-07 2018-09-28 Aggamin Llc Procedimientos y sistemas para tratar o prevenir trastornos hipertensivos gestacionales
WO2012154983A2 (en) 2011-05-10 2012-11-15 Biocare Medical, Llc Systems and methods for anti-pax8 antibodies
JO3412B1 (ar) * 2011-06-17 2019-10-20 Regeneron Pharma أجسام مضادة ل angptl3 واستخداماتها
KR20230107908A (ko) * 2011-06-21 2023-07-18 알닐람 파마슈티칼스 인코포레이티드 안지오포이에틴-유사 3(ANGPTL3) iRNA 조성물 및 그사용 방법
EP2723769B2 (en) 2011-06-23 2022-06-15 Ablynx NV Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains
MY170089A (en) 2011-09-16 2019-07-04 Regeneron Pharma Methods for reducing lipoproten(a) levels by administering an inhibitor of proprotein convertase subtilisin kexin-9 (pcsk9)
US10316103B1 (en) 2012-03-30 2019-06-11 Biocare Medical, Llc Systems and methods for anti-Uroplakin III antibodies
HRP20211641T1 (hr) 2012-07-13 2022-02-04 Roche Glycart Ag Bispecifična protutijela anti-vegf/anti-ang-2 i njihova primjena u liječenju vaskularnih očnih bolesti
EP2882778B1 (en) 2012-08-13 2018-04-11 Regeneron Pharmaceuticals, Inc. Anti-pcsk9 antibodies with ph-dependent binding characteristics
WO2014052672A1 (en) 2012-09-27 2014-04-03 Biocare Medical, Llc Anti-uroplakin ii antibodies systems and methods
GB201219487D0 (en) * 2012-10-30 2012-12-12 Cancer Rec Tech Ltd Anti-S100A4 antibody molecules and their uses
US10429390B2 (en) 2012-12-18 2019-10-01 Biocare Medical, Llc Antibody cocktail systems and methods for classification of histologic subtypes in lung cancer
ES2720483T3 (es) 2013-02-28 2019-07-22 Biocare Medical Llc Sistemas y procedimientos de anticuerpos anti p40
US9487587B2 (en) 2013-03-05 2016-11-08 Macrogenics, Inc. Bispecific molecules that are immunoreactive with immune effector cells of a companion animal that express an activating receptor and cells that express B7-H3 and uses thereof
JO3564B1 (ar) 2013-03-08 2020-07-05 Novartis Ag ببتيدات وتركيبات لعلاج ضرر المفاصل
US9301971B2 (en) 2013-03-08 2016-04-05 Novartis Ag Peptides and compositions for treatment of joint damage
CN105378085B (zh) 2013-05-01 2019-02-15 Ionis制药公司 用于调节hbv和ttr表达的组合物和方法
US10111953B2 (en) 2013-05-30 2018-10-30 Regeneron Pharmaceuticals, Inc. Methods for reducing remnant cholesterol and other lipoprotein fractions by administering an inhibitor of proprotein convertase subtilisin kexin-9 (PCSK9)
US9816997B2 (en) 2013-10-03 2017-11-14 Biocare Medical, Llc Anti-SOX10 antibody systems and methods
ES2754209T3 (es) 2013-12-13 2020-04-16 Stora Enso Oyj Cartón multicapa
KR102298476B1 (ko) * 2013-12-24 2021-09-03 아이오니스 파마수티컬즈, 인코포레이티드 안지오포이에틴-유사 3 발현의 조절
PL3137605T3 (pl) 2014-05-01 2021-04-19 Ionis Pharmaceuticals, Inc. Kompozycje i sposoby modulowania ekspresji białka angiopoetynopodobnego 3
WO2015184105A1 (en) 2014-05-29 2015-12-03 Trustees Of Dartmouth College Method for selectively inhibiting acat1 in the treatment of neurodegenerative diseases
US9527922B2 (en) * 2014-12-31 2016-12-27 Development Center For Biotechnology Humanized alpha-enolase specific antibodies and methods of uses in cancer therapy
TW202124714A (zh) 2015-04-13 2021-07-01 美商阿尼拉製藥公司 類血管生成素３（ＡＮＧＰＴＬ３）ｉＲＮＡ組成物及其用途方法
PE20181180A1 (es) 2015-11-06 2018-07-20 Ionis Pharmaceuticals Inc MODULAR LA EXPRESION DE APOLIPOPROTEINA (a)
WO2017142832A1 (en) * 2016-02-17 2017-08-24 Regeneron Pharmaceuticals, Inc. Methods for treating or preventing atherosclerosis by administering an inhibitor of angptl3
US10961311B2 (en) 2016-04-15 2021-03-30 Macrogenics, Inc. B7-H3 binding molecules, antibody drug conjugates thereof and methods of use thereof
KR20220148299A (ko) * 2016-04-28 2022-11-04 리제너론 파아마슈티컬스, 인크. 가족성 고콜레스테롤혈증을 지닌 환자를 치료하는 방법
CA3042236A1 (en) * 2016-10-28 2018-05-03 Washington University Anti-apoe antibodies
CN107085112B (zh) * 2017-05-10 2019-03-19 武汉圣润生物科技有限公司 一种用于检测白血病的试剂盒
WO2019195561A2 (en) * 2018-04-06 2019-10-10 BioLegend, Inc. Anti-tetraspanin 33 agents and compositions and methods for making and using the same
WO2020028832A1 (en) 2018-08-02 2020-02-06 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating dystrophinopathies
AR116566A1 (es) 2018-10-03 2021-05-19 Novartis Ag Administración sostenida de polipéptidos similares a la angiopoyetina 3
TWI747098B (zh) 2018-12-21 2021-11-21 美商美國禮來大藥廠 抗angptl3/8複合物抗體及其使用方法
US20200369760A1 (en) 2019-05-24 2020-11-26 Regeneron Pharmaceuticals, Inc. Stabilized formulations containing anti-angptl3 antibodies
CN112062844B (zh) * 2019-06-10 2022-07-19 山东博安生物技术股份有限公司 抗angptl3抗体及其用途
WO2021001804A1 (en) * 2019-07-04 2021-01-07 Cadila Healthcare Limited Angptl3 based vaccine for the treatment of liver disease
WO2021041300A2 (en) * 2019-08-23 2021-03-04 Ab Therapeutics, Inc. Bispecific antibodies and uses thereof
CN110938144B (zh) * 2019-11-27 2022-07-26 复旦大学附属儿科医院 一种抗angptl3单克隆抗体及其在制备治疗肾病综合征药物中的用途
US20230138315A1 (en) * 2020-01-22 2023-05-04 Jiangsu Hengrui Medicine Co., Ltd. Anti-angptl3 antibody and use thereof
WO2022109443A1 (en) * 2020-11-23 2022-05-27 The Regents Of The University Of Michigan Single-chain antibody against flavivirus ns1 protein
IL305442A (en) 2021-03-04 2023-10-01 Alnylam Pharmaceuticals Inc Angiopoietin-like 3 (ANGPTL3) IRNA compositions and methods of using them
US20240141029A1 (en) * 2021-03-05 2024-05-02 Anji Pharmaceuticals Inc. Methods and compositions for treating sepsis
JPWO2022244845A1 (pt) * 2021-05-19 2022-11-24
MX2024000492A (es) * 2021-07-09 2024-04-09 Dyne Therapeutics Inc Complejos dirigidos al musculo y usos de los mismos para tratar las distrofinopatías.
KR20240035825A (ko) 2021-07-09 2024-03-18 다인 세라퓨틱스, 인크. 디스트로핀병증을 치료하기 위한 근육 표적화 복합체 및 제제
US11771776B2 (en) 2021-07-09 2023-10-03 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating dystrophinopathies
WO2023283613A1 (en) * 2021-07-09 2023-01-12 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating dystrophinopathies
AU2022314036A1 (en) * 2021-07-21 2024-02-01 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Pharmaceutical composition of anti-angptl3 antibody or antigen binding fragment thereof and its application
CN116284377A (zh) * 2021-12-21 2023-06-23 复旦大学 抗人血管生成素3纳米抗体及其应用
KR20230156844A (ko) 2022-05-02 2023-11-14 노보 노르디스크 에이/에스 고농도 조성물 및 피하 투여에 적합한 신규한 항-angptl3 항체
CN117447594B (zh) * 2022-07-26 2024-06-25 北京东方百泰生物科技股份有限公司 一种抗Siglec-15单克隆抗体
CN116199779B (zh) * 2022-12-08 2023-08-11 北京东方百泰生物科技股份有限公司 一种抗lilrb4单克隆抗体、其抗原结合片段及其应用
WO2024130165A1 (en) 2022-12-16 2024-06-20 Regeneron Pharmaceuticals, Inc. Angptl3 inhibitors for triglyceride reduction in multifactorial chylomicronemia syndrome

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US4263428A (en) 1978-03-24 1981-04-21 The Regents Of The University Of California Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same
US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
IE52535B1 (en) 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
DE3374837D1 (en) 1982-02-17 1988-01-21 Ciba Geigy Ag Lipids in the aqueous phase
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
HUT35524A (en) 1983-08-02 1985-07-29 Hoechst Ag Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance
DE3474511D1 (en) 1983-11-01 1988-11-17 Terumo Corp Pharmaceutical composition containing urokinase
US4740461A (en) 1983-12-27 1988-04-26 Genetics Institute, Inc. Vectors and methods for transformation of eucaryotic cells
DE3572982D1 (en) 1984-03-06 1989-10-19 Takeda Chemical Industries Ltd Chemically modified lymphokine and production thereof
US4959455A (en) 1986-07-14 1990-09-25 Genetics Institute, Inc. Primate hematopoietic growth factors IL-3 and pharmaceutical compositions
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
DE3785186T2 (de) 1986-09-02 1993-07-15 Enzon Lab Inc Bindungsmolekuele mit einzelpolypeptidkette.
US5260203A (en) 1986-09-02 1993-11-09 Enzon, Inc. Single polypeptide chain binding molecules
US4912040A (en) 1986-11-14 1990-03-27 Genetics Institute, Inc. Eucaryotic expression system
EP0401384B1 (en) 1988-12-22 1996-03-13 Kirin-Amgen, Inc. Chemically modified granulocyte colony stimulating factor
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
ATE139258T1 (de) 1990-01-12 1996-06-15 Cell Genesys Inc Erzeugung xenogener antikörper
US6075181A (en) 1990-01-12 2000-06-13 Abgenix, Inc. Human antibodies derived from immunized xenomice
US6552170B1 (en) 1990-04-06 2003-04-22 Amgen Inc. PEGylation reagents and compounds formed therewith
US5877397A (en) 1990-08-29 1999-03-02 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
AU1674292A (en) 1991-03-15 1992-10-21 Synergen, Inc. Pegylation of polypeptides
US5869619A (en) 1991-12-13 1999-02-09 Xoma Corporation Modified antibody variable domains
JP4157160B2 (ja) 1991-12-13 2008-09-24 ゾーマ テクノロジー リミテッド 改変抗体可変領域の調製のための方法
US5446090A (en) 1993-11-12 1995-08-29 Shearwater Polymers, Inc. Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules
US5912000A (en) 1994-09-23 1999-06-15 Zonagen, Inc. Chitosan induced immunopotentiation
US5824784A (en) 1994-10-12 1998-10-20 Amgen Inc. N-terminally chemically modified protein compositions and methods
TW313568B (pt) 1994-12-20 1997-08-21 Hoffmann La Roche
US6127977A (en) 1996-11-08 2000-10-03 Cohen; Nathan Microstrip patch antenna with fractal structure
ATE549918T1 (de) 1996-12-03 2012-04-15 Amgen Fremont Inc Menschliche antikörper, die ausdrücklich menschliches tnf alpha binden
US20030100051A1 (en) 1998-05-12 2003-05-29 Ruben Steven M. 97 human secreted proteins
US5980912A (en) 1997-03-25 1999-11-09 Zonagen, Inc. Chitosan induced immunopotentiation
US6030831A (en) * 1997-09-19 2000-02-29 Genetech, Inc. Tie ligand homologues
AU4643699A (en) * 1998-06-24 2000-01-10 Compugen Ltd. Angiopoietin-like growth factor sequences
RU2002115295A (ru) 1999-12-09 2004-01-10 Санкио Компани, Лимитед (Jp) Способ испытания терапевтического или профилактического средства от гиперлипидемии
IL159153A0 (en) 2001-06-08 2004-06-01 Sankyo Co Methods for testing drugs for treating or preventing diseases such as hyperlipidemia
MXPA04004609A (es) * 2001-11-16 2004-08-12 Genentech Inc Composicion que comprende y metodo para utilizar angptl3 de proteina 3 como angiopoyetina.
EA016185B1 (ru) 2005-01-07 2012-03-30 Лексикон Фармасьютикалз, Инк. Моноклональное антитело или его фрагмент к подобному ангиопоэтину белку 4 (angptl4) и их применение
EA019661B1 (ru) * 2006-12-08 2014-05-30 Лексикон Фармасьютикалз, Инк. Моноклональные антитела против angptl3

Also Published As

Publication number Publication date
EP2121751B1 (en) 2017-01-25
US7935796B2 (en) 2011-05-03
KR20090088925A (ko) 2009-08-20
JP2010512320A (ja) 2010-04-22
US8742075B2 (en) 2014-06-03
CA2672049C (en) 2016-05-10
EA019661B1 (ru) 2014-05-30
CN101855241A (zh) 2010-10-06
IL199216A (en) 2016-02-29
TW200846364A (en) 2008-12-01
EA200970556A1 (ru) 2010-04-30
DK2121751T3 (en) 2017-04-24
AU2007332855B2 (en) 2012-08-16
ES2618830T3 (es) 2017-06-22
PL2121751T3 (pl) 2017-07-31
CN101855241B (zh) 2013-11-06
MX2009006082A (es) 2009-08-18
KR101503937B1 (ko) 2015-03-18
NO20092215L (no) 2009-08-19
EP2121751A2 (en) 2009-11-25
HUE033960T2 (en) 2018-01-29
AU2007332855A1 (en) 2008-06-19
AR064205A1 (es) 2009-03-18
US20080177045A1 (en) 2008-07-24
CA2672049A1 (en) 2008-06-19
EP2121751A4 (en) 2012-01-11
WO2008073300A3 (en) 2009-12-23
JP5484063B2 (ja) 2014-05-07
WO2008073300A2 (en) 2008-06-19
US20110243948A1 (en) 2011-10-06
ZA200904022B (en) 2010-08-25
PT2121751T (pt) 2017-04-18

Similar Documents

Publication Publication Date Title
BRPI0720218A2 (pt) Anticorpos monoclonais contra angptl3
CY2021027I1 (el) Σκευασματα αντισωματων anti-cd20
CY2019004I1 (el) Τροποποιημενα αντισωματα αντι-ιl-23ρ19
NO344963B1 (no) Humanisert antistoff
CY2016030I1 (el) Αντισωματα εναντι της il-17
DK2066695T3 (da) Anti-myostatin-antistoffer
DK2059533T3 (da) Multispecifikke antistoffer
EP2021373A4 (en) MONOCLONAL ANTIBODY VCAM-1 SPECIFIC
BRPI0907532A2 (pt) Anticorpos anti-c5ar humanizados
IL194995A0 (en) Modified humanised anti-interleukin-18 antibodies
BRPI0809677A2 (pt) Anticorpos anti-ige
DOP2006000093A (es) Anticuerpos contra miostatina
DK2044121T3 (da) Glyco-konstruerede antistoffer
DK2131860T3 (da) Anti-sclerostin-antistoffer
BRPI0814252A2 (pt) Formulações de anticorpo
BRPI0821777A2 (pt) Anticorpos biespecíficos bivalentes
BRPI0907237A2 (pt) Anticorpo anti-cldn6
BRPI0819165A2 (pt) Anticorpos anti-vegf
SG10201601279SA (en) Monoclonal Antibody STRO-4
BRPI0814111A2 (pt) Anticorpo monoclonal citotóxico anticâncer
FI20075278A0 (fi) Uudet täysin ihmisperäiset anti-VAP-1 monoklonaaliset vasta-aineet
GB0615662D0 (en) Antibody
BRPI0807991A2 (pt) Anticorpos anti-il-23r elaborados.
CR10705A (es) Anticuerpos para linfotoxina-alfa
IL200168A0 (en) Monoclonal anti-cxcl13 antibodies

Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]