ATE437841T1 - Verfahren zur herstellung von mikrostrukturen mit mehreren mikroelementen mit durchgangslöchern - Google Patents
Verfahren zur herstellung von mikrostrukturen mit mehreren mikroelementen mit durchgangslöchernInfo
- Publication number
- ATE437841T1 ATE437841T1 AT04714107T AT04714107T ATE437841T1 AT E437841 T1 ATE437841 T1 AT E437841T1 AT 04714107 T AT04714107 T AT 04714107T AT 04714107 T AT04714107 T AT 04714107T AT E437841 T1 ATE437841 T1 AT E437841T1
- Authority
- AT
- Austria
- Prior art keywords
- holes
- microelements
- embossing
- producing microstructures
- pressing step
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B81—MICROSTRUCTURAL TECHNOLOGY
- B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
- B81C1/00—Manufacture or treatment of devices or systems in or on a substrate
- B81C1/00015—Manufacture or treatment of devices or systems in or on a substrate for manufacturing microsystems
- B81C1/00023—Manufacture or treatment of devices or systems in or on a substrate for manufacturing microsystems without movable or flexible elements
- B81C1/00111—Tips, pillars, i.e. raised structures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B26—HAND CUTTING TOOLS; CUTTING; SEVERING
- B26F—PERFORATING; PUNCHING; CUTTING-OUT; STAMPING-OUT; SEVERING BY MEANS OTHER THAN CUTTING
- B26F1/00—Perforating; Punching; Cutting-out; Stamping-out; Apparatus therefor
- B26F1/24—Perforating by needles or pins
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B26—HAND CUTTING TOOLS; CUTTING; SEVERING
- B26F—PERFORATING; PUNCHING; CUTTING-OUT; STAMPING-OUT; SEVERING BY MEANS OTHER THAN CUTTING
- B26F1/00—Perforating; Punching; Cutting-out; Stamping-out; Apparatus therefor
- B26F1/26—Perforating by non-mechanical means, e.g. by fluid jet
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0053—Methods for producing microneedles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B81—MICROSTRUCTURAL TECHNOLOGY
- B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
- B81B2201/00—Specific applications of microelectromechanical systems
- B81B2201/05—Microfluidics
- B81B2201/055—Microneedles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B81—MICROSTRUCTURAL TECHNOLOGY
- B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
- B81C2201/00—Manufacture or treatment of microstructural devices or systems
- B81C2201/03—Processes for manufacturing substrate-free structures
- B81C2201/034—Moulding
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B81—MICROSTRUCTURAL TECHNOLOGY
- B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
- B81C2201/00—Manufacture or treatment of microstructural devices or systems
- B81C2201/03—Processes for manufacturing substrate-free structures
- B81C2201/036—Hot embossing
Landscapes
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Forests & Forestry (AREA)
- Manufacturing & Machinery (AREA)
- Mechanical Engineering (AREA)
- Medical Informatics (AREA)
- Animal Behavior & Ethology (AREA)
- Analytical Chemistry (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Microelectronics & Electronic Packaging (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Micromachines (AREA)
- Shaping Of Tube Ends By Bending Or Straightening (AREA)
- Laminated Bodies (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/373,251 US7578954B2 (en) | 2003-02-24 | 2003-02-24 | Method for manufacturing microstructures having multiple microelements with through-holes |
PCT/US2004/005382 WO2004076339A2 (en) | 2003-02-24 | 2004-02-24 | Method for manufacturing microstructures having multiple microelements with through-holes |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE437841T1 true ATE437841T1 (de) | 2009-08-15 |
Family
ID=32868669
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT04714107T ATE437841T1 (de) | 2003-02-24 | 2004-02-24 | Verfahren zur herstellung von mikrostrukturen mit mehreren mikroelementen mit durchgangslöchern |
Country Status (8)
Country | Link |
---|---|
US (1) | US7578954B2 (de) |
EP (1) | EP1599410B1 (de) |
JP (1) | JP4787738B2 (de) |
AT (1) | ATE437841T1 (de) |
AU (2) | AU2004215417A1 (de) |
CA (1) | CA2517988C (de) |
DE (1) | DE602004022260D1 (de) |
WO (1) | WO2004076339A2 (de) |
Families Citing this family (86)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6821281B2 (en) * | 2000-10-16 | 2004-11-23 | The Procter & Gamble Company | Microstructures for treating and conditioning skin |
US7828827B2 (en) | 2002-05-24 | 2010-11-09 | Corium International, Inc. | Method of exfoliation of skin using closely-packed microstructures |
US20070053812A1 (en) * | 2003-03-07 | 2007-03-08 | Tosoh Corporation | Minute flow path structure body and die |
US7572405B2 (en) * | 2003-06-02 | 2009-08-11 | Corium International Inc. | Method for manufacturing microstructures having hollow microelements using fluidic jets during a molding operation |
CN100540086C (zh) * | 2004-03-12 | 2009-09-16 | 新加坡科技研究局 | 用来制造侧开口微型针的方法及模具 |
JP5085317B2 (ja) | 2004-03-24 | 2012-11-28 | コリウム インターナショナル, インコーポレイテッド | 経皮送達デバイス |
US8690865B2 (en) * | 2004-05-28 | 2014-04-08 | Georgia Tech Research Corporation | Methods and devices for thermal treatment |
SE0402100D0 (sv) * | 2004-08-30 | 2004-08-30 | Bonsens Ab | Molded micro-needles |
ES2645676T3 (es) | 2004-10-19 | 2017-12-07 | Meagan Medical, Inc. | Medios para la estimulación eléctrica de receptores sensitivos cutáneos |
US8417352B2 (en) * | 2004-10-19 | 2013-04-09 | Meagan Medical, Inc. | System and method for stimulating sensory nerves |
SG159515A1 (en) * | 2005-02-17 | 2010-03-30 | Agency Science Tech & Res | Method of low temperature imprinting process with high pattern transfer yield |
EP1869414A4 (de) * | 2005-03-29 | 2010-07-28 | Arkal Medical Inc | Vorrichtungen, systeme, verfahren und werkzeuge zur kontinuierlichen glucoseüberwachung |
SG128494A1 (en) * | 2005-06-09 | 2007-01-30 | Nanyang Polytechnic | Polymeric microneedle array and apparatus and method for manufacturing of the same |
US20080306325A1 (en) | 2006-10-02 | 2008-12-11 | Emkinetics | Method and apparatus for magnetic induction therapy |
US9610459B2 (en) | 2009-07-24 | 2017-04-04 | Emkinetics, Inc. | Cooling systems and methods for conductive coils |
US9339641B2 (en) | 2006-01-17 | 2016-05-17 | Emkinetics, Inc. | Method and apparatus for transdermal stimulation over the palmar and plantar surfaces |
US20070202186A1 (en) | 2006-02-22 | 2007-08-30 | Iscience Interventional Corporation | Apparatus and formulations for suprachoroidal drug delivery |
US8250729B2 (en) * | 2006-07-12 | 2012-08-28 | University Of Utah Research Foundation | 3D fabrication of needle tip geometry and knife blade |
JP4396776B2 (ja) * | 2006-07-27 | 2010-01-13 | 凸版印刷株式会社 | マイクロニードルの製造方法 |
JPWO2008020632A1 (ja) * | 2006-08-18 | 2010-01-07 | 凸版印刷株式会社 | マイクロニードル及びマイクロニードルパッチ |
EP2073888A4 (de) * | 2006-08-28 | 2011-01-19 | Agency Science Tech & Res | Mikronadeln und verfahren zur herstellung von mikronadeln |
US20080058726A1 (en) * | 2006-08-30 | 2008-03-06 | Arvind Jina | Methods and Apparatus Incorporating a Surface Penetration Device |
US11224742B2 (en) | 2006-10-02 | 2022-01-18 | Emkinetics, Inc. | Methods and devices for performing electrical stimulation to treat various conditions |
US9005102B2 (en) | 2006-10-02 | 2015-04-14 | Emkinetics, Inc. | Method and apparatus for electrical stimulation therapy |
US10786669B2 (en) | 2006-10-02 | 2020-09-29 | Emkinetics, Inc. | Method and apparatus for transdermal stimulation over the palmar and plantar surfaces |
EP2121111B1 (de) | 2007-01-22 | 2018-03-14 | Corium International, Inc. | Applikator für mikronadelanordnung |
CA2686093C (en) | 2007-04-16 | 2018-05-08 | Corium International, Inc. | Solvent-cast microneedle arrays containing active |
US8143719B2 (en) * | 2007-06-07 | 2012-03-27 | United Test And Assembly Center Ltd. | Vented die and package |
US20080312518A1 (en) * | 2007-06-14 | 2008-12-18 | Arkal Medical, Inc | On-demand analyte monitor and method of use |
WO2009048607A1 (en) | 2007-10-10 | 2009-04-16 | Corium International, Inc. | Vaccine delivery via microneedle arrays |
US20100256569A1 (en) * | 2007-10-27 | 2010-10-07 | Debiotech S.A. | Medical injection device with microneedles |
CN102123680B (zh) * | 2008-07-29 | 2014-04-16 | 盛势达瑞士有限公司 | 齿间清洁器及其制造方法 |
CN102458559B (zh) | 2009-04-10 | 2014-06-04 | 3M创新有限公司 | 制造中空微针阵列的方法以及由其制得的制品和用途 |
FI20095433A0 (fi) | 2009-04-20 | 2009-04-20 | Valtion Teknillinen | Mikroneula |
JP5820805B2 (ja) * | 2009-04-24 | 2015-11-24 | コリウム インターナショナル, インコーポレイテッド | マイクロプロジェクションのアレイの製造のためのプロセス |
EP2275164A1 (de) * | 2009-07-15 | 2011-01-19 | Debiotech S.A. | Mikronadeln mit mehreren Kanälen |
US8834423B2 (en) | 2009-10-23 | 2014-09-16 | University of Pittsburgh—of the Commonwealth System of Higher Education | Dissolvable microneedle arrays for transdermal delivery to human skin |
JP2013508119A (ja) | 2009-10-26 | 2013-03-07 | エムキネティクス, インコーポレイテッド | 神経、筋肉および身体組織の電磁刺激のための方法および装置 |
US20110144591A1 (en) * | 2009-12-11 | 2011-06-16 | Ross Russell F | Transdermal Delivery Device |
WO2011100576A1 (en) * | 2010-02-11 | 2011-08-18 | Yung-Chieh Tan | Systems for and methods of manufacturing micro-structures |
US9358158B2 (en) * | 2010-03-16 | 2016-06-07 | Kci Licensing, Inc. | Patterned neo-epithelialization dressings, systems, and methods |
MX2012012567A (es) | 2010-04-28 | 2012-11-21 | Kimberly Clark Co | Metodo para aumentar la permeabilidad de una barrera epitelial. |
KR101799612B1 (ko) | 2010-04-28 | 2017-11-20 | 킴벌리-클라크 월드와이드, 인크. | 류마티스 관절염 의약의 전달 기구 |
RU2570280C2 (ru) | 2010-04-28 | 2015-12-10 | Кимберли-Кларк Ворлдвайд, Инк. | Композитная матрица микроигл, содержащая на поверхности наноструктуры |
RU2585138C2 (ru) | 2010-04-28 | 2016-05-27 | Кимберли-Кларк Ворлдвайд, Инк. | Медицинские устройства для доставки кирнк |
WO2011140274A2 (en) | 2010-05-04 | 2011-11-10 | Corium International, Inc. | Method and device for transdermal delivery of parathyroid hormone using a microprojection array |
US8588884B2 (en) | 2010-05-28 | 2013-11-19 | Emkinetics, Inc. | Microneedle electrode |
WO2012051575A2 (en) | 2010-10-15 | 2012-04-19 | Iscience Interventional Corporation | Device for ocular access |
JP2014517777A (ja) * | 2011-02-24 | 2014-07-24 | ホーワキ,リミテッド ライアビリティー カンパニー | 微細構造を有する部品を押出し加工するシステムおよび方法 |
US8696637B2 (en) | 2011-02-28 | 2014-04-15 | Kimberly-Clark Worldwide | Transdermal patch containing microneedles |
US8636696B2 (en) | 2011-06-10 | 2014-01-28 | Kimberly-Clark Worldwide, Inc. | Transdermal device containing microneedles |
US20170246439A9 (en) | 2011-10-27 | 2017-08-31 | Kimberly-Clark Worldwide, Inc. | Increased Bioavailability of Transdermally Delivered Agents |
HUE058275T2 (hu) | 2011-10-27 | 2022-07-28 | Sorrento Therapeutics Inc | Beültethetõ eszközök biológiailag hatásos szerek tobábbítására |
CA2853214C (en) | 2011-10-27 | 2020-03-24 | Kimberly-Clark Worldwide, Inc. | Transdermal delivery of high viscosity bioactive agents |
DE102011089752A1 (de) * | 2011-12-23 | 2013-06-27 | Robert Bosch Gmbh | Verfahren zur Herstellung von Silizium-Mikronadelarrays mit Löchern und Mikronadelarray |
AU2013256348B2 (en) | 2012-05-01 | 2017-06-15 | Carnegie Mellon University | Tip-loaded microneedle arrays for transdermal insertion |
US20150209180A1 (en) * | 2012-08-27 | 2015-07-30 | Clearside Biomedical, Inc. | Apparatus and Methods for Drug Delivery Using Microneedles |
CN105073178B (zh) | 2012-12-21 | 2019-07-30 | 考里安国际公司 | 用于治疗剂递送的微阵列及其使用方法 |
US9962546B2 (en) | 2013-02-21 | 2018-05-08 | Meagan Medical, Inc. | Cutaneous field stimulation with disposable and rechargeable components |
KR102332671B1 (ko) | 2013-03-12 | 2021-11-30 | 코리움, 인크. | 미세돌기 어플리케이터 |
EP2968118B1 (de) | 2013-03-15 | 2022-02-09 | Corium, Inc. | Mikroarray zur freisetzung therapeutischer wirkstoffe und verfahren zur verwendung |
CA2903763C (en) | 2013-03-15 | 2021-11-16 | Corium International, Inc. | Microarray with polymer-free microstructures, methods of making, and methods of use |
WO2014150285A2 (en) | 2013-03-15 | 2014-09-25 | Corium International, Inc. | Multiple impact microprojection applicators and methods of use |
JP2016512754A (ja) | 2013-03-15 | 2016-05-09 | コリウム インターナショナル, インコーポレイテッド | 治療剤の送達のためのマイクロアレイ、使用方法および製造方法 |
EP4378444A3 (de) | 2013-05-03 | 2024-07-03 | Clearside Biomedical, Inc. | Vorrichtung und verfahren zur augeninjektion |
CN106163607B (zh) * | 2014-04-30 | 2018-03-27 | 金伯利-克拉克环球有限公司 | 披盖的微针阵列 |
WO2016036866A1 (en) | 2014-09-04 | 2016-03-10 | Corium International, Inc. | Microstructure array, methods of making, and methods of use |
JP5967595B2 (ja) * | 2014-09-08 | 2016-08-10 | 株式会社かいわ | 穿刺器具 |
JP6586329B2 (ja) * | 2015-08-17 | 2019-10-02 | 花王株式会社 | 微細中空突起物の製造方法 |
CN107073249B (zh) * | 2014-10-17 | 2021-01-01 | 花王株式会社 | 微细中空突起物的制造方法 |
WO2016060020A1 (ja) * | 2014-10-17 | 2016-04-21 | 花王株式会社 | 微細中空突起物の製造方法 |
US10441768B2 (en) | 2015-03-18 | 2019-10-15 | University of Pittsburgh—of the Commonwealth System of Higher Education | Bioactive components conjugated to substrates of microneedle arrays |
US10619307B2 (en) * | 2015-06-12 | 2020-04-14 | The C.W. Zumbiel Company | Support needles for laser cutting of paperboard |
US10857093B2 (en) | 2015-06-29 | 2020-12-08 | Corium, Inc. | Microarray for delivery of therapeutic agent, methods of use, and methods of making |
WO2017066768A1 (en) | 2015-10-16 | 2017-04-20 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Mullti-component biio-active drug delivery and controlled release to the skin by microneedle array devices |
WO2017120322A1 (en) | 2016-01-05 | 2017-07-13 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Skin microenvironment targeted delivery for promoting immune and other responses |
JP2017131397A (ja) | 2016-01-27 | 2017-08-03 | 花王株式会社 | 微細中空突起具の製造方法 |
WO2017192565A1 (en) | 2016-05-02 | 2017-11-09 | Clearside Biomedical, Inc. | Systems and methods for ocular drug delivery |
CN110177527B (zh) | 2016-08-12 | 2022-02-01 | 科尼尔赛德生物医学公司 | 用于调节药剂递送用针的插入深度的装置和方法 |
CN110494126A (zh) * | 2016-12-22 | 2019-11-22 | 俄亥俄州国家创新基金会 | 用于基于纳米通道的货物递送的贯穿微结构 |
WO2019058328A1 (en) * | 2017-09-22 | 2019-03-28 | Sabic Global Technologies B.V. | MICRO NEEDLE NETWORKS |
WO2020028230A2 (en) * | 2018-07-29 | 2020-02-06 | Bvw Holding Ag | Patterned surfaces with suction |
USD919327S1 (en) * | 2018-09-19 | 2021-05-18 | Damian Hagglund | Massage mat |
IT201800020530A1 (it) * | 2018-12-27 | 2020-06-27 | Fameccanica Data Spa | Apparato e procedimento di deformazione di un telo |
WO2020232394A1 (en) | 2019-05-16 | 2020-11-19 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Microneedle arrays with undercut features for cutaneous and non-cutaneous drug delivery |
CN111002600B (zh) * | 2019-12-18 | 2021-06-25 | 香港中文大学(深圳) | 悬浮封闭孔阵列结构及其制备方法、应用以及制备装置 |
Family Cites Families (140)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3874207A (en) * | 1957-10-22 | 1975-04-01 | Jerome H Lemelson | Extrusion apparatus |
US3964482A (en) * | 1971-05-17 | 1976-06-22 | Alza Corporation | Drug delivery device |
US3957943A (en) * | 1971-11-09 | 1976-05-18 | Nippon Gakki Seizo Kabushiki Kaisha | Method for producing glass fiber reinforced plastic molded articles with decorative patterns and article produced thereby |
FR2232331B1 (de) | 1973-06-06 | 1978-03-24 | Guerin A Ets | |
US4005029A (en) * | 1973-08-01 | 1977-01-25 | The Procter & Gamble Company | Laundering adjunct |
US4040162A (en) * | 1973-09-17 | 1977-08-09 | Aisin Seiki Kabushiki Kaisha | Method of producing composite extruded aluminum products from aluminum swarf |
LU69549A1 (de) * | 1974-03-04 | 1976-02-04 | ||
US4143112A (en) * | 1974-05-30 | 1979-03-06 | Johnson & Johnson | Method for making probe covers for electronic thermometers |
AT347283B (de) | 1975-03-07 | 1978-12-27 | Collo Gmbh | Schaumstoffkoerper fuer reinigungs-, scheuer- und/oder polierzwecke u. dgl. |
US4180232A (en) | 1977-01-13 | 1979-12-25 | Hardigg James S | Truss panel mold |
US4381963A (en) * | 1980-07-30 | 1983-05-03 | The University Of Rochester | Micro fabrication molding process |
US4585991A (en) * | 1982-06-03 | 1986-04-29 | Texas Instruments Incorporated | Solid state multiprobe testing apparatus |
US4708716A (en) | 1983-08-18 | 1987-11-24 | Drug Delivery Systems Inc. | Transdermal drug applicator |
US5591123A (en) * | 1983-08-18 | 1997-01-07 | Drug Delivery Systems Inc. | Programmable control mounting system for transdermal drug applicator |
US5135477A (en) * | 1984-10-29 | 1992-08-04 | Medtronic, Inc. | Iontophoretic drug delivery |
US4671757A (en) * | 1985-06-06 | 1987-06-09 | Beta Raven, Inc. | Microwave heating in a pellet mill |
US4784737A (en) | 1986-04-18 | 1988-11-15 | The United States Department Of Energy | Electromicroinjection of particles into living cells |
US4837049A (en) * | 1986-06-17 | 1989-06-06 | Alfred E. Mann Foundation For Scientific Research | Method of making an electrode array |
JPS63182136A (ja) * | 1987-01-23 | 1988-07-27 | Tokai Rubber Ind Ltd | 繊維補強ゴムホ−スの製造方法 |
US4842794A (en) * | 1987-07-30 | 1989-06-27 | Applied Extrusion Technologies, Inc. | Method of making apertured films and net like fabrics |
US5362307A (en) * | 1989-01-24 | 1994-11-08 | The Regents Of The University Of California | Method for the iontophoretic non-invasive-determination of the in vivo concentration level of an inorganic or organic substance |
US5198192A (en) * | 1988-05-18 | 1993-03-30 | Inax Corporation | Apparatus for detecting ingredient in urine, a toilet stool equipped with a urine detecting device and a room for urine detecting facility |
US5134079A (en) * | 1989-03-27 | 1992-07-28 | International Technidyne Corp. | Fluid sample collection and delivery system and methods particularly adapted for body fluid sampling |
US5531675A (en) * | 1989-05-10 | 1996-07-02 | Yoo; Tae W. | Micro-acupuncture needle for a finger of a hand |
EP0429842B1 (de) | 1989-10-27 | 1996-08-28 | Korea Research Institute Of Chemical Technology | Vorrichtung zur transdermalen Applikation von Protein- oder Peptid-Medikamenten |
US5215088A (en) * | 1989-11-07 | 1993-06-01 | The University Of Utah | Three-dimensional electrode device |
US5697901A (en) | 1989-12-14 | 1997-12-16 | Elof Eriksson | Gene delivery by microneedle injection |
US5380479A (en) * | 1989-12-26 | 1995-01-10 | The Dow Chemical Company | Method and apparatus for producing multilayer plastic articles |
US5244711A (en) * | 1990-03-12 | 1993-09-14 | Mcneil-Ppc, Inc. | Apertured non-woven fabric |
US5162043A (en) | 1990-03-30 | 1992-11-10 | Alza Corporation | Iontophoretic delivery device |
TW279133B (de) | 1990-12-13 | 1996-06-21 | Elan Med Tech | |
US5156591A (en) | 1990-12-13 | 1992-10-20 | S. I. Scientific Innovations Ltd. | Skin electrode construction and transdermal drug delivery device utilizing same |
US5279544A (en) * | 1990-12-13 | 1994-01-18 | Sil Medics Ltd. | Transdermal or interdermal drug delivery devices |
US5527288A (en) * | 1990-12-13 | 1996-06-18 | Elan Medical Technologies Limited | Intradermal drug delivery device and method for intradermal delivery of drugs |
US5158073A (en) | 1990-12-18 | 1992-10-27 | Bukowski Voytek Z | Acupressure foot massage mat |
US5312456A (en) | 1991-01-31 | 1994-05-17 | Carnegie Mellon University | Micromechanical barb and method for making the same |
TW273531B (en) * | 1991-08-14 | 1996-04-01 | Chicopee | Textile-like apertured plastic films |
JPH05162076A (ja) * | 1991-12-13 | 1993-06-29 | Sony Corp | 遊離微粒子噴射加工装置 |
US5256360A (en) | 1992-03-25 | 1993-10-26 | Panasonic Technologies, Inc. | Method of manufacturing a precision micro-filter |
NL9202249A (nl) * | 1992-04-02 | 1993-11-01 | Stork Rms Bv | Verdovingsinrichting voor slachtvee. |
US5318557A (en) * | 1992-07-13 | 1994-06-07 | Elan Medical Technologies Limited | Medication administering device |
IE930532A1 (en) * | 1993-07-19 | 1995-01-25 | Elan Med Tech | Liquid material dispenser and valve |
US5250067A (en) | 1992-11-30 | 1993-10-05 | Ala Gelfer | Body treatment pad having a multiple number of sharpened skin-penetration protuberances |
US5383512A (en) * | 1993-01-27 | 1995-01-24 | Midwest Research Institute | Method for fabricating a substrate having spaced apart microcapillaries thereon |
US5728089A (en) * | 1993-06-04 | 1998-03-17 | The Regents Of The University Of California | Microfabricated structure to be used in surgery |
US5320600A (en) * | 1993-06-14 | 1994-06-14 | Lambert Wm S | Plural content container for simultaneous ejection |
CA2132277C (en) | 1993-10-22 | 2005-05-10 | Giorgio Cirelli | Injection device |
US5536263A (en) * | 1994-03-30 | 1996-07-16 | Lectec Corporation | Non-occulusive adhesive patch for applying medication to the skin |
US5533985A (en) * | 1994-04-20 | 1996-07-09 | Wang; James C. | Tubing |
US5611806A (en) * | 1994-05-23 | 1997-03-18 | Samsung Electro-Mechanics Co., Ltd. | Skin perforating device for transdermal medication |
KR0134151B1 (ko) | 1994-05-23 | 1998-04-14 | 이형도 | 인슐린 패치 |
CA2149836C (en) | 1994-05-23 | 1999-07-06 | Sang Bae Choi | Perforating device for dermal administration |
US5512219A (en) * | 1994-06-03 | 1996-04-30 | Reflexite Corporation | Method of casting a microstructure sheet having an array of prism elements using a reusable polycarbonate mold |
US5591139A (en) * | 1994-06-06 | 1997-01-07 | The Regents Of The University Of California | IC-processed microneedles |
US5487726A (en) * | 1994-06-16 | 1996-01-30 | Ryder International Corporation | Vaccine applicator system |
US5771890A (en) * | 1994-06-24 | 1998-06-30 | Cygnus, Inc. | Device and method for sampling of substances using alternating polarity |
US5498235A (en) * | 1994-09-30 | 1996-03-12 | Becton Dickinson And Company | Iontophoresis assembly including patch/controller attachment |
US5773042A (en) * | 1994-10-14 | 1998-06-30 | Kabushiki Kaisha Kobe Seiko Sho | Injection molding unit for long fiber-reinforced thermoplastic resin |
US5551953A (en) * | 1994-10-31 | 1996-09-03 | Alza Corporation | Electrotransport system with remote telemetry link |
IE72524B1 (en) | 1994-11-04 | 1997-04-23 | Elan Med Tech | Analyte-controlled liquid delivery device and analyte monitor |
US6120488A (en) | 1994-11-28 | 2000-09-19 | The Procter & Gamble Company | Absorbent articles having cuffs and topsheet with skin care composition(s) disposed thereon |
US5641423A (en) * | 1995-03-23 | 1997-06-24 | Stericycle, Inc. | Radio frequency heating apparatus for rendering medical materials |
WO1996037155A1 (en) * | 1995-05-22 | 1996-11-28 | Silicon Microdevices, Inc. | Micromechanical device and method for enhancing delivery of compounds through the skin |
DE19525607A1 (de) | 1995-07-14 | 1997-01-16 | Boehringer Ingelheim Kg | Transcorneales Arzneimittelfreigabesystem |
IE77523B1 (en) | 1995-09-11 | 1997-12-17 | Elan Med Tech | Medicament delivery device |
US5735273A (en) * | 1995-09-12 | 1998-04-07 | Cygnus, Inc. | Chemical signal-impermeable mask |
US5645977A (en) * | 1995-09-22 | 1997-07-08 | Industrial Technology Research Institute | Method of making molds for manufacturing multiple-lead microstructures |
US5658515A (en) * | 1995-09-25 | 1997-08-19 | Lee; Abraham P. | Polymer micromold and fabrication process |
JP3430771B2 (ja) * | 1996-02-05 | 2003-07-28 | 株式会社デンソー | 半導体力学量センサの製造方法 |
JPH09215755A (ja) | 1996-02-09 | 1997-08-19 | Poritoronikusu:Kk | 皮接治療具 |
US5948488A (en) | 1996-04-30 | 1999-09-07 | 3M Innovative Properties Company | Glittering cube-corner article |
AU3399197A (en) * | 1996-06-18 | 1998-01-07 | Alza Corporation | Device for enhancing transdermal agent delivery or sampling |
ES2200187T3 (es) * | 1996-07-03 | 2004-03-01 | Altea Therapeutics Corporation | Microporacion mecanica multiple de la piel o de la mucosa. |
WO1998011937A1 (en) | 1996-09-17 | 1998-03-26 | Deka Products Limited Partnership | System for delivery of drugs by transport |
US5873849A (en) * | 1997-04-24 | 1999-02-23 | Ichor Medical Systems, Inc. | Electrodes and electrode arrays for generating electroporation inducing electrical fields |
US6241701B1 (en) * | 1997-08-01 | 2001-06-05 | Genetronics, Inc. | Apparatus for electroporation mediated delivery of drugs and genes |
US6055453A (en) * | 1997-08-01 | 2000-04-25 | Genetronics, Inc. | Apparatus for addressing needle array electrodes for electroporation therapy |
US6216034B1 (en) * | 1997-08-01 | 2001-04-10 | Genetronics, Inc. | Method of programming an array of needle electrodes for electroporation therapy of tissue |
US6047208A (en) * | 1997-08-27 | 2000-04-04 | Becton, Dickinson And Company | Iontophoretic controller |
JPH1177787A (ja) * | 1997-09-02 | 1999-03-23 | Daikin Ind Ltd | 高導電性ポリテトラフルオロエチレンシートの製造方法及び高導電性ポリテトラフルオロエチレン幅広長尺状シート |
US5938684A (en) * | 1997-12-09 | 1999-08-17 | Sierra Self Healing Products, Inc. | Accupressure device for therapeutic relief |
WO1999029364A1 (en) * | 1997-12-11 | 1999-06-17 | Alza Corporation | Device for enhancing transdermal agent flux |
DE69831268T2 (de) * | 1997-12-11 | 2006-03-09 | Alza Corp., Palo Alto | Vorrichtung zur erhöhung des transdermalen wirkstoffeflusses |
AU757230B2 (en) | 1997-12-11 | 2003-02-06 | Alza Corporation | Device for enhancing transdermal agent flux |
US6135990A (en) | 1997-12-17 | 2000-10-24 | University Of South Florida | Electroporation device and method |
US6778853B1 (en) * | 1997-12-17 | 2004-08-17 | University Of South Florida | Electroporation device |
US6024553A (en) * | 1997-12-22 | 2000-02-15 | Mcneil-Ppc, Inc. | Apparatus for supporting a starting web during formation of the apertured web |
JPH11230707A (ja) * | 1998-02-10 | 1999-08-27 | Mitsutoyo Corp | マイクロセンサデバイスの製造方法 |
US6106751A (en) * | 1998-03-18 | 2000-08-22 | The Regents Of The University Of California | Method for fabricating needles via conformal deposition in two-piece molds |
US6091975A (en) * | 1998-04-01 | 2000-07-18 | Alza Corporation | Minimally invasive detecting device |
US6503231B1 (en) * | 1998-06-10 | 2003-01-07 | Georgia Tech Research Corporation | Microneedle device for transport of molecules across tissue |
GB9815819D0 (en) * | 1998-07-22 | 1998-09-16 | Secr Defence | Transferring materials into cells and a microneedle array |
WO2000012173A1 (en) * | 1998-08-31 | 2000-03-09 | Johnson & Johnson Consumer Companies, Inc. | Electrotransport device comprising blades |
US6036659A (en) * | 1998-10-09 | 2000-03-14 | Flexsite Diagnostics, Inc. | Collection device for biological samples and methods of use |
US6038465A (en) * | 1998-10-13 | 2000-03-14 | Agilent Technologies, Inc. | Telemedicine patient platform |
US6611706B2 (en) * | 1998-11-09 | 2003-08-26 | Transpharma Ltd. | Monopolar and bipolar current application for transdermal drug delivery and analyte extraction |
JP4214584B2 (ja) * | 1998-11-27 | 2009-01-28 | 株式会社デンソー | 半導体力学量センサおよびその製造方法 |
US6689103B1 (en) * | 1999-05-07 | 2004-02-10 | Scimed Life System, Inc. | Injection array apparatus and method |
US6743211B1 (en) * | 1999-11-23 | 2004-06-01 | Georgia Tech Research Corporation | Devices and methods for enhanced microneedle penetration of biological barriers |
US6611707B1 (en) * | 1999-06-04 | 2003-08-26 | Georgia Tech Research Corporation | Microneedle drug delivery device |
US6312612B1 (en) | 1999-06-09 | 2001-11-06 | The Procter & Gamble Company | Apparatus and method for manufacturing an intracutaneous microneedle array |
US6256533B1 (en) * | 1999-06-09 | 2001-07-03 | The Procter & Gamble Company | Apparatus and method for using an intracutaneous microneedle array |
US6379324B1 (en) * | 1999-06-09 | 2002-04-30 | The Procter & Gamble Company | Intracutaneous microneedle array apparatus |
US6461716B1 (en) | 1999-06-24 | 2002-10-08 | The Procter & Gamble Company | Apertured webs having permanent hydrophilicity and absorbent articles using such webs |
JP3654059B2 (ja) * | 1999-06-25 | 2005-06-02 | 松下電工株式会社 | 赤外線センサーの製造方法 |
JP3387897B2 (ja) * | 1999-08-30 | 2003-03-17 | キヤノン株式会社 | 構造体の製造方法、並びに該製造方法により製造される構造体及び該構造体を用いた構造体デバイス |
US6355054B1 (en) * | 1999-11-05 | 2002-03-12 | Ceramoptec Industries, Inc. | Laser system for improved transbarrier therapeutic radiation delivery |
JP2003514677A (ja) * | 1999-11-17 | 2003-04-22 | ザ・リージェンツ・オブ・ザ・ユニバーシティー・オブ・カリフォルニア | ナノメートルスケールの細孔のある膜を形成するための装置及び方法 |
US6511463B1 (en) * | 1999-11-18 | 2003-01-28 | Jds Uniphase Corporation | Methods of fabricating microneedle arrays using sacrificial molds |
WO2001041863A1 (en) * | 1999-12-10 | 2001-06-14 | Alza Corporation | Device and method for enhancing microprotrusion skin piercing |
ATE290822T1 (de) * | 1999-12-16 | 2005-04-15 | Alza Corp | Vorrichtung zur erhöhung des transdermalen flusses von probenwirkstoffen |
US6375627B1 (en) * | 2000-03-02 | 2002-04-23 | Agilent Technologies, Inc. | Physiological fluid extraction with rapid analysis |
US6558361B1 (en) * | 2000-03-09 | 2003-05-06 | Nanopass Ltd. | Systems and methods for the transport of fluids through a biological barrier and production techniques for such systems |
US6565532B1 (en) * | 2000-07-12 | 2003-05-20 | The Procter & Gamble Company | Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup |
JP4001311B2 (ja) * | 2000-06-01 | 2007-10-31 | 株式会社リコー | 液滴吐出ヘッド、インクジェット記録装置、マイクロアクチュエータ |
US6537242B1 (en) * | 2000-06-06 | 2003-03-25 | Becton, Dickinson And Company | Method and apparatus for enhancing penetration of a member for the intradermal sampling or administration of a substance |
US6494830B1 (en) | 2000-06-22 | 2002-12-17 | Guidance Interactive Technologies, Inc. | Handheld controller for monitoring/using medical parameters |
US6603987B2 (en) * | 2000-07-11 | 2003-08-05 | Bayer Corporation | Hollow microneedle patch |
US6440096B1 (en) * | 2000-07-14 | 2002-08-27 | Becton, Dickinson And Co. | Microdevice and method of manufacturing a microdevice |
AU2000261716A1 (en) * | 2000-07-25 | 2002-02-05 | Dickinson Legg Limited | Lamina separator |
AU2001293460A1 (en) * | 2000-10-05 | 2002-04-15 | Thomas Marsoner | Medical injection device |
US6821281B2 (en) * | 2000-10-16 | 2004-11-23 | The Procter & Gamble Company | Microstructures for treating and conditioning skin |
US6533884B1 (en) * | 2000-11-03 | 2003-03-18 | Printpack Illinois, Inc. | Method and system for extrusion embossing |
JP3525177B2 (ja) * | 2000-11-14 | 2004-05-10 | 関西ティー・エル・オー株式会社 | X線を用いた材料の加工方法 |
US6591133B1 (en) * | 2000-11-27 | 2003-07-08 | Microlin Llc | Apparatus and methods for fluid delivery using electroactive needles and implantable electrochemical delivery devices |
EP1345646A2 (de) * | 2000-12-14 | 2003-09-24 | Georgia Tech Research Corporation | Mikronadel-vorrichtungen und deren herstellung |
US6508947B2 (en) * | 2001-01-24 | 2003-01-21 | Xerox Corporation | Method for fabricating a micro-electro-mechanical fluid ejector |
EP1364396A4 (de) * | 2001-02-05 | 2005-08-31 | Becton Dickinson Co | Mikrovorsprungsarray und verfahren zur herstellung eines mikrovorsprungs |
US6663820B2 (en) * | 2001-03-14 | 2003-12-16 | The Procter & Gamble Company | Method of manufacturing microneedle structures using soft lithography and photolithography |
US6591124B2 (en) * | 2001-05-11 | 2003-07-08 | The Procter & Gamble Company | Portable interstitial fluid monitoring system |
US6767341B2 (en) * | 2001-06-13 | 2004-07-27 | Abbott Laboratories | Microneedles for minimally invasive drug delivery |
JP4011867B2 (ja) * | 2001-07-09 | 2007-11-21 | 本田技研工業株式会社 | 燃料電池用セパレータの製造方法 |
JP5055672B2 (ja) * | 2001-07-31 | 2012-10-24 | 大日本印刷株式会社 | 薄膜パターン形成用スタンプ |
JP4919446B2 (ja) * | 2001-08-09 | 2012-04-18 | 学校法人東京電機大学 | 微細溝加工方法及びその装置 |
US6881203B2 (en) * | 2001-09-05 | 2005-04-19 | 3M Innovative Properties Company | Microneedle arrays and methods of manufacturing the same |
US8361037B2 (en) * | 2001-09-19 | 2013-01-29 | Valeritas, Inc. | Microneedles, microneedle arrays, and systems and methods relating to same |
US20030093028A1 (en) * | 2001-11-09 | 2003-05-15 | Michael Spiegel | Appararus and method for magnetic induction of therapeutic electric fields |
US6780171B2 (en) * | 2002-04-02 | 2004-08-24 | Becton, Dickinson And Company | Intradermal delivery device |
AR040819A1 (es) * | 2002-08-08 | 2005-04-20 | Alza Corp | Dispositivo de administracion transdermica de vacuna que tiene microproyecciones revestidas |
EP1531896B1 (de) * | 2002-08-29 | 2016-07-20 | Becton Dickinson and Company | Microprojektionanordung zur verabreichung von stoffen in gewebe und verfahren zur verwendung |
-
2003
- 2003-02-24 US US10/373,251 patent/US7578954B2/en not_active Expired - Lifetime
-
2004
- 2004-02-24 DE DE602004022260T patent/DE602004022260D1/de not_active Expired - Lifetime
- 2004-02-24 WO PCT/US2004/005382 patent/WO2004076339A2/en active Application Filing
- 2004-02-24 AU AU2004215417A patent/AU2004215417A1/en not_active Abandoned
- 2004-02-24 JP JP2006503829A patent/JP4787738B2/ja not_active Expired - Fee Related
- 2004-02-24 CA CA2517988A patent/CA2517988C/en not_active Expired - Lifetime
- 2004-02-24 AT AT04714107T patent/ATE437841T1/de not_active IP Right Cessation
- 2004-02-24 EP EP04714107A patent/EP1599410B1/de not_active Expired - Lifetime
-
2009
- 2009-12-17 AU AU2009250998A patent/AU2009250998B2/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
WO2004076339A3 (en) | 2005-01-13 |
EP1599410A2 (de) | 2005-11-30 |
JP2006518675A (ja) | 2006-08-17 |
AU2004215417A1 (en) | 2004-09-10 |
CA2517988A1 (en) | 2004-09-10 |
US20040164454A1 (en) | 2004-08-26 |
AU2009250998B2 (en) | 2012-03-15 |
WO2004076339A2 (en) | 2004-09-10 |
AU2009250998A1 (en) | 2010-01-14 |
DE602004022260D1 (de) | 2009-09-10 |
JP4787738B2 (ja) | 2011-10-05 |
CA2517988C (en) | 2013-07-30 |
US7578954B2 (en) | 2009-08-25 |
EP1599410B1 (de) | 2009-07-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE437841T1 (de) | Verfahren zur herstellung von mikrostrukturen mit mehreren mikroelementen mit durchgangslöchern | |
DE602004009813D1 (de) | Klebfähige erzeugnisse mit nanopartikulärem grundiermittel sowie verfahren zu deren herstellung | |
ES2169094T3 (es) | Pelicula orientada de polimero termoplastico con cuerpos huecos en forma de particulas, proceso para su produccion y su utilizacion. | |
WO2002098657A3 (en) | Multilayer polymeric article with intercrosslinked polymer layers and method of making same | |
DE60218347D1 (de) | Mesoporöse permeationsschichten zur verwendung an elektronischen aktivmatrixbauelementen | |
KR970701524A (ko) | 거시적으로 팽창된, 3차원의 천공된 적층 웹 및 그의 제조 방법(three-dimensional, macroscopically expanded, apertured laminate webs and method for making) | |
WO2002064193A3 (en) | Microneedle devices and production thereof | |
WO2004110717A3 (en) | Method for manufacturing perforated microstructures by using fluidic jets | |
ATE303606T1 (de) | Microreliefelement und seine herstellung | |
DE69009052D1 (de) | Absorbierende körper sowie deren vorstufen. | |
DE60214226D1 (de) | Verfahren zur herstellung von folienstrukturen | |
AR043326A1 (es) | Metodos y sistemas para producir un objeto a traves de una fabricacion de formas libres solidas | |
ATE456587T1 (de) | Herstellung von polymeren | |
EP1106617A3 (de) | Alkylspiroboratsalze zur Anwendung in elektrochemischen Zellen | |
ATE493246T1 (de) | Verfahren zur herstellung von farbigen osb- platten | |
DE60122479D1 (de) | Poröses oder nicht-poröses substrat, beschichtet mit einem hydrophile funktionelle gruppen aufweisenden polymer sowie verfahren zu dessen herstellung | |
PL374803A1 (en) | Belt and method of marking | |
NO20060533L (no) | Langpressnippbelte laget av harpiksimpregnert termoplastikk | |
JP2005305945A5 (de) | ||
DE60106973D1 (de) | Verfahren und vorrichtung zur herstellung eines schichtelementes | |
US8845911B2 (en) | Method for production of a microstructured molded object | |
DE60114429D1 (de) | Verfahren zur herstellung von verbundwerkstoff mit geschäumter schicht und oberflächenschicht | |
DE3670044D1 (de) | Verfahren und vorrichtung zur herstellung einer hohlkammerplatte aus kunststoff. | |
ATE334820T1 (de) | Verfahren zum herstellen einer verbundfolie | |
US20200376817A1 (en) | Multilayer composite, method for the production thereof and its use |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |