BRPI0719210A2 - Uso de compostos espiro-oxindol como agentes terapêuticos - Google Patents
Uso de compostos espiro-oxindol como agentes terapêuticosInfo
- Publication number
- BRPI0719210A2 BRPI0719210A2 BRPI0719210A BRPI0719210A2 BR PI0719210 A2 BRPI0719210 A2 BR PI0719210A2 BR PI0719210 A BRPI0719210 A BR PI0719210A BR PI0719210 A2 BRPI0719210 A2 BR PI0719210A2
- Authority
- BR
- Brazil
- Prior art keywords
- spiro
- therapeutic agents
- oxindole compounds
- oxindole
- compounds
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85178706P | 2006-10-12 | 2006-10-12 | |
| PCT/US2007/081247 WO2008060789A2 (en) | 2006-10-12 | 2007-10-12 | Use of spiro-oxindole compounds as therapeutic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0719210A2 true BRPI0719210A2 (pt) | 2015-05-05 |
Family
ID=39339863
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0719210 BRPI0719210A2 (pt) | 2006-10-12 | 2007-10-12 | Uso de compostos espiro-oxindol como agentes terapêuticos |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8466188B2 (pt) |
| EP (1) | EP2073806B1 (pt) |
| JP (2) | JP5460324B2 (pt) |
| CN (2) | CN103271906A (pt) |
| AR (1) | AR063280A1 (pt) |
| AT (1) | ATE545416T1 (pt) |
| AU (1) | AU2007319580B2 (pt) |
| BR (1) | BRPI0719210A2 (pt) |
| CA (1) | CA2665698A1 (pt) |
| CL (1) | CL2007002950A1 (pt) |
| MX (1) | MX2009003876A (pt) |
| RU (1) | RU2009117642A (pt) |
| TW (1) | TW200833695A (pt) |
| WO (1) | WO2008060789A2 (pt) |
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| AR053710A1 (es) * | 2005-04-11 | 2007-05-16 | Xenon Pharmaceuticals Inc | Compuestos espiroheterociclicos y sus usos como agentes terapeuticos |
| MY144968A (en) * | 2005-04-11 | 2011-11-30 | Xenon Pharmaceuticals Inc | Spiro-oxindole compounds and their uses as therapeutic agents |
| RU2009117642A (ru) | 2006-10-12 | 2010-11-20 | Ксенон Фармасьютикалз Инк. (Ca) | Применение спирооксиндоловых соединений в качестве терапевтических средств |
| TW200825091A (en) * | 2006-10-12 | 2008-06-16 | Xenon Pharmaceuticals Inc | Spiro-oxindole compounds useful in treating sodium channel-mediated diseases or conditions |
| WO2010045251A2 (en) * | 2008-10-17 | 2010-04-22 | Xenon Pharmaceuticals, Inc. | Spiro-oxindole compounds and their use as therapeutic agents |
| CA2741024A1 (en) | 2008-10-17 | 2010-04-22 | Xenon Pharmaceuticals Inc. | Spiro-oxindole compounds and their use as therapeutic agents |
| US8217051B2 (en) * | 2009-02-17 | 2012-07-10 | Hoffmann-La Roche Inc. | Spiroindolinone derivatives |
| AR077252A1 (es) | 2009-06-29 | 2011-08-10 | Xenon Pharmaceuticals Inc | Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos |
| JP5752136B2 (ja) * | 2009-10-14 | 2015-07-22 | ゼノン・ファーマシューティカルズ・インコーポレイテッドＸｅｎｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． | スピロ−オキシインドール化合物のための合成方法 |
| WO2011047173A2 (en) * | 2009-10-14 | 2011-04-21 | Xenon Pharmaceuticals Inc. | Pharmaceutical compositions for oral administration |
| CN102946859B (zh) * | 2010-02-26 | 2016-03-02 | 泽农医药公司 | 用于局部给药的螺-羟吲哚化合物的药物组合物及其作为治疗剂的用途 |
| CA2794153C (en) | 2010-03-25 | 2018-01-02 | Glaxosmithkline Llc | Substituted indoline derivatives as perk inhibitors |
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| CN102321095B (zh) * | 2011-05-26 | 2014-09-10 | 兰州大学 | 手性螺环吲哚-吡喃嘧啶碱类化合物及其制备和应用 |
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| CN103554120B (zh) * | 2013-10-16 | 2015-06-24 | 华东师范大学 | 3,3-螺(2-四氢呋喃)氧化吲哚多环状化合物的制备方法 |
| CN103554121B (zh) * | 2013-10-16 | 2015-06-24 | 华东师范大学 | 3,3-螺(2-四氢呋喃)氧化吲哚多环状化合物及其应用 |
| UA121379C2 (uk) | 2013-12-13 | 2020-05-25 | Вертекс Фармасьютикалз Інкорпорейтед | Проліки піридонамідів, застосовувані як модулятори натрієвих каналів |
| JP6532474B2 (ja) * | 2014-02-06 | 2019-06-19 | アッヴィ・インコーポレイテッド | ６−ヘテロアリールオキシ−および６−アリールオキシ−キノリン−２−カルボキシアミドならびにその使用 |
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| TW201722938A (zh) | 2015-09-04 | 2017-07-01 | 魯賓有限公司 | 作為電位閘控鈉通道調節子之磺醯胺化合物 |
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| WO2018163077A1 (en) | 2017-03-08 | 2018-09-13 | Lupin Limited | Indanyl compounds as voltage gated sodium channel modulators |
| BR112019024016A2 (pt) | 2017-05-16 | 2020-06-09 | Vertex Pharma | amidas de piridona deuteradas e profármacos das mesmas como moduladores de canais de sódio |
| WO2019014352A1 (en) | 2017-07-11 | 2019-01-17 | Vertex Pharmaceuticals Incorporated | CARBOXAMIDES AS INHIBITORS OF SODIUM CHANNELS |
| TW202002971A (zh) | 2018-02-12 | 2020-01-16 | 美商維泰克斯製藥公司 | 治療疼痛的方法 |
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| US11834441B2 (en) | 2019-12-06 | 2023-12-05 | Vertex Pharmaceuticals Incorporated | Substituted tetrahydrofurans as modulators of sodium channels |
| KR20240031300A (ko) | 2021-06-04 | 2024-03-07 | 버텍스 파마슈티칼스 인코포레이티드 | 나트륨 채널 조절제로서의 n-(하이드록시알킬 (헤테로)아릴) 테트라하이드로푸란 카르복스아미드 |
| AU2022285758A1 (en) | 2021-06-04 | 2023-11-30 | Vertex Pharmaceuticals Incorporated | Substituted tetrahydrofuran analogs as modulators of sodium channels |
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| CA3221960A1 (en) | 2021-06-04 | 2022-12-08 | Vertex Pharmaceuticals Incorporated | Hydroxy and (halo)alkoxy substituted tetrahydrofurans as modulators of sodium channels |
| AU2022286438A1 (en) | 2021-06-04 | 2023-11-30 | Vertex Pharmaceuticals Incorporated | N-(hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamide analogs as modulators of sodium channels |
| WO2022256708A1 (en) | 2021-06-04 | 2022-12-08 | Vertex Pharmaceuticals Incorporated | Solid dosage forms and dosing regimens comprising (2r,3s,4s,5r)-4-[[3-(3,4-difluoro-2-methoxy-phenyl)-4,5-dimethyl-5-(trifluoromethyl) tetrahydrofuran-2-carbonyl]amino]pyridine-2-carboxamide |
| US20230373925A1 (en) | 2022-04-22 | 2023-11-23 | Vertex Pharma | Heteroaryl compounds for the treatment of pain |
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| WO2024123815A1 (en) | 2022-12-06 | 2024-06-13 | Vertex Pharmaceuticals Incorporated | Process for the synthesis of substituted tetrahydrofuran modulators of sodium channels |
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-
2007
- 2007-10-12 RU RU2009117642/15A patent/RU2009117642A/ru not_active Application Discontinuation
- 2007-10-12 BR BRPI0719210 patent/BRPI0719210A2/pt not_active IP Right Cessation
- 2007-10-12 AT AT07868434T patent/ATE545416T1/de active
- 2007-10-12 JP JP2009532606A patent/JP5460324B2/ja not_active Expired - Fee Related
- 2007-10-12 CN CN2013101646702A patent/CN103271906A/zh active Pending
- 2007-10-12 CN CN200780038111A patent/CN101631546A/zh active Pending
- 2007-10-12 AU AU2007319580A patent/AU2007319580B2/en not_active Ceased
- 2007-10-12 AR ARP070104540A patent/AR063280A1/es unknown
- 2007-10-12 EP EP07868434A patent/EP2073806B1/en not_active Not-in-force
- 2007-10-12 CL CL200702950A patent/CL2007002950A1/es unknown
- 2007-10-12 US US12/445,264 patent/US8466188B2/en active Active
- 2007-10-12 TW TW096138356A patent/TW200833695A/zh unknown
- 2007-10-12 WO PCT/US2007/081247 patent/WO2008060789A2/en active Application Filing
- 2007-10-12 CA CA002665698A patent/CA2665698A1/en not_active Abandoned
- 2007-10-12 MX MX2009003876A patent/MX2009003876A/es active IP Right Grant
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2013
- 2013-09-30 JP JP2013204440A patent/JP2013256539A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008060789A3 (en) | 2008-07-24 |
| RU2009117642A (ru) | 2010-11-20 |
| AU2007319580A1 (en) | 2008-05-22 |
| JP2010506854A (ja) | 2010-03-04 |
| MX2009003876A (es) | 2009-05-11 |
| EP2073806B1 (en) | 2012-02-15 |
| CL2007002950A1 (es) | 2008-02-01 |
| CA2665698A1 (en) | 2008-05-22 |
| EP2073806A2 (en) | 2009-07-01 |
| US20110172282A9 (en) | 2011-07-14 |
| JP2013256539A (ja) | 2013-12-26 |
| CN101631546A (zh) | 2010-01-20 |
| ATE545416T1 (de) | 2012-03-15 |
| JP5460324B2 (ja) | 2014-04-02 |
| WO2008060789A2 (en) | 2008-05-22 |
| AU2007319580B2 (en) | 2012-11-29 |
| CN103271906A (zh) | 2013-09-04 |
| US20100173967A1 (en) | 2010-07-08 |
| TW200833695A (en) | 2008-08-16 |
| AR063280A1 (es) | 2009-01-21 |
| US8466188B2 (en) | 2013-06-18 |
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