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AR037493A1 - Proceso para la preparacion de hidrobromuro de citalopram - Google Patents

Proceso para la preparacion de hidrobromuro de citalopram

Info

Publication number
AR037493A1
AR037493A1 ARP020102723A ARP020102723A AR037493A1 AR 037493 A1 AR037493 A1 AR 037493A1 AR P020102723 A ARP020102723 A AR P020102723A AR P020102723 A ARP020102723 A AR P020102723A AR 037493 A1 AR037493 A1 AR 037493A1
Authority
AR
Argentina
Prior art keywords
citalopram
preparation
hydrobromide
citalopram hydrobromide
formula
Prior art date
Application number
ARP020102723A
Other languages
English (en)
Inventor
Swargam Sathyanarayana
Velayudhan Nair Gopa Kumar
Tarun Kant Sharma
Sujay Biswas
Bakthavathsalan Vijayaraghavan
Original Assignee
Ranbaxy Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ranbaxy Lab Ltd filed Critical Ranbaxy Lab Ltd
Publication of AR037493A1 publication Critical patent/AR037493A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)

Abstract

Proceso industrialmente ventajoso para la preparación de hidrobromuro de citalopram puro de fórmula 1, el cual comprende: i) convertir el citalopram crudo en el correspondiente carbamoilftalano-5 de la fórmula 2, y ii) hacerlo reaccionar con un agente deshidratante para obtener el citalopram que se convierte en su sal de hidrobromuro. El hidrobromuro de citalopram puede contener menos de 0,2% de citalopram desciano
ARP020102723A 2001-07-19 2002-07-19 Proceso para la preparacion de hidrobromuro de citalopram AR037493A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN779DE2001 IN192057B (es) 2001-07-19 2001-07-19

Publications (1)

Publication Number Publication Date
AR037493A1 true AR037493A1 (es) 2004-11-17

Family

ID=11097086

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP020102723A AR037493A1 (es) 2001-07-19 2002-07-19 Proceso para la preparacion de hidrobromuro de citalopram

Country Status (7)

Country Link
US (1) US20040254385A1 (es)
EP (1) EP1412340A4 (es)
AR (1) AR037493A1 (es)
AU (1) AU2002317420A1 (es)
CA (1) CA2454335A1 (es)
IN (1) IN192057B (es)
WO (1) WO2003007872A2 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5095615B2 (ja) 2005-06-27 2012-12-12 バリアント・インターナショナル・（バルバドス）・ソサイアティーズ・ウィズ・リストリクティッド・ライアビリティ ブプロピオン塩の放出調整製剤
BRPI0814556A2 (pt) * 2007-07-10 2015-01-06 Thomson Licensing Método para determinar automaticamente um grupo de pares localizados próximo a outro par em uma rede de comunicação e servidor associado, dispositivo de análise e dispositivo de comunicação
PE20091156A1 (es) * 2007-12-17 2009-09-03 Astrazeneca Ab Sales de (3-{[[3-(6-amino-2-butoxi-8-oxo-7,8-dihidro-9h-purin-9-il)propil](3-morfolin-4-ilpropil)amino]metil}fenil)acetato de metilo
ES2569984T3 (es) 2010-07-23 2016-05-13 H. Lundbeck A/S Procedimiento para la purificación de sales farmacéuticamente aceptables de escitalopram
CN103936702A (zh) * 2014-05-07 2014-07-23 成都诺维尔生物医药有限公司 艾司西酞普兰杂质j的合成方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
EA001728B1 (ru) * 1997-07-08 2001-08-27 Х.Лундбекк А/С Способ получения циталопрама
AR032455A1 (es) * 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva

Also Published As

Publication number Publication date
IN192057B (es) 2004-02-14
EP1412340A4 (en) 2004-12-01
WO2003007872A2 (en) 2003-01-30
EP1412340A2 (en) 2004-04-28
CA2454335A1 (en) 2003-01-30
US20040254385A1 (en) 2004-12-16
AU2002317420A1 (en) 2003-03-03
WO2003007872A3 (en) 2003-10-23

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal