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DK149824C - Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyrer i insuliner - Google Patents

Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyrer i insuliner

Info

Publication number
DK149824C
DK149824C DK27782A DK27782A DK149824C DK 149824 C DK149824 C DK 149824C DK 27782 A DK27782 A DK 27782A DK 27782 A DK27782 A DK 27782A DK 149824 C DK149824 C DK 149824C
Authority
DK
Denmark
Prior art keywords
amino acid
ins
group
insulin
formula
Prior art date
Application number
DK27782A
Other languages
English (en)
Other versions
DK149824B (da
DK27782A (da
Inventor
Klaus Breddam
Jack Taaning Johansen
Original Assignee
Carlsberg Biotechnology Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Carlsberg Biotechnology Ltd filed Critical Carlsberg Biotechnology Ltd
Priority to DK27782A priority Critical patent/DK149824C/da
Priority to US06/458,847 priority patent/US4579820A/en
Priority to AU10608/83A priority patent/AU549272B2/en
Priority to ES519127A priority patent/ES8402875A1/es
Priority to DE8383300309T priority patent/DE3363449D1/de
Priority to CA000420025A priority patent/CA1195940A/en
Priority to AT83300309T priority patent/ATE19790T1/de
Priority to EP83300309A priority patent/EP0085516B1/en
Publication of DK27782A publication Critical patent/DK27782A/da
Publication of DK149824B publication Critical patent/DK149824B/da
Application granted granted Critical
Publication of DK149824C publication Critical patent/DK149824C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/63—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from plants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Botany (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK27782A 1982-01-22 1982-01-22 Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyrer i insuliner DK149824C (da)

Priority Applications (8)

Application Number Priority Date Filing Date Title
DK27782A DK149824C (da) 1982-01-22 1982-01-22 Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyrer i insuliner
US06/458,847 US4579820A (en) 1982-01-22 1983-01-18 Process for enzymatic replacement of the B-30 amino acid in insulins
AU10608/83A AU549272B2 (en) 1982-01-22 1983-01-19 Insulin b30 amino acid interchange using carboxypeptidase
ES519127A ES8402875A1 (es) 1982-01-22 1983-01-20 Procedimiento para la substitucion enzimatica de insulinas.
DE8383300309T DE3363449D1 (en) 1982-01-22 1983-01-21 A process for enzymatic replacement of the b-30 amino acid in insulins
CA000420025A CA1195940A (en) 1982-01-22 1983-01-21 Process for enzymatic replacement of the b-30 amino acid in insulins
AT83300309T ATE19790T1 (de) 1982-01-22 1983-01-21 Verfahren zum enzymatischen ersetzen von b-30 aminosaeuren in insulinen.
EP83300309A EP0085516B1 (en) 1982-01-22 1983-01-21 A process for enzymatic replacement of the b-30 amino acid in insulins

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK27782A DK149824C (da) 1982-01-22 1982-01-22 Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyrer i insuliner
DK27782 1982-01-22

Publications (3)

Publication Number Publication Date
DK27782A DK27782A (da) 1983-07-23
DK149824B DK149824B (da) 1986-10-06
DK149824C true DK149824C (da) 1987-03-16

Family

ID=8091736

Family Applications (1)

Application Number Title Priority Date Filing Date
DK27782A DK149824C (da) 1982-01-22 1982-01-22 Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyrer i insuliner

Country Status (8)

Country Link
US (1) US4579820A (da)
EP (1) EP0085516B1 (da)
AT (1) ATE19790T1 (da)
AU (1) AU549272B2 (da)
CA (1) CA1195940A (da)
DE (1) DE3363449D1 (da)
DK (1) DK149824C (da)
ES (1) ES8402875A1 (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3333640A1 (de) * 1983-09-17 1985-04-25 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von insulin-derivaten, deren b-kette c-terminal verlaengert ist, neue basisch modifizierte insulin-derivate diese enthaltende mittel und ihre verwendung
ZA877505B (en) * 1986-10-14 1989-05-30 Lilly Co Eli Process for transforming a human insulin precursor to human insulin
BR8803346A (pt) * 1988-06-30 1990-02-13 Biobras Bioquimica Do Brasil S Processo aperfeicoado para producao em larga escala de cristais de insulina purificada
US5234820A (en) * 1989-06-30 1993-08-10 Board Of Regents Of The University Of Nebraska Exopeptidase catalyzed site-specific bonding of supports, labels and bioactive agents to proteins
US5279954A (en) * 1989-06-30 1994-01-18 Board Of Regents Of The University Of Nebraska And Bionebraska Exopeptidase catalyzed site-specific bonding of supports, labels and bioactive agents to proteins
US6187579B1 (en) 1993-10-28 2001-02-13 Carlsberg A/S Customized proteases
US5985627A (en) * 1997-02-28 1999-11-16 Carlsberg Laboratory Modified carboxypeptidase
BR0213583A (pt) 2001-11-19 2004-08-24 Novo Nordisk As Processo para preparar um composto de insulina, e, composto de insulina
US7396903B2 (en) * 2001-11-19 2008-07-08 Novo Nordisk A/S Process for preparing insulin compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3276961A (en) * 1963-04-08 1966-10-04 Squibb & Sons Inc Process for preparing human insulin
US4086136A (en) * 1975-10-23 1978-04-25 (Zaidanhojin) Sagami Chemical Research Center Process for producing a peptide using a serine or thiol proteinase
JPS6339237B2 (da) * 1979-04-06 1988-08-04 Karuruberugu Baiotekunorojii Ltd As
EP0017938B1 (en) * 1979-04-13 1983-08-03 Shionogi & Co., Ltd. Process for preparing a b30-threonine insulin
DK147437A (en) * 1980-02-11 1900-01-01 Process for preparing human insulin or threonine B30 esters of human insulin, or a salt or complex thereof

Also Published As

Publication number Publication date
CA1195940A (en) 1985-10-29
EP0085516B1 (en) 1986-05-14
DE3363449D1 (en) 1986-06-19
EP0085516A3 (en) 1983-09-07
ES519127A0 (es) 1984-03-16
ES8402875A1 (es) 1984-03-16
AU549272B2 (en) 1986-01-23
DK149824B (da) 1986-10-06
DK27782A (da) 1983-07-23
EP0085516A2 (en) 1983-08-10
ATE19790T1 (de) 1986-05-15
AU1060883A (en) 1983-07-28
US4579820A (en) 1986-04-01

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