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BR112012012947B8 - sal de hemitartarato e composição farmacêutica compreendendo o mesmo - Google Patents

sal de hemitartarato e composição farmacêutica compreendendo o mesmo

Info

Publication number
BR112012012947B8
BR112012012947B8 BR112012012947A BR112012012947A BR112012012947B8 BR 112012012947 B8 BR112012012947 B8 BR 112012012947B8 BR 112012012947 A BR112012012947 A BR 112012012947A BR 112012012947 A BR112012012947 A BR 112012012947A BR 112012012947 B8 BR112012012947 B8 BR 112012012947B8
Authority
BR
Brazil
Prior art keywords
hemitartrate
formula
salt
same
pharmaceutical composition
Prior art date
Application number
BR112012012947A
Other languages
English (en)
Other versions
BR112012012947B1 (pt
BR112012012947A2 (pt
Inventor
Harianawala Abizer
Willis Chris
Siegel Craig
P Copeland Diane
Palace Gerard
Liu Hanlan
Skell Jeffrey
Kochling Jianmei
Marshall John
Peterschmitt Judith
Bhardwaj Renu
Cheng Seng
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43431870&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112012012947(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genzyme Corp filed Critical Genzyme Corp
Publication of BR112012012947A2 publication Critical patent/BR112012012947A2/pt
Publication of BR112012012947B1 publication Critical patent/BR112012012947B1/pt
Publication of BR112012012947B8 publication Critical patent/BR112012012947B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

sal de hermitatarato, usos dos mesmos e composições farmacêuticas que oo compreendem. a presente invenção refere-se ao sal de hemitartara to de um composto representado por meio da seguinte fórmula estrutural: (hemitartarato de fórmula i), que pode ser utilizado em aplicações farmacêuticas. as formas cristalinas individuais particulares de hemitartarato de fórmula (i) são caracterizadas por meio de uma variedade de propriedades e medições físicas. , bem como, métodos de produção de hermitartarato de fórmula (i) cristalinos, e são usados para inibir a glicosilceramida sintase ou diminuir as concentrações glicoesfingolipídeos em indivíduos para o tratamento de um número de doenças. as composições farmacêuticas são também descritas.
BR112012012947A 2009-11-27 2010-11-24 sal de hemitartarato e composição farmacêutica compreendendo o mesmo BR112012012947B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26474809P 2009-11-27 2009-11-27
US61/264,748 2009-11-27
PCT/US2010/057952 WO2011066352A1 (en) 2009-11-27 2010-11-24 An amorphous and a crystalline form of genz 112638 hemitartrat as inhibitor of glucosylceramide synthase

Publications (3)

Publication Number Publication Date
BR112012012947A2 BR112012012947A2 (pt) 2017-03-01
BR112012012947B1 BR112012012947B1 (pt) 2021-04-06
BR112012012947B8 true BR112012012947B8 (pt) 2021-05-25

Family

ID=43431870

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012012947A BR112012012947B8 (pt) 2009-11-27 2010-11-24 sal de hemitartarato e composição farmacêutica compreendendo o mesmo

Country Status (41)

Country Link
US (6) US11458119B2 (pt)
EP (5) EP2796457B1 (pt)
JP (6) JP2013512252A (pt)
KR (5) KR20200013105A (pt)
CN (5) CN105753846B (pt)
AR (3) AR079152A1 (pt)
AU (3) AU2010324810B2 (pt)
BR (1) BR112012012947B8 (pt)
CA (3) CA3140959A1 (pt)
CL (2) CL2012001348A1 (pt)
CR (1) CR20120277A (pt)
CY (3) CY1115880T1 (pt)
DK (3) DK3133070T3 (pt)
DO (2) DOP2012000141A (pt)
EA (3) EA201890254A3 (pt)
EC (2) ECSP12011926A (pt)
ES (4) ES2586947T3 (pt)
GT (1) GT201200161A (pt)
HK (2) HK1203485A1 (pt)
HR (3) HRP20140780T4 (pt)
HU (2) HUE045784T2 (pt)
IL (4) IL310635A (pt)
LT (2) LT3133070T (pt)
MA (1) MA33838B1 (pt)
ME (1) ME02477B (pt)
MX (1) MX358345B (pt)
MY (2) MY160542A (pt)
NI (1) NI201200096A (pt)
NZ (3) NZ600155A (pt)
PE (2) PE20171255A1 (pt)
PH (1) PH12015502514A1 (pt)
PL (4) PL2796457T3 (pt)
PT (4) PT3599237T (pt)
RS (3) RS54978B1 (pt)
SG (2) SG10201800136QA (pt)
SI (3) SI2504332T2 (pt)
SM (1) SMT201600273B (pt)
TN (1) TN2012000237A1 (pt)
TW (3) TWI656873B (pt)
UA (1) UA113491C2 (pt)
WO (1) WO2011066352A1 (pt)

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