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BG91463A - Холестираминова таблетка и метод за получаването й - Google Patents

Холестираминова таблетка и метод за получаването й

Info

Publication number
BG91463A
BG91463A BG091463A BG9146390A BG91463A BG 91463 A BG91463 A BG 91463A BG 091463 A BG091463 A BG 091463A BG 9146390 A BG9146390 A BG 9146390A BG 91463 A BG91463 A BG 91463A
Authority
BG
Bulgaria
Prior art keywords
core
weight
agglomerates
tablet
cholestyramine
Prior art date
Application number
BG091463A
Other languages
English (en)
Other versions
BG60501B1 (bg
Inventor
Robert Bequette
Bruce Bonenberger
Claude Gallian
John Reckelhoff
Original Assignee
Bristol - Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol - Myers Squibb Company filed Critical Bristol - Myers Squibb Company
Publication of BG91463A publication Critical patent/BG91463A/bg
Publication of BG60501B1 publication Critical patent/BG60501B1/bg

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/282—Organic compounds, e.g. fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/2853—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

Изобретението намира приложение във фармацевтичната промишленост. Таблетката се състои от сърцевина от холестираминови агломерати с обемно тегло в уплътнено състояние 0,45-0,5 г/мл и влагосъдържание от 8 до 14% тегловни. Агломератите са образувани от много малки, неправилно оформени с остри начупени краища с относително малко на брой големи гладки или плоски повърхности, като сърцевината има твърдост от 18 до 26 sсu, свободно от разтворител покритие, което включва в тегл.% От 60 до 95 стеаринова киселина, от 5 до 40 полиетиленгликол и от 10 до 20 частично хидрирано соево масло. По метода омокрените холестираминови частици се смилат в мелница за микронизиране и смлените частици се сушат при температура от 48 до 580с до влагосъдържание от 8 до 14% тегловни. Изсушеният материал се фракционира, при което се получават холестираминови агломерати, които се пресуват директно за получаване на сърцевина на таблетката. Върху сърцевината се нанася покритието, свободно от разтворител. 5 претенции
BG91463A 1989-03-16 1990-03-14 Холестираминова таблетка и метод за получаванетой BG60501B1 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/324,167 US4956182A (en) 1989-03-16 1989-03-16 Direct compression cholestyramine tablet and solvent-free coating therefor

Publications (2)

Publication Number Publication Date
BG91463A true BG91463A (bg) 1993-12-24
BG60501B1 BG60501B1 (bg) 1995-06-30

Family

ID=23262387

Family Applications (1)

Application Number Title Priority Date Filing Date
BG91463A BG60501B1 (bg) 1989-03-16 1990-03-14 Холестираминова таблетка и метод за получаванетой

Country Status (34)

Country Link
US (1) US4956182A (bg)
EP (1) EP0387885B1 (bg)
JP (1) JP2974719B2 (bg)
KR (1) KR0140211B1 (bg)
CN (1) CN1047935C (bg)
AR (1) AR246012A1 (bg)
AT (1) ATE128031T1 (bg)
AU (1) AU617601B2 (bg)
BG (1) BG60501B1 (bg)
CA (1) CA2012300A1 (bg)
CS (1) CS277488B6 (bg)
CY (1) CY1899A (bg)
DD (1) DD292837A5 (bg)
DE (1) DE69022452T2 (bg)
DK (1) DK0387885T3 (bg)
EG (1) EG19669A (bg)
ES (1) ES2078917T3 (bg)
FI (1) FI92464C (bg)
GR (1) GR3017460T3 (bg)
HK (1) HK51396A (bg)
HU (1) HU209958B (bg)
IE (1) IE70591B1 (bg)
IL (1) IL93720A0 (bg)
MY (1) MY109744A (bg)
NO (1) NO176043C (bg)
NZ (1) NZ232864A (bg)
OA (1) OA09198A (bg)
PL (1) PL163301B1 (bg)
PT (1) PT93452B (bg)
RO (1) RO106953B1 (bg)
RU (1) RU2069558C1 (bg)
YU (1) YU52390A (bg)
ZA (1) ZA902001B (bg)
ZW (1) ZW1890A1 (bg)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5372823A (en) * 1989-03-16 1994-12-13 Bristol-Myers Squibb Company Direct compression cholestyramine tablet and solvent-free coating thereof
US5262167A (en) * 1990-12-20 1993-11-16 Basf Corporation Edible, non-baked low moisture cholestyramine composition
CA2129079C (en) * 1993-08-03 2006-01-17 Tatsuo Nomura Orally administrable cholesterol lowering agent
ES2196079T3 (es) * 1994-09-22 2003-12-16 Akzo Nobel Nv Procedimiento de fabricacion de unidades posologicas por medio de una granulacion por via humeda.
TW592727B (en) * 1997-04-04 2004-06-21 Chugai Pharmaceutical Co Ltd Phosphate-binding polymer preparations
PL205109B1 (pl) 1998-11-02 2010-03-31 Elan Pharma Int Ltd Wielocząstkowa kompozycja metylofenidatu o modyfikowanym uwalnianiu i jej zastosowanie
US6733780B1 (en) 1999-10-19 2004-05-11 Genzyme Corporation Direct compression polymer tablet core
US20020054903A1 (en) * 1999-10-19 2002-05-09 Joseph Tyler Direct compression polymer tablet core
CN107213128A (zh) 1999-10-29 2017-09-29 欧罗赛铁克股份有限公司 控释氢可酮制剂
US10179130B2 (en) 1999-10-29 2019-01-15 Purdue Pharma L.P. Controlled release hydrocodone formulations
KR100968128B1 (ko) 2000-10-30 2010-07-06 유로-셀티크 소시에떼 아노뉨 서방성 하이드로코돈 제형
WO2002064118A1 (en) * 2001-02-13 2002-08-22 Astrazeneca Ab Novel modified release formulation
US7838026B2 (en) 2001-09-28 2010-11-23 Mcneil-Ppc, Inc. Burst-release polymer composition and dosage forms comprising the same
US6982094B2 (en) 2001-09-28 2006-01-03 Mcneil-Ppc, Inc. Systems, methods and apparatuses for manufacturing dosage forms
US7122143B2 (en) 2001-09-28 2006-10-17 Mcneil-Ppc, Inc. Methods for manufacturing dosage forms
US7323192B2 (en) * 2001-09-28 2008-01-29 Mcneil-Ppc, Inc. Immediate release tablet
WO2003026613A1 (en) 2001-09-28 2003-04-03 Mcneil-Ppc, Inc. Fondant-based pharmaceutical composition
US7807197B2 (en) 2002-09-28 2010-10-05 Mcneil-Ppc, Inc. Composite dosage forms having an inlaid portion
WO2005115352A1 (de) * 2004-05-24 2005-12-08 Mepha Ag Trockenbeschichtungsverfahren
PL1811957T3 (pl) * 2004-10-19 2009-05-29 Krka Tovarna Zdravil D D Stała kompozycja farmaceutyczna zawierająca chlorowodorek donepezylu
US7985418B2 (en) 2004-11-01 2011-07-26 Genzyme Corporation Aliphatic amine polymer salts for tableting
US20060177415A1 (en) * 2004-11-01 2006-08-10 Burke Steven K Once a day formulation for phosphate binders
CA2620406A1 (en) 2005-09-02 2007-03-08 Genzyme Corporation Method for removing phosphate and polymer used therefore
HUE026628T2 (en) 2005-09-15 2016-06-28 Genzyme Corp Pouches for amine polymers
DE102005060377A1 (de) * 2005-12-16 2007-06-21 Ratiopharm Gmbh Pharmazeutische Zusammensetzung enthaltend Donepezilhydrochlorid, Tablette hieraus und Verfahren zu deren Herstellung
EP2050456A4 (en) * 2006-08-09 2013-01-23 Mitsubishi Tanabe Pharma Corp COMPRESSED
BRPI0717545A2 (pt) 2006-09-29 2013-10-22 Gezyme Corp Composição farmacêutica, método para tratar uma doença, polímero de amida, rede de polímero, e, método para preparar um polímero de amida
US8163799B2 (en) 2006-12-14 2012-04-24 Genzyme Corporation Amido-amine polymer compositions
MX356111B (es) 2012-04-18 2018-05-15 SpecGx LLC Composiciones farmaceuticas disuasorias de abuso, de liberacion inmediata.
CN105848894B (zh) 2013-10-25 2018-01-23 株式会社可乐丽 多层薄膜和包含其的夹层玻璃用中间膜
PT3164117T (pt) 2014-07-03 2023-12-12 SpecGx LLC Formulações de libertação imediata de dissuasão de abuso compreendendo polissacáridos não celulósicos
WO2017138877A1 (en) * 2016-02-09 2017-08-17 Albireo Ab Oral cholestyramine formulation and use thereof
CN108601739B (zh) * 2016-02-09 2022-01-04 阿尔比里奥公司 考来烯胺丸剂及其制备方法
CA3112030A1 (en) 2018-09-25 2020-04-02 SpecGx LLC Abuse deterrent immediate release capsule dosage forms
CN114053234A (zh) * 2021-12-29 2022-02-18 江苏省药物研究所有限公司 一种阿卡波糖片及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB595444A (en) * 1945-07-09 1947-12-04 Gwilym Lloyd Thomas Improvements in or relating to medicaments, and to the preparation thereof
US3383237A (en) * 1964-01-29 1968-05-14 Richardson Merrell Inc Tablet coating
JPS56140915A (en) * 1980-04-07 1981-11-04 Yamanouchi Pharmaceut Co Ltd Pharmaceutical preparation for solid drug
US4895723A (en) * 1986-09-08 1990-01-23 Amer And Company Cholestyramine compositions and method for preparation thereof
ZA876640B (en) * 1986-09-26 1988-03-08 Warner-Lambert Company Treated lipid regulator
IT1200217B (it) * 1986-09-30 1989-01-05 Valducci Roberto Membrana per uso farmaceutico ed industriale

Also Published As

Publication number Publication date
DE69022452D1 (de) 1995-10-26
FI92464B (fi) 1994-08-15
EG19669A (en) 1995-08-30
JPH03236326A (ja) 1991-10-22
EP0387885A3 (en) 1992-06-17
GR3017460T3 (en) 1995-12-31
PL163301B1 (en) 1994-03-31
AU5136790A (en) 1990-09-20
ZW1890A1 (en) 1990-10-31
PT93452B (pt) 1996-12-31
AU617601B2 (en) 1991-11-28
CY1899A (en) 1990-03-15
HK51396A (en) 1996-03-29
DD292837A5 (de) 1991-08-14
FI92464C (fi) 1994-11-25
KR900013946A (ko) 1990-10-22
RU2069558C1 (ru) 1996-11-27
NO901183D0 (no) 1990-03-14
DE69022452T2 (de) 1996-03-14
YU52390A (en) 1991-10-31
HUT54489A (en) 1991-03-28
OA09198A (fr) 1992-06-30
BG60501B1 (bg) 1995-06-30
KR0140211B1 (ko) 1998-06-01
US4956182A (en) 1990-09-11
ATE128031T1 (de) 1995-10-15
IL93720A0 (en) 1990-12-23
JP2974719B2 (ja) 1999-11-10
DK0387885T3 (da) 1995-11-06
PT93452A (pt) 1990-11-07
HU901429D0 (en) 1990-06-28
EP0387885A2 (en) 1990-09-19
CN1045921A (zh) 1990-10-10
NZ232864A (en) 1992-04-28
CS277488B6 (en) 1993-03-17
NO176043B (no) 1994-10-17
CA2012300A1 (en) 1990-09-16
NO901183L (no) 1990-09-17
IE900941L (en) 1990-09-16
NO176043C (no) 1995-01-25
FI901241A0 (fi) 1990-03-13
CN1047935C (zh) 2000-01-05
ES2078917T3 (es) 1996-01-01
EP0387885B1 (en) 1995-09-20
MY109744A (en) 1997-05-31
AR246012A1 (es) 1994-03-30
HU209958B (en) 1994-12-28
RO106953B1 (ro) 1993-08-30
IE70591B1 (en) 1996-12-11
ZA902001B (en) 1990-11-28

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