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AU2020289459A1 - Bicyclic derivatives for treating endoparasites - Google Patents

Bicyclic derivatives for treating endoparasites Download PDF

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Publication number
AU2020289459A1
AU2020289459A1 AU2020289459A AU2020289459A AU2020289459A1 AU 2020289459 A1 AU2020289459 A1 AU 2020289459A1 AU 2020289459 A AU2020289459 A AU 2020289459A AU 2020289459 A AU2020289459 A AU 2020289459A AU 2020289459 A1 AU2020289459 A1 AU 2020289459A1
Authority
AU
Australia
Prior art keywords
alkyl
dihydro
carboxamide
benzoxazin
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
AU2020289459A
Other languages
English (en)
Inventor
Pierre Ducray
Francois Pautrat
Denise RAGEOT
Chouaib Tahtaoui
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Elanco Tiergesundheit AG
Original Assignee
Elanco Tiergesundheit AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elanco Tiergesundheit AG filed Critical Elanco Tiergesundheit AG
Publication of AU2020289459A1 publication Critical patent/AU2020289459A1/en
Pending legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10Spiro-condensed systems
    • C07D491/107Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/10Anthelmintics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D265/00Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/281,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/341,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/361,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2020289459A 2019-06-07 2020-06-05 Bicyclic derivatives for treating endoparasites Pending AU2020289459A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962858465P 2019-06-07 2019-06-07
US62/858,465 2019-06-07
US201962947852P 2019-12-13 2019-12-13
US62/947,852 2019-12-13
PCT/US2020/036322 WO2020247747A1 (en) 2019-06-07 2020-06-05 Bicyclic derivatives for treating endoparasites

Publications (1)

Publication Number Publication Date
AU2020289459A1 true AU2020289459A1 (en) 2022-01-06

Family

ID=71899822

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2020289459A Pending AU2020289459A1 (en) 2019-06-07 2020-06-05 Bicyclic derivatives for treating endoparasites

Country Status (8)

Country Link
US (2) US20200385398A1 (ja)
EP (1) EP3980414A1 (ja)
JP (1) JP7693558B2 (ja)
CN (1) CN114206860B (ja)
AU (1) AU2020289459A1 (ja)
BR (1) BR112021024726A2 (ja)
CA (1) CA3141905A1 (ja)
WO (1) WO2020247747A1 (ja)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11202012922VA (en) 2018-07-09 2021-01-28 Boehringer Ingelheim Animal Health Usa Inc Anthelminthic heterocyclic compounds
JP7637630B2 (ja) 2019-03-19 2025-02-28 ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハー 駆虫性アザベンゾチオフェンおよびアザベンゾフラン化合物
EP4185589A1 (en) 2020-05-29 2023-05-31 Boehringer Ingelheim Animal Health USA Inc. Anthelmintic heterocyclic compounds
US20240059680A1 (en) * 2020-11-18 2024-02-22 Elanco Tiergesundheit Ag N-(2,3-dihydro-1,4-benzoxazin-4-yl)-3-isopropyl-7-(2,3,5-trifluorophenyl)benzo-thiophene-2-carboxamide derivatives and similar compounds for the treatment of heartworm infections
CN116888124A (zh) * 2020-12-04 2023-10-13 礼蓝动物保健有限公司 二环衍生物
EP4148052A1 (en) * 2021-09-09 2023-03-15 Bayer Animal Health GmbH New quinoline derivatives
JP2024540166A (ja) 2021-11-01 2024-10-31 ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハー 駆虫性ピロロピリダジン化合物
IL314175A (en) * 2022-01-14 2024-09-01 Enko Chem Inc Protoporphyrinogen oxidase inhibitors
CN114890920B (zh) * 2022-05-27 2023-12-12 东营施普瑞石油工程技术有限公司 一种防水锁剂及其制备方法
WO2024213752A1 (en) 2023-04-14 2024-10-17 Elanco Animal Health Gmbh Long-term prevention and/or treatment of a disease by slo-1 inhibitors
WO2025027117A1 (en) 2023-08-02 2025-02-06 Intervet International B.V. Carboxamide-4-quinoline compounds with anthelmintic activity

Family Cites Families (21)

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DE4440193A1 (de) * 1994-11-10 1996-05-15 Bayer Ag Verwendung von Dioxomorpholinen zur Bekämpfung von Endoparasiten, neue Dioxomorpholine und Verfahren zur ihrer Herstellung
EP0925300A1 (en) 1996-02-15 1999-06-30 Cambridge Neuroscience, Inc. Pharmaceutically active compounds and methods of use
AU740745B2 (en) * 1997-12-11 2001-11-15 Biochem Pharma Inc. Antiviral compounds
EP1154997A4 (en) * 1999-01-26 2002-11-04 Dana Farber Cancer Inst Inc PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE
TW200300140A (en) * 2001-11-14 2003-05-16 Novartis Ag Organic compounds
AU2008248751A1 (en) * 2007-05-02 2008-11-13 Novartis Ag Heterocyclic compounds and their use as pesticides
WO2010027002A1 (ja) 2008-09-05 2010-03-11 塩野義製薬株式会社 Pi3k阻害活性を有する縮環モルホリン誘導体
KR20140038527A (ko) * 2011-06-20 2014-03-28 이 아이 듀폰 디 네모아 앤드 캄파니 연충 감염을 치료하기 위한 복소환식 화합물
US9221835B2 (en) * 2012-09-07 2015-12-29 Zoetis Services Llc Spirocyclic derivatives as antiparasitic agents
JP6298472B2 (ja) * 2012-11-19 2018-03-20 ノバルティス アーゲー 寄生虫病の処置のための化合物および組成物
UY35940A (es) * 2014-01-03 2015-07-31 Bayer Cropscience Ag Nuevas pirazolil-heteroarilamidas como agentes plaguicidas
CN106470683A (zh) * 2014-07-11 2017-03-01 英特维特国际股份有限公司 针对犬心丝虫的抗蠕虫剂的用途
RU2769448C2 (ru) 2016-04-15 2022-03-31 Байер Энимэл Хельс ГмбХ Новые пиразолпиримидиновые производные
EP3538512B1 (en) 2016-11-11 2021-06-16 Bayer Animal Health GmbH New anthelmintic quinoline-3-carboxamide derivatives
EP3585791B1 (en) 2017-04-27 2024-10-16 Elanco Animal Health GmbH New bicyclic pyrazole derivatives
EP3615527B1 (en) 2017-06-30 2024-03-06 Elanco Animal Health GmbH New azaquinoline derivatives
MX2020001403A (es) 2017-08-04 2020-03-09 Bayer Animal Health Gmbh Nuevos derivados de quinolina.
ES3019808T3 (en) * 2018-12-18 2025-05-21 Elanco Tiergesundheit Ag Bicyclic derivatives
CA3122105A1 (en) * 2018-12-18 2020-06-25 Elanco Tiergesundheit Ag Bicyclic derivatives
US20240059680A1 (en) 2020-11-18 2024-02-22 Elanco Tiergesundheit Ag N-(2,3-dihydro-1,4-benzoxazin-4-yl)-3-isopropyl-7-(2,3,5-trifluorophenyl)benzo-thiophene-2-carboxamide derivatives and similar compounds for the treatment of heartworm infections
TW202237600A (zh) 2020-12-04 2022-10-01 瑞士商禮藍動物保健股份有限公司 雙環衍生物

Also Published As

Publication number Publication date
WO2020247747A1 (en) 2020-12-10
JP2022535110A (ja) 2022-08-04
CN114206860A (zh) 2022-03-18
US20220242857A1 (en) 2022-08-04
JP7693558B2 (ja) 2025-06-17
US20200385398A1 (en) 2020-12-10
EP3980414A1 (en) 2022-04-13
CN114206860B (zh) 2025-02-18
CA3141905A1 (en) 2020-12-10
BR112021024726A2 (pt) 2022-01-18

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