AU2020289459A1 - Bicyclic derivatives for treating endoparasites - Google Patents
Bicyclic derivatives for treating endoparasites Download PDFInfo
- Publication number
- AU2020289459A1 AU2020289459A1 AU2020289459A AU2020289459A AU2020289459A1 AU 2020289459 A1 AU2020289459 A1 AU 2020289459A1 AU 2020289459 A AU2020289459 A AU 2020289459A AU 2020289459 A AU2020289459 A AU 2020289459A AU 2020289459 A1 AU2020289459 A1 AU 2020289459A1
- Authority
- AU
- Australia
- Prior art keywords
- alkyl
- dihydro
- carboxamide
- benzoxazin
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962858465P | 2019-06-07 | 2019-06-07 | |
US62/858,465 | 2019-06-07 | ||
US201962947852P | 2019-12-13 | 2019-12-13 | |
US62/947,852 | 2019-12-13 | ||
PCT/US2020/036322 WO2020247747A1 (en) | 2019-06-07 | 2020-06-05 | Bicyclic derivatives for treating endoparasites |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2020289459A1 true AU2020289459A1 (en) | 2022-01-06 |
Family
ID=71899822
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2020289459A Pending AU2020289459A1 (en) | 2019-06-07 | 2020-06-05 | Bicyclic derivatives for treating endoparasites |
Country Status (8)
Country | Link |
---|---|
US (2) | US20200385398A1 (ja) |
EP (1) | EP3980414A1 (ja) |
JP (1) | JP7693558B2 (ja) |
CN (1) | CN114206860B (ja) |
AU (1) | AU2020289459A1 (ja) |
BR (1) | BR112021024726A2 (ja) |
CA (1) | CA3141905A1 (ja) |
WO (1) | WO2020247747A1 (ja) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SG11202012922VA (en) | 2018-07-09 | 2021-01-28 | Boehringer Ingelheim Animal Health Usa Inc | Anthelminthic heterocyclic compounds |
JP7637630B2 (ja) | 2019-03-19 | 2025-02-28 | ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハー | 駆虫性アザベンゾチオフェンおよびアザベンゾフラン化合物 |
EP4185589A1 (en) | 2020-05-29 | 2023-05-31 | Boehringer Ingelheim Animal Health USA Inc. | Anthelmintic heterocyclic compounds |
US20240059680A1 (en) * | 2020-11-18 | 2024-02-22 | Elanco Tiergesundheit Ag | N-(2,3-dihydro-1,4-benzoxazin-4-yl)-3-isopropyl-7-(2,3,5-trifluorophenyl)benzo-thiophene-2-carboxamide derivatives and similar compounds for the treatment of heartworm infections |
CN116888124A (zh) * | 2020-12-04 | 2023-10-13 | 礼蓝动物保健有限公司 | 二环衍生物 |
EP4148052A1 (en) * | 2021-09-09 | 2023-03-15 | Bayer Animal Health GmbH | New quinoline derivatives |
JP2024540166A (ja) | 2021-11-01 | 2024-10-31 | ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハー | 駆虫性ピロロピリダジン化合物 |
IL314175A (en) * | 2022-01-14 | 2024-09-01 | Enko Chem Inc | Protoporphyrinogen oxidase inhibitors |
CN114890920B (zh) * | 2022-05-27 | 2023-12-12 | 东营施普瑞石油工程技术有限公司 | 一种防水锁剂及其制备方法 |
WO2024213752A1 (en) | 2023-04-14 | 2024-10-17 | Elanco Animal Health Gmbh | Long-term prevention and/or treatment of a disease by slo-1 inhibitors |
WO2025027117A1 (en) | 2023-08-02 | 2025-02-06 | Intervet International B.V. | Carboxamide-4-quinoline compounds with anthelmintic activity |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4440193A1 (de) * | 1994-11-10 | 1996-05-15 | Bayer Ag | Verwendung von Dioxomorpholinen zur Bekämpfung von Endoparasiten, neue Dioxomorpholine und Verfahren zur ihrer Herstellung |
EP0925300A1 (en) | 1996-02-15 | 1999-06-30 | Cambridge Neuroscience, Inc. | Pharmaceutically active compounds and methods of use |
AU740745B2 (en) * | 1997-12-11 | 2001-11-15 | Biochem Pharma Inc. | Antiviral compounds |
EP1154997A4 (en) * | 1999-01-26 | 2002-11-04 | Dana Farber Cancer Inst Inc | PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE |
TW200300140A (en) * | 2001-11-14 | 2003-05-16 | Novartis Ag | Organic compounds |
AU2008248751A1 (en) * | 2007-05-02 | 2008-11-13 | Novartis Ag | Heterocyclic compounds and their use as pesticides |
WO2010027002A1 (ja) | 2008-09-05 | 2010-03-11 | 塩野義製薬株式会社 | Pi3k阻害活性を有する縮環モルホリン誘導体 |
KR20140038527A (ko) * | 2011-06-20 | 2014-03-28 | 이 아이 듀폰 디 네모아 앤드 캄파니 | 연충 감염을 치료하기 위한 복소환식 화합물 |
US9221835B2 (en) * | 2012-09-07 | 2015-12-29 | Zoetis Services Llc | Spirocyclic derivatives as antiparasitic agents |
JP6298472B2 (ja) * | 2012-11-19 | 2018-03-20 | ノバルティス アーゲー | 寄生虫病の処置のための化合物および組成物 |
UY35940A (es) * | 2014-01-03 | 2015-07-31 | Bayer Cropscience Ag | Nuevas pirazolil-heteroarilamidas como agentes plaguicidas |
CN106470683A (zh) * | 2014-07-11 | 2017-03-01 | 英特维特国际股份有限公司 | 针对犬心丝虫的抗蠕虫剂的用途 |
RU2769448C2 (ru) | 2016-04-15 | 2022-03-31 | Байер Энимэл Хельс ГмбХ | Новые пиразолпиримидиновые производные |
EP3538512B1 (en) | 2016-11-11 | 2021-06-16 | Bayer Animal Health GmbH | New anthelmintic quinoline-3-carboxamide derivatives |
EP3585791B1 (en) | 2017-04-27 | 2024-10-16 | Elanco Animal Health GmbH | New bicyclic pyrazole derivatives |
EP3615527B1 (en) | 2017-06-30 | 2024-03-06 | Elanco Animal Health GmbH | New azaquinoline derivatives |
MX2020001403A (es) | 2017-08-04 | 2020-03-09 | Bayer Animal Health Gmbh | Nuevos derivados de quinolina. |
ES3019808T3 (en) * | 2018-12-18 | 2025-05-21 | Elanco Tiergesundheit Ag | Bicyclic derivatives |
CA3122105A1 (en) * | 2018-12-18 | 2020-06-25 | Elanco Tiergesundheit Ag | Bicyclic derivatives |
US20240059680A1 (en) | 2020-11-18 | 2024-02-22 | Elanco Tiergesundheit Ag | N-(2,3-dihydro-1,4-benzoxazin-4-yl)-3-isopropyl-7-(2,3,5-trifluorophenyl)benzo-thiophene-2-carboxamide derivatives and similar compounds for the treatment of heartworm infections |
TW202237600A (zh) | 2020-12-04 | 2022-10-01 | 瑞士商禮藍動物保健股份有限公司 | 雙環衍生物 |
-
2020
- 2020-06-05 WO PCT/US2020/036322 patent/WO2020247747A1/en active Application Filing
- 2020-06-05 US US16/894,017 patent/US20200385398A1/en not_active Abandoned
- 2020-06-05 CA CA3141905A patent/CA3141905A1/en active Pending
- 2020-06-05 BR BR112021024726A patent/BR112021024726A2/pt unknown
- 2020-06-05 AU AU2020289459A patent/AU2020289459A1/en active Pending
- 2020-06-05 EP EP20750396.2A patent/EP3980414A1/en active Pending
- 2020-06-05 JP JP2021571965A patent/JP7693558B2/ja active Active
- 2020-06-05 CN CN202080055095.0A patent/CN114206860B/zh active Active
- 2020-06-05 US US17/616,436 patent/US20220242857A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
WO2020247747A1 (en) | 2020-12-10 |
JP2022535110A (ja) | 2022-08-04 |
CN114206860A (zh) | 2022-03-18 |
US20220242857A1 (en) | 2022-08-04 |
JP7693558B2 (ja) | 2025-06-17 |
US20200385398A1 (en) | 2020-12-10 |
EP3980414A1 (en) | 2022-04-13 |
CN114206860B (zh) | 2025-02-18 |
CA3141905A1 (en) | 2020-12-10 |
BR112021024726A2 (pt) | 2022-01-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU2019401442B2 (en) | Bicyclic derivatives | |
AU2019405444B2 (en) | Bicyclic derivatives | |
AU2020289459A1 (en) | Bicyclic derivatives for treating endoparasites | |
AU2021390173A9 (en) | Bicyclic derivatives | |
JP6534675B2 (ja) | mIDH1阻害剤としてのベンズイミダゾール−2−アミン | |
CN107312009B (zh) | 喹啉类化合物、其制备方法、中间体、药物组合物和应用 | |
WO2015134171A1 (en) | Heteroarylamide inhibitors of tbk1 | |
RU2794895C2 (ru) | Бициклические производные | |
CN116888124A (zh) | 二环衍生物 | |
CN112480119B (zh) | 吡咯并吡唑类衍生物、其制备方法及其在医药上的应用 |