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BR0213583A - Processo para preparar um composto de insulina, e, composto de insulina - Google Patents

Processo para preparar um composto de insulina, e, composto de insulina

Info

Publication number
BR0213583A
BR0213583A BR0213583-3A BR0213583A BR0213583A BR 0213583 A BR0213583 A BR 0213583A BR 0213583 A BR0213583 A BR 0213583A BR 0213583 A BR0213583 A BR 0213583A
Authority
BR
Brazil
Prior art keywords
insulin compound
insulin
preparing
compound
ester
Prior art date
Application number
BR0213583-3A
Other languages
English (en)
Inventor
Are Bogsnes
Ingun Christiansen
Per Balschmidt
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of BR0213583A publication Critical patent/BR0213583A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Wood Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Obesity (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Emergency Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

"PROCESSO PARA PREPARAR UM COMPOSTO DE INSULINA, E, COMPOSTO DE INSULINA". Um caminho preferido de converter precursores de insulina em compostos de insulina é realizar uma clivagem de peptídeo enzimática em um meio aquoso e, depois disso, sem remoção do produto intermediário formado, adicionar um éster de aminoácido ou um éster de peptídeo e um solvente orgânico para que a ligação desejada ocorra.
BR0213583-3A 2001-11-19 2002-11-15 Processo para preparar um composto de insulina, e, composto de insulina BR0213583A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200101716 2001-11-19
PCT/DK2002/000765 WO2003044210A2 (en) 2001-11-19 2002-11-15 Process for preparing insulin compounds

Publications (1)

Publication Number Publication Date
BR0213583A true BR0213583A (pt) 2004-08-24

Family

ID=8160841

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0213583-3A BR0213583A (pt) 2001-11-19 2002-11-15 Processo para preparar um composto de insulina, e, composto de insulina

Country Status (15)

Country Link
EP (1) EP1448786B1 (pt)
JP (1) JP4404631B2 (pt)
KR (1) KR100925381B1 (pt)
CN (1) CN100424179C (pt)
AT (1) ATE464390T1 (pt)
AU (1) AU2002342597A1 (pt)
BR (1) BR0213583A (pt)
CA (1) CA2464616C (pt)
DE (1) DE60236014D1 (pt)
ES (1) ES2344448T3 (pt)
HU (1) HU228934B1 (pt)
IL (2) IL161358A0 (pt)
PL (1) PL210437B1 (pt)
RU (1) RU2376379C2 (pt)
WO (1) WO2003044210A2 (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006031955A1 (de) 2006-07-11 2008-01-17 Sanofi-Aventis Deutschland Gmbh Verfahren zur Herstellung von Insulinanaloga mit dibasischem B-Kettenende
DE102006031962A1 (de) 2006-07-11 2008-01-17 Sanofi-Aventis Deutschland Gmbh Amidiertes Insulin Glargin
TW200902708A (en) * 2007-04-23 2009-01-16 Wyeth Corp Methods of protein production using anti-senescence compounds
PT2349324T (pt) 2008-10-17 2017-12-06 Sanofi Aventis Deutschland Combinação de uma insulina e de um agonista do glp-1
ES2625125T3 (es) * 2009-08-11 2017-07-18 Biocon Limited Procesos cromatográficos
EP3417871B1 (de) 2009-11-13 2020-12-23 Sanofi-Aventis Deutschland GmbH Pharmazeutische zusammensetzung umfassend einen glp-1-agonisten, ein insulin und methionin
EP2498801B1 (de) 2009-11-13 2018-01-24 Sanofi-Aventis Deutschland GmbH HARMAZEUTISCHE ZUSAMMENSETZUNG UMFASSEND desPro36Exendin-4(1-39)-Lys6-NH2 UND METHIONIN
CA2809321C (en) 2010-08-30 2018-08-14 Sanofi-Aventis Deutschland Gmbh Use of ave0010 for the manufacture of a medicament for the treatment of diabetes mellitus type 2
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
AU2012300978B2 (en) 2011-08-29 2017-04-27 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for use in glycemic control in diabetes type 2 patients
AR087744A1 (es) 2011-09-01 2014-04-16 Sanofi Aventis Deutschland Composicion farmaceutica para uso en el tratamiento de una enfermedad neurodegenerativa
CN102703552B (zh) * 2012-05-15 2014-10-29 山东阿华生物药业有限公司 重组人胰岛素的制备方法及其产品
CN102816819B (zh) * 2012-08-13 2014-10-29 山东阿华生物药业有限公司 提高人胰岛素前体融合蛋白酶切转换成b30缺苏氨酸人胰岛素产率的方法
CN103305581B (zh) * 2013-07-04 2015-05-27 珠海联邦制药股份有限公司 一种重组人胰岛素的制备方法
WO2015097643A1 (en) 2013-12-23 2015-07-02 Biocon Research Limited Method of production of human insulin methyl ester
LT3229828T (lt) 2014-12-12 2023-06-12 Sanofi-Aventis Deutschland Gmbh Insulino glargino/liksisenatido fiksuoto santykio kompozicija
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療
EP3341405A4 (en) * 2015-09-24 2019-05-01 Hanmi Pharm. Co., Ltd. PROCESS FOR INSULIN PRODUCTION

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE50892B1 (en) 1980-02-11 1986-08-06 Novo Industri As Process for preparing insulin esters
AU550062B2 (en) 1981-08-10 1986-02-27 Nordisk Insulinlaboratorium A process for the preparation of an insulin derivative
JPS58501455A (ja) 1981-09-15 1983-09-01 ノルデイスク　インシユリンラボラトリユ−ム 人インシユリンまたはそのｂ−３０エステルの製造法
DK149824C (da) 1982-01-22 1987-03-16 Carlsberg Biotechnology Ltd Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyrer i insuliner
WO1983002772A1 (en) 1982-02-08 1983-08-18 Robin Ewart Offord An improved method for preparing human insulin from non-human insulin
DK347086D0 (da) 1986-07-21 1986-07-21 Novo Industri As Novel peptides
PH25772A (en) 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
ZA877505B (en) 1986-10-14 1989-05-30 Lilly Co Eli Process for transforming a human insulin precursor to human insulin
PT86819B (pt) 1987-02-25 1992-05-29 Novo Industri As Processo para a preparacao de novos derivados da insulina e de composicoes farmaceuticas que os contem
EP1132404A3 (en) 1993-09-17 2002-03-27 Novo Nordisk A/S Acylated insulin
US6011007A (en) 1993-09-17 2000-01-04 Novo Nordisk A/S Acylated insulin
ATE397017T1 (de) 1999-12-29 2008-06-15 Novo Nordisk As Verfahren zur herstellung von insulinvorläufern und von analogen von insulinvorläufern
AU1995701A (en) 1999-12-29 2001-07-16 Novo Nordisk A/S Method for making insulin precursors and insulin precursor analogues having improved fermentation yield in yeast
WO2001079250A1 (en) 2000-04-14 2001-10-25 University Of Maryland Biotechnology Institute Enhanced protein thermostability and temperature resistance
WO2002079254A1 (en) 2001-03-29 2002-10-10 Janoff Edward N Human monoclonal antibodies against capsular polysaccharides of streptococcus pneumoniae

Also Published As

Publication number Publication date
WO2003044210A2 (en) 2003-05-30
CA2464616C (en) 2012-07-24
RU2004118503A (ru) 2005-06-10
KR100925381B1 (ko) 2009-11-09
HUP0500037A2 (hu) 2005-03-29
JP2005509687A (ja) 2005-04-14
CN1589328A (zh) 2005-03-02
IL161358A (en) 2011-05-31
EP1448786A2 (en) 2004-08-25
EP1448786B1 (en) 2010-04-14
WO2003044210A3 (en) 2004-03-25
CN100424179C (zh) 2008-10-08
JP4404631B2 (ja) 2010-01-27
HU228934B1 (hu) 2013-06-28
IL161358A0 (en) 2004-09-27
DE60236014D1 (de) 2010-05-27
PL369447A1 (en) 2005-04-18
KR20050044855A (ko) 2005-05-13
AU2002342597A8 (en) 2003-06-10
CA2464616A1 (en) 2003-05-30
RU2376379C2 (ru) 2009-12-20
ES2344448T3 (es) 2010-08-27
HUP0500037A3 (en) 2010-01-28
ATE464390T1 (de) 2010-04-15
AU2002342597A1 (en) 2003-06-10
PL210437B1 (pl) 2012-01-31

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: A CLASSIFICACAO ANTERIOR ERA: C12P 21/02

Ipc: C12P 21/02 (2006.01), C07K 14/62 (2006.01), A61K 3

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]
B10A Cessation: cessation confirmed

Free format text: HOMOLOGADA A DESISTENCIA DO PEDIDO SOLICITADA ATRAVES DA PETICAO NO 870180149807 DE 09/11/2018.