BR112012011740A2 - polipeptídeo, composição compreendendo o referido polipeptídeo, complexo de proteína, seqüência de nucleotídeo, vetor de expressão célula, e métodos para a preparação do complexo de proteína, para a preparação de um fviii, e para intensificar uma propriedade farmacocinética no plasma de um fviii - Google Patents
polipeptídeo, composição compreendendo o referido polipeptídeo, complexo de proteína, seqüência de nucleotídeo, vetor de expressão célula, e métodos para a preparação do complexo de proteína, para a preparação de um fviii, e para intensificar uma propriedade farmacocinética no plasma de um fviiiInfo
- Publication number
- BR112012011740A2 BR112012011740A2 BR112012011740A BR112012011740A BR112012011740A2 BR 112012011740 A2 BR112012011740 A2 BR 112012011740A2 BR 112012011740 A BR112012011740 A BR 112012011740A BR 112012011740 A BR112012011740 A BR 112012011740A BR 112012011740 A2 BR112012011740 A2 BR 112012011740A2
- Authority
- BR
- Brazil
- Prior art keywords
- fviii
- polypeptide
- preparing
- protein complex
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
polipeptídeo, composição compreendendo o referido polipeptídeo, complexo de proteína, seqüência de nucleotídeo, vetor de expressão célula, e métodos para a preparação do complexo de proteína, para a preparação de um fviii, e para intensificar uma propriedade farmacocinética no plasma de um fviii. a presente invenção refere-se aos métodos, composições e kits para a preparação de fviii e o seu emprego. também são fornecidos polipeptídeos de vwf e moléculas de ácido nucleico que os codificam.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26114509P | 2009-11-13 | 2009-11-13 | |
| PCT/US2010/056496 WO2011060242A2 (en) | 2009-11-13 | 2010-11-12 | Von willebrand factor (vwf)-containing preparations, and methods, kits, and uses related thereto |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112012011740A2 true BR112012011740A2 (pt) | 2018-03-27 |
Family
ID=43992414
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112012011740A BR112012011740A2 (pt) | 2009-11-13 | 2010-11-12 | polipeptídeo, composição compreendendo o referido polipeptídeo, complexo de proteína, seqüência de nucleotídeo, vetor de expressão célula, e métodos para a preparação do complexo de proteína, para a preparação de um fviii, e para intensificar uma propriedade farmacocinética no plasma de um fviii |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8759293B2 (pt) |
| EP (1) | EP2499165B1 (pt) |
| JP (1) | JP5876416B2 (pt) |
| KR (1) | KR101808751B1 (pt) |
| CN (1) | CN102648212B (pt) |
| AU (1) | AU2010319425B2 (pt) |
| BR (1) | BR112012011740A2 (pt) |
| CA (1) | CA2780542C (pt) |
| CL (1) | CL2012001258A1 (pt) |
| ES (1) | ES2600879T3 (pt) |
| HK (1) | HK1170244A1 (pt) |
| HU (1) | HUE029454T2 (pt) |
| IL (1) | IL219679A (pt) |
| MX (1) | MX2012005527A (pt) |
| NZ (1) | NZ600278A (pt) |
| PL (1) | PL2499165T3 (pt) |
| PT (1) | PT2499165T (pt) |
| RU (1) | RU2579977C2 (pt) |
| WO (1) | WO2011060242A2 (pt) |
| ZA (1) | ZA201203795B (pt) |
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| ES2587742T3 (es) | 2007-12-27 | 2016-10-26 | Baxalta GmbH | Métodos para diferenciar en una muestra proteína derivada de plasma de proteína recombinante |
| TW201731488A (zh) | 2007-12-28 | 2017-09-16 | 巴克斯歐塔公司 | 重組ｖｗｆ調配物 |
| JP5832285B2 (ja) * | 2008-06-24 | 2015-12-16 | ツェー・エス・エル・ベーリング・ゲー・エム・ベー・ハー | 延長されたインビボ半減期を有する第ｖｉｉｉ因子、フォン・ヴィレブランド因子又はそれらの複合体 |
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| US20110086362A1 (en) | 2009-10-09 | 2011-04-14 | Massachusetts Institute Of Technology | High-Throughput Method for Quantifying Sialylation of Glycoproteins |
| PL2499165T3 (pl) | 2009-11-13 | 2017-04-28 | Grifols Therapeutics Inc. | Preparaty zawierające czynnik von willenbranda (vwf) oraz sposoby, zestawy i zastosowania z nim powiązane |
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2010
- 2010-11-12 PL PL10830777T patent/PL2499165T3/pl unknown
- 2010-11-12 MX MX2012005527A patent/MX2012005527A/es active IP Right Grant
- 2010-11-12 US US13/509,309 patent/US8759293B2/en active Active
- 2010-11-12 AU AU2010319425A patent/AU2010319425B2/en active Active
- 2010-11-12 EP EP10830777.8A patent/EP2499165B1/en active Active
- 2010-11-12 CA CA2780542A patent/CA2780542C/en active Active
- 2010-11-12 HU HUE10830777A patent/HUE029454T2/en unknown
- 2010-11-12 CN CN201080051549.3A patent/CN102648212B/zh active Active
- 2010-11-12 ES ES10830777.8T patent/ES2600879T3/es active Active
- 2010-11-12 RU RU2012122402/10A patent/RU2579977C2/ru not_active IP Right Cessation
- 2010-11-12 NZ NZ600278A patent/NZ600278A/en not_active IP Right Cessation
- 2010-11-12 PT PT108307778T patent/PT2499165T/pt unknown
- 2010-11-12 BR BR112012011740A patent/BR112012011740A2/pt not_active Application Discontinuation
- 2010-11-12 JP JP2012539007A patent/JP5876416B2/ja active Active
- 2010-11-12 KR KR1020127013906A patent/KR101808751B1/ko active IP Right Grant
- 2010-11-12 WO PCT/US2010/056496 patent/WO2011060242A2/en active Application Filing
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2012
- 2012-05-09 IL IL219679A patent/IL219679A/en not_active IP Right Cessation
- 2012-05-14 CL CL2012001258A patent/CL2012001258A1/es unknown
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Also Published As
| Publication number | Publication date |
|---|---|
| CN102648212A (zh) | 2012-08-22 |
| IL219679A0 (en) | 2012-07-31 |
| AU2010319425B2 (en) | 2015-07-02 |
| WO2011060242A2 (en) | 2011-05-19 |
| PL2499165T3 (pl) | 2017-04-28 |
| AU2010319425A1 (en) | 2012-06-14 |
| CA2780542C (en) | 2020-03-24 |
| CN102648212B (zh) | 2014-12-03 |
| PT2499165T (pt) | 2016-10-28 |
| RU2579977C2 (ru) | 2016-04-10 |
| US20120289468A1 (en) | 2012-11-15 |
| US8759293B2 (en) | 2014-06-24 |
| WO2011060242A3 (en) | 2011-10-13 |
| KR20120113214A (ko) | 2012-10-12 |
| EP2499165B1 (en) | 2016-09-14 |
| HUE029454T2 (en) | 2017-03-28 |
| KR101808751B1 (ko) | 2017-12-13 |
| ES2600879T3 (es) | 2017-02-13 |
| NZ600278A (en) | 2014-04-30 |
| EP2499165A4 (en) | 2013-09-11 |
| ZA201203795B (en) | 2014-10-29 |
| HK1170244A1 (zh) | 2013-02-22 |
| MX2012005527A (es) | 2012-08-08 |
| CA2780542A1 (en) | 2011-05-19 |
| IL219679A (en) | 2016-11-30 |
| EP2499165A2 (en) | 2012-09-19 |
| RU2012122402A (ru) | 2013-12-20 |
| CL2012001258A1 (es) | 2012-09-14 |
| JP5876416B2 (ja) | 2016-03-02 |
| JP2013510581A (ja) | 2013-03-28 |
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