BR9812056A - Peptìdeos que contem um mimético de arginina para o tratamento de distúrbios metabólicos ósseos, sua produção, e drogas que contem esses compostos - Google Patents
Peptìdeos que contem um mimético de arginina para o tratamento de distúrbios metabólicos ósseos, sua produção, e drogas que contem esses compostosInfo
- Publication number
- BR9812056A BR9812056A BR9812056-5A BR9812056A BR9812056A BR 9812056 A BR9812056 A BR 9812056A BR 9812056 A BR9812056 A BR 9812056A BR 9812056 A BR9812056 A BR 9812056A
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- production
- alkyl
- treatment
- drugs
- Prior art date
Links
- 229940079593 drug Drugs 0.000 title abstract 4
- 239000003814 drug Substances 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 239000004475 Arginine Substances 0.000 title abstract 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 title abstract 2
- 210000000988 bone and bone Anatomy 0.000 title abstract 2
- 208000030159 metabolic disease Diseases 0.000 title abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 125000001151 peptidyl group Chemical group 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- -1 hydroxy, amino Chemical group 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Endocrinology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Rheumatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
<B><MU>PEPTìDEOS QUE CONTêM UM MIMéTICO DE ARGININA PARA O TRATAMENTO DE DISTúRBIOS METABóLICOS óSSEOS, SUA PRODUçãO, E DROGAS QUE CONTêM ESTES COMPOSTOS<MV><D> Refere-se a presente invenção a compostos da fórmula geral (I) em que R~ 1~, R~ 2~, R~ 3~ e X podem ser iguais ou diferentes, e em que R~ 1~, R~ 2~ representam hidrogênio, um aminoácido, peptidil, resíduo de alquila ou aril; R~ 3~ representa hidróxi, alcóxi inferior, ou um resíduo -NR~ 31~R~ 32~, onde R~ 31~,R~ 32~ representam independentemente hidrogênio, um aminoácido, peptidil, resíduo de alquila ou aril; X representa um aminoácido ou um peptídio; R~ 4~ representa hidrogênio, hidróxi, amino ou alquila C1-C4; m representa um número entre 0 e 5; R~ 5~ representa uma metade mono- ou bicíclica saturada ou insaturada, opcionalmente substituída, que poderá conter um ou mais heteroátomos, um grupo alquila C1-C11 que poderá ter substituições ou heteroátomos intermitentes, seus tautómeros, isómeros ópticos, sais farmaceuticamente aceitáveis e pró-drogas, bem como a sua produção e sua utilização como medicamentos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97115402A EP0902036A1 (en) | 1997-09-05 | 1997-09-05 | Peptide containing an arginine mimetic for the treatment of osteoporosis, their production, and drugs containing these compounds |
| PCT/EP1998/005547 WO1999012970A1 (en) | 1997-09-05 | 1998-09-02 | Peptides containing an arginine mimetic for the treatment of bone metabolic disorders, their production, and drugs containing these compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9812056A true BR9812056A (pt) | 2000-09-26 |
Family
ID=8227319
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9812056-5A BR9812056A (pt) | 1997-09-05 | 1998-09-02 | Peptìdeos que contem um mimético de arginina para o tratamento de distúrbios metabólicos ósseos, sua produção, e drogas que contem esses compostos |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6429288B1 (pt) |
| EP (2) | EP0902036A1 (pt) |
| JP (1) | JP2001515919A (pt) |
| KR (1) | KR20010023656A (pt) |
| CN (1) | CN1269806A (pt) |
| AR (1) | AR013462A1 (pt) |
| AU (1) | AU9439398A (pt) |
| BR (1) | BR9812056A (pt) |
| CA (1) | CA2301969A1 (pt) |
| TR (1) | TR200000598T2 (pt) |
| WO (1) | WO1999012970A1 (pt) |
| ZA (1) | ZA988095B (pt) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR0115079A (pt) * | 2000-10-30 | 2003-08-19 | Warner Lambert Co | Ligandos do receptor de serotonina à base de amidino-uréia e composições destes, seus usos farmacêuticos e métodos para a suas sìnteses |
| US6946562B2 (en) * | 2001-12-12 | 2005-09-20 | Eastman Kodak Company | Synthesis of peptoid substituted azole compounds |
| US8775112B2 (en) | 2003-09-15 | 2014-07-08 | Nvidia Corporation | System and method for increasing die yield |
| US8732644B1 (en) | 2003-09-15 | 2014-05-20 | Nvidia Corporation | Micro electro mechanical switch system and method for testing and configuring semiconductor functional circuits |
| US8775997B2 (en) | 2003-09-15 | 2014-07-08 | Nvidia Corporation | System and method for testing and configuring semiconductor functional circuits |
| US8711161B1 (en) | 2003-12-18 | 2014-04-29 | Nvidia Corporation | Functional component compensation reconfiguration system and method |
| US8723231B1 (en) | 2004-09-15 | 2014-05-13 | Nvidia Corporation | Semiconductor die micro electro-mechanical switch management system and method |
| US8711156B1 (en) | 2004-09-30 | 2014-04-29 | Nvidia Corporation | Method and system for remapping processing elements in a pipeline of a graphics processing unit |
| US8021193B1 (en) * | 2005-04-25 | 2011-09-20 | Nvidia Corporation | Controlled impedance display adapter |
| US7793029B1 (en) | 2005-05-17 | 2010-09-07 | Nvidia Corporation | Translation device apparatus for configuring printed circuit board connectors |
| US8417838B2 (en) * | 2005-12-12 | 2013-04-09 | Nvidia Corporation | System and method for configurable digital communication |
| US8412872B1 (en) | 2005-12-12 | 2013-04-02 | Nvidia Corporation | Configurable GPU and method for graphics processing using a configurable GPU |
| US8724483B2 (en) | 2007-10-22 | 2014-05-13 | Nvidia Corporation | Loopback configuration for bi-directional interfaces |
| US8687639B2 (en) * | 2009-06-04 | 2014-04-01 | Nvidia Corporation | Method and system for ordering posted packets and non-posted packets transfer |
| US9176909B2 (en) | 2009-12-11 | 2015-11-03 | Nvidia Corporation | Aggregating unoccupied PCI-e links to provide greater bandwidth |
| US9331869B2 (en) * | 2010-03-04 | 2016-05-03 | Nvidia Corporation | Input/output request packet handling techniques by a device specific kernel mode driver |
| US9330031B2 (en) | 2011-12-09 | 2016-05-03 | Nvidia Corporation | System and method for calibration of serial links using a serial-to-parallel loopback |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5645591A (en) | 1990-05-29 | 1997-07-08 | Stryker Corporation | Synthetic bone matrix |
| HUT64565A (en) * | 1990-12-13 | 1994-01-28 | Genentech Inc | Method for producing compounds and preparatives inhibiting resorption of bones |
| JP3351525B2 (ja) | 1991-06-21 | 2002-11-25 | ジェネティックス・インスティテュート・インコーポレイテッド | 骨形成性蛋白医薬処方物 |
| WO1993020859A1 (en) | 1992-04-20 | 1993-10-28 | Board Of Regents Of The University Of Washington | Sustained release compositions for delivery of growth factors |
| CA2093836A1 (en) | 1992-04-24 | 1993-10-25 | Wayne Gombotz | Biodegradable tgf-.beta. delivery system for bone regeneration |
| NO940913L (no) | 1993-03-26 | 1994-09-27 | Bristol Myers Squibb Co | Preparater for kontrollert frigivelse av biologisk aktiv TGF- |
| WO1994024153A1 (en) | 1993-04-08 | 1994-10-27 | Ciba-Geigy Ag | Cyclic compounds and compositions which inhibit bone resorption |
| JP2000502078A (ja) * | 1995-12-09 | 2000-02-22 | ベーリンガー マンハイム ゲゼルシャフト ミット ベシュレンクテル ハフツング | 擬似アルギニン特性を有する３―アミノエチル―ｎ―アミジノ―２，５―ジヒドロピロール誘導体 |
-
1997
- 1997-09-05 EP EP97115402A patent/EP0902036A1/en not_active Withdrawn
-
1998
- 1998-09-02 JP JP2000510775A patent/JP2001515919A/ja active Pending
- 1998-09-02 CN CN98808822A patent/CN1269806A/zh active Pending
- 1998-09-02 CA CA002301969A patent/CA2301969A1/en not_active Abandoned
- 1998-09-02 TR TR2000/00598T patent/TR200000598T2/xx unknown
- 1998-09-02 US US09/486,679 patent/US6429288B1/en not_active Expired - Fee Related
- 1998-09-02 BR BR9812056-5A patent/BR9812056A/pt not_active IP Right Cessation
- 1998-09-02 WO PCT/EP1998/005547 patent/WO1999012970A1/en not_active Application Discontinuation
- 1998-09-02 KR KR1020007002308A patent/KR20010023656A/ko not_active Application Discontinuation
- 1998-09-02 EP EP98947498A patent/EP1009770A1/en not_active Withdrawn
- 1998-09-02 AU AU94393/98A patent/AU9439398A/en not_active Abandoned
- 1998-09-03 AR ARP980104401A patent/AR013462A1/es unknown
- 1998-09-04 ZA ZA9808095A patent/ZA988095B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU9439398A (en) | 1999-03-29 |
| CA2301969A1 (en) | 1999-03-18 |
| EP1009770A1 (en) | 2000-06-21 |
| JP2001515919A (ja) | 2001-09-25 |
| AR013462A1 (es) | 2000-12-27 |
| CN1269806A (zh) | 2000-10-11 |
| ZA988095B (en) | 2000-03-22 |
| TR200000598T2 (tr) | 2000-07-21 |
| US6429288B1 (en) | 2002-08-06 |
| KR20010023656A (ko) | 2001-03-26 |
| WO1999012970A1 (en) | 1999-03-18 |
| EP0902036A1 (en) | 1999-03-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application fees: application dismissed [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A,7A,8A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1876 DE 19/12/2006. |