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EA199700302A1 - Биологически активные уреидо-производные, полезные при лечении рассеянного склероза - Google Patents

Биологически активные уреидо-производные, полезные при лечении рассеянного склероза

Info

Publication number
EA199700302A1
EA199700302A1 EA199700302A EA199700302A EA199700302A1 EA 199700302 A1 EA199700302 A1 EA 199700302A1 EA 199700302 A EA199700302 A EA 199700302A EA 199700302 A EA199700302 A EA 199700302A EA 199700302 A1 EA199700302 A1 EA 199700302A1
Authority
EA
Eurasian Patent Office
Prior art keywords
treatment
multiple sclerosis
ureid
derivatives
useful
Prior art date
Application number
EA199700302A
Other languages
English (en)
Other versions
EA000166B1 (ru
Inventor
Ракель Алзани
Елена Коцци
Никола Монджелли
Андреа Ломбарди Борджа
Массимо Темпони
Франческо Колотта
Original Assignee
Фармация Энд Апджон С.П.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Фармация Энд Апджон С.П.А. filed Critical Фармация Энд Апджон С.П.А.
Publication of EA199700302A1 publication Critical patent/EA199700302A1/ru
Publication of EA000166B1 publication Critical patent/EA000166B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Использование при получении лекарственного препарата для лечения рассеянного склероза соединения, являющегося уреидопроизводным формулы (I)где каждый из m и n, которые являются одинаковыми, представляют целое число от 1 до 3; и каждая из R-групп, которые являются одинаковыми, представляет собой нафтильную группу, замещенную 1-3 сульфокислотными группами, или его фармацевтически приемлемой солью.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199700302A 1996-02-09 1997-01-24 Биологически активные уреидо-производные, полезные при лечении рассеянного склероза EA000166B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9602721.4A GB9602721D0 (en) 1996-02-09 1996-02-09 Biologically active ureido derivatives useful in the treatment of multiple sclerosis
PCT/EP1997/000412 WO1997028796A1 (en) 1996-02-09 1997-01-24 Biologically active ureido derivatives useful in the treatment of multiple sclerosis

Publications (2)

Publication Number Publication Date
EA199700302A1 true EA199700302A1 (ru) 1998-04-30
EA000166B1 EA000166B1 (ru) 1998-10-29

Family

ID=10788461

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199700302A EA000166B1 (ru) 1996-02-09 1997-01-24 Биологически активные уреидо-производные, полезные при лечении рассеянного склероза

Country Status (22)

Country Link
US (1) US5859046A (ru)
EP (1) EP0820284B1 (ru)
JP (1) JPH11504041A (ru)
KR (1) KR19980703718A (ru)
AR (1) AR005724A1 (ru)
AT (1) ATE189388T1 (ru)
AU (1) AU1720097A (ru)
BR (1) BR9702075A (ru)
CA (1) CA2217008A1 (ru)
DE (1) DE69701243T2 (ru)
DK (1) DK0820284T3 (ru)
EA (1) EA000166B1 (ru)
ES (1) ES2144844T3 (ru)
GB (1) GB9602721D0 (ru)
GR (1) GR3033332T3 (ru)
HU (1) HUP9900796A2 (ru)
IL (1) IL121808A0 (ru)
NO (1) NO974651L (ru)
PL (1) PL322717A1 (ru)
PT (1) PT820284E (ru)
WO (1) WO1997028796A1 (ru)
ZA (1) ZA97902B (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6562859B1 (en) 1997-12-04 2003-05-13 The United States Of America As Represented By The Department Of Health And Human Services Ureido derivatives of poly-4-amino-2-carboxy-1-methyl pyrrole compounds for inhibition of inflammation
GB9727524D0 (en) 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Synergistic antitumor composition containing a biologically active ureido compound
US6348464B1 (en) 1999-11-12 2002-02-19 Guilford Pharmaceuticals, Inc. Pyrrolecarbonylimino derivatives as naaladase inhibitors
JP4773951B2 (ja) 2003-03-03 2011-09-14 エーザイ インコーポレーテッド チオラクトン
EP3381897A1 (en) 2017-03-27 2018-10-03 Leadiant Biosciences SA Derivatives of the disodium 2,2'-{carbonylbis[imino-3,1-phenylenecarbonylimino(1-methyl-1h-pyrrole-4,2-diyl)carbonylimino]}dinaphthalene-1,5-disulfonate salt and related compounds as heparanase inhibitors for the treatment of cancer

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9304589D0 (en) * 1993-03-05 1993-04-21 Erba Carlo Spa Biologically active ureido derivatives useful as antimetastic agents
GB9307948D0 (en) * 1993-04-16 1993-06-02 Erba Carlo Spa Biologically active ureido derivatives useful in the treatment of lentivirus-induced disease

Also Published As

Publication number Publication date
ES2144844T3 (es) 2000-06-16
MX9707673A (es) 1997-11-29
EA000166B1 (ru) 1998-10-29
GR3033332T3 (en) 2000-09-29
AR005724A1 (es) 1999-07-14
WO1997028796A1 (en) 1997-08-14
US5859046A (en) 1999-01-12
GB9602721D0 (en) 1996-04-10
HUP9900796A2 (hu) 1999-07-28
KR19980703718A (ko) 1998-12-05
ATE189388T1 (de) 2000-02-15
DK0820284T3 (da) 2000-07-24
BR9702075A (pt) 1998-06-09
AU1720097A (en) 1997-08-28
PT820284E (pt) 2000-07-31
ZA97902B (en) 1997-08-01
IL121808A0 (en) 1998-02-22
EP0820284A1 (en) 1998-01-28
JPH11504041A (ja) 1999-04-06
PL322717A1 (en) 1998-02-16
NO974651L (no) 1997-12-02
EP0820284B1 (en) 2000-02-02
DE69701243D1 (de) 2000-03-09
DE69701243T2 (de) 2000-09-07
NO974651D0 (no) 1997-10-08
CA2217008A1 (en) 1997-08-14

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY KZ RU