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BG94837A - О-метилни производни на азитромицин а, метод за тяхното получаване и приложението им като фармацевтични препарати - Google Patents

О-метилни производни на азитромицин а, метод за тяхното получаване и приложението им като фармацевтични препарати

Info

Publication number
BG94837A
BG94837A BG094837A BG9483791A BG94837A BG 94837 A BG94837 A BG 94837A BG 094837 A BG094837 A BG 094837A BG 9483791 A BG9483791 A BG 9483791A BG 94837 A BG94837 A BG 94837A
Authority
BG
Bulgaria
Prior art keywords
azithromycin
preparation
application
pharmaceutical preparations
methyl
Prior art date
Application number
BG094837A
Other languages
English (en)
Other versions
BG60593B1 (bg
Inventor
Gabrijela Kobrehel
Slobodan Djokic
Gorjana Lazarevski
Original Assignee
Pliva-Istrazivacki Institut D.O.O.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pliva-Istrazivacki Institut D.O.O. filed Critical Pliva-Istrazivacki Institut D.O.O.
Publication of BG94837A publication Critical patent/BG94837A/bg
Publication of BG60593B1 publication Critical patent/BG60593B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

0-метилните производни на азитромицин а са биологично активни вещества и се използват за лечение на инфекциозни заболявания при хора и животни. Имат обща формула в която r1 и r2 означават бензилоксикарбонил, водород или метил; r3 до r4 означават водород или метил. Съединенията имат изразена активност спрямо грамположителни и грамотрицателни микроорганизми, по-силна от тази на азитромицина. 15 претенции
BG94837A 1990-07-18 1991-07-17 О-метилни производни на азитромицин а, метод за тяхното получаване и приложението им като фармацевтични препарати BG60593B1 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
YU140990 1990-07-18

Publications (2)

Publication Number Publication Date
BG94837A true BG94837A (bg) 1993-12-24
BG60593B1 BG60593B1 (bg) 1995-09-29

Family

ID=25554060

Family Applications (1)

Application Number Title Priority Date Filing Date
BG94837A BG60593B1 (bg) 1990-07-18 1991-07-17 О-метилни производни на азитромицин а, метод за тяхното получаване и приложението им като фармацевтични препарати

Country Status (20)

Country Link
US (1) US5250518A (bg)
EP (1) EP0467331B1 (bg)
JP (1) JP2657132B2 (bg)
CN (1) CN1029738C (bg)
AT (1) ATE129715T1 (bg)
BG (1) BG60593B1 (bg)
CA (1) CA2046956C (bg)
CZ (1) CZ280640B6 (bg)
DE (1) DE69114198T2 (bg)
DK (1) DK0467331T3 (bg)
ES (1) ES2081397T3 (bg)
GR (1) GR3018330T3 (bg)
HR (1) HRP920491B1 (bg)
HU (4) HUT59935A (bg)
PL (1) PL166379B1 (bg)
RO (1) RO109338B1 (bg)
RU (1) RU2045533C1 (bg)
SI (1) SI9011409A (bg)
SK (1) SK279075B6 (bg)
UA (1) UA27105A1 (bg)

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HRP930014A2 (en) * 1993-01-08 1994-08-31 Pliva Pharm & Chem Works 9-deoxo-9a-aza-11-deoxy-9a-homoeritromycin a 9a, 11-cyclic carbamates
HRP931480B1 (en) * 1993-12-08 1997-08-31 Sour Pliva 9a-N-(N'-CARBAMONYL) and 9a-N-(N'-THIOCARBAMONYL) DERIVATES OF 9-DEOXO-9a-HOMOERYTHROMYCIN A
US5605889A (en) * 1994-04-29 1997-02-25 Pfizer Inc. Method of administering azithromycin
SI1036083T1 (en) * 1997-10-16 2004-10-31 Pliva-Istra�iva�ki institut d.o.o. Novel 9a-azalides
US6861411B1 (en) 1997-12-02 2005-03-01 Pfizer, Inc. Method of treating eye infections with azithromycin
TW546302B (en) 1998-05-08 2003-08-11 Biochemie Sa Improvements in macrolide production
UA70972C2 (uk) 1998-11-20 2004-11-15 Пфайзер Продактс Інк. 13-членні азаліди і їх застосування як антибіотиків
HRP980646B1 (en) * 1998-12-30 2008-02-29 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. Novel oleandomycin derivatives
US7056893B2 (en) 1999-03-31 2006-06-06 Insite Vision, Inc. Topical treatment for prevention of ocular infections
US6239113B1 (en) 1999-03-31 2001-05-29 Insite Vision, Incorporated Topical treatment or prevention of ocular infections
HRP990116B1 (en) * 1999-04-20 2007-10-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. NOVEL 8a AND 9a- 15-MEMBERED LACTAMES
US6465437B1 (en) * 1999-06-30 2002-10-15 Pfizer Inc. Diphosphate salt of a 4″-substituted-9-deoxo-9A-AZA-9A- homoerythromycin derivative and its pharmaceutical composition
US6787342B2 (en) 2000-02-16 2004-09-07 Merial Limited Paste formulations
JP2004506664A (ja) 2000-08-23 2004-03-04 ウォックハート・リミテッド 無水アジトロマイシンの製造法
HRP20010301A2 (en) * 2001-04-27 2001-12-31 Pliva D D New therapeutic indication for azithromycin in the treatment of non-infective inflammatory diseases
NZ535354A (en) 2002-02-15 2008-01-31 Merckle Gmbh Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
US20060099660A1 (en) 2002-02-15 2006-05-11 Synovo Gmbh Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
CA2476448A1 (en) 2002-02-15 2003-08-28 Sympore Gmbh Antibiotic conjugates
ITMI20022292A1 (it) * 2002-10-29 2004-04-30 Zambon Spa 9a-azalidi ad attivita' antiinfiammatoria.
WO2004106353A1 (en) * 2003-05-30 2004-12-09 Pliva - Istrazivacki Institut D.O.O. Process for selective alkylation of macrolide and azalide derivatives
US7435805B2 (en) 2003-05-30 2008-10-14 Glaxpsmithkline Istrazivacki O-alkyl macrolide and azalide derivatives and regioselective process for their preparation
AU2003267675A1 (en) * 2003-09-02 2005-03-16 Pliva - Istrazivacki Institut D.O.O. O-alkyl macrolide and azalide derivatives and regioselective process for their preparation
US7468428B2 (en) 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
ATE476438T1 (de) * 2005-01-13 2010-08-15 Glaxosmithkline Zagreb Makrolide mit entzündungshemmender wirkung
US8362086B2 (en) 2005-08-19 2013-01-29 Merial Limited Long acting injectable formulations
MA32997B1 (fr) * 2009-01-30 2012-01-02 Glaxo Group Ltd Macrolide anti-inflammatoire
WO2010086350A1 (en) 2009-01-30 2010-08-05 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. 9-deoxo- 9a-methyl- 9a- aza- 9a-h0m0erythr0mycin a derivatives for the treatment of neutrophil dominated inflammatory diseases
CN101830949B (zh) * 2009-03-13 2012-05-23 上海医药工业研究院 一种阿奇霉素衍生物、其中间体及其制备方法和应用
WO2011131749A1 (en) 2010-04-23 2011-10-27 Glaxo Group Limited New 14 and 15 membered macrolides for the treatment of neutrophil dominated inflammatory diseases
CN102952166A (zh) * 2011-08-28 2013-03-06 山东方明药业集团股份有限公司 聚合物支载硼氢阴离子还原剂合成阿奇霉素中间体的方法
CA2869461A1 (en) * 2012-03-27 2013-10-03 Michael W. BURNET Anti-inflammatory macrolides
GB201608236D0 (en) 2016-05-11 2016-06-22 Fidelta D O O Seco macrolide compounds
WO2018193125A1 (en) * 2017-04-20 2018-10-25 Novintum Biotechnology Gmbh Azithromycin derivatives containing a phosphonium ion as anticancer agents
CN110799516A (zh) * 2017-04-20 2020-02-14 来兴泰德基金会 作为抗癌剂的包含鏻离子的阿奇霉素衍生物
WO2018195434A1 (en) 2017-04-21 2018-10-25 Lisanti Michael P Vitamin c and doxycycline: a synthetic lethal combination therapy for eradicating cancer stem cells (cscs)
WO2018195446A1 (en) 2017-04-21 2018-10-25 Lisanti Michael P Targeting hypoxic cancer stem cells (cscs) with doxycycline: implications for improving anti-angiogenic therapy
JP6938682B2 (ja) 2017-05-19 2021-09-22 ルネラ・バイオテック・インコーポレーテッド アンチミトシン：癌幹細胞を根絶するためのミトコンドリア生合成の標的阻害薬
EP3624897A4 (en) 2017-05-19 2021-07-14 Lunella Biotech, Inc. COMPANION DIAGNOSIS FOR MITOCHONDRIAL INHIBITORS
MX2019014806A (es) 2017-06-26 2020-02-10 Lunella Biotech Inc Mitocetoscinas: agentes terapeuticos basados en mitocondrias que fijan como objetivo el metabolismo de cetonas en celulas cancerosas.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4474768A (en) * 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
JPS61103890A (ja) * 1984-10-26 1986-05-22 Taisho Pharmaceut Co Ltd ６−０−メチルエリスロマイシンａ誘導体
EP0184921A3 (en) * 1984-12-08 1986-10-29 Beecham Group Plc Erythromycin derivatives
JPS63107994A (ja) * 1986-05-02 1988-05-12 Taisho Pharmaceut Co Ltd エリスロマイシン誘導体
WO1989002271A1 (en) * 1987-09-10 1989-03-23 Pfizer Azithromycin and derivatives as antiprotozoal agents

Also Published As

Publication number Publication date
JPH05132497A (ja) 1993-05-28
UA27105A1 (uk) 2000-02-28
DE69114198T2 (de) 1996-06-27
HUT59935A (en) 1992-07-28
DE69114198D1 (de) 1995-12-07
EP0467331B1 (en) 1995-11-02
BG60593B1 (bg) 1995-09-29
SK279075B6 (sk) 1998-06-03
US5250518A (en) 1993-10-05
CN1059728A (zh) 1992-03-25
GR3018330T3 (en) 1996-03-31
HRP920491B1 (en) 1998-10-31
HU912408D0 (en) 1991-12-30
HU211659A9 (en) 1995-12-28
CS219591A3 (en) 1992-03-18
PL166379B1 (en) 1995-05-31
HUT62307A (en) 1993-04-28
HU9802439D0 (en) 1998-12-28
RU2045533C1 (ru) 1995-10-10
HU221803B1 (hu) 2003-01-28
CA2046956C (en) 1999-01-05
HU9202619D0 (en) 1992-12-28
ATE129715T1 (de) 1995-11-15
ES2081397T3 (es) 1996-03-01
CZ280640B6 (cs) 1996-03-13
CA2046956A1 (en) 1992-01-19
RO109338B1 (ro) 1995-01-30
HU215158B (hu) 1998-12-28
SI9011409A (en) 1995-10-31
CN1029738C (zh) 1995-09-13
HRP920491A2 (en) 1994-08-31
EP0467331A1 (en) 1992-01-22
JP2657132B2 (ja) 1997-09-24
PL291130A1 (en) 1992-11-16
DK0467331T3 (da) 1996-02-05

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